{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T22:48:24Z","timestamp":1757630904513,"version":"3.44.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002857","name":"China Pharmaceutical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jep.2025.120432","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T06:42:21Z","timestamp":1755153741000},"page":"120432","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PB","title":["Systematic reevaluation on the antipyretic, analgesic effects, and uncover the mechanisms of Chaiqin Qingning capsule, a traditional Chinese medicine, via establishing lipopolysaccharide - induced fever models, physical and chemical - stimuli pain models"],"prefix":"10.1016","volume":"353","author":[{"given":"Lianzhan","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buliduhong","family":"Halihaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuansheng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jep.2025.120432_bib1","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.jep.2025.120432_bib2","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.3390\/plants9091102","article-title":"Effects of green Brazilian propolis alcohol extract on nociceptive pain models in rats","volume":"9","author":"Al-Hariri","year":"2020","journal-title":"Plants"},{"issue":"4","key":"10.1016\/j.jep.2025.120432_bib3","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1177\/1073858418760481","article-title":"Neural mechanisms of inflammation-induced fever","volume":"24","author":"Blomqvist","year":"2018","journal-title":"Neuroscientist"},{"issue":"12","key":"10.1016\/j.jep.2025.120432_bib4","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.3390\/molecules25122900","article-title":"Anti-proliferative, analgesic and anti-inflammatory properties of Syzygium mundagam bark methanol extract","volume":"25","author":"Chandran","year":"2020","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.jep.2025.120432_bib5","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.brainresbull.2005.01.016","article-title":"Increase of phosphorylation of calcium\/calmodulin-dependent protein kinase-II in several brain regions by substance P administered intrathecally in mice","volume":"65","author":"Choi","year":"2005","journal-title":"Brain Res. Bull."},{"issue":"1","key":"10.1016\/j.jep.2025.120432_bib6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.brainres.2006.06.048","article-title":"Involvement of phosphorylated Ca2+\/calmodulin-dependent protein kinase II and phosphorylated extracellular signal-regulated protein in the mouse formalin pain model","volume":"1108","author":"Choi","year":"2006","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.jep.2025.120432_bib7","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.niox.2011.06.004","article-title":"Pain and analgesia: the dual effect of nitric oxide in the nociceptive system","volume":"25","author":"Cury","year":"2011","journal-title":"Nitric Oxide"},{"issue":"1","key":"10.1016\/j.jep.2025.120432_bib8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s10194-017-0760-z","article-title":"The NO-cGMP-PKG signal transduction pathway is involved in the analgesic effect of early hyperbaric oxygen treatment of neuropathic pain","volume":"18","author":"Ding","year":"2017","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.jep.2025.120432_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115757","article-title":"Analgesic, anti-inflammatory activity and metabolite profiling of the methanolic extract of Callicarpa arborea roxb. leaves","volume":"300","author":"Ema","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.jep.2025.120432_bib10","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.imbio.2013.04.019","article-title":"Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK\/AP-1 and IKK\/NF-kappaB-induced inflammatory mediators production in RAW 264.7 cells","volume":"218","author":"Endale","year":"2013","journal-title":"Immunobiology"},{"issue":"7","key":"10.1016\/j.jep.2025.120432_bib11","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1080\/15548627.2024.2330038","article-title":"Impaired neuronal macroautophagy in the prelimbic cortex contributes to comorbid anxiety-like behaviors in rats with chronic neuropathic pain","volume":"20","author":"Fu","year":"2024","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.jep.2025.120432_bib12","first-page":"129","article-title":"Expert consensus on application of Chinese patent medicine for acute upper respiratory tract infection","author":"Fang","year":"2019","journal-title":"Chin. J. TCM. WM. Crit. Care."},{"issue":"4","key":"10.1016\/j.jep.2025.120432_bib13","doi-asserted-by":"crossref","first-page":"278","DOI":"10.2174\/0113816128280351240112044430","article-title":"Network pharmacology and in vitro experimental verification to explore the mechanism of chaiqin qingning capsule in the treatment of pain","volume":"30","author":"Gao","year":"2024","journal-title":"Curr. Pharm. Des."},{"issue":"Pt B","key":"10.1016\/j.jep.2025.120432_bib14","article-title":"Vitro UPLC analysis and mass method identification, and in vivo or cellular immune anti-inflammatory function of sanhuang xiexin decoction (SHXD)","volume":"318","author":"Gao","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120432_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.106000","article-title":"Elucidation of the anti-inflammatory mechanism of Er miao san by integrative approach of network pharmacology and experimental verification","volume":"175","author":"Guo","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.jep.2025.120432_bib16","first-page":"479","article-title":"Experimental study on \u201cdosage-time-toxicity\u201d relationship of hepatotoxicity induced by cold medicine containing acetaminophen and chaiqin qingning capsules with single administration in mice","volume":"40","author":"Gao","year":"2017","journal-title":"Drug Eva. Res."},{"issue":"5","key":"10.1016\/j.jep.2025.120432_bib17","first-page":"620","article-title":"Experimental study on \u201cdose-time-toxicity\u201d relationship of hepatotoxicity in mice with multiple administration of cold medicine containing acetaminophen and chaiqin qingning capsules","volume":"40","author":"Gao","year":"2017","journal-title":"Drug Eva. Res."},{"issue":"12","key":"10.1016\/j.jep.2025.120432_bib18","first-page":"147","article-title":"Efficacy and safety of chaiqin qingning capsule in the treatment of acute upper respiratory tract infection","volume":"28","author":"Guo","year":"2022","journal-title":"Contemp. Med."},{"issue":"1","key":"10.1016\/j.jep.2025.120432_bib19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/j.2040-4603.2014.tb00544.x","article-title":"Fever, immunity, and molecular adaptations","volume":"4","author":"Hasday","year":"2014","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.jep.2025.120432_bib20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jep.2018.02.002","article-title":"Anti-nociceptive effect of methanol extract of leaves of Senna singueana in mice","volume":"217","author":"Hishe","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120432_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114776","article-title":"Qianghuo shengshi decoction exerts anti-inflammatory and analgesic via MAPKs\/CREB signaling pathway","volume":"284","author":"Hu","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2025.120432_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/cbdd.14451","article-title":"Investigation on the antipyretic mechanism of chaiqin qingning capsule for the treatment of fever based on network pharmacology, molecular docking, and in vitro experimental validation","volume":"103","author":"Huang","year":"2024","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.jep.2025.120432_bib23","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jchromb.2017.05.018","article-title":"Comparative pharmacokinetic study of baicalin and its metabolites after oral administration of baicalin and chaiqin qingning capsule in normal and febrile rats","volume":"1059","author":"Huo","year":"2017","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jep.2025.120432_bib24","article-title":"Antinociceptive, antineuropathic, and antimigraine-like activities ofFritillariaimperialis L. rich in verticinone on rats: mechanisms of action","volume":"339","author":"Jabbari","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.jep.2025.120432_bib25","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.3390\/molecules23092099","article-title":"Analgesic effect of 5-(3,4-Dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one in experimental animal models of nociception","volume":"23","author":"Kamarudin","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.120432_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116375","article-title":"Bupleurum chinense exerts a mild antipyretic effect on LPS-Induced pyrexia rats involving inhibition of peripheral TNF-\u03b1 production","volume":"310","author":"Kang","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120432_bib27","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.intimp.2014.06.007","article-title":"The analgesic and anti-inflammatory effects of Litsea japonica fruit are mediated via suppression of NF-\u03baB and JNK\/p38 MAPK activation","volume":"22","author":"Koo","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.120432_bib28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1744-8069-8-40","article-title":"Ethyl pyruvate attenuates formalin-induced inflammatory nociception by inhibiting neuronal ERK phosphorylation","volume":"8","author":"Lee","year":"2012","journal-title":"Mol. Pain"},{"issue":"52","key":"10.1016\/j.jep.2025.120432_bib29","doi-asserted-by":"crossref","first-page":"566","DOI":"10.4103\/pm.pm_81_17","article-title":"Simultaneous determination of ten constituents in chaiqin qingning capsule by high-performance liquid chromatography coupled with triple-quadrupole mass spectrometry","volume":"13","author":"Li","year":"2017","journal-title":"Pharmacogn. Mag."},{"issue":"3","key":"10.1016\/j.jep.2025.120432_bib30","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.pbb.2012.06.007","article-title":"Analgesic effect of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (rubiaceae) on spared nerve injury rat model of neuropathic pain","volume":"102","author":"Liu","year":"2012","journal-title":"Pharmacol., Biochem. Behav."},{"issue":"6","key":"10.1016\/j.jep.2025.120432_bib31","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1111\/bph.17419","article-title":"The paracetamol metabolite N-acetyl-4-benzoquinoneimine (NAPQI) prevents modulation of K(V)7 channels via G-protein coupled receptors by interference with PIP2 and Ca2+ sensitivity","volume":"182","author":"Losgott","year":"2024","journal-title":"Br. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.jep.2025.120432_bib32","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1111\/bph.13080","article-title":"LPS exacerbates functional and inflammatory responses to ovalbumin and decreases sensitivity to inhaled fluticasone propionate in a Guinea pig model of asthma","volume":"172","author":"Lowe","year":"2015","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2025.120432_bib33","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","article-title":"LPS\/TLR4 signal transduction pathway","volume":"42","author":"Lu","year":"2008","journal-title":"Cytokine"},{"issue":"3","key":"10.1016\/j.jep.2025.120432_bib34","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s10753-018-0733-7","article-title":"Plantamajoside inhibits lipopolysaccharide-induced MUC5AC expression and inflammation through suppressing the PI3K\/Akt and NF-\u03baB signaling pathways in human airway epithelial cells","volume":"41","author":"Ma","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2025.120432_bib35","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejphar.2017.03.007","article-title":"Pharmacological evidence for systemic and peripheral antinociceptive activities of pioglitazone in the rat formalin test: role of PPAR\u03b3 and nitric oxide","volume":"805","author":"Mansouri","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.120432_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154983","article-title":"Biancaea decapetala (roth) o.Deg. Extract exerts an anti-inflammatory effect by regulating the TNF\/Akt\/NF-\u03baB pathway","volume":"119","author":"Meng","year":"2023","journal-title":"Phytomedicine"},{"issue":"20","key":"10.1016\/j.jep.2025.120432_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252011111","article-title":"Exploring the therapeutic potential of N-Methyl-D-Aspartate receptor antagonists in neuropathic pain management","volume":"25","author":"Pu\u015fca\u015fu","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.120432_bib38","doi-asserted-by":"crossref","DOI":"10.1177\/1744806917737462","article-title":"Propofol produces preventive analgesia via GluN2B-containing NMDA Receptor\/ERK1\/2 signaling pathway in a rat model of inflammatory pain","volume":"13","author":"Qiu","year":"2017","journal-title":"Mol. Pain"},{"issue":"6","key":"10.1016\/j.jep.2025.120432_bib39","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1189\/jlb.0405223","article-title":"Leukocytes in the regulation of pain and analgesia","volume":"78","author":"Rittner","year":"2005","journal-title":"J. Leukoc. Biol."},{"issue":"4","key":"10.1016\/j.jep.2025.120432_bib40","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/j.2040-4603.2014.tb00582.x","article-title":"Mechanisms of fever production and lysis: lessons from experimental LPS fever","volume":"4","author":"Roth","year":"2014","journal-title":"Compr. Physiol."},{"issue":"2","key":"10.1016\/j.jep.2025.120432_bib41","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1089-8603(02)00165-9","article-title":"Inhibition of cyclic guanosine 5'-monophosphate-dependent protein kinase I (PKG-I) in lumbar spinal cord reduces formalin-induced hyperalgesia and PKG upregulation","volume":"8","author":"Schmidtko","year":"2003","journal-title":"Nitric Oxide"},{"issue":"1","key":"10.1016\/j.jep.2025.120432_bib42","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2174\/1871520618666180628155931","article-title":"Pharmacological effects and chemical constituents of bupleurum","volume":"19","author":"Sun","year":"2019","journal-title":"Mini Rev. Med. Chem."},{"issue":"1","key":"10.1016\/j.jep.2025.120432_bib43","doi-asserted-by":"crossref","first-page":"7234","DOI":"10.1038\/s41467-023-43022-7","article-title":"Epigenetic regulation of beta-endorphin synthesis in hypothalamic arcuate nucleus neurons modulates neuropathic pain in a rodent pain model","volume":"14","author":"Tao","year":"2023","journal-title":"Nat. Commun."},{"issue":"Suppl. 5","key":"10.1016\/j.jep.2025.120432_bib44","doi-asserted-by":"crossref","first-page":"S190","DOI":"10.1086\/317519","article-title":"Endogenous antipyretics","volume":"31","author":"Tatro","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jep.2025.120432_bib45","article-title":"Reveal the patterns of prescriptions for recurrent respiratory tract infections' treatment based on multiple illustrious senior traditional Chinese medicine practitioners. Evid. Based. Complement. Alternat","volume":"2023","author":"Wang","year":"2023","journal-title":"Med"},{"key":"10.1016\/j.jep.2025.120432_bib46","article-title":"Network pharmacological analysis and experimental study of the antipharyngitis mechanism of the chaiqin qingning capsule","volume":"2022","author":"Wang","year":"2022","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jep.2025.120432_bib47","article-title":"Pharmacological effects of baicalin in lung diseases","volume":"4","author":"Wang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120432_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.107032","article-title":"Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: a comprehensive review with future perspectives","volume":"199","author":"Wang","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.jep.2025.120432_bib49","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/13880209.2018.1492620","article-title":"A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis","volume":"56","author":"Wang","year":"2018","journal-title":"Pharm. Biol."},{"issue":"20","key":"10.1016\/j.jep.2025.120432_bib50","first-page":"30","article-title":"Efficacy and safety of the chaiqin qingning capsule on acute upper respiratory tract infection in children","volume":"12","author":"Wang","year":"2020","journal-title":"Clin. J. Chin. Med."},{"issue":"3","key":"10.1016\/j.jep.2025.120432_bib51","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1142\/S0192415X23500258","article-title":"Traditional Chinese medicine for the common cold: evidence and potential mechanisms","volume":"51","author":"Wu","year":"2023","journal-title":"Am. J. Chin. Med."},{"issue":"8","key":"10.1016\/j.jep.2025.120432_bib52","first-page":"1446","article-title":"Clinical observation of chaiqin qingning capsule in the treatment of acute upper respiratory tract infection with air temperature disease and heat attack on lungs syndrome","volume":"26","author":"Wei","year":"2017","journal-title":"J. Emerg. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2025.120432_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctim.2022.102840","article-title":"The effectiveness and safety of chaiqin qingning capsule in upper respiratory tract infections with fever: a prospective, double-blinded, randomized, multicenter controlled trial","volume":"68","author":"Xu","year":"2022","journal-title":"Compl. Ther. Med."},{"issue":"21","key":"10.1016\/j.jep.2025.120432_bib54","first-page":"85","article-title":"Clinical study on chaiqin qingning capsule in the treatment of air temperature disease and heat attack on lungs syndrome in the children with upper respiratory tract infection","volume":"58","author":"Xie","year":"2020","journal-title":"China Modern Doc"},{"key":"10.1016\/j.jep.2025.120432_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.787084","article-title":"Bupleuri radix for acute uncomplicated respiratory tract infection: a systematic review of randomized controlled trials","volume":"12","author":"Yan","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120432_bib56","article-title":"Radix bupleuri: a review of traditional uses, botany, phytochemistry, pharmacology, and toxicology","volume":"2017","author":"Yang","year":"2017","journal-title":"BioMed Res. Int."},{"issue":"1","key":"10.1016\/j.jep.2025.120432_bib57","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jep.2012.02.038","article-title":"Puerarin exerts antipyretic effect on lipopolysaccharide-induced fever in rats involving inhibition of pyrogen production from macrophages","volume":"141","author":"Yao","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120432_bib58","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.intimp.2014.12.028","article-title":"The effects of baicalin on the TLR2\/4 signaling pathway in the peripheral blood mononuclear cells of a lipopolysaccharide-induced rat fever model","volume":"25","author":"Ye","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.120432_bib59","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ctim.2016.10.008","article-title":"Seasonal variations of prescriptions for the major syndrome types and manifestations of upper respiratory tract infection in tradition Chinese medicine","volume":"29","author":"Yeh","year":"2016","journal-title":"Compl. Ther. Med."},{"key":"10.1016\/j.jep.2025.120432_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.172909","article-title":"The intraperitoneal administration of MOTS-c produces antinociceptive and anti-inflammatory effects through the activation of AMPK pathway in the mouse formalin test","volume":"870","author":"Yin","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.120432_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112649","article-title":"Calculus bovis: a review of the traditional usages, origin, chemistry, pharmacological activities and toxicology","volume":"254","author":"Yu","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120432_bib62","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1080\/13880209.2016.1262433","article-title":"A systematic review of the active saikosaponins and extracts isolated from Radix bupleuri and their applications","volume":"55","author":"Yuan","year":"2017","journal-title":"Pharm. Biol."},{"issue":"3","key":"10.1016\/j.jep.2025.120432_bib63","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3390\/ph16030343","article-title":"Kaurenoic acid reduces ongoing chronic constriction injury-induced neuropathic pain: nitric oxide silencing of dorsal root ganglia neurons","volume":"16","author":"Zaninelli","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jep.2025.120432_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113435","article-title":"An integrative metabolomics and network pharmacology method for exploring the effect and mechanism of Radix bupleuri and Radix paeoniae Alba on anti-depression","volume":"189","author":"Zhang","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2025.120432_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117561","article-title":"The antioxidant, anti-inflammatory and analgesic activity effect of ethyl acetate extract from the flowers of Syringa pubescens turcz","volume":"322","author":"Zhang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120432_bib66","article-title":"Chaiqin qingning capsule inhibits influenza virus infection and inflammation in vitro and in vivo","volume":"2021","author":"Zhao","year":"2021","journal-title":"Evid. Based. Complement. Alternat. Med."},{"issue":"9","key":"10.1016\/j.jep.2025.120432_bib67","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1111\/jphp.13129","article-title":"Scutellaria baicalensis georgi. (lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology","volume":"71","author":"Zhao","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2025.120432_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118643","article-title":"Integrating serum pharmacochemistry, network pharmacology and untargeted metabolomics strategies to reveal the material basis and mechanism of action of feining keli in the treatment of chronic bronchitis","volume":"335","author":"Zhu","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.jep.2025.120432_bib69","first-page":"88","article-title":"Study on the effect of chaiqin qingning capsule combineds with sseltamivir granules in the treatment of influenza B virus infected patients","volume":"32","author":"Zhang","year":"2022","journal-title":"Shenzhen J. Integra. Tradit. Chin. and West. Med."},{"issue":"3","key":"10.1016\/j.jep.2025.120432_bib70","first-page":"475","article-title":"Clinical study on chaiqin qingning capsules combined with ribavirin in treatment of acute upper respiratory tract infection","volume":"36","author":"Zhao","year":"2021","journal-title":"Drugs Clin."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125011249?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125011249?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:57:43Z","timestamp":1757541463000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125011249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":70,"alternative-id":["S0378874125011249"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120432","relation":{},"ISSN":["0378-8741"],"issn-type":[{"type":"print","value":"0378-8741"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic reevaluation on the antipyretic, analgesic effects, and uncover the mechanisms of Chaiqin Qingning capsule, a traditional Chinese medicine, via establishing lipopolysaccharide - induced fever models, physical and chemical - stimuli pain models","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120432","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120432"}}