{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:33:51Z","timestamp":1783352031980,"version":"3.54.6"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Liaoning Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024-MS-12 2"],"award-info":[{"award-number":["2024-MS-12 2"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010086","name":"Foundation of Liaoning Province Education Administration","doi-asserted-by":"publisher","award":["LJKZ0901"],"award-info":[{"award-number":["LJKZ0901"]}],"id":[{"id":"10.13039\/501100010086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008844","name":"Liaoning University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2023QJ01001"],"award-info":[{"award-number":["2023QJ01001"]}],"id":[{"id":"10.13039\/501100008844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jep.2025.120317","type":"journal-article","created":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T14:25:14Z","timestamp":1753021514000},"page":"120317","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"PA","title":["Buzhong yiqi decoction improves cisplatin resistance in non-small cell lung cancer by inhibiting PCBP1 to activate the ferritinophagy-mediated ferroptosis pathway"],"prefix":"10.1016","volume":"353","author":[{"given":"Yue-tong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-ran","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-rui","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-yi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jep.2025.120317_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41419-020-2419-y","article-title":"Autophagy inhibition potentiates the anti-EMT effects of alteronol through TGF-\u03b2\/Smad3 signaling in melanoma cells","volume":"11","author":"Bao","year":"2020","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.jep.2025.120317_bib2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.celrep.2015.12.065","article-title":"NCOA4 deficiency impairs systemic iron homeostasis","volume":"14","author":"Bellelli","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.jep.2025.120317_bib3","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.freeradbiomed.2014.07.046","article-title":"Nox family NADPH oxidases: molecular mechanisms of activation","volume":"76","author":"Brandes","year":"2014","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.jep.2025.120317_bib4","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1124\/dmd.113.056176","article-title":"Inhibition of the multidrug resistance P-glycoprotein: time for a change of strategy?","volume":"42","author":"Callaghan","year":"2014","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jep.2025.120317_bib5","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bbrc.2021.02.077","article-title":"miR-324-3p reverses cisplatin resistance by inducing GPX4-mediated ferroptosis in lung adenocarcinoma cell line A549","volume":"549","author":"Deng","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.jep.2025.120317_bib6","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/ncb3053","article-title":"Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo","volume":"16","author":"Dowdle","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jep.2025.120317_bib7","first-page":"33","article-title":"Macroautophagy signaling and regulation","volume":"335","author":"Esclatine","year":"2009","journal-title":"Curr. Top. Microbiol. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2025.120317_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12032-023-02237-w","article-title":"Moving beyond cisplatin resistance: mechanisms, challenges, and prospects for overcoming recurrence in clinical cancer therapy","volume":"41","author":"Fu","year":"2023","journal-title":"Med. Oncol."},{"issue":"1","key":"10.1016\/j.jep.2025.120317_bib9","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41420-021-00574-1","article-title":"TRIB2 desensitizes ferroptosis via \u03b2TrCP-mediated TFRC ubiquitiantion in liver cancer cells","volume":"7","author":"Guo","year":"2021","journal-title":"Cell Death Discov."},{"issue":"8","key":"10.1016\/j.jep.2025.120317_bib10","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1080\/15548627.2016.1187366","article-title":"Autophagy promotes ferroptosis by degradation of ferritin","volume":"12","author":"Hou","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.jep.2025.120317_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4928703","article-title":"Growth inhibition of a novel iron chelator, DpdtC, against hepatoma carcinoma cell lines partly attributed to ferritinophagy-mediated lysosomal ROS generation","volume":"2018","author":"Huang","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2025.120317_bib12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.freeradbiomed.2021.08.232","article-title":"Mitochondrial dysfunction in mouse livers depleted of iron chaperone PCBP1","volume":"175","author":"Jadhav","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.jep.2025.120317_bib13","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jep.2025.120317_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2021.103367","article-title":"Iron overload-induced oxidative stress in myelodysplastic syndromes and its cellular sequelae","volume":"163","author":"Kim","year":"2021","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"2","key":"10.1016\/j.jep.2025.120317_bib15","first-page":"202","article-title":"Clinical study on the effect of modified buzhong yiqi decoction on the prognosis of patients with ventilator-associated pneumonia","volume":"20","author":"Kou","year":"2011","journal-title":"Zhong Guo Zhong Yi Ji Zheng"},{"issue":"2","key":"10.1016\/j.jep.2025.120317_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23020331","article-title":"Cell migration related to MDR-another impediment to effective chemotherapy?","volume":"23","author":"Kryczka","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.120317_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102276","article-title":"Poly(rC)-binding protein 1 represses ferritinophagy-mediated ferroptosis in head and neck cancer","volume":"51","author":"Lee","year":"2022","journal-title":"Redox Biol."},{"issue":"10","key":"10.1016\/j.jep.2025.120317_bib18","first-page":"79","article-title":"Buzhong yiqitang regulates endoplasmic reticulum stress via Nrf2\/ROS\/PERK\/CHOPSignaling pathway to attenuate cisplatin resistance in NSCLC","volume":"31","author":"Li","year":"2025","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"5","key":"10.1016\/j.jep.2025.120317_bib19","first-page":"607","article-title":"Effects of buzhong yiqi decoction medicated serum combined with cisplatin on Nrf2, PRX1, SOD and GPX4 protein in human lung adenocarcinoma A549\/DDP cells","volume":"46","author":"Li","year":"2024","journal-title":"Intl Journal of Tradit Chin Med"},{"key":"10.1016\/j.jep.2025.120317_bib20","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jep.2017.10.031","article-title":"Characteristics of Chinese herbal medicine usage and its effect on survival of lung cancer patients in Taiwan","volume":"213","author":"Li","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120317_bib21","article-title":"Ferroptosis in lung cancer: dual role, multi-level regulation, and new therapeutic strategies","volume":"14","author":"Li","year":"2024","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.jep.2025.120317_bib22","first-page":"323","article-title":"Erastin\/Sorafenib induces cisplatin-resistant non-small cell lung cancer cell ferroptosis through inhibition of the Nrf2\/xCT pathway","volume":"19","author":"Li","year":"2020","journal-title":"Oncol. Lett."},{"issue":"2","key":"10.1016\/j.jep.2025.120317_bib23","first-page":"164","article-title":"Mechanism of \u201cactivating blood and resolving phlegm\u201d method in the prevention and treatment of EGFRTKI resistance in lung cancer","volume":"41","author":"Liu","year":"2022","journal-title":"J Beijing Univ Tradit Chin Med"},{"issue":"6","key":"10.1016\/j.jep.2025.120317_bib24","first-page":"814","article-title":"The mechanism of protective effect of jianpi yichang powder on intestinal mucosa of rats with ulcerative colitis based on autophagy","volume":"35","author":"Liu","year":"2024","journal-title":"Tradit. Chin. Drug Res. Clin. Pharmacol."},{"issue":"7498","key":"10.1016\/j.jep.2025.120317_bib25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature13148","article-title":"Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy","volume":"509","author":"Mancias","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jep.2025.120317_bib26","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.redox.2017.08.015","article-title":"Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis","volume":"14","author":"Masaldan","year":"2018","journal-title":"Redox Biol."},{"issue":"16","key":"10.1016\/j.jep.2025.120317_bib27","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1158\/1078-0432.CCR-22-3699","article-title":"FDA approval summary: atezolizumab as adjuvant treatment following surgical resection and platinum-based chemotherapy for stage II to IIIA NSCLC","volume":"29","author":"Mathieu","year":"2023","journal-title":"Clin. Cancer Res."},{"issue":"7182","key":"10.1016\/j.jep.2025.120317_bib28","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"issue":"18","key":"10.1016\/j.jep.2025.120317_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax7881","article-title":"Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1\/PD-L1 immunotherapy","volume":"6","author":"Noman","year":"2020","journal-title":"Sci. Adv."},{"issue":"12","key":"10.1016\/j.jep.2025.120317_bib30","first-page":"1457","article-title":"Curative effect of buzhong yiqi decoction in the treatment of multidrug-resistant pneumonia after stroke","volume":"35","author":"Peng","year":"2019","journal-title":"Journal of Practical Traditional Chinese Medicine"},{"issue":"5","key":"10.1016\/j.jep.2025.120317_bib31","doi-asserted-by":"crossref","DOI":"10.1093\/mtomcs\/mfab021","article-title":"Chemistry and biology of ferritin","volume":"13","author":"Plays","year":"2021","journal-title":"Metallomics"},{"key":"10.1016\/j.jep.2025.120317_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1198768","article-title":"Effectiveness and safety of shenqi fuzheng injection combined with platinum-based chemotherapy for treatment of advanced non-small cell lung cancer: a systematic review and meta-analysis","volume":"13","author":"Qiao","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jep.2025.120317_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156836","article-title":"Regulation of inflammation by chaihu-shugan-san: targeting the IL-17\/NF-\u03baB pathway to combat breast cancer-related depression","volume":"143","author":"Qu","year":"2025","journal-title":"Phytomedicine"},{"issue":"16","key":"10.1016\/j.jep.2025.120317_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14163898","article-title":"A review of medicinal plants of the himalayas with anti-proliferative activity for the treatment of various cancers","volume":"14","author":"Regassa","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"4","key":"10.1016\/j.jep.2025.120317_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ph11040114","article-title":"The role of NCOA4-Mediated ferritinophagy in health and disease","volume":"11","author":"Santana-Codina","year":"2018","journal-title":"Pharmaceuticals"},{"issue":"20","key":"10.1016\/j.jep.2025.120317_bib36","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.4155\/fmc-2020-0190","article-title":"Targeting interleukins in chronic airway diseases using advanced drug delivery","volume":"12","author":"Satija","year":"2020","journal-title":"Future Med. Chem."},{"issue":"1","key":"10.1016\/j.jep.2025.120317_bib37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41420-021-00554-5","article-title":"Platinum drugs and taxanes: can we overcome resistance?","volume":"7","author":"Sazonova","year":"2021","journal-title":"Cell Death Discov."},{"issue":"10","key":"10.1016\/j.jep.2025.120317_bib38","doi-asserted-by":"crossref","first-page":"6868","DOI":"10.1002\/jcp.30346","article-title":"TRIM11 suppresses ferritinophagy and gemcitabine sensitivity through UBE2N\/TAX1BP1 signaling in pancreatic ductal adenocarcinoma","volume":"236","author":"Shang","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.jep.2025.120317_bib39","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1021\/acsomega.2c04078","article-title":"Advances in lung cancer treatment using nanomedicines","volume":"8","author":"Sharma","year":"2023","journal-title":"ACS Omega"},{"issue":"1","key":"10.1016\/j.jep.2025.120317_bib40","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"14","key":"10.1016\/j.jep.2025.120317_bib41","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.jep.2025.120317_bib42","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jep.2025.120317_bib43","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/tkm2.1264","article-title":"Basic pharmacological mechanisms and clinical evidence of the efficacy of hochuekkito against infectious diseases and its potential for use against COVID\u201019","volume":"8","author":"Takayama","year":"2021","journal-title":"Traditional & Kampo Medicine"},{"issue":"8","key":"10.1016\/j.jep.2025.120317_bib44","first-page":"1938","article-title":"Meta-analysis and trial sequential analysis of the efficacy and safety of traditional Chinese medicine combined with gefitinib in the treatment of advanced non-small cell lung cancer","volume":"42","author":"Wang","year":"2019","journal-title":"J. Chin. Med. Mater."},{"issue":"6","key":"10.1016\/j.jep.2025.120317_bib45","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.7150\/thno.51797","article-title":"Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2","volume":"11","author":"Wang","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.jep.2025.120317_bib46","doi-asserted-by":"crossref","unstructured":"Wang, H., Liu, C., Zhao, Y., Gao, G., 2020. Mitochondria regulation in ferroptosis. Eur. J. Cell Biol., 99(1): 151058.http:\/\/doi.org\/10.1016\/j.ejcb.2019.151058.","DOI":"10.1016\/j.ejcb.2019.151058"},{"key":"10.1016\/j.jep.2025.120317_bib47","unstructured":"Wang, Y., Huang, J., Liu, Y., Li, H., Yu, D., Liu, C., Gao, Y., Exploring the molecular mechanism of buzhong yigi decoctioncombined with cisplatin in enhancing the sensitivity of A549 celltransplantation tumors to cisplatin based on the Wnt\/JNK signalingpathway. Liaoning Journal of Traditional Chinese Medicine: 1-13."},{"issue":"5","key":"10.1016\/j.jep.2025.120317_bib48","first-page":"2694","article-title":"Analysis of clinical efficacy and related factors of 'treating qi first' rehabilitation therapy for postoperative symptoms of lung cancer","volume":"36","author":"Wang","year":"2021","journal-title":"China J Tradit Chin Med Pharm"},{"issue":"1","key":"10.1016\/j.jep.2025.120317_bib49","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1080\/10717544.2022.2120566","article-title":"Monoclonal antibody as a targeting mediator for nanoparticle targeted delivery system for lung cancer","volume":"29","author":"Wathoni","year":"2022","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jep.2025.120317_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2025.106602","article-title":"Phytochemical profile of bioactive Siraitia grosvenorii root fraction and its potential against nonsmall cell lung cancer in vitro and in vivo","volume":"184","author":"Wei","year":"2025","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2025.120317_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102131","article-title":"Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis","volume":"46","author":"Wu","year":"2021","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.jep.2025.120317_bib52","first-page":"523","article-title":"Role of microRNAs in the resistance of colorectal cancer to chemoradiotherapy","volume":"8","author":"Wu","year":"2018","journal-title":"Mol Clin Oncol"},{"issue":"5","key":"10.1016\/j.jep.2025.120317_bib53","first-page":"1010","article-title":"Clinical efficacy of buzhong yiqi decoction in the treatment of hospital-acquired pneumonia with multi-drug resistant bacteria: a prospective, randomized, multicenter controlled trial","volume":"43","author":"Xiangru","year":"2023","journal-title":"J. Tradit. Chin. Med."},{"issue":"1\u20132","key":"10.1016\/j.jep.2025.120317_bib54","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.jep.2025.120317_bib55","first-page":"685","article-title":"Study on the mechanism of buzhong yiqi decoction on the recovery period of COVID-19 based on network pharmacology","volume":"45","author":"Yin","year":"2021","journal-title":"J. Shandong Univ. Traditional Chin. Med"},{"issue":"9","key":"10.1016\/j.jep.2025.120317_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18091865","article-title":"Monitoring and measuring autophagy","volume":"18","author":"Yoshii","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.120317_bib57","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1476-4598-9-72","article-title":"PCBP-1 regulates alternative splicing of the CD44 gene and inhibits invasion in human hepatoma cell line HepG2 cells","volume":"9","author":"Zhang","year":"2010","journal-title":"Mol. Cancer"},{"issue":"23","key":"10.1016\/j.jep.2025.120317_bib58","first-page":"73","article-title":"Effect of buzhong yiqi tang on cisplatin resistance A549\/DDP cells in nude mice with lung adenocarcinoma","volume":"25","author":"Zhang","year":"2019","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"1","key":"10.1016\/j.jep.2025.120317_bib59","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/s42003-023-04959-z","article-title":"KLF11 regulates lung adenocarcinoma ferroptosis and chemosensitivity by suppressing GPX4","volume":"6","author":"Zhao","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.jep.2025.120317_bib60","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.2147\/OTT.S254995","article-title":"The role of erastin in ferroptosis and its prospects in cancer therapy","volume":"13","author":"Zhao","year":"2020","journal-title":"OncoTargets Ther."},{"issue":"6","key":"10.1016\/j.jep.2025.120317_bib61","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","article-title":"The metabolic underpinnings of ferroptosis","volume":"32","author":"Zheng","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.jep.2025.120317_bib62","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.semcancer.2019.03.002","article-title":"Ferroptosis is a type of autophagy-dependent cell death","volume":"66","author":"Zhou","year":"2020","journal-title":"Semin. Cancer Biol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125010098?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125010098?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:00:13Z","timestamp":1778540413000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125010098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":62,"alternative-id":["S0378874125010098"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120317","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Buzhong yiqi decoction improves cisplatin resistance in non-small cell lung cancer by inhibiting PCBP1 to activate the ferritinophagy-mediated ferroptosis pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120317","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"120317"}}