{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:44:03Z","timestamp":1786992243211,"version":"build-2736575974"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130116"],"award-info":[{"award-number":["82130116"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007956","name":"Nanjing University of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2020MS08101"],"award-info":[{"award-number":["2020MS08101"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jep.2025.120435","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T15:44:48Z","timestamp":1755618288000},"page":"120435","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"PB","title":["Chebulinic acid shields Villin 1 from covalent attack to mitigate Euphorbia fischeriana enterotoxicity: A basis for safer anti-ascites therapy"],"prefix":"10.1016","volume":"353","author":[{"given":"Hang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruolan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinman","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronglu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laga","family":"Litong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8382-7203","authenticated-orcid":false,"given":"Xinzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120435_bib1","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2021.1996830","article-title":"Epithelial integrity, junctional complexes, and biomarkers associated with intestinal functions","volume":"10","author":"Alizadeh","year":"2022","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.jep.2025.120435_bib2","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S2221-1691(13)60059-3","article-title":"The development of Terminalia chebula Retz. (Combretaceae) in clinical research","volume":"3","author":"Bag","year":"2013","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.jep.2025.120435_bib3","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1073\/pnas.76.5.2321","article-title":"Villin: the major microfilament-associated protein of the intestinal microvillus","volume":"76","author":"Bretscher","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jep.2025.120435_bib4","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/0092-8674(80)90330-X","article-title":"Villin is a major protein of the microvillus cytoskeleton which binds both G and F actin in a calcium-dependent manner","volume":"20","author":"Bretscher","year":"1980","journal-title":"Cell"},{"key":"10.1016\/j.jep.2025.120435_bib7","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1136\/gutjnl-2019-318427","article-title":"Leaky gut: mechanisms, measurement and clinical implications in humans","volume":"68","author":"Camilleri","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.jep.2025.120435_bib8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13020-021-00472-9","article-title":"The toxicology and detoxification of aconitum: traditional and modern views","volume":"16","author":"Chan","year":"2021","journal-title":"Chin. Med. (Lond.)"},{"key":"10.1016\/j.jep.2025.120435_bib9","article-title":"Study on the mechanism of reducing intestinal toxic side effects of Langdu processed with Terminalia chebula decoction based on proteomics","author":"Chen","year":"2025","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.jep.2025.120435_bib10","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1038\/s41596-021-00607-0","article-title":"Controlling the polarity of human gastrointestinal organoids to investigate epithelial biology and infectious diseases","volume":"16","author":"Co","year":"2021","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jep.2025.120435_bib11","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1021\/acschembio.8b00381","article-title":"Chemoproteomics-enabled covalent ligand screening reveals ALDH3A1 as a lung cancer therapy target","volume":"13","author":"Counihan","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.jep.2025.120435_bib12","series-title":"Paozhi Ming Zang [A Clear Mirror of Pharmaceutical Processing in Tibetan Medicine]","author":"Danzeng","year":"1995"},{"key":"10.1016\/j.jep.2025.120435_bib13","series-title":"Study on Processing Technology of Two Tibetan Medical Processed Products of Terminalia chebula and Changes in their Chemical Constituents Before and After Processing [Dissertation]","author":"Fei","year":"2017"},{"key":"10.1016\/j.jep.2025.120435_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153479","article-title":"In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit","volume":"83","author":"Feng","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120435_bib15","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0092-8674(89)90030-5","article-title":"Villin induces microvilli growth and actin redistribution in transfected fibroblasts","volume":"59","author":"Friederich","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.jep.2025.120435_bib16","doi-asserted-by":"crossref","first-page":"26751","DOI":"10.1074\/jbc.274.38.26751","article-title":"Villin function in the organization of the actin cytoskeleton","volume":"274","author":"Friederich","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2025.120435_bib17","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1038\/s41596-020-0352-2","article-title":"A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes","volume":"15","author":"Fu","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jep.2025.120435_bib18","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1091\/mbc.E20-02-0158","article-title":"F-actin-bundling sites are conserved in proteins with villin-type headpiece domains","volume":"31","author":"George","year":"2020","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jep.2025.120435_bib19","doi-asserted-by":"crossref","first-page":"8156","DOI":"10.1016\/S0021-9258(18)43401-1","article-title":"Demonstration of at least two different actin-binding sites in villin, a calcium-regulated modulator of F-actin organization","volume":"256","author":"Glenney","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2025.120435_bib20","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1200\/JCO.23.02745","article-title":"Systemic therapy for advanced hepatocellular carcinoma: ASCO guideline update","volume":"42","author":"Gordan","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jep.2025.120435_bib21","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.yexcr.2004.06.008","article-title":"Early enterocytic differentiation of HT-29 cells: biochemical changes and strength increases of adherens junctions","volume":"299","author":"Gout","year":"2004","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jep.2025.120435_bib22","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1016\/j.str.2008.09.015","article-title":"The 3D structure of villin as an unusual F-actin crosslinker","volume":"16","author":"Hampton","year":"2008","journal-title":"Structure"},{"key":"10.1016\/j.jep.2025.120435_bib23","first-page":"330","article-title":"Research progress on the toxicity and processing methods of Langdu (Euphorbia spp.)","volume":"36","author":"Han","year":"2013","journal-title":"Zhong Yao Cai"},{"key":"10.1016\/j.jep.2025.120435_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-80544-6","article-title":"A comprehensive metabolome profiling of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica to explore the medicinal potential of triphala","volume":"14","author":"Hegde","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2025.120435_bib26","article-title":"Measuring protein binding to F-actin by co-sedimentation","volume":"123","author":"Heier","year":"2017","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jep.2025.120435_bib28","doi-asserted-by":"crossref","first-page":"512","DOI":"10.2353\/ajpath.2010.100168","article-title":"Cytoskeletal regulation of epithelial barrier function during inflammation","volume":"177","author":"Ivanov","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jep.2025.120435_bib29","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1021\/acs.jmedchem.6b00788","article-title":"Covalent modifiers: a chemical perspective on the reactivity of \u03b1, \u03b2-unsaturated carbonyls with thiols via hetero-Michael addition reactions","volume":"60","author":"Jackson","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jep.2025.120435_bib30","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.febslet.2008.02.040","article-title":"Regulation of cell structure and function by actin-binding proteins: villin's perspective","volume":"582","author":"Khurana","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jep.2025.120435_bib31","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s12257-022-0090-0","article-title":"Terminalia chebula medicinal uses: a review of in vitro and in vivo studies","volume":"27","author":"Kim","year":"2022","journal-title":"Biotechnol. Bioproc. Eng."},{"key":"10.1016\/j.jep.2025.120435_bib32","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s11418-016-0987-z","article-title":"Euphorins A\u2013H: bioactive diterpenoids from Euphorbia fischeriana","volume":"70","author":"Kuang","year":"2016","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.jep.2025.120435_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114095","article-title":"Existing knowledge on Euphorbia fischeriana Steud. (Euphorbiaceae): traditional uses, clinical applications, phytochemistry, pharmacology and toxicology","volume":"275","author":"Li","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120435_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2022.105296","article-title":"Structurally diverse diterpenoids from the roots of Euphorbia fischeriana Steud","volume":"162","author":"Li","year":"2022","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2025.120435_bib35","first-page":"2441","article-title":"Correlation study on changes in intestinal toxicity and chemical composition of toxic parts of Langdu (Euphorbia ebracteolata) before and after processing with Terminalia chebula decoction","volume":"49","author":"Lin","year":"2024","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.jep.2025.120435_bib36","first-page":"23548","article-title":"Effect of traditional medicine on clinical cancer","volume":"30","author":"Liu","year":"2020","journal-title":"Biomed. J. Sci. Tech. Res."},{"key":"10.1016\/j.jep.2025.120435_bib38","first-page":"2516","article-title":"Effects of Langdu (Euphorbia fischeriana) processed with vinegar on intestinal toxicity and colonic aquaporin expression in mice","volume":"43","author":"Liu","year":"2018","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.jep.2025.120435_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2017.09.019","article-title":"Gastroprotective effects of chebulagic acid against ethanol-induced gastric injury in rats","volume":"278","author":"Liu","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2025.120435_bib40","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/ecco-jcc\/jjy201","article-title":"Role of epithelial-to-mesenchymal transition in inflammatory bowel disease","volume":"13","author":"Lovisa","year":"2019","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.jep.2025.120435_bib41","first-page":"2742","article-title":"On the inheritance and development of traditional Mongolian pharmaceutical processing","volume":"44","author":"Lyu","year":"2019","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.jep.2025.120435_bib42","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1080\/14786419.2019.1678619","article-title":"Optimization of extraction for diterpenoids from Euphorbia fischeriana Steud using response surface methodology and structure identification by UPLC-Q-TOF-MS","volume":"35","author":"Ma","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2025.120435_bib43","first-page":"738","article-title":"Overview of ancient and modern processing research on Euphorbiaceae Chinese materia medica","volume":"24","author":"Ma","year":"2006","journal-title":"Zhong Yi Yao Xue Kan"},{"key":"10.1016\/j.jep.2025.120435_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1258843","article-title":"Role of the epithelial barrier in intestinal fibrosis associated with inflammatory bowel disease: relevance of the epithelial-to mesenchymal transition","volume":"11","author":"Macias-Ceja","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jep.2025.120435_bib45","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1242\/dev.115.3.717","article-title":"Developmental regulation of villin gene expression in the epithelial cell lineages of mouse digestive and urogenital tracts","volume":"115","author":"Maunoury","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.jep.2025.120435_bib46","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1002\/ptr.6702","article-title":"Fruits of Terminalia chebula Retz.: a review on traditional uses, bioactive chemical constituents and pharmacological activities","volume":"34","author":"Nigam","year":"2020","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2025.120435_bib47","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1142\/S0192415X23500635","article-title":"Review on processing methods of toxic chinese materia medica and the related mechanisms of action","volume":"51","author":"Pan","year":"2023","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2025.120435_bib48","doi-asserted-by":"crossref","first-page":"C1046","DOI":"10.1152\/ajpcell.2001.281.3.C1046","article-title":"Regulation of phospholipase C-gamma(1) by the actin-regulatory protein villin","volume":"281","author":"Panebra","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.jep.2025.120435_bib49","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s11101-013-9321-5","article-title":"Traditional Mongolian medicine: history and status quo","volume":"12","author":"Pitschmann","year":"2013","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.jep.2025.120435_bib50","first-page":"4291","article-title":"Research status of Euphorbia fischeriana and analysis of its clinical application in Tibetan medicine","volume":"38","author":"Poba","year":"2023","journal-title":"Zhonghua Zhongyiyao Zazhi"},{"key":"10.1016\/j.jep.2025.120435_bib51","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1038\/s41596-021-00589-z","article-title":"Intestinal organoid cocultures with microbes","volume":"16","author":"Puschhof","year":"2021","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jep.2025.120435_bib52","first-page":"52","article-title":"Similarities, differences, and prospects of Terminalia chebula use in Chinese and Mongolian medicine","volume":"27","author":"Qu","year":"2008","journal-title":"Zhong Wai Yi Liao"},{"key":"10.1016\/j.jep.2025.120435_bib53","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1053\/j.gastro.2017.12.016","article-title":"Villin-1 and gelsolin regulate changes in actin dynamics that affect cell survival signaling pathways and intestinal inflammation","volume":"154","author":"Roy","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2025.120435_bib54","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ymeth.2012.12.005","article-title":"Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions","volume":"59","author":"Seidel","year":"2013","journal-title":"Methods"},{"key":"10.1016\/j.jep.2025.120435_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155623","article-title":"Detoxification and underlying mechanisms towards toxic alkaloids by traditional Chinese medicine processing: a comprehensive review","volume":"129","author":"Shan","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120435_bib56","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1111\/bph.13630","article-title":"Proanthocyanidins and hydrolysable tannins: occurrence, dietary intake and pharmacological effects","volume":"174","author":"Smeriglio","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.120435_bib57","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cancergen.2024.06.002","article-title":"Cancer treatments: past, present, and future","volume":"286\u2013287","author":"Sonkin","year":"2024","journal-title":"Cancer Genet."},{"key":"10.1016\/j.jep.2025.120435_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114911","article-title":"Mechanism exploration of ancient pharmaceutic processing (Paozhi) improving the gastroprotective efficacy of aucklandiae radix","volume":"287","author":"Song","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120435_bib59","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.stemcr.2015.05.004","article-title":"Expression of \u03b1-smooth muscle actin determines the fate of mesenchymal stromal cells","volume":"4","author":"Talele","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.jep.2025.120435_bib60","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.fitote.2011.10.020","article-title":"Comparative characteristic of the inflammatory diterpenes in the roots of Euphorbia fischeriana with different preparation method using HPLC\u2013ELSD","volume":"83","author":"Tang","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2025.120435_bib61","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13020-018-0197-6","article-title":"Triphala: current applications and new perspectives on the treatment of functional gastrointestinal disorders","volume":"13","author":"Tarasiuk","year":"2018","journal-title":"Chin. Med. (Lond.)"},{"key":"10.1016\/j.jep.2025.120435_bib62","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.765","article-title":"Gut microbiota disorder caused by diterpenoids extracted from Euphorbia pekinensis aggravates intestinal mucosal damage","volume":"9","author":"Wang","year":"2021","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.jep.2025.120435_bib63","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1038\/cdd.2012.28","article-title":"Actin reorganization as the molecular basis for the regulation of apoptosis in gastrointestinal epithelial cells","volume":"19","author":"Wang","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jep.2025.120435_bib64","doi-asserted-by":"crossref","first-page":"9454","DOI":"10.1074\/jbc.M707962200","article-title":"A novel role for villin in intestinal epithelial cell survival and homeostasis","volume":"283","author":"Wang","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2025.120435_bib65","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1002\/cam4.3660","article-title":"Perspectives and controversies regarding the use of natural products for the treatment of lung cancer","volume":"10","author":"Wen","year":"2021","journal-title":"Cancer Med."},{"key":"10.1016\/j.jep.2025.120435_bib66","doi-asserted-by":"crossref","first-page":"12253","DOI":"10.1074\/jbc.M113.457499","article-title":"Epithelial cell adhesion molecule (EpCAM) regulates claudin dynamics and tight junctions","volume":"288","author":"Wu","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2025.120435_bib67","article-title":"Berberine attenuates 5-fluorouracil-induced intestinal mucosal injury by modulating the gut microbiota without compromising its anti-tumor efficacy","volume":"10","author":"Wu","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2025.120435_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2019.112064","article-title":"Euphonoids A-G, cytotoxic diterpenoids from Euphorbia fischeriana","volume":"166","author":"Yan","year":"2019","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2025.120435_bib69","first-page":"183","article-title":"Textual research and modern research overview of Mongolian medicine Tarinu (Langdu)","volume":"31","author":"Yu","year":"2024","journal-title":"Zhongguo Zhongyiyao Xinxi Zazhi"},{"key":"10.1016\/j.jep.2025.120435_bib70","first-page":"674","article-title":"Study on the detoxification mechanism of Euphorbia fischeriana processed with Terminalia chebula decoction based on LC-MS and simulated processing","volume":"40","author":"Zhang","year":"2024","journal-title":"Nanjing Zhongyiyao Daxue Xuebao"},{"key":"10.1016\/j.jep.2025.120435_bib71","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1080\/14786419.2023.2169686","article-title":"Antiproliferative ent-abietane diterpenoids from Euphorbia fischeriana","volume":"37","author":"Zhao","year":"2023","journal-title":"Nat. Prod. Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125011274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125011274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:13:43Z","timestamp":1772810023000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125011274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":66,"alternative-id":["S0378874125011274"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120435","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chebulinic acid shields Villin 1 from covalent attack to mitigate Euphorbia fischeriana enterotoxicity: A basis for safer anti-ascites therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120435","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120435"}}