{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:10:39Z","timestamp":1785161439937,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"am","delay-in-days":355,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["MDA-MB-231"],"award-info":[{"award-number":["MDA-MB-231"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["R15AT011047"],"award-info":[{"award-number":["R15AT011047"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000063","name":"National Institutes of Health Office of Dietary Supplements","doi-asserted-by":"publisher","award":["R15AT011047"],"award-info":[{"award-number":["R15AT011047"]}],"id":[{"id":"10.13039\/100000063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jep.2025.120361","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T02:24:36Z","timestamp":1754447076000},"page":"120361","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"PA","title":["A\u00e7a\u00ed extract and anticancer drug combination promotes synergistic toxicity and apoptosis in MCF-10A cells of breast cancer model"],"prefix":"10.1016","volume":"353","author":[{"given":"Destini","family":"Thornton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kabre","family":"Heck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Patrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinbam","family":"Kromtit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Benedict","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyanarayana R.","family":"Pondugula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0836-635X","authenticated-orcid":false,"given":"Angela I.","family":"Calder\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jep.2025.120361_bib1","article-title":"Euterpe oleracea extract (a\u00e7a\u00ed) exhibits cardioprotective effects after chemotherapy treatment in a breast cancer model","volume":"23","author":"Alessandra-Perini","year":"2023","journal-title":"BMC Complementary Med. Ther"},{"key":"10.1016\/j.jep.2025.120361_bib3","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1016\/j.biopha.2018.08.100","article-title":"Phytoestrogens and breast cancer: in vitro anticancer activities of isoflavones, lignans, coumestans, stilbenes and their analogs and derivatives","volume":"107","author":"Basu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.120361_bib4","doi-asserted-by":"crossref","DOI":"10.1586\/eem.11.28","article-title":"Endocrinology of breast cancer: results, tasks and hopes","author":"Berstein","year":"2011","journal-title":"Expet Rev. Endocrinol. Metabol."},{"key":"10.1016\/j.jep.2025.120361_bib5","article-title":"Drug combination studies and their synergy quantification using the chou-talalay method","author":"Chou","year":"2010","journal-title":"Cancer Res."},{"issue":"6159","key":"10.1016\/j.jep.2025.120361_bib6","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1136\/bmj.1.6159.298","article-title":"Comparison of intravenous and oral high-dose methotrexate in treatment of solid tumours","volume":"1","author":"Christophidis","year":"1979","journal-title":"Br. Med. J."},{"issue":"3","key":"10.1016\/j.jep.2025.120361_bib7","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1177\/2472555218812429","article-title":"Implementation of the NCI-60 human tumor cell line panel to screen 2260 cancer drug combinations to generate >3 million data points used to populate A Large Matrix of Anti-Neoplastic Agent Combinations (ALMANAC) database","volume":"24","author":"Close","year":"2019","journal-title":"SLAS Discovery"},{"key":"10.1016\/j.jep.2025.120361_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.slasd.2025.100230","article-title":"Combinatorial screen with apoptosis pathway-targeted agents alrizomadlin, pelcitoclax, and dasminapant in multi-cell type tumor spheroids","volume":"33","author":"Coussens","year":"2025","journal-title":"SLAS Discovery"},{"key":"10.1016\/j.jep.2025.120361_bib10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/ijms16022352","article-title":"Antiproliferative and antioxidant properties of anthocyanin rich extracts from blueberry and blackcurrant juice","volume":"16","author":"Diaconeasa","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.120361_bib11","doi-asserted-by":"crossref","DOI":"10.1124\/pr.115.010843","article-title":"Botanicals and their bioactive phytochemicals for women's health","author":"Dietz","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jep.2025.120361_bib12","first-page":"2","article-title":"Adverse event reporting patterns of concomitant botanical dietary supplements with CYP3A4 interactive & CYP3A4 non-interactive anticancer drugs in the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS)","volume":"18","author":"Fahim","year":"2019","journal-title":"Expet Opin. Drug Saf."},{"issue":"6","key":"10.1016\/j.jep.2025.120361_bib13","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nmeth.3853","article-title":"Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs","volume":"13","author":"Hafner","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jep.2025.120361_bib14","series-title":"Extraction Technologies for Medicinal and Aromatic Plants","first-page":"21","article-title":"An overview of extraction techniques for medicinal and aromatic plants","author":"Handa","year":"2008"},{"key":"10.1016\/j.jep.2025.120361_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2023.105155","article-title":"Standardization of a\u00e7a\u00ed extracts for in-vitro assays based on anthocyanin quantitation","volume":"118","author":"Heck","year":"2023","journal-title":"J. Food Compos. Anal."},{"key":"10.1016\/j.jep.2025.120361_bib16","article-title":"A comparative metabolomics analysis of A\u00e7a\u00ed (Euterpe oleracea Mart.) fruit, food powder, and botanical dietary supplement extracts","author":"Heck","year":"2024","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.jep.2025.120361_bib18","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1055\/a-0605-3786","article-title":"A review of the toxicity of compounds found in herbal dietary supplements","volume":"84","author":"Hudson","year":"2018","journal-title":"Planta Med."},{"issue":"24 Pt 1","key":"10.1016\/j.jep.2025.120361_bib19","doi-asserted-by":"crossref","first-page":"8722","DOI":"10.1158\/1078-0432.CCR-05-0915","article-title":"Effect of exemestane on tamoxifen pharmacokinetics in postmenopausal women treated for breast cancer","volume":"11","author":"Hutson","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jep.2025.120361_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/nu15040989","article-title":"A\u00e7a\u00ed (Euterpe oleracea Mart.) in health and disease: a critical review","author":"Laurindo","year":"2023","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.jep.2025.120361_bib21","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/mc.22110","article-title":"Withaferin A inhibits experimental epithelial\u2013mesenchymal transition in MCF-10A cells and suppresses vimentin protein level in vivo in breast tumors","volume":"54","author":"Lee","year":"2015","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.jep.2025.120361_bib22","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/cncr.31183","article-title":"Trends in botanical dietary supplement use among US adults by cancer status: the National Health and Nutrition Examination Survey, 1999 to 2014","volume":"124","author":"Li","year":"2018","journal-title":"Cancer"},{"issue":"19","key":"10.1016\/j.jep.2025.120361_bib23","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.7150\/jca.31045","article-title":"Combination of quercetin and cisplatin enhances apoptosis in OSCC cells by downregulating xIAP through the NF-\u03baB pathway","volume":"10","author":"Li","year":"2019","journal-title":"J. Cancer"},{"key":"10.1016\/j.jep.2025.120361_bib24","doi-asserted-by":"crossref","DOI":"10.1007\/s12229-011-9086-8","article-title":"Palm uses in Northwestern South America: a quantitative review","author":"Mac\u00eda","year":"2011","journal-title":"Bot. Rev."},{"key":"10.1016\/j.jep.2025.120361_bib25","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1177\/0884533617721687","article-title":"Dietary supplements commonly used by cancer survivors: are there any benefits?","volume":"32","author":"Marian","year":"2017","journal-title":"Nutr. Clin. Pract."},{"issue":"19","key":"10.1016\/j.jep.2025.120361_bib26","doi-asserted-by":"crossref","first-page":"6529","DOI":"10.1128\/MCB.21.19.6529-6536.2001","article-title":"Human MCF10A mammary epithelial cells undergo apoptosis following actin depolymerization that is independent of attachment and rescued by Bcl-2","volume":"21","author":"Martin","year":"2001","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jep.2025.120361_bib27","doi-asserted-by":"crossref","first-page":"7796","DOI":"10.1021\/jf8007037","article-title":"Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich a\u00e7ai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers","volume":"56","author":"Mertens-Talcott","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2025.120361_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2022.847573","article-title":"Methotrexate-Lactoferrin targeted exemestane cubosomes for synergistic breast cancer therapy","volume":"10","author":"Mokhtar","year":"2022","journal-title":"Front. Chem."},{"key":"10.1016\/j.jep.2025.120361_bib29","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1021\/bi035613d","article-title":"Genistein and daidzein induce cell proliferation and their metabolites cause oxidative DNA damage in relation to isoflavone-induced cancer of estrogen-sensitive organs","volume":"43","author":"Murata","year":"2004","journal-title":"Biochemistry"},{"issue":"3","key":"10.1016\/j.jep.2025.120361_bib30","first-page":"83","article-title":"The role of epithelial and vascular-endothelial cadherin in the differentiation and maintenance of tissue integrity","volume":"44","author":"Nachtigal","year":"2001","journal-title":"Acta Med."},{"key":"10.1016\/j.jep.2025.120361_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-78847-5","article-title":"Effect of extraction temperature and solvent type on the bioactive potential of Ocimum gratissimum L. extracts","volume":"10","author":"Onyebuchi","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2025.120361_bib33","doi-asserted-by":"crossref","first-page":"388","DOI":"10.33594\/000000145","article-title":"Euterpe oleracea Mart. (A\u00e7ai) supplementation attenuates acute doxorubicin-induced cardiotoxicity in rats","volume":"53","author":"Polegato","year":"2019","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.jep.2025.120361_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113885","article-title":"Increased acute blood flow induced by the aqueous extract of Euterpe oleracea Mart. Fruit pulp in rats in vivo is not related to the direct activation of endothelial cells","volume":"271","author":"Pontes","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120361_bib35","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1038\/s41598-018-37796-w","article-title":"Cytotoxicity of eupatorin in MCF-7 and MDA-MB-231 human breast cancer cells via cell cycle arrest, anti-angiogenesis and induction of apoptosis","volume":"9","author":"Razak","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2025.120361_bib37","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2023.41.16_suppl.10528","article-title":"Breast cancer: global patterns of incidence, mortality, and trends","volume":"41","author":"Sedeta","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jep.2025.120361_bib38","first-page":"22","article-title":"Traditional uses, phytochemistry, pharmacology and anticancer activity of a\u00e7a\u00ed (Euterpe oleracea Mart): a narrative review","volume":"7","author":"Silva","year":"2020","journal-title":"Curr. Tradit. Med."},{"key":"10.1016\/j.jep.2025.120361_bib39","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.3390\/molecules26123546","article-title":"A\u00e7ai (Euterpe oleracea mart.) seed extract induces ROS production and cell death in MCF-7 breast cancer cell line","volume":"26","author":"Silva","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.120361_bib40","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1080\/01913123.2022.2141404","article-title":"Ultrastructural changes induced by a\u00e7a\u00ed (Euterpe oleracea mart) in MCF-7 breast cancer cell line","volume":"46","author":"Silva","year":"2022","journal-title":"Ultrastruct. Pathol."},{"key":"10.1016\/j.jep.2025.120361_bib42","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1177\/1060028017744316","article-title":"Dietary supplement adverse event report data from the FDA Center for Food Safety and Applied Nutrition Adverse Event Reporting System (CAERS), 2004-2013","volume":"52","author":"Timbo","year":"2018","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.jep.2025.120361_bib45","series-title":"Questions and Answers on Dietary Supplements","year":"2024"},{"key":"10.1016\/j.jep.2025.120361_bib46","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.csbj.2015.09.001","article-title":"Searching for drug synergy in complex dose-response landscapes using an interaction potency model","volume":"13","author":"Yadav","year":"2015","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.jep.2025.120361_bib48","first-page":"97","article-title":"Synergistic combination of microtubule targeting anticancer fludelone with cytoprotective panaxytriol derived from panax ginseng against MX-1 cells in vitro: experimental design and data analysis using the combination index method","volume":"6","author":"Zhang","year":"2016","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.jep.2025.120361_bib49","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.gpb.2022.01.004","article-title":"SynergyFinder plus: toward better interpretation and annotation of drug combination screening datasets","volume":"20","author":"Zheng","year":"2022","journal-title":"Genom. Proteom. Bioinform."},{"key":"10.1016\/j.jep.2025.120361_bib50","author":"Zheng"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125010530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125010530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:45:57Z","timestamp":1772819157000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125010530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":41,"alternative-id":["S0378874125010530"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120361","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A\u00e7a\u00ed extract and anticancer drug combination promotes synergistic toxicity and apoptosis in MCF-10A cells of breast cancer model","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120361","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120361"}}