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Biotechnol."},{"key":"10.1016\/j.jep.2025.120274_bib94","first-page":"724","article-title":"Study on the mechanism of traditional Chinese medicine on immune system regulation. China Life Care Association","author":"Liu","year":"2024","journal-title":"Symp. Life Care Intell. Health Care-Icebreaking Action Nurs. Manag. Zhejiang Sanhe Bioeng. Co. Ltd."},{"issue":"1","key":"10.1016\/j.jep.2025.120274_bib95","article-title":"Effect of regulation of miR-34a by saikosaponin D on the proliferation and autophagy of glioma cell line C6","volume":"39","author":"Liu","year":"2024","journal-title":"J. North Sichuan Med. Coll."},{"issue":"13","key":"10.1016\/j.jep.2025.120274_bib96","first-page":"354","article-title":"Application status of foam fractionation in food and chemical industry","volume":"34","author":"Liu","year":"2013","journal-title":"Sci. Technol. 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Food Ind."},{"issue":"10","key":"10.1016\/j.jep.2025.120274_bib131","first-page":"127","article-title":"Extraction process optimization of saikosaponin with ultrasonic-assisted deep-eutectic solvents and study on its antioxidant activity","volume":"54","author":"Tan","year":"2022","journal-title":"Shandong Agric. Sci."},{"issue":"S1","key":"10.1016\/j.jep.2025.120274_bib132","first-page":"160","article-title":"Study on flash extraction of saikosaponin from Bupleuri Radix","volume":"40","author":"Tang","year":"2009","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"10.1016\/j.jep.2025.120274_bib133","first-page":"1","article-title":"Saikosaponin A inhibits porcine rotavirus replication in vitro","author":"Tao","year":"2025","journal-title":"Chin. 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Physiol."},{"key":"10.1016\/j.jep.2025.120274_bib137","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116729","article-title":"Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress","volume":"316","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120274_bib138","article-title":"Corrigendum to \"Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB\/BDNF pathway\"","volume":"403","author":"Wang","year":"2023","journal-title":"Behav. Brain Res."},{"issue":"9","key":"10.1016\/j.jep.2025.120274_bib139","first-page":"15137","article-title":"Saikosaponin-d attenuates ventilator-induced lung injury in rats","volume":"8","author":"Wang","year":"2015","journal-title":"Int. J. Clin. Exp. 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Commun."},{"issue":"2","key":"10.1016\/j.jep.2025.120274_bib141","article-title":"Saikosaponin A alleviates depressive-like behavior induced by reserpine in mice by regulating gut microflora and inflammatory responses","volume":"20","author":"Wang","year":"2025","journal-title":"PLoS One"},{"issue":"18","key":"10.1016\/j.jep.2025.120274_bib142","first-page":"2546","article-title":"Optimization of water extraction technology of saikosaponin a and saikosaponin d from bupleurum chinense by electromagnetic cracking","volume":"30","author":"Wang","year":"2019","journal-title":"China Pharm."},{"key":"10.1016\/j.jep.2025.120274_bib143","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.etap.2017.04.002","article-title":"Content decline of SERCA inhibitors saikosaponin a and d attenuates cardiotoxicity and hepatotoxicity of vinegar-baked Radix bupleuri","volume":"52","author":"Wang","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"9","key":"10.1016\/j.jep.2025.120274_bib144","article-title":"A novel compound C12 inhibits inflammatory cytokine production and protects from inflammatory injury in vivo","volume":"6","author":"Wang","year":"2011","journal-title":"PLoS One"},{"issue":"20","key":"10.1016\/j.jep.2025.120274_bib145","first-page":"4928","article-title":"Species discrimination of Bupleuri Radix in herbs works of past dynasties","volume":"49","author":"Wang","year":"2018","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"1","key":"10.1016\/j.jep.2025.120274_bib146","first-page":"96","article-title":"Chemical compositions and pharmacological effects of Chinese thorowax root: review. Jilin Tradit","volume":"44","author":"Wang","year":"2024","journal-title":"Chin. 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