{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T09:03:38Z","timestamp":1792746218848,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2023AH020047"],"award-info":[{"award-number":["2023AH020047"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270737"],"award-info":[{"award-number":["82270737"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470732"],"award-info":[{"award-number":["82470732"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jep.2025.120368","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T02:13:33Z","timestamp":1754619213000},"page":"120368","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"PB","title":["Atractylenolide III attenuates acute kidney injury through phosphorylation of PIK3CA: Functional activation and molecular interaction analysis"],"prefix":"10.1016","volume":"353","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6134-7505","authenticated-orcid":false,"given":"Jianmin","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxue","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"20","key":"10.1016\/j.jep.2025.120368_bib1","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1056\/NEJMoa1813904","article-title":"Alpelisib for PIK3CA-Mutated, Hormone Receptor-positive advanced breast cancer","volume":"380","author":"Andr\u00e9","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2025.120368_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103476","article-title":"The spatiotemporal and paradoxical roles of NRF2 in renal toxicity and kidney diseases","volume":"79","author":"Bian","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2025.120368_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154306","article-title":"Role of curcumin in the treatment of acute kidney injury: research challenges and opportunities","volume":"104","author":"Cai","year":"2022","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2025.120368_bib4","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/s13023-021-01929-8","article-title":"A review of mechanisms of disease across PIK3CA-related disorders with vascular manifestations","volume":"16","author":"Canaud","year":"2021","journal-title":"Orphanet J. Rare Dis."},{"issue":"4","key":"10.1016\/j.jep.2025.120368_bib5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrneph.2017.2","article-title":"Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup","volume":"13","author":"Chawla","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"issue":"2","key":"10.1016\/j.jep.2025.120368_bib6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/boc.201500033","article-title":"miR-490-5p suppresses tumour growth in renal cell carcinoma through targeting PIK3CA","volume":"108","author":"Chen","year":"2016","journal-title":"Biol. Cell."},{"issue":"1","key":"10.1016\/j.jep.2025.120368_bib7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13018-024-05444-x","article-title":"LINC01271 promotes fracture healing via regulating miR-19a-3p\/PIK3CA axis","volume":"20","author":"Chen","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.jep.2025.120368_bib8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cbi.2019.05.040","article-title":"Hesperetin relieves cisplatin-induced acute kidney injury by mitigating oxidative stress, inflammation and apoptosis","volume":"308","author":"Chen","year":"2019","journal-title":"Chem. Biol. Interact."},{"issue":"5","key":"10.1016\/j.jep.2025.120368_bib9","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.3390\/curroncol29050236","article-title":"PIK3CA mutation as potential poor prognostic marker in Asian female breast cancer patients who received adjuvant chemotherapy","volume":"29","author":"Cho","year":"2022","journal-title":"Curr. Oncol."},{"key":"10.1016\/j.jep.2025.120368_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.115158","article-title":"Atractylenolide III ameliorates DSS-induced colitis by improving intestinal epithelial barrier via suppressing the NF-\u03baB-Mediated MLCK-pMLC signaling pathway","volume":"196","author":"Dai","year":"2025","journal-title":"Food Chem. Toxicol."},{"issue":"7","key":"10.1016\/j.jep.2025.120368_bib11","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s12272-021-01342-6","article-title":"Atractylenolides (I, II, and III): a review of their pharmacology and pharmacokinetics","volume":"44","author":"Deng","year":"2021","journal-title":"Arch Pharm. Res. (Seoul)"},{"issue":"5","key":"10.1016\/j.jep.2025.120368_bib12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nrneph.2018.9","article-title":"Mitochondrial dysfunction in diabetic kidney disease","volume":"14","author":"Forbes","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jep.2025.120368_bib13","article-title":"Atractylenolide III attenuates angiogenesis in gastric precancerous lesions through the downregulation of delta-like ligand 4","volume":"13","author":"Gao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120368_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2019.04.001","article-title":"Acute kidney injury overview: from basic findings to new prevention and therapy strategies","volume":"200","author":"Gonsalez","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jep.2025.120368_bib15","doi-asserted-by":"crossref","DOI":"10.1177\/09603271241288508","article-title":"Protective effects of atractylenolide III on oxygen-glucose-deprivation\/reperfusion-induced injury in HT22 cells","volume":"43","author":"Guo","year":"2024","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.jep.2025.120368_bib16","doi-asserted-by":"crossref","DOI":"10.1007\/s12975-025-01360-2","article-title":"Clinical significance of somatic PIK3CA and MAP3K3 mutations in cerebral and spinal cavernous malformations","author":"Hongo","year":"2025","journal-title":"Transl Stroke Res"},{"issue":"1","key":"10.1016\/j.jep.2025.120368_bib17","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1080\/0886022X.2020.1751658","article-title":"The renoprotective effect of curcumin against cisplatin-induced acute kidney injury in mice: involvement of miR-181a\/PTEN axis","volume":"42","author":"Huang","year":"2020","journal-title":"Ren. Fail."},{"issue":"23","key":"10.1016\/j.jep.2025.120368_bib18","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.1002\/cncr.27614","article-title":"Alterations of the p53 and PIK3CA\/AKT\/mTOR pathways in angiosarcomas: a pattern distinct from other sarcomas with complex genomics","volume":"118","author":"Italiano","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.jep.2025.120368_bib19","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2501796","article-title":"Overall survival with inavolisib in PIK3CA-mutated advanced breast cancer","author":"Jhaveri","year":"2025","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.jep.2025.120368_bib20","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3109\/08923973.2015.1122617","article-title":"Anti-inflammatory activity of atractylenolide III through inhibition of nuclear factor-\u03baB and mitogen-activated protein kinase pathways in mouse macrophages","volume":"38","author":"Ji","year":"2016","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"2","key":"10.1016\/j.jep.2025.120368_bib21","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jtcme.2024.11.015","article-title":"Mechanism of Atractylenolide \u2162 alleviating pyrotinib-induced diarrhea by regulating AMPK\/CFTR pathway through metabolite of gut microbiota","volume":"15","author":"Jiang","year":"2025","journal-title":"J. Tradit. Complement. Med."},{"issue":"2","key":"10.1016\/j.jep.2025.120368_bib22","doi-asserted-by":"crossref","first-page":"531","DOI":"10.4143\/crt.2022.221","article-title":"PIK3CA mutation is associated with poor response to HER2-targeted therapy in breast cancer patients","volume":"55","author":"Kim","year":"2023","journal-title":"Cancer Res. Treat."},{"issue":"2","key":"10.1016\/j.jep.2025.120368_bib23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41581-023-00775-0","article-title":"Oxidative stress and the role of redox signalling in chronic kidney disease","volume":"20","author":"Kishi","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"10.1016\/j.jep.2025.120368_bib24","first-page":"58","article-title":"Acute kidney injury: current concepts and new insights","volume":"8","author":"Koza","year":"2016","journal-title":"J Inj Violence Res"},{"key":"10.1016\/j.jep.2025.120368_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s44161-025-00655-9","article-title":"Angiopoietin-TIE2 feedforward circuit promotes PIK3CA-driven venous malformations","author":"Kraft","year":"2025","journal-title":"Nat Cardiovasc Res"},{"key":"10.1016\/j.jep.2025.120368_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113825","article-title":"Atractylenolide-III restrains cardiac fibrosis after myocardial infarction via suppression of the RhoA\/ROCK1 and ERK1\/2 pathway","volume":"145","author":"Li","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.120368_bib27","article-title":"Identification and validation of PIK3CA as a marker associated with prognosis and immune infiltration in renal clear cell carcinoma","volume":"2021","author":"Li","year":"2021","journal-title":"J. Oncol."},{"key":"10.1016\/j.jep.2025.120368_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156704","article-title":"Atractylenolide-\u2162 binds non-structural protein-1 to suppress influenza A by modulating macrophage polarization and alternative polyadenylation","volume":"141","author":"Liang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120368_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119436","article-title":"Integration of single-cell RNA sequencing and network pharmacology to elucidate the effect of Yantiao Formula on alleviating ALI by regulating the polarization of alveolar macrophages","volume":"343","author":"Liu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120368_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118420","article-title":"Pharmacokinetic study and neuropharmacological effects of atractylenolide \u2162 to improve cognitive impairment via PI3K\/AKT\/GSK3\u03b2 pathway in intracerebroventricular-streptozotocin rats","volume":"333","author":"Liu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120368_bib31","doi-asserted-by":"crossref","first-page":"6223","DOI":"10.2147\/DDDT.S486286","article-title":"Network pharmacology and metabolomics reveal anti-ferroptotic effects of curcumin in acute kidney injury","volume":"18","author":"Liu","year":"2024","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.jep.2025.120368_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116852","article-title":"Chemopreventive effects of atractylenolide-III on mammary tumorigenesis via activation of the Nrf2\/ARE pathway through autophagic degradation of Keap1","volume":"176","author":"Long","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.120368_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41431-025-01885-y","article-title":"First report of successful pregnancies after treatment with alpelisib for PIK3CA-related overgrowth spectrum","author":"Morin","year":"2025","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.jep.2025.120368_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1559032","article-title":"Curcumin: a potential anti-photoaging agent","volume":"16","author":"Nie","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.jep.2025.120368_bib35","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s00134-021-06454-7","article-title":"Acute kidney injury in the critically ill: an updated review on pathophysiology and management","volume":"47","author":"Pickkers","year":"2021","journal-title":"Intensive Care Med."},{"issue":"11","key":"10.1016\/j.jep.2025.120368_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e21224","article-title":"Atractylenolide III ameliorated reflux esophagitis via PI3K\/AKT\/NF-\u03baB\/iNOS pathway in rats","volume":"9","author":"Si","year":"2023","journal-title":"Heliyon"},{"issue":"17","key":"10.1016\/j.jep.2025.120368_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.70101","article-title":"PIK3CA mutational status in tissue and plasma as a prognostic biomarker in HR+\/HER2- breast cancer","volume":"13","author":"Ter\u00e1n","year":"2024","journal-title":"Cancer Med."},{"key":"10.1016\/j.jep.2025.120368_bib38","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.addr.2015.01.009","article-title":"The application of in silico drug-likeness predictions in pharmaceutical research","volume":"86","author":"Tian","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"6","key":"10.1016\/j.jep.2025.120368_bib39","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s44321-025-00235-1","article-title":"Embryological cellular origins and hypoxia-mediated mechanisms in PIK3CA-driven refractory vascular malformations","volume":"17","author":"Torii","year":"2025","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.jep.2025.120368_bib40","article-title":"Atractylenolide III attenuates muscle wasting in chronic kidney disease via the oxidative stress-mediated PI3K\/AKT\/mTOR pathway","volume":"2019","author":"Wang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"2","key":"10.1016\/j.jep.2025.120368_bib41","article-title":"Oncogenic activation of PI K3 CA in cancers: emerging targeted therapies in precision oncology","volume":"12","author":"Wang","year":"2025","journal-title":"Genes Dis"},{"issue":"2","key":"10.1016\/j.jep.2025.120368_bib42","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/his.14816","article-title":"Low-grade oncocytic tumour of the kidney is characterised by genetic alterations of TSC1, TSC2, MTOR or PIK3CA and consistent GATA3 positivity","volume":"82","author":"Williamson","year":"2023","journal-title":"Histopathology"},{"key":"10.1016\/j.jep.2025.120368_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156345","article-title":"Mechanism of Fangji Huangqi decoction against acute kidney injury based on network pharmacology and experimental validation","volume":"136","author":"Xiao","year":"2025","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.jep.2025.120368_bib44","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3892\/or.2015.4041","article-title":"Downregulation of miR-19a exhibits inhibitory effects on metastatic renal cell carcinoma by targeting PIK3CA and inactivating Notch signaling in vitro","volume":"34","author":"Xiao","year":"2015","journal-title":"Oncol. Rep."},{"issue":"10","key":"10.1016\/j.jep.2025.120368_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28103987","article-title":"Chemical constitution, pharmacological effects and the underlying mechanism of atractylenolides: a review","volume":"28","author":"Xie","year":"2023","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jep.2025.120368_bib46","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s12882-020-01898-3","article-title":"miR-10a overexpression aggravates renal ischemia-reperfusion injury associated with decreased PIK3CA expression","volume":"21","author":"Xu","year":"2020","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.jep.2025.120368_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.762603","article-title":"The pharmacological mechanism of guchangzhixie capsule against experimental colitis","volume":"12","author":"Yan","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120368_bib48","article-title":"A review of the ethnopharmacology, phytochemistry, pharmacology, application, quality control, processing, toxicology, and pharmacokinetics of the dried rhizome of Atractylodes macrocephala","volume":"12","author":"Yang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120368_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119206","article-title":"3-Bromopyruvate decreased kidney fibrosis and fibroblast activation by suppressing aerobic glycolysis in unilateral ureteral obstruction mice model","volume":"272","author":"Yu","year":"2021","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.jep.2025.120368_bib50","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.kint.2022.05.026","article-title":"Insulin-like growth factor binding protein 7 promotes acute kidney injury by alleviating poly ADP ribose polymerase 1 degradation","volume":"102","author":"Yu","year":"2022","journal-title":"Kidney Int."},{"issue":"41","key":"10.1016\/j.jep.2025.120368_bib51","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.1038\/onc.2008.245","article-title":"PI3K pathway alterations in cancer: variations on a theme","volume":"27","author":"Yuan","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.jep.2025.120368_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2025.112708","article-title":"Anti-fibrosis effect and its mechanism of atractylenolide III on post-traumatic extending knee joint contracture in rats","volume":"201","author":"Zhang","year":"2025","journal-title":"Exp. Gerontol."},{"issue":"4","key":"10.1016\/j.jep.2025.120368_bib53","doi-asserted-by":"crossref","DOI":"10.1002\/fsn3.70177","article-title":"Ganoderic acid A prevented osteoporosis by modulating the PIK3CA\/p-Akt\/TWIST1 signaling pathway","volume":"13","author":"Zhao","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.jep.2025.120368_bib54","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jep.2018.08.023","article-title":"The traditional uses, phytochemistry, and pharmacology of Atractylodes macrocephala Koidz.: a review","volume":"226","author":"Zhu","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.jep.2025.120368_bib55","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1111\/1440-1681.13306","article-title":"Atractylenolide III reduces NLRP3 inflammasome activation and Th1\/Th2 imbalances in both in vitro and in vivo models of asthma","volume":"47","author":"Zhu","year":"2020","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"16","key":"10.1016\/j.jep.2025.120368_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/cells11162508","article-title":"\"PI3K\/AKT\/mTOR-Targeted therapy for breast cancer.\"","volume":"11","author":"Zhu","year":"2022","journal-title":"Cells"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125010608?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125010608?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:19:56Z","timestamp":1772799596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125010608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":56,"alternative-id":["S0378874125010608"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120368","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Atractylenolide III attenuates acute kidney injury through phosphorylation of PIK3CA: Functional activation and molecular interaction analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120368","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120368"}}