{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:11:03Z","timestamp":1793722263606,"version":"4.6.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174078"],"award-info":[{"award-number":["82174078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014978","name":"Hunan University of Chinese Medicine","doi-asserted-by":"publisher","award":["202202"],"award-info":[{"award-number":["202202"]}],"id":[{"id":"10.13039\/501100014978","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JJ6344"],"award-info":[{"award-number":["2024JJ6344"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JJ8128"],"award-info":[{"award-number":["2024JJ8128"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jep.2025.120278","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T15:00:14Z","timestamp":1752591614000},"page":"120278","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Integrated network pharmacology and metabolomics to explore the mechanism of Kadsura coccinea root in alleviating acetaminophen-induced liver injury"],"prefix":"10.1016","volume":"352","author":[{"given":"Ya-shi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-qi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-xuan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang-he","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-wen","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-pei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120278_bib1","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1038\/s41467-017-01970-x","article-title":"The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury","volume":"8","author":"Barbier-Torres","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2025.120278_bib2","doi-asserted-by":"crossref","first-page":"719","DOI":"10.2174\/1389200215666141125121659","article-title":"Cytochrome P450s: mechanisms and biological implications in drug metabolism and its interaction with oxidative stress","volume":"15","author":"Bhattacharyya","year":"2014","journal-title":"Curr. Drug Metabol."},{"key":"10.1016\/j.jep.2025.120278_bib3","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1586\/17512433.2014.904744","article-title":"A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States","volume":"7","author":"Blieden","year":"2014","journal-title":"Expet Rev. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2025.120278_bib4","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1038\/s41467-023-39412-6","article-title":"USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice","volume":"14","author":"Cai","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2025.120278_bib5","article-title":"Network pharmacology-based strategy for elucidating the molecular basis forthe pharmacologic effects of licorice (glycyrrhiza spp.)","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120278_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.136843","article-title":"Schisandra chinensis polysaccharide prevents alcohol-associated liver disease in mice by modulating the gut microbiota-tryptophan metabolism-AHR pathway axis","volume":"282","author":"Chi","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2025.120278_bib7","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S0168-8278(03)00005-9","article-title":"Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis [hepatology 1981;1:431-435]","volume":"38","author":"Desmet","year":"2003","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2025.120278_bib8","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1517\/17425255.2015.1071353","article-title":"Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity","volume":"11","author":"Du","year":"2015","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.jep.2025.120278_bib9","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41420-025-02328-9","article-title":"Insights on the crosstalk among different cell death mechanisms","volume":"11","author":"Eskander","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.jep.2025.120278_bib10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1471-230X-13-73","article-title":"Metabonomic analysis of liver tissue from BALB\/c mice with D-galactosamine\/lipopolysaccharide-induced acute hepatic failure","volume":"13","author":"Feng","year":"2013","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.jep.2025.120278_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156348","article-title":"Schisandra sphenanthera extract modulates sweet taste receptor pathway, IRS\/PI3K, AMPK\/mTOR pathway and endogenous metabolites against T2DM","volume":"136","author":"Feng","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120278_bib12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41408-025-01215-x","article-title":"Exploring BCL2 regulation and upstream signaling transduction in venetoclax resistance in multiple myeloma: potential avenues for therapeutic intervention","volume":"15","author":"Fonseca","year":"2025","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.jep.2025.120278_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123133","article-title":"A mitochondria-targeted nanozyme with enhanced antioxidant activity to prevent acute liver injury by remodeling mitochondria respiratory chain","volume":"318","author":"Gao","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.jep.2025.120278_bib14","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.7150\/ijbs.69116","article-title":"Urolithin A protects against acetaminophen-induced liver injury in mice via sustained activation of Nrf2","volume":"18","author":"Gao","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jep.2025.120278_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2025.127597","article-title":"Mitigative effects of didymin against cadmium-induced renal injury via regulating Nrf-2\/Keap-1, apoptosis, inflammation and oxidative stress","volume":"88","author":"Hamza","year":"2025","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.jep.2025.120278_bib16","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/ptr.6271","article-title":"Schisandrin C targets Keap1 and attenuates oxidative stress by activating Nrf2 pathway in ang II-challenged vascular endothelium","volume":"33","author":"Han","year":"2019","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2025.120278_bib17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.tips.2013.01.009","article-title":"Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria","volume":"34","author":"Han","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jep.2025.120278_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117740","article-title":"Network pharmacology and experimental validation of effects of total saponins extracted from Abrus cantoniensis hance on acetaminophen-induced liver injury","volume":"324","author":"He","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120278_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117740","article-title":"Network pharmacology and experimental validation of effects of total saponins extracted from Abrus cantoniensis hance on acetaminophen-induced liver injury","volume":"324","author":"He","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120278_bib20","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.3390\/nu14224932","article-title":"Molecular mechanisms for ketone body metabolism, signaling functions, and therapeutic potential in cancer","volume":"14","author":"Hwang","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2025.120278_bib21","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1124\/dmd.123.001279","article-title":"Central mechanisms of acetaminophen hepatotoxicity: mitochondrial dysfunction by protein adducts and oxidant stress","volume":"52","author":"Jaeschke","year":"2024","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jep.2025.120278_bib22","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s00228-012-1410-7","article-title":"Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations","volume":"69","author":"James","year":"2013","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2025.120278_bib23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00204-014-1432-2","article-title":"Acetaminophen hepatotoxicity: an updated review","volume":"89","author":"Lancaster","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jep.2025.120278_bib24","doi-asserted-by":"crossref","first-page":"26087","DOI":"10.3390\/ijms161125942","article-title":"The role of oxidative stress and antioxidants in liver diseases","volume":"16","author":"Li","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.120278_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2024.102505","article-title":"Glutathione dynamics in subcellular compartments and implications for drug development","volume":"81","author":"Lin","year":"2024","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.jep.2025.120278_bib26","doi-asserted-by":"crossref","first-page":"8742","DOI":"10.3390\/ijms25168742","article-title":"Xanthoxylin attenuates lipopolysaccharide-induced lung injury through modulation of Akt\/HIF-1\u03b1\/NF-\u03baB and Nrf2 pathways","volume":"25","author":"Liu","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.120278_bib27","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2174\/157340609787049316","article-title":"Bicyclol: a novel drug for treating chronic viral hepatitis B and C","volume":"5","author":"Liu","year":"2009","journal-title":"Med. Chem."},{"key":"10.1016\/j.jep.2025.120278_bib28","first-page":"740","article-title":"Pharmacological actions and clinical use of fructus schizandrae","volume":"102","author":"Liu","year":"1989","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.jep.2025.120278_bib29","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.phymed.2014.01.015","article-title":"Genus kadsura, a good source with considerable characteristic chemical constituents and potential bioactivities","volume":"21","author":"Liu","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120278_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118934","article-title":"Integrating UPLC-Q-Exactive Orbitrap\/MS, network pharmacology and experimental validation to reveal the potential mechanism of Kadsura coccinea roots in Colon cancer","volume":"337","author":"Liu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120278_bib31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1161\/HYPERTENSIONAHA.112.191478","article-title":"Knockdown of cytochrome P450 2E1 inhibits oxidative stress and apoptosis in the cTnT(R141W) dilated cardiomyopathy transgenic mice","volume":"60","author":"Lu","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.jep.2025.120278_bib32","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.3390\/cells13221838","article-title":"Apoptosis: a comprehensive overview of signaling pathways, morphological changes, and physiological significance and therapeutic implications","volume":"13","author":"Mustafa","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.jep.2025.120278_bib34","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1101\/gad.276725.115","article-title":"Inactivation of prosurvival Bcl-2 proteins activates bax\/bak through the outer mitochondrial membrane","volume":"30","author":"O'Neill","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.jep.2025.120278_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117682","article-title":"Network pharmacology combines machine learning, molecular simulation dynamics and experimental validation to explore the mechanism of acetylbinankadsurin A in the treatment of liver fibrosis","volume":"323","author":"Peng","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120278_bib36","doi-asserted-by":"crossref","first-page":"133","DOI":"10.14348\/molcells.2023.0028","article-title":"Molecular basis of the KEAP1-NRF2 signaling pathway","volume":"46","author":"Suzuki","year":"2023","journal-title":"Mol. Cells"},{"key":"10.1016\/j.jep.2025.120278_bib37","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.freeradbiomed.2018.02.001","article-title":"Activation of Nrf2 by ginsenoside Rh3 protects retinal pigment epithelium cells and retinal ganglion cells from UV","volume":"117","author":"Tang","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2025.120278_bib38","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00204-023-03476-6","article-title":"ROS-Induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis","volume":"97","author":"Wang","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jep.2025.120278_bib39","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1007\/s11255-024-04064-y","article-title":"Deletion of Nrf2 induced severe oxidative stress and apoptosis in mice model of diabetic bladder dysfunction","volume":"56","author":"Wang","year":"2024","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.jep.2025.120278_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118127","article-title":"An herbal formulation \u201cShugan Xiaozhi decoction\u201d ameliorates methionine\/choline deficiency-induced nonalcoholic steatohepatitis through regulating inflammation and apoptosis-related pathways","volume":"329","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120278_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156053","article-title":"Shaoyao-gancao decoction, a famous Chinese medicine formula, protects against APAP-Induced liver injury by promoting autophagy\/mitophagy","volume":"135","author":"Wu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120278_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105277","article-title":"Dibenzocyclooctadiene lignans from Kadsura coccinea alleviate APAP-induced hepatotoxicity via oxidative stress inhibition and activating the Nrf2 pathway in vitro","volume":"115","author":"Yang","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.jep.2025.120278_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2019.104368","article-title":"New lignans from roots of Kadsura coccinea","volume":"139","author":"Yang","year":"2019","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2025.120278_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2021.113018","article-title":"Sesquiterpenes from Kadsura coccinea attenuate rheumatoid arthritis-related inflammation by inhibiting the NF-\u03baB and JAK2\/STAT3 signal pathways","volume":"194","author":"Yang","year":"2022","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2025.120278_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.808870","article-title":"Triterpenoids from Kadsura coccinea with their anti-inflammatory and inhibited proliferation of rheumatoid arthritis-fibroblastoid synovial cells activities","volume":"9","author":"Yang","year":"2021","journal-title":"Front. Chem."},{"key":"10.1016\/j.jep.2025.120278_bib46","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1002\/ptr.7527","article-title":"Heilaohuacid G, a new triterpenoid from Kadsura coccinea inhibits proliferation, induces apoptosis, and ameliorates inflammation in RA-FLS and RAW 264.7 cells via suppressing NF-\u03baB pathway","volume":"36","author":"Yang","year":"2022","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2025.120278_bib47","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1021\/acs.jafc.4c06072","article-title":"Intestinal microbiomics and liver metabolomics insights into the ameliorative effects of selenium-enriched Lactobacillus fermentum FZU3103 on alcohol-induced liver injury in mice","volume":"73","author":"Yang","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2025.120278_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112177","article-title":"Integration of transcriptomics and metabolomics confirmed hepatoprotective effects of steamed shoot extracts of ginseng (Panax ginseng C.A. meyer) on toxicity caused by overdosed acetaminophen","volume":"143","author":"Yao","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.120278_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2025.117264","article-title":"Magnolin ameliorates acetaminophen-induced liver injury in mice via modulating the MAPK pathway and lipid metabolism","volume":"497","author":"Yao","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2025.120278_bib50","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrm2308","article-title":"The BCL-2 protein family: opposing activities that mediate cell death","volume":"9","author":"Youle","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jep.2025.120278_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.111902","article-title":"Analgesic and anti-inflammatory effects and molecular mechanisms of kadsura heteroclita stems, an anti-arthritic Chinese Tujia ethnomedicinal herb","volume":"238","author":"Yu","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120278_bib52","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3389\/fphar.2020.00463","article-title":"Bicyclol attenuates acute liver injury by activating autophagy, anti-oxidative and anti-inflammatory capabilities in mice","volume":"11","author":"Zhao","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120278_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2018.11.020","article-title":"Schisandra fruits for the management of drug-induced liver injury in China: a review","volume":"59","author":"Zhu","year":"2019","journal-title":"Phytomedicine"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125009687?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125009687?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:46:27Z","timestamp":1777571187000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125009687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":52,"alternative-id":["S0378874125009687"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120278","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated network pharmacology and metabolomics to explore the mechanism of Kadsura coccinea root in alleviating acetaminophen-induced liver injury","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120278","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120278"}}