{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:52:56Z","timestamp":1791910376456,"version":"4.3.4"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274134"],"award-info":[{"award-number":["82274134"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1702200"],"award-info":[{"award-number":["2017YFC1702200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1702202"],"award-info":[{"award-number":["2017YFC1702202"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2025C02183"],"award-info":[{"award-number":["2025C02183"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024C03104"],"award-info":[{"award-number":["2024C03104"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024C03104,2025C02183"],"award-info":[{"award-number":["2024C03104,2025C02183"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jep.2025.120247","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T20:36:22Z","timestamp":1751661382000},"page":"120247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Shoutai Pill synergistically inhibits internal reproductive organ apoptosis: coordinated EGFR\/PI3K\/AKT modulation in primary ovarian insufficiency"],"prefix":"10.1016","volume":"352","author":[{"given":"Yi-Piao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Mei","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Liang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Long","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Feng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Yuan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jep.2025.120247_bib1","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1038\/s41467-021-21644-z","article-title":"Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation","volume":"12","author":"Abbassi","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jep.2025.120247_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-12451-y","article-title":"MiR-449a regulates caprine endometrial stromal cell apoptosis and endometrial receptivity","volume":"7","author":"An","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.jep.2025.120247_bib3","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/jcp.30613","article-title":"Role of autophagy in follicular development and maintenance of primordial follicular pool in the ovary","volume":"237","author":"Bhardwaj","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.jep.2025.120247_bib4","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s10020-024-01022-3","article-title":"Bioinformatics based exploration of the anti-NAFLD mechanism of Wang's empirical formula via TLR4\/NF-\u03baB\/COX2 pathway","volume":"30","author":"Chen","year":"2024","journal-title":"Mol. Med."},{"issue":"1","key":"10.1016\/j.jep.2025.120247_bib5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12929-024-01017-6","article-title":"A matter of new life and cell death: programmed cell death in the Mammalian ovary","volume":"31","author":"Chesnokov","year":"2024","journal-title":"J. Biomed. Sci."},{"issue":"1","key":"10.1016\/j.jep.2025.120247_bib6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13287-023-03333-4","article-title":"Comparison of the different animal modeling and therapy methods of premature ovarian failure in animal model","volume":"14","author":"Dai","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jep.2025.120247_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117782","article-title":"Zishen yutai pills restore fertility in premature ovarian failure through regulating arachidonic acid metabolism and the ATK pathway","volume":"324","author":"Dang","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"9744","key":"10.1016\/j.jep.2025.120247_bib8","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0140-6736(10)60355-8","article-title":"Primary ovarian insufficiency","volume":"376","author":"De Vos","year":"2010","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jep.2025.120247_bib9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41592-019-0638-x","article-title":"DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput","volume":"17","author":"Demichev","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jep.2025.120247_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155816","article-title":"Beneficial effects of Dendrobium officinale national herbal drink on metabolic immune crosstalk via regulate SCFAs-Th17\/Treg","volume":"132","author":"Dong","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120247_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155468","article-title":"The mechanism of curcumin to protect mouse ovaries from oxidative damage by regulating AMPK\/mTOR mediated autophagy","volume":"128","author":"Duan","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2025.120247_bib12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41419-021-04374-4","article-title":"CPEB3 deficiency in mice affect ovarian follicle development and causes premature ovarian insufficiency","volume":"13","author":"E","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2025.120247_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1464803","article-title":"Primary ovarian insufficiency: update on clinical and genetic findings","volume":"15","author":"Federici","year":"2024","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.jep.2025.120247_bib14","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12958-024-01288-6","article-title":"Asiaticoside ameliorates uterine injury induced by zearalenone in mice by reversing endometrial barrier disruption, oxidative stress and apoptosis","volume":"22","author":"Gao","year":"2024","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"14","key":"10.1016\/j.jep.2025.120247_bib15","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202400211RR","article-title":"Ginkgetin improved experimental colitis by inhibiting intestinal epithelial cell apoptosis through EGFR\/PI3K\/AKT signaling","volume":"38","author":"Geng","year":"2024","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.jep.2025.120247_bib16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/13697137.2019.1574738","article-title":"The global prevalence of primary ovarian insufficiency and early menopause: a meta-analysis","volume":"22","author":"Golezar","year":"2019","journal-title":"Climacteric"},{"key":"10.1016\/j.jep.2025.120247_bib17","article-title":"Estrogen receptor \u03b2 mediates the feedback loop between 17\u03b2-Estradiol and CYP19A1, which controls transcriptomic stability, inhibits granulosa cell apoptosis, induces oocyte maturation and influences sow fertility","author":"Guo","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.jep.2025.120247_bib18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12951-025-03121-7","article-title":"Maternal exposure to fullerenols impairs placental development in mice by inhibiting estriol synthesis and reducing ER\u03b1","volume":"23","author":"He","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"3","key":"10.1016\/j.jep.2025.120247_bib19","doi-asserted-by":"crossref","first-page":"864","DOI":"10.7150\/ijbs.89795","article-title":"Endometrial stem cells: orchestrating dynamic regeneration of endometrium and their implications in diverse endometrial disorders","volume":"20","author":"Hong","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jep.2025.120247_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116242","article-title":"Jinfeng pills ameliorate premature ovarian insufficiency induced by cyclophosphamide in rats and correlate to modulating IL-17A\/IL-6 axis and MEK\/ERK signals","volume":"307","author":"Hu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120247_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155630","article-title":"Bushen huoxue recipe ameliorates ovarian function via promoting BMSCs proliferation and homing to ovaries in POI mice","volume":"129","author":"Huang","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2025.120247_bib22","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s00210-024-03293-3","article-title":"Revitalizing premature ovarian failure: quercetin counteracts imatinib-induced apoptosis via the PI3K\/AKT signaling pathway based on network pharmacology","volume":"398","author":"Ji","year":"2025","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.jep.2025.120247_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1237686","article-title":"Therapeutic role of wuda granule in gastrointestinal motility disorder through promoting gastrointestinal motility and decreasing inflammatory level","volume":"14","author":"Jiang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120247_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.116054","article-title":"Potential therapeutic drug targets and pathways prediction for premature ovarian insufficiency \u2014based on network pharmacologic method","volume":"304","author":"Ju","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120247_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.855992","article-title":"The evaluation of ovarian function recovery following treatment of primary ovarian insufficiency: a systematic review","volume":"13","author":"Kuang","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"12","key":"10.1016\/j.jep.2025.120247_bib26","doi-asserted-by":"crossref","first-page":"5524","DOI":"10.1039\/D0FO02890H","article-title":"Beneficial effects of Dendrobium officinale on metabolic hypertensive rats by triggering the enteric-origin SCFA-GPCR43\/41 pathway","volume":"12","author":"Li","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2025.120247_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119345","article-title":"Preventive vs. therapeutic effects of shoutai wan: maintaining an acidic microenvironment at the maternal-fetal interface to promote angiogenesis and minimize pregnancy loss in RSA mice","volume":"342","author":"Li","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120247_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114387","article-title":"Research progress on pharmacokinetics, anti-inflammatory and immunomodulatory effects of kaempferol","volume":"152","author":"Li","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120247_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.70026","article-title":"Melatonin alleviates circadian rhythm disruption-induced enhanced luteinizing hormone pulse frequency and ovarian dysfunction","volume":"77","author":"Li","year":"2025","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.jep.2025.120247_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117756","article-title":"Study on the effects and mechanisms of wenzhong bushen formula in improving ovarian reserve decline in mice based on network pharmacology","volume":"324","author":"Liang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120247_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.608703","article-title":"Clinical practice guideline for tripterygium glycosides\/tripterygium wilfordii tablets in the treatment of rheumatoid arthritis","volume":"11","author":"Lin","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120247_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.116046","article-title":"Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells","volume":"304","author":"Liu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120247_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113789","article-title":"Zihuai recipe alleviates cyclophosphamide-induced diminished ovarian reserve via suppressing PI3K\/AKT-mediated apoptosis","volume":"277","author":"Liu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120247_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115842","article-title":"Network and experimental pharmacology on mechanism of si-wu-tang improving ovarian function in a mouse model of premature ovarian failure induced by cyclophosphamide","volume":"301","author":"Liu","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"13","key":"10.1016\/j.jep.2025.120247_bib35","first-page":"1139","article-title":"LUO songping's experience in treating infertility due to decreased ovarian reserve function","volume":"61","author":"Lv","year":"2020","journal-title":"J. Tradit. Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2025.120247_bib36","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1262\/jrd.10-124H","article-title":"Expression and function of apoptosis initiator FOXO3 in granulosa cells during follicular atresia in pig ovaries","volume":"57","author":"Matsuda","year":"2011","journal-title":"J. Reprod. Dev."},{"issue":"5","key":"10.1016\/j.jep.2025.120247_bib37","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1210\/jcem.82.5.3941","article-title":"In vivo estrogen regulation of epidermal growth factor receptor in human endometrium","volume":"82","author":"Mcbean","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jep.2025.120247_bib38","series-title":"Clinical Diagnosis and Treatment Guidelines for Chinese Medicine Gynecology","author":"Medicine","year":"2019"},{"issue":"7","key":"10.1016\/j.jep.2025.120247_bib39","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1001\/jama.288.7.872","article-title":"Postmenopausal hormone replacement therapy: scientific review","volume":"288","author":"Nelson","year":"2002","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.jep.2025.120247_bib40","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1056\/NEJMcp0808697","article-title":"Clinical practice. Primary ovarian insufficiency","volume":"360","author":"Nelson","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2025.120247_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116399","article-title":"F-53B mediated ROS affects uterine development in rats during puberty by inducing apoptosis","volume":"277","author":"Nie","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jep.2025.120247_bib42","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.freeradbiomed.2025.03.007","article-title":"Trimethylamine N-oxide (TMAO) treatment triggers premature ovarian insufficiency (POI) via the activation of mitochondrial pathway apoptosis in granulosa cells","volume":"232","author":"Peng","year":"2025","journal-title":"Free Radic. Biol. Med."},{"issue":"9","key":"10.1016\/j.jep.2025.120247_bib43","doi-asserted-by":"crossref","first-page":"8210","DOI":"10.3390\/ijms24098210","article-title":"Red ginseng improves D-galactose-Induced premature ovarian failure in mice based on network pharmacology","volume":"24","author":"Shang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.jep.2025.120247_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2019.101323","article-title":"Insights into the autoimmune aspect of premature ovarian insufficiency","volume":"33","author":"Sharif","year":"2019","journal-title":"Best Pract. Res. Clin. Endocrinol. Metabol."},{"issue":"8","key":"10.1016\/j.jep.2025.120247_bib45","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.3390\/antiox12081601","article-title":"The role of lifestyle and dietary factors in the development of premature ovarian insufficiency","volume":"12","author":"Shelling","year":"2023","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.jep.2025.120247_bib46","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/ptr.8066","article-title":"Luteolin, a flavone ingredient: anticancer mechanisms, combined medication strategy, pharmacokinetics, clinical trials, and pharmaceutical researches","volume":"38","author":"Shi","year":"2024","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2025.120247_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116703","article-title":"Dingkun pill modulate ovarian function in chemotherapy-induced premature ovarian insufficiency mice by regulating PTEN\/PI3K\/AKT\/FOXO3a signaling pathway","volume":"315","author":"Su","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.jep.2025.120247_bib48","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/j.fertnstert.2016.09.046","article-title":"Hormone replacement therapy in young women with primary ovarian insufficiency and early menopause","volume":"106","author":"Sullivan","year":"2016","journal-title":"Fertil. Steril."},{"issue":"13","key":"10.1016\/j.jep.2025.120247_bib49","first-page":"1883","article-title":"Shoutai pills regulate female reproductive system: discussion based on the theory of essence and blood from the same source","volume":"18","author":"Sun","year":"2023","journal-title":"World Chin. Med."},{"issue":"12","key":"10.1016\/j.jep.2025.120247_bib50","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s12272-022-01417-y","article-title":"Effects of phytoestrogens on reproductive organ health","volume":"45","author":"Swathi Krishna","year":"2022","journal-title":"Arch Pharm. Res. (Seoul)"},{"issue":"5","key":"10.1016\/j.jep.2025.120247_bib51","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.3390\/ijms22052594","article-title":"Autoimmune diseases in patients with premature ovarian insufficiency\u2014our current state of knowledge","volume":"22","author":"Szeliga","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.jep.2025.120247_bib52","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41419-023-05759-3","article-title":"FHL2 deficiency impairs follicular development and fertility by attenuating EGF\/EGFR\/YAP signaling in ovarian granulosa cells","volume":"14","author":"Wang","year":"2023","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.jep.2025.120247_bib53","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nmeth.1322","article-title":"Universal sample preparation method for proteome analysis","volume":"6","author":"Wi\u015bniewski","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jep.2025.120247_bib54","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13020-017-0131-3","article-title":"Effects of bushen tianjing recipe in a rat model of tripterygium glycoside-induced premature ovarian failure","volume":"12","author":"Xu","year":"2017","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2025.120247_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155920","article-title":"Bu-shen-ning-xin decoction ameliorates premature ovarian insufficiency by suppressing oxidative stress through rno_circRNA_012284\/rno_miR-760-3p\/HBEGF pathway","volume":"133","author":"Xu","year":"2024","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.jep.2025.120247_bib56","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20203955","article-title":"Exploring the mechanism of (-)-Epicatechin on premature ovarian insufficiency based on network pharmacology and experimental evaluation","volume":"41","author":"Yan","year":"2021","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.jep.2025.120247_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.617843","article-title":"The role of oxidative stress and natural antioxidants in ovarian aging","volume":"11","author":"Yang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120247_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.153975","article-title":"Zuogui pills maintain the stemness of oogonial stem cells and alleviate cyclophosphamide-induced ovarian aging through notch signaling pathway","volume":"99","author":"Zeng","year":"2022","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2025.120247_bib59","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12958-021-00787-0","article-title":"Down-regulation of S100P induces apoptosis in endometrial epithelial cell during GnRH antagonist protocol","volume":"19","author":"Zhang","year":"2021","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.jep.2025.120247_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116502","article-title":"Shoutai wan regulates glycolysis imbalance at the maternal-fetal interface in threatened abortion mice","volume":"312","author":"Zhang","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120247_bib61","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s13577-022-00829-8","article-title":"Repeated controlled ovarian stimulation-induced ovarian and uterine damage in mice through the PI3K\/AKT signaling pathway","volume":"36","author":"Zhang","year":"2023","journal-title":"Hum. Cell"},{"key":"10.1016\/j.jep.2025.120247_bib62","article-title":"Mechanisms of primordial follicle activation and new pregnancy opportunity for premature ovarian failure patients","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jep.2025.120247_bib63","doi-asserted-by":"crossref","first-page":"7647","DOI":"10.1038\/srep07647","article-title":"Hyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression","volume":"5","author":"Zhao","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2025.120247_bib64","doi-asserted-by":"crossref","first-page":"887","DOI":"10.2147\/DDDT.S402503","article-title":"Network pharmacology and experimental validation to explore that celastrol targeting PTEN is the potential mechanism of Tripterygium wilfordii (l\u00e9v.) hutch against IgA nephropathy","volume":"17","author":"Zhao","year":"2023","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.jep.2025.120247_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114536","article-title":"FGFR3 phosphorylates EGFR to promote cisplatin-resistance in ovarian cancer","volume":"190","author":"Zhao","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2025.120247_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2024.106033","article-title":"Protective effect of functional food containing Dendrobium officinale via mediation of the FSHR\/PI3K\/AKT signaling pathway on menopausal syndrome in rats","volume":"113","author":"Zheng","year":"2024","journal-title":"J. Funct.Foods"},{"issue":"1","key":"10.1016\/j.jep.2025.120247_bib67","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13048-022-01085-y","article-title":"Plasma metabolomic characterization of premature ovarian insufficiency","volume":"16","author":"Zhou","year":"2023","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.jep.2025.120247_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154974","article-title":"Cuyun recipe ameliorates pregnancy loss by regulating macrophage polarization and hypercoagulable state during the peri-implantation period in an ovarian hyperstimulation mouse model","volume":"119","author":"Zhu","year":"2023","journal-title":"Phytomedicine"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125009377?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125009377?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:21:05Z","timestamp":1778631665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125009377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":68,"alternative-id":["S0378874125009377"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120247","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shoutai Pill synergistically inhibits internal reproductive organ apoptosis: coordinated EGFR\/PI3K\/AKT modulation in primary ovarian insufficiency","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120247","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"120247"}}