{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:51:51Z","timestamp":1792623111697,"version":"4.5.0"},"reference-count":174,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["2022LYJSZX15"],"award-info":[{"award-number":["2022LYJSZX15"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["ZYYCXTD-D-202001"],"award-info":[{"award-number":["ZYYCXTD-D-202001"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014985","name":"European Society of Radiology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014985","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018597","name":"Ministry of Education of the People's Republic of China Cultivation Fund of the Key Scientific and Technical Innovation Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018597","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jep.2025.120272","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T19:40:59Z","timestamp":1751917259000},"page":"120272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"PA","title":["Dioscorea nipponica Makino: Unraveling multi-target mechanisms and clinical potential in autoimmune disease therapy"],"prefix":"10.1016","volume":"353","author":[{"given":"Ling","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinli","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aru","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumeng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"34","key":"10.1016\/j.jep.2025.120272_bib1","doi-asserted-by":"crossref","first-page":"15105","DOI":"10.1073\/pnas.1005419107","article-title":"T-Cell receptor complex is essential for fas signal transduction","volume":"107","author":"Akimzhanov","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.jep.2025.120272_bib2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s00392-023-02291-4","article-title":"Cardiovascular events risk in patients with systemic autoimmune diseas es: a prognostic systematic review and meta-analysis","volume":"113","author":"Asenjo-Lobos","year":"2024","journal-title":"Clin. Res. Cardiol."},{"issue":"4 Pt 2","key":"10.1016\/j.jep.2025.120272_bib176","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/j.lpm.2014.02.007","article-title":"Autoimmune neutropenia","volume":"43","author":"Autrel-Moignet","year":"2014","journal-title":"Presse Med"},{"issue":"17","key":"10.1016\/j.jep.2025.120272_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23179923","article-title":"Dioscorea nipponica makino rhizome extract and its active compound dioscin protect against neuroinflammation and scopolamine-induced memory deficits","volume":"23","author":"Azam","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.jep.2025.120272_bib4","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/ni.2072","article-title":"NF-\u039aB is 25","volume":"12","author":"Baltimore","year":"2011","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.jep.2025.120272_bib5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jsps.2021.01.005","article-title":"Calming the inflammatory storm in severe COVID-19 infections: role of Biologics- A narrative review","volume":"29","author":"Banji","year":"2021","journal-title":"Saudi Pharm. J."},{"issue":"12","key":"10.1016\/j.jep.2025.120272_bib6","first-page":"1637","article-title":"Mechanism study on the inhibition of Dioscorea nipponica makino saponin to the aplastic anemia P-MtoR\/P-S6","volume":"20","author":"Bao-Shan","year":"2014","journal-title":"Journal Of Basic Chinese Medicine"},{"issue":"12","key":"10.1016\/j.jep.2025.120272_bib7","first-page":"4441","article-title":"Study on dioscorea saponin regulating immune Co-Stimulatory molecule in aplastic anemia","volume":"30","author":"Bao-Shan","year":"2015","journal-title":"China Journal Of Traditional Chinese Medicine And Pharmacy"},{"issue":"6","key":"10.1016\/j.jep.2025.120272_bib8","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nrrheum.2011.59","article-title":"Role of GILZ in immune regulation, glucocorticoid actions and rheumatoid arthritis","volume":"7","author":"Beaulieu","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"issue":"10","key":"10.1016\/j.jep.2025.120272_bib9","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/sj.cdd.4400914","article-title":"Inhibition of histone deacetylase activity enhances fas receptor-mediated apoptosis in leukemic lymphoblasts","volume":"8","author":"Bernhard","year":"2001","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jep.2025.120272_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114147","article-title":"Non-steroidal anti-inflammatory drugs (nsaids) and organ damage: a current perspective","volume":"180","author":"Bindu","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.120272_bib11","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.jaip.2016.12.006","article-title":"Adverse and hypersensitivity reactions to prescription nonsteroidal anti-inflammatory agents in A large health care system","volume":"5","author":"Blumenthal","year":"2017","journal-title":"J. Allergy Clin. Immunol. Pract."},{"issue":"8657","key":"10.1016\/j.jep.2025.120272_bib12","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0140-6736(89)90430-3","article-title":"Inhibitory effect of TNF alpha antibodies on synovial cell Interleukin-1 production in rheumatoid arthritis","volume":"2","author":"Brennan","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2025.120272_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106511","article-title":"Glucocorticoids and COVID-19","volume":"185","author":"Bruscoli","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"367","key":"10.1016\/j.jep.2025.120272_bib14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1095-8339.1960.tb02508.x","article-title":"The organography and the evolution of dioscoreaceae, the family of the yams","volume":"56","author":"Burkill","year":"1960","journal-title":"J. Linn. Soc. Lond. Bot."},{"issue":"1","key":"10.1016\/j.jep.2025.120272_bib15","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/aps.2013.133","article-title":"Diosgenin relieves goiter via the inhibition of thyrocyte proliferation in A mouse model of graves' disease","volume":"35","author":"Cai","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"issue":"4","key":"10.1016\/j.jep.2025.120272_bib16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nri.2017.1","article-title":"Immune regulation by glucocorticoids","volume":"17","author":"Cain","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.jep.2025.120272_bib17","first-page":"1103","article-title":"Influence of rhizoma dioscoreae nipponicae on expression of Th1\/Th2 cytokines in patients with hashimoto's thyroiditis China","volume":"31","author":"Cao","year":"2016","journal-title":"Journal Of Traditional Chinese Medicine And Pharmacy"},{"issue":"8","key":"10.1016\/j.jep.2025.120272_bib18","first-page":"126","article-title":"The influence of Dioscorea nipponica makino on the expression of Th17 and treg cells and related factors in peripheral blood mononuclear cells of patients with hashimoto\u2019s thyroiditis","volume":"34","author":"Cao","year":"2016","journal-title":"Journal Of Sichuan Of Traditional Chinese"},{"issue":"2","key":"10.1016\/j.jep.2025.120272_bib19","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1142\/S0192415X19500216","article-title":"Dioscin, A steroidal saponin isolated from Dioscorea nipponica, attenuates collagen-induced arthritis by inhibiting Th17 cell response","volume":"47","author":"Cao","year":"2019","journal-title":"Am. J. Chin. Med."},{"issue":"10","key":"10.1016\/j.jep.2025.120272_bib20","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nrrheum.2016.137","article-title":"The global burden of SLE: prevalence, health disparities and socioeconomic impact","volume":"12","author":"Carter","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"issue":"3","key":"10.1016\/j.jep.2025.120272_bib21","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.4049\/jimmunol.163.3.1521","article-title":"Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following Anti-TNF-Alpha therapy in rheumatoid arthritis","volume":"163","author":"Charles","year":"1999","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.jep.2025.120272_bib22","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/rheumatology\/key339","article-title":"Clinical significance of janus kinase inhibitor selectivity","volume":"58","author":"Choy","year":"2019","journal-title":"Rheumatology"},{"issue":"10","key":"10.1016\/j.jep.2025.120272_bib23","first-page":"1464","article-title":"Experimental study on the therapeutic effect of dioscin on collagen-induced arthritis in rats","volume":"28","author":"Chu","year":"2012","journal-title":"Chin. Pharmacol. Bull."},{"issue":"1","key":"10.1016\/j.jep.2025.120272_bib24","first-page":"5","article-title":"The immunomodulatory effect of dioscin on rats with collagen-induced arthritis","volume":"17","author":"Chu","year":"2013","journal-title":"Journal Of Clinical Medicine In Practice"},{"issue":"3","key":"10.1016\/j.jep.2025.120272_bib25","first-page":"341","article-title":"The inhibitory effect of dioscin on Cyclooxygenase-2 and NF-\u039aB in A rat model of collagen-induced arthritis","volume":"27","author":"Chu","year":"2013","journal-title":"Chin. Pharmacol. Bull."},{"issue":"36","key":"10.1016\/j.jep.2025.120272_bib26","first-page":"4196","article-title":"Influence of total saponin from rhizoma dioscoreae nipponicae on TNF-\u03b1 in serum and synovial tissues in collagen-induced arthritis rats","volume":"15","author":"Chun","year":"2012","journal-title":"Chinese General Practice"},{"key":"10.1016\/j.jep.2025.120272_bib27","series-title":"Pharmacopoeia of the People's Republic of China (Part IV; 2015 Edition) English Version","year":"2017"},{"key":"10.1016\/j.jep.2025.120272_bib28","series-title":"Chinese Pharmacopoeia","year":"2020"},{"issue":"10391","key":"10.1016\/j.jep.2025.120272_bib29","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1016\/S0140-6736(23)00457-9","article-title":"Incidence, prevalence, and Co-Occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: a population-based cohort study of 22 million individuals in the UK","volume":"401","author":"Conrad","year":"2023","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.jep.2025.120272_bib30","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nri2800","article-title":"Innate IL-17-Producing cells: the sentinels of the immune system","volume":"10","author":"Cua","year":"2010","journal-title":"Nat. Rev. Immunol."},{"issue":"16","key":"10.1016\/j.jep.2025.120272_bib31","doi-asserted-by":"crossref","first-page":"9217","DOI":"10.1111\/jcmm.15563","article-title":"Dioscin elicits anti-tumour immunity by inhibiting macrophage M2 polarization via JNK and STAT3 pathways in lung cancer","volume":"24","author":"Cui","year":"2020","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.jep.2025.120272_bib32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm3722","article-title":"Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy","volume":"15","author":"Czabotar","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"645","key":"10.1016\/j.jep.2025.120272_bib33","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3399\/bjgp16X684433","article-title":"The dangers of nsaids: look both ways","volume":"66","author":"Davis","year":"2016","journal-title":"Br. J. Gen. Pract."},{"issue":"9","key":"10.1016\/j.jep.2025.120272_bib34","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1002\/1529-0131(200009)43:9<2056::AID-ANR17>3.0.CO;2-2","article-title":"Suppression of arthritis and protection from bone destruction by treatment with TNP-470\/AGM-1470 in A transgenic mouse model of rheumatoid arthritis","volume":"43","author":"De Bandt","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jep.2025.120272_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101482","article-title":"Sex differences in inflammation, redox biology, mitochondria and autoimmunity","volume":"31","author":"Di Florio","year":"2020","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.jep.2025.120272_bib36","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1002\/jcp.29197","article-title":"Dioscin inhibits the growth of human osteosarcoma by inducing G2\/M-Phase arrest, apoptosis, and GSDME-dependent cell death in vitro and in vivo","volume":"235","author":"Ding","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.jep.2025.120272_bib37","first-page":"907","article-title":"Patterns in use and costs of conventional and biologic disease-modifying anti-rheumatic drugs in Australia","volume":"35","author":"Donges","year":"2017","journal-title":"Clin. Exp. Rheumatol."},{"issue":"6","key":"10.1016\/j.jep.2025.120272_bib38","first-page":"1396","article-title":"Inhibition effect of water-solubility nipponica saponin on NF-KB pathway of rheumatoid cellular model","volume":"16","author":"Duan","year":"2014","journal-title":"Modernization Of Traditional Chinese Medicine And Materia Medica-World Science And Technology"},{"issue":"7","key":"10.1016\/j.jep.2025.120272_bib39","first-page":"1625","article-title":"The influence of dioscin tablets on the expression of nuclear transcription Factor-\u039aB P65 in RSC-364 cells","volume":"16","author":"Duan","year":"2014","journal-title":"Modernization Of Traditional Chinese Medicine And Materia Medica-World Science And Technology"},{"issue":"1","key":"10.1016\/j.jep.2025.120272_bib40","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bbrc.2017.06.190","article-title":"BCL-2 proteins and apoptosis: recent insights and unknowns","volume":"500","author":"Edlich","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.jep.2025.120272_bib41","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.canlet.2012.08.018","article-title":"Angiopoietins in angiogenesis","volume":"328","author":"Fagiani","year":"2013","journal-title":"Cancer Lett."},{"issue":"D1","key":"10.1016\/j.jep.2025.120272_bib42","doi-asserted-by":"crossref","first-page":"D1197","DOI":"10.1093\/nar\/gkaa1063","article-title":"HERB: a high-throughput Experiment- and reference-guided database of traditional Chinese medicine","volume":"49","author":"Fang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2025.120272_bib43","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev.immunol.19.1.163","article-title":"Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?","volume":"19","author":"Feldmann","year":"2001","journal-title":"Annu. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.jep.2025.120272_bib44","first-page":"1077","article-title":"The influence of dioscin on ROR\u0393T and Foxp3 in A collagen-induced arthritis mouse model","volume":"31","author":"Feng","year":"2015","journal-title":"Immunological Journal"},{"issue":"16","key":"10.1016\/j.jep.2025.120272_bib45","first-page":"42","article-title":"Effect of chuanshanlong granule on TLR4\/Myd88\/NF-\u039aB signaling pathway in rats with autoimmune thyroiditis","volume":"28","author":"Fengying","year":"2022","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"6","key":"10.1016\/j.jep.2025.120272_bib46","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nm0603-669","article-title":"The biology of VEGF and its receptors","volume":"9","author":"Ferrara","year":"2003","journal-title":"Nat. Med."},{"issue":"9","key":"10.1016\/j.jep.2025.120272_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/biom11091325","article-title":"Tailored functionalization of natural phenols to improve biological activity","volume":"11","author":"Floris","year":"2021","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.jep.2025.120272_bib48","first-page":"468","article-title":"Reconstruction of Chinese materia medica\u2014\u2014japanese yam rhizome","volume":"43","author":"Geng","year":"2023","journal-title":"Jilin Journal Of Chinese Medicine"},{"issue":"1","key":"10.1016\/j.jep.2025.120272_bib49","first-page":"1","article-title":"State-target strategy: a bridge for the integration of Chinese and Western medicine","volume":"41","author":"Gou","year":"2021","journal-title":"Journal Of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan"},{"issue":"9583","key":"10.1016\/j.jep.2025.120272_bib50","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0140-6736(07)61128-3","article-title":"Pathogenesis and clinical features of psoriasis","volume":"370","author":"Griffiths","year":"2007","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.jep.2025.120272_bib51","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jcma.2015.10.012","article-title":"Effects of total saponins from rhizoma dioscoreae nipponicae on expression of vascular endothelial growth factor and Angiopoietin-2 and Tie-2 receptors in the synovium of rats with rheumatoid arthritis","volume":"79","author":"Guo","year":"2016","journal-title":"J. Chin. Med. Assoc."},{"issue":"1","key":"10.1016\/j.jep.2025.120272_bib52","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","article-title":"NF-\u039aB in biology and targeted therapy: new insights and translational implications","volume":"9","author":"Guo","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"11","key":"10.1016\/j.jep.2025.120272_bib53","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s11916-016-0591-7","article-title":"Nsaids in the treatment of postoperative pain","volume":"20","author":"Gupta","year":"2016","journal-title":"Curr. Pain Headache Rep."},{"issue":"4","key":"10.1016\/j.jep.2025.120272_bib54","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.semarthrit.2015.08.001","article-title":"The CD27-CD70 pathway and pathogenesis of autoimmune disease","volume":"45","author":"Han","year":"2016","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.jep.2025.120272_bib55","series-title":"Chinese Dioscoreaceae (Color Plate Edition in Chinese and English)","author":"Hang","year":"1994"},{"issue":"11","key":"10.1016\/j.jep.2025.120272_bib56","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17-Producing CD4+ effector T cells develop via A lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.jep.2025.120272_bib57","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","article-title":"Shared principles in NF-Kappab signaling","volume":"132","author":"Hayden","year":"2008","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.jep.2025.120272_bib58","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1021\/np900690z","article-title":"Diosgenin, A plant-derived sapogenin, enhances regulatory T-Cell immunity in the intestine of mice with food allergy","volume":"73","author":"Huang","year":"2010","journal-title":"J. Nat. Prod."},{"issue":"22","key":"10.1016\/j.jep.2025.120272_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24224022","article-title":"Development of an oriental medicine discrimination method through analysis of steroidal saponins in Dioscorea nipponica makino and their anti-osteosarcoma effects","volume":"24","author":"Hwang","year":"2019","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.jep.2025.120272_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052719","article-title":"The role of tumor necrosis factor alpha (TNF-\u0391) in autoimmune disease and current TNF-\u0391 inhibitors in therapeutics","volume":"22","author":"Jang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.120272_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123427","article-title":"Screening and identification of lipase inhibitors extracted from Dioscorea nipponica makino by UV-Vis and HPLC coupled to UPLC-Q-TOF-MS\/MS","volume":"230","author":"Jin","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"27","key":"10.1016\/j.jep.2025.120272_bib62","first-page":"2486","article-title":"A study of the impact of Dioscorea nipponica on the level of serum TSH,Tgab and TPO-Ab of hashimoto's thyroiditis patient","volume":"16","author":"Jun","year":"2013","journal-title":"Chinese General Practice"},{"key":"10.1016\/j.jep.2025.120272_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113798","article-title":"Dietary phytoestrogen diosgenin interrupts metabolism, physiology, and reproduction of Swiss albino mice: possible mode of action as an emerging environmental contaminant, endocrine disruptor and reproductive toxicant","volume":"176","author":"Khushboo","year":"2023","journal-title":"Food Chem. Toxicol."},{"issue":"22","key":"10.1016\/j.jep.2025.120272_bib64","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.260790","article-title":"Expanding roles of BCL-2 proteins in apoptosis execution and beyond","volume":"136","author":"King","year":"2023","journal-title":"J. Cell Sci."},{"issue":"11","key":"10.1016\/j.jep.2025.120272_bib65","doi-asserted-by":"crossref","first-page":"Itc81","DOI":"10.7326\/AITC202006020","article-title":"Systemic lupus erythematosus","volume":"172","author":"Kiriakidou","year":"2020","journal-title":"Ann. Intern. Med."},{"issue":"8","key":"10.1016\/j.jep.2025.120272_bib66","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s00415-017-8505-0","article-title":"Oral and intravenous steroids for multiple sclerosis relapse: a systematic review and meta-analysis","volume":"264","author":"Lattanzi","year":"2017","journal-title":"J. Neurol."},{"key":"10.1016\/j.jep.2025.120272_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106378","article-title":"The relationship between TIGIT(+) regulatory T cells and auto immune disease","volume":"83","author":"Lee","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2025.120272_bib68","first-page":"646","article-title":"Clinical effect of compound chuanshanlong granule in the treatment of rheumatoid arthritis","volume":"37","author":"Li","year":"2017","journal-title":"Journal Of Hunan University Of Chinese Medicine"},{"issue":"15","key":"10.1016\/j.jep.2025.120272_bib69","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1016\/j.bmcl.2017.03.095","article-title":"Phenanthrene And Isocoumarin From The Rhizomes Of Dioscorea Nipponica Makino Subsp. Rosthornii (Prain Et Burkill) C. T. Ting (Dioscoreaceae)","volume":"27","author":"Li","year":"2017","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"12","key":"10.1016\/j.jep.2025.120272_bib70","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1111\/jphp.12825","article-title":"Combination of cheminformatics and bioinformatics to explore the chemical basis of the rhizomes and aerial parts of Dioscorea nipponica makino","volume":"69","author":"Li","year":"2017","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2025.120272_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114018","article-title":"Dioscin and diosgenin: insights into their potential protective effects in cardiac diseases","volume":"274","author":"Li","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2025.120272_bib72","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.3892\/etm.2016.3586","article-title":"Anti-angiogenic effect of total saponins of rhizoma Dioscorea nipponica on collagen induced-arthritis in rats","volume":"12","author":"Liang","year":"2016","journal-title":"Exp. Ther. Med."},{"issue":"4","key":"10.1016\/j.jep.2025.120272_bib73","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040880","article-title":"Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis","volume":"9","author":"Lin","year":"2020","journal-title":"Cells"},{"issue":"23","key":"10.1016\/j.jep.2025.120272_bib74","first-page":"119","article-title":"Dioscorea nippouica","volume":"33","author":"Liu","year":"2024","journal-title":"Chin. J. Ethnomed. Ethnopharmacy"},{"key":"10.1016\/j.jep.2025.120272_bib75","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u039aB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.jep.2025.120272_bib76","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jneuroim.2017.10.018","article-title":"Therapeutic effects of diosgenin in experimental autoimmune encephalom yelitis","volume":"313","author":"Liu","year":"2017","journal-title":"J. Neuroimmunol."},{"issue":"13","key":"10.1016\/j.jep.2025.120272_bib78","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1080\/14786410903283457","article-title":"Dihydrophenanthrenes from the stems and leaves of Dioscorea nipponica makino","volume":"24","author":"Lu","year":"2010","journal-title":"Nat. Prod. Res."},{"issue":"1","key":"10.1016\/j.jep.2025.120272_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10286020903403626","article-title":"Phenanthrene derivatives from the stems and leaves of Dioscorea nipponica makino","volume":"12","author":"Lu","year":"2010","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"6","key":"10.1016\/j.jep.2025.120272_bib173","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0952-7915(01)00275-8","article-title":"Dendritic cells in autoimmune diseases","volume":"13","author":"Ludewig","year":"2001","journal-title":"Curr Opin Immunol"},{"issue":"4","key":"10.1016\/j.jep.2025.120272_bib80","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.carbpol.2007.06.023","article-title":"Identification of structure and antioxidant activity of A fraction of polysaccharide purified from Dioscorea nipponica makino","volume":"71","author":"Luo","year":"2008","journal-title":"Carbohydr. Polym."},{"issue":"3","key":"10.1016\/j.jep.2025.120272_bib81","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s12016-012-8332-0","article-title":"Traditional Chinese medicine and immune regulation","volume":"44","author":"Ma","year":"2013","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jep.2025.120272_bib82","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev-immunol-020711-074934","article-title":"Immune regulatory function of B cells","volume":"30","author":"Mauri","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jep.2025.120272_bib83","series-title":"Comprehensive Dictionary of Traditional Chinese Medicine","author":"Medicine","year":"2014"},{"key":"10.1016\/j.jep.2025.120272_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2022.102266","article-title":"The increasing prevalence of autoimmunity and autoimmune diseases: an urgent call to action for improved understanding, diagnosis, treatment, and prevention","volume":"80","author":"Miller","year":"2023","journal-title":"Curr. Opin. Immunol."},{"issue":"5","key":"10.1016\/j.jep.2025.120272_bib85","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1053\/jhep.2003.50204","article-title":"Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma","volume":"37","author":"Mitsuhashi","year":"2003","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.jep.2025.120272_bib174","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/nrrheum.2017.43","article-title":"Immunometabolism in systemic lupus erythematosus","volume":"13","author":"Morel","year":"2017","journal-title":"Nat Rev Rheumatol"},{"issue":"97","key":"10.1016\/j.jep.2025.120272_bib86","first-page":"200","article-title":"Autoimmune disease results from multiple interactive defects in apoptosis induction molecules and signaling pathways","author":"Mountz","year":"1996","journal-title":"Behring Inst. Mitt."},{"key":"10.1016\/j.jep.2025.120272_bib87","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1749-6632.2010.05749.x","article-title":"Apoptosis and autoimmune diseases","volume":"1209","author":"Nagata","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jep.2025.120272_bib88","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev-immunol-042617-053010","article-title":"Apoptosis and clearance of apoptotic cells","volume":"36","author":"Nagata","year":"2018","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2025.120272_bib89","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s000110050369","article-title":"Apoptosis and autoimmune disease","volume":"48","author":"O'Reilly","year":"1999","journal-title":"Inflamm. Res."},{"issue":"4","key":"10.1016\/j.jep.2025.120272_bib90","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.immuni.2012.03.014","article-title":"JAK and STAT signaling molecules in immunoregulation and immune-mediated disease","volume":"36","author":"O'Shea","year":"2012","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.jep.2025.120272_bib91","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13065-018-0423-4","article-title":"Dioscorea nipponica makino: a systematic review on its ethnobotany, phytochemical and pharmacological profiles","volume":"12","author":"Ou-Yang","year":"2018","journal-title":"Chem. Cent. J."},{"issue":"11","key":"10.1016\/j.jep.2025.120272_bib92","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1111\/all.15449","article-title":"Regulatory T cells and immunoglobulin E: a new therapeutic link for autoimmunity?","volume":"77","author":"Palomares","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.jep.2025.120272_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110036","article-title":"Autoimmune pathogenesis, immunosuppressive therapy and pharmacological mechanism in aplastic anemia","volume":"117","author":"Pan","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2025.120272_bib94","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5114\/reum.2017.69779","article-title":"Glucocorticoid management in rheumatoid arthritis: morning or night low dose?","volume":"55","author":"Paolino","year":"2017","journal-title":"Reumatologia"},{"key":"10.1016\/j.jep.2025.120272_bib95","volume":"vol. 16","author":"Pei","year":"1985"},{"issue":"8","key":"10.1016\/j.jep.2025.120272_bib96","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41581-023-00720-1","article-title":"Pathogenesis of autoimmune disease","volume":"19","author":"Pisetsky","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"issue":"23","key":"10.1016\/j.jep.2025.120272_bib97","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21239181","article-title":"NF-\u039aB and disease","volume":"21","author":"Poma","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.120272_bib98","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.3389\/fphar.2018.01170","article-title":"Di'ao xinxuekang capsule, A Chinese medicinal product, decreases serum lipids levels in high-fat diet-fed Apoe(-\/-) mice by downregulating PCSK9","volume":"9","author":"Qu","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"20","key":"10.1016\/j.jep.2025.120272_bib99","first-page":"3160","article-title":"International clinical practice guidelines for rheumatoid arthritis in traditional Chinese medicine (2019-10-11)","volume":"15","author":"Quan","year":"2020","journal-title":"World Chinese Medicine"},{"issue":"3","key":"10.1016\/j.jep.2025.120272_bib100","first-page":"251","article-title":"Current strategies for the treatment of autoimmune diseases","volume":"24","author":"Rosato","year":"2010","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.jep.2025.120272_bib101","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/nyas.12726","article-title":"Angiopoietin-2: a multifaceted cytokine that functions in both angioge nesis and inflammation","volume":"1347","author":"Scholz","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jep.2025.120272_bib102","series-title":"By the National Healthcare Security Administration and Ministry of Human Resources and Social Security","article-title":"Notice on the issuance of the \"National Medical Insurance, Work Injury Insurance, And Maternity Insurance Drug List (2022 Edition)\"","year":"2024"},{"key":"10.1016\/j.jep.2025.120272_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2020.112568","article-title":"Natural isocoumarins: structural styles and biological activities, the revelations carry on","volume":"181","author":"Shabir","year":"2021","journal-title":"Phytochemistry"},{"issue":"5","key":"10.1016\/j.jep.2025.120272_bib104","first-page":"126","article-title":"Effect of diosgenin on expressions of PPAR\u03b3,C\/EBP\u0391 and adipokine secretion in aplastic anemia mice","volume":"25","author":"Shan","year":"2019","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2025.120272_bib105","doi-asserted-by":"crossref","DOI":"10.1016\/j.coph.2022.102242","article-title":"Immune tolerance therapies for autoimmune diseases: shifting the goalpost to cure","volume":"65","author":"Sharkey","year":"2022","journal-title":"Curr. Opin. Pharmacol."},{"issue":"9","key":"10.1016\/j.jep.2025.120272_bib106","first-page":"1323","article-title":"The expermiental study on immunoregulatory effects of W hole saponin of rhizoma dioscreae nipponicae on AA rat","author":"Shou-Jun","year":"2007","journal-title":"Liaoning Journal Of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2025.120272_bib107","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jsbmb.2014.04.006","article-title":"Synthesis of diosgenin analogues as potential anti-inflammatory agents","volume":"143","author":"Singh","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"10055","key":"10.1016\/j.jep.2025.120272_bib108","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2025.120272_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172887","article-title":"Estrogenic and anti-inflammatory effects of pseudoprotodioscin in atherosclerosis-prone mice: insights into endothelial cells and perivascular adipose tissues","volume":"869","author":"Sun","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.jep.2025.120272_bib110","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3109\/08820139.2015.1137935","article-title":"Trillin reduces liver chronic inflammation and fibrosis in carbon tetrachloride (Ccl4) induced liver injury in mice","volume":"45","author":"Tan","year":"2016","journal-title":"Immunol. Investig."},{"key":"10.1016\/j.jep.2025.120272_bib111","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jep.2015.10.004","article-title":"Cardioprotective effect of total saponins from three medicinal species of dioscorea against isoprenaline-induced myocardial ischemia","volume":"175","author":"Tang","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120272_bib112","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.phrs.2016.05.003","article-title":"Dioscin reduces ovariectomy-induced bone loss by enhancing osteoblasto genesis and inhibiting osteoclastogenesis","volume":"108","author":"Tao","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2025.120272_bib113","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.3389\/fimmu.2019.01545","article-title":"A general introduction to glucocorticoid biology","volume":"10","author":"Timmermans","year":"2019","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.jep.2025.120272_bib114","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1172\/JCI200418975","article-title":"Enhancement of MEK\/ERK signaling promotes glucocorticoid resistance in CD4+ T cells","volume":"113","author":"Tsitoura","year":"2004","journal-title":"J. Clin. Investig."},{"issue":"25","key":"10.1016\/j.jep.2025.120272_bib115","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/newbio231232a0","article-title":"Inhibition of prostaglandin synthesis as A mechanism of action for aspirin-like drugs","volume":"231","author":"Vane","year":"1971","journal-title":"Nat. New Biol."},{"issue":"9","key":"10.1016\/j.jep.2025.120272_bib116","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41577-022-00693-5","article-title":"The link between circulating follicular helper T cells and autoimmunity","volume":"22","author":"Walker","year":"2022","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.jep.2025.120272_bib117","first-page":"16","article-title":"Medicinal plants used by the Tujia ethnic group in Hubei Province for traumatic injuries: an ethnobotanical study","author":"Wan","year":"1990","journal-title":"J. Chin. Med. Mater."},{"issue":"1","key":"10.1016\/j.jep.2025.120272_bib118","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jep.2011.11.001","article-title":"Trillin, A steroidal saponin isolated from the rhizomes of Dioscorea nipponica, exerts protective effects against hyperlipidemia and oxidative stress","volume":"139","author":"Wang","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2025.120272_bib119","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/joim.12395","article-title":"Human autoimmune diseases: a comprehensive update","volume":"278","author":"Wang","year":"2015","journal-title":"J. Intern. Med."},{"issue":"2","key":"10.1016\/j.jep.2025.120272_bib120","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1142\/S0192415X15500196","article-title":"Effects of the total saponins from Dioscorea nipponica on immunoregulation in aplastic anemia mice","volume":"43","author":"Wang","year":"2015","journal-title":"Am. J. Chin. Med."},{"issue":"3","key":"10.1016\/j.jep.2025.120272_bib121","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1007\/s10753-020-01389-5","article-title":"Diosgenin inhibits excessive proliferation and inflammatory response of synovial fibroblasts in rheumatoid arthritis by targeting PDE3B","volume":"44","author":"Wang","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2025.120272_bib122","article-title":"Dioscorea nipponica makino relieves ovalbumin-induced asthma in mice through regulating RKIP-mediated Raf-1\/MEK\/MAPK\/ERK signaling pathway","volume":"2022","author":"Wang","year":"2022","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jep.2025.120272_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154580","article-title":"Flavonoids and saponins: what have we got or missed?","volume":"109","author":"Wang","year":"2023","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.jep.2025.120272_bib124","first-page":"420","article-title":"HPLC-ELSD simultaneous determination of 3 components in di\u2019aoxinxuekang capsules","volume":"29","author":"Wei","year":"2009","journal-title":"Chinese Journal Of Pharmaceutical Analysis"},{"issue":"5","key":"10.1016\/j.jep.2025.120272_bib125","first-page":"589","article-title":"Professor TONG xiaolin used the experience of dioscoreae nipponicae","volume":"40","author":"Weiwei","year":"2020","journal-title":"Jilin Journal Of Chinese Medicine"},{"issue":"9","key":"10.1016\/j.jep.2025.120272_bib126","first-page":"986","article-title":"Effects of vascular endothelial growth factor and its receptor Flk-1 in synovium of CIA rats by the yam saponin","volume":"18","author":"Wen-Juan","year":"2012","journal-title":"Journal Of Basic Chinese Medicine"},{"issue":"2","key":"10.1016\/j.jep.2025.120272_bib127","first-page":"101","article-title":"Effects of total saponin of rhizoma dioscreae nipponicae on Vegf,Ang-2 and receptor Tie-2 in synovial tissue of cia rats","volume":"48","author":"Wen-Juan","year":"2013","journal-title":"Chin. Pharmaceut. J."},{"issue":"6","key":"10.1016\/j.jep.2025.120272_bib128","doi-asserted-by":"crossref","first-page":"655","DOI":"10.4187\/respcare.06314","article-title":"Clinical pharmacology of corticosteroids","volume":"63","author":"Williams","year":"2018","journal-title":"Respir. Care"},{"issue":"13","key":"10.1016\/j.jep.2025.120272_bib129","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1016\/j.bmcl.2013.04.073","article-title":"Anti-neuroinflammatory diarylheptanoids from the rhizomes of Dioscorea nipponica","volume":"23","author":"Woo","year":"2013","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"11","key":"10.1016\/j.jep.2025.120272_bib130","first-page":"2607","article-title":"The influence of dioscin on cytokine expression levels in peritoneal macrophages and immune function in rats with collagen-induced arthritis","volume":"36","author":"Wu","year":"2016","journal-title":"Chinese Journal Of Gerontology"},{"issue":"7","key":"10.1016\/j.jep.2025.120272_bib131","first-page":"886","article-title":"Research progress on the treatment of rheumatoid arthritis and its complicated pulmonary interstitial disease with Dioscorea zingiberensis","volume":"37","author":"Wu","year":"2017","journal-title":"Chin. J. Integrated Tradit. West Med."},{"key":"10.1016\/j.jep.2025.120272_bib132","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106223","article-title":"Role of Angiopoietin-2 in inflammatory autoimmune diseases: a comprehensive review","volume":"80","author":"Wu","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.120272_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117115","article-title":"The potential of diosgenin in treating psoriasis: studies from hacat keratinocytes and imiquimod-induced murine model","volume":"241","author":"Wu","year":"2020","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.jep.2025.120272_bib134","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s12906-023-04086-6","article-title":"Isolation and identification of active ingredients and biological activity of Dioscorea nipponica makino","volume":"23","author":"Xia","year":"2023","journal-title":"BMC Complement Med Ther"},{"issue":"1","key":"10.1016\/j.jep.2025.120272_bib135","doi-asserted-by":"crossref","first-page":"C128","DOI":"10.1152\/ajpcell.00538.2009","article-title":"Estrogen receptor mediates the effects of pseudoprotodiocsin on adipogenesis in 3T3-L1 cells","volume":"299","author":"Xiao","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"1","key":"10.1016\/j.jep.2025.120272_bib136","article-title":"Total saponins from RHizoma dioscoreae nipponicae attenuate pulmonary fibrosis in RHeumatoid Arthritis- associated interstitial lung disease through TGF- \u0392\/Smad signaling pathway","volume":"41","author":"Xiaodong","year":"2023","journal-title":"Chinese Archives Of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2025.120272_bib137","article-title":"Diosgenin from Dioscorea nipponica rhizoma against graves' Disease-On network pharmacology and experimental evaluation","volume":"12","author":"Xin","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.120272_bib138","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/JCMA.0000000000000029","article-title":"Effects of dioscin on T helper 17 and regulatory T-Cell subsets in chicken collagen type II-Induced arthritis mice","volume":"82","author":"Xing","year":"2019","journal-title":"J. Chin. Med. Assoc."},{"issue":"2","key":"10.1016\/j.jep.2025.120272_bib139","first-page":"117","article-title":"Acute toxicity study of whole saponin of rhizoma dioscoreae nippponicae in mice","volume":"27","author":"Xiu-Jun","year":"2010","journal-title":"Journal Of Chengde Medical University"},{"issue":"3","key":"10.1016\/j.jep.2025.120272_bib140","first-page":"522","article-title":"Effects of total saponin from RHizoma Dioscorea nipponica on inflammatory cytokines in Collagen- induced arthritis rats","volume":"24","author":"Xiu-Jun","year":"2013","journal-title":"Lishizhen Medicine And Materia Medica Research"},{"issue":"4","key":"10.1016\/j.jep.2025.120272_bib141","first-page":"712","article-title":"Effects of dioscornin tablets on VEGF in synovial tissue of CIA rats","volume":"40","author":"Ya-Chun","year":"2013","journal-title":"Mod. Prev. Med."},{"issue":"9","key":"10.1016\/j.jep.2025.120272_bib142","first-page":"986","article-title":"Effects of total saponin from rhizoma dioscreae nipponicae on NF-\u039aB P65 activity and STAT3 protein expression in joint synovium of CIA rats","volume":"18","author":"Ya-Xian","year":"2012","journal-title":"J. China Med. Univ."},{"issue":"6","key":"10.1016\/j.jep.2025.120272_bib143","first-page":"485","article-title":"Effects of total saponin from rhizoma dioscreae nipponicae on NF-\u039aB P65 activity and STAT3 protein expression in joint synovium of CIA rats","volume":"41","author":"Ya-Xian","year":"2012","journal-title":"J. China Med. Univ."},{"issue":"21","key":"10.1016\/j.jep.2025.120272_bib144","first-page":"2593","article-title":"Effect of diosgenin on treg cell and its transcription factor in collagen-induced arthritis mice in vitro","volume":"35","author":"Ya-Xian","year":"2019","journal-title":"Chinese Journal Of Immunology"},{"issue":"9","key":"10.1016\/j.jep.2025.120272_bib145","first-page":"1823","article-title":"Subchronic toxicological assessment of diosgenin in kunming mice","volume":"17","author":"Yachun","year":"2015","journal-title":"Modernization Of Traditional Chinese Medicine And Materia Medica-World Science And Technology"},{"issue":"10","key":"10.1016\/j.jep.2025.120272_bib146","first-page":"45","article-title":"The influence of Dioscorea zingiberensis saponins on the expression of Caspase-3 and Caspase-8 proteins in mice with aplastic anemia","volume":"31","author":"Yan","year":"2013","journal-title":"Journal Of Sichuan Of Traditional Chinese Medicine"},{"issue":"14","key":"10.1016\/j.jep.2025.120272_bib147","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1089\/ars.2017.7382","article-title":"Oxidative modifications in tissue pathology and autoimmune disease","volume":"29","author":"Yang","year":"2018","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.jep.2025.120272_bib148","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2022.123531","article-title":"Identification of anti-inflammatory components in Dioscorea nipponica makino based on HPLC-MS\/MS, quantitative analysis of multiple components by single marker and chemometric methods","volume":"1213","author":"Yang","year":"2022","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jep.2025.120272_bib149","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115551","article-title":"UPLC-Q TOF-MS-Based metabolomics and anti-myocardial ischemia activity of dioscoreae nipponicae rhizoma from different geographical origins","volume":"234","author":"Yang","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2025.120272_bib150","series-title":"Illustrated Monograph of Medicinal Plant Resources in Northeast China","author":"Yao","year":"2021"},{"key":"10.1016\/j.jep.2025.120272_bib151","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3389\/fphar.2017.00120","article-title":"Protective effects of dioscin against lipopolysaccharide-induced acute lung injury through inhibition of oxidative stress and inflammation","volume":"8","author":"Yao","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120272_bib152","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3389\/fimmu.2019.00145","article-title":"Advances in research on immunoregulation of macrophages by plant polysaccharides","volume":"10","author":"Yin","year":"2019","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.jep.2025.120272_bib153","first-page":"3294","article-title":"Effects of Dioscorea nipponica on the expression of Th17\/Treg cytokines in patients with hashimoto thyroiditis","volume":"31","author":"Yong-Jun","year":"2016","journal-title":"China Journal Of Traditional Chinese Medicine And Pharmacy"},{"issue":"1","key":"10.1016\/j.jep.2025.120272_bib154","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/08916934.2020.1855428","article-title":"Dioscin alleviates hashimoto's thyroiditis by regulating the sumoylation of IRF4 to promote CD4(+)CD25(+)Foxp3(+) treg cell differentiation","volume":"54","author":"Yongjun","year":"2021","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jep.2025.120272_bib155","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.841732","article-title":"Pyroptosis and its role in autoimmune disease: a potential therapeutic target","volume":"13","author":"You","year":"2022","journal-title":"Front. Immunol."},{"issue":"17","key":"10.1016\/j.jep.2025.120272_bib156","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1056\/NEJMra1413485","article-title":"Aplastic anemia","volume":"379","author":"Young","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.jep.2025.120272_bib157","first-page":"434","article-title":"Zhu liangchun's experience in applying the chuanshan dragon","volume":"32","author":"Yu","year":"2013","journal-title":"Shandong J. Tradit. Chin. Med."},{"issue":"2","key":"10.1016\/j.jep.2025.120272_bib158","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.intimp.2014.01.019","article-title":"Protective effects of the total saponins from Dioscorea nipponica makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation","volume":"19","author":"Yu","year":"2014","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2025.120272_bib159","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/ptr.5243","article-title":"Potent effects of the total saponins from Dioscorea nipponica makino against streptozotocin-induced type 2 diabetes mellitus in rats","volume":"29","author":"Yu","year":"2015","journal-title":"Phytother Res."},{"issue":"4","key":"10.1016\/j.jep.2025.120272_bib160","first-page":"655","article-title":"Selective COX-2 inhibitors: a review of their structure-activity relationships","volume":"10","author":"Zarghi","year":"2011","journal-title":"Iran. J. Pharm. Res. (IJPR)"},{"key":"10.1016\/j.jep.2025.120272_bib161","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2021.103211","article-title":"Diosgenin ameliorates cellular and molecular changes in multiple sclerosis in C57BL\/6 mice","volume":"55","author":"Zeinali","year":"2021","journal-title":"Mult Scler Relat Disord"},{"issue":"1","key":"10.1016\/j.jep.2025.120272_bib162","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1423-0127-21-30","article-title":"Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines","volume":"21","author":"Zhang","year":"2014","journal-title":"J. Biomed. Sci."},{"issue":"5","key":"10.1016\/j.jep.2025.120272_bib163","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.105954","article-title":"Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality","volume":"55","author":"Zhang","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.jep.2025.120272_bib164","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106749","article-title":"Baricitinib, A drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19","volume":"86","author":"Zhang","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120272_bib165","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.1038\/s41598-021-85822-1","article-title":"Transcriptome analysis of the effect of diosgenin on autoimmune thyroiditis in A rat model","volume":"11","author":"Zhang","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2025.120272_bib166","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.2147\/DDDT.S410901","article-title":"Dioscin ameliorates experimental autoimmune thyroiditis via the mtor and TLR4\/NF-\u039aB signaling","volume":"17","author":"Zhang","year":"2023","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.jep.2025.120272_bib167","article-title":"New insights into the Lck-NF-\u039aB signaling pathway","volume":"11","author":"Zhang","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jep.2025.120272_bib168","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109814","article-title":"Dioscin ameliorates silica-aggravated systemic lupus erythematosus via suppressing apoptosis and improving LC3-Associated phagocytosis in MRL\/lpr mice","volume":"116","author":"Zhang","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2025.120272_bib169","first-page":"1037","article-title":"Analysis of adverse reactions of di'ao xinxue kang capsules","volume":"33","author":"Zhaobao","year":"2011","journal-title":"Chin. Tradit. Pat. Med."},{"key":"10.1016\/j.jep.2025.120272_bib170","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jep.2017.04.024","article-title":"Influence of the total saponin fraction from Dioscorea nipponica makino on TLR2\/4-IL1R receptor singnal pathway in rats of gouty arthritis","volume":"206","author":"Zhou","year":"2017","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120272_bib171","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s12906-020-03055-7","article-title":"Anti-inflammation effects of the total saponin fraction from Dioscorea nipponica makino on rats with gouty arthritis by influencing MAPK signalling pathway","volume":"20","author":"Zhou","year":"2020","journal-title":"BMC Complement Med Ther"},{"issue":"6","key":"10.1016\/j.jep.2025.120272_bib172","first-page":"449","article-title":"Determination of diosgenin in di\u2019ao xinxuekang capsule by HPLC","author":"Zhuo","year":"2007","journal-title":"China Pharm."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125009626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125009626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T01:59:06Z","timestamp":1762307946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125009626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":174,"alternative-id":["S0378874125009626"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120272","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dioscorea nipponica Makino: Unraveling multi-target mechanisms and clinical potential in autoimmune disease therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120272","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120272"}}