{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:46:23Z","timestamp":1789577183542,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["KYCX21_1682"],"award-info":[{"award-number":["KYCX21_1682"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274454"],"award-info":[{"award-number":["82274454"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["SBK20250406600"],"award-info":[{"award-number":["SBK20250406600"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jep.2025.120470","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:51:24Z","timestamp":1756277484000},"page":"120470","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Maidong Dishao Decoction can inhibit the activation of the cGAS-STING signaling pathway of Sj\u00f6gren's syndrome by reducing oxidative stress in salivary gland epithelial cells"],"prefix":"10.1016","volume":"354","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7224-6729","authenticated-orcid":false,"given":"Wen","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.jep.2025.120470_bib1","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1080\/1744666X.2023.2234641","article-title":"Why do drug treatments fail in Sj\u00f6gren's disease? Considerations for treatment, trial design and interpretation of clinical efficacy","volume":"19","author":"Arends","year":"2023","journal-title":"Expet Rev. Clin. Immunol."},{"issue":"8","key":"10.1016\/j.jep.2025.120470_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2021.102867","article-title":"Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: potential role in Sj\u00f6gren's syndrome","volume":"20","author":"Barrera","year":"2021","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jep.2025.120470_bib3","article-title":"Traditional Chinese medicine in patients with primary Sjogren's Syndrome: a randomized, Double-Blind, placebo-controlled clinical trial","volume":"8","author":"Chen","year":"2021","journal-title":"Front. Med."},{"issue":"2","key":"10.1016\/j.jep.2025.120470_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22020658","article-title":"The involvement of innate and adaptive immunity in the initiation and perpetuation of Sj\u00f6gren's Syndrome","volume":"22","author":"Chivasso","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.jep.2025.120470_bib5","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/art.42018","article-title":"Maladaptive autophagy in the pathogenesis of autoimmune Epithelitis in Sj\u00f6gren's Syndrome","volume":"74","author":"Colafrancesco","year":"2022","journal-title":"Arthritis Rheumatol."},{"issue":"2","key":"10.1016\/j.jep.2025.120470_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbspin.2022.105479","article-title":"Autoimmune epithelitis in primary Sj\u00f6gren's syndrome","volume":"90","author":"Desvaux","year":"2023","journal-title":"Jt. Bone Spine"},{"issue":"5","key":"10.1016\/j.jep.2025.120470_bib7","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1093\/rheumatology\/kez142","article-title":"Treatment of Sj\u00f6gren's syndrome: current therapy and future directions","volume":"60","author":"Fox","year":"2021","journal-title":"Rheumatology"},{"key":"10.1016\/j.jep.2025.120470_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125541","article-title":"Fucoidan-proanthocyanidins nanoparticles protect against cisplatin-induced acute kidney injury by activating mitophagy and inhibiting mtDNA-cGAS\/STING signaling pathway","volume":"245","author":"Gao","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.jep.2025.120470_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/antiox13030284","article-title":"Calocedrus formosana essential oils induce ROS-Mediated autophagy and apoptosis by targeting SIRT1 in Colon cancer cells","volume":"13","author":"Islam","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2025.120470_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102335","article-title":"Autoimmune epithelitis (Sj\u00f6gren's syndrome); the impact of metabolic status of glandular epithelial cells on auto-immunogenicity","volume":"104","author":"Katsiougiannis","year":"2019","journal-title":"J. Autoimmun."},{"issue":"4","key":"10.1016\/j.jep.2025.120470_bib11","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"issue":"2","key":"10.1016\/j.jep.2025.120470_bib12","first-page":"174","article-title":"Discussion on the treatment of Sjogren's Syndrome with the method of combined therapy for the lung and intestine","volume":"56","author":"Li","year":"2015","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2025.120470_bib13","article-title":"A link between mitochondrial dysfunction and the immune microenvironment of salivary glands in primary Sjogren's Syndrome","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.120470_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109806","article-title":"Catalpol ameliorates Sj\u00f6gren's Syndrome by modulating interplay of T and B cells","volume":"123","author":"Lin","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.jep.2025.120470_bib15","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s40744-021-00334-8","article-title":"Sj\u00f6gren's Syndrome and viral infections","volume":"8","author":"Liu","year":"2021","journal-title":"Rheumatol Ther"},{"key":"10.1016\/j.jep.2025.120470_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102305","article-title":"XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury","volume":"52","author":"Liu","year":"2022","journal-title":"Redox Biol."},{"issue":"15","key":"10.1016\/j.jep.2025.120470_bib17","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.159430","article-title":"Somatic gene mutations expose cytoplasmic DNA to co-opt the cGAS\/STING\/NLRP3 axis in myelodysplastic syndromes","volume":"7","author":"McLemore","year":"2022","journal-title":"JCI Insight"},{"issue":"3","key":"10.1016\/j.jep.2025.120470_bib18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"8","key":"10.1016\/j.jep.2025.120470_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.28936","article-title":"Severe adverse events during sirolimus \"off-label\" therapy for vascular anomalies","volume":"68","author":"R\u00f6ssler","year":"2021","journal-title":"Pediatr. Blood Cancer"},{"issue":"6","key":"10.1016\/j.jep.2025.120470_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22063090","article-title":"Role of the innate immunity signaling pathway in the pathogenesis of Sj\u00f6gren's Syndrome","volume":"22","author":"Shimizu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jep.2025.120470_bib21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/jleuko\/qiad049","article-title":"The role of epithelial cells in the immunopathogenesis of Sj\u00f6gren's syndrome","volume":"115","author":"Tang","year":"2024","journal-title":"J. Leukoc. Biol."},{"issue":"5","key":"10.1016\/j.jep.2025.120470_bib22","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41584-023-00932-6","article-title":"Genetics and epigenetics of primary Sj\u00f6gren syndrome: implications for future therapies","volume":"19","author":"Thorlacius","year":"2023","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2025.120470_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102381","article-title":"Cell-autonomous epithelial activation of AIM2 (absent in melanoma-2) inflammasome by cytoplasmic DNA accumulations in primary Sj\u00f6gren's syndrome","volume":"108","author":"Vakrakou","year":"2020","journal-title":"J. Autoimmun."},{"issue":"6","key":"10.1016\/j.jep.2025.120470_bib24","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41584-021-00605-2","article-title":"Epithelial-immune cell interplay in primary Sj\u00f6gren syndrome salivary gland pathogenesis","volume":"17","author":"Verstappen","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2025.120470_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155394","article-title":"Gegen Qinlian tablets delay Alzheimer's disease progression via inhibiting glial neuroinflammation and remodeling gut microbiota homeostasis","volume":"128","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.jep.2025.120470_bib26","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.7150\/ijbs.57825","article-title":"Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway","volume":"17","author":"Wu","year":"2021","journal-title":"Int. J. Biol. Sci."},{"issue":"10","key":"10.1016\/j.jep.2025.120470_bib27","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.7150\/ijms.83801","article-title":"Lactate-induced mtDNA accumulation activates cGAS-STING signaling and the inflammatory response in Sj\u00f6gren's Syndrome","volume":"20","author":"Xu","year":"2023","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.jep.2025.120470_bib28","article-title":"Clinical observation of the therapeutic efficacy of Maidong Dishao Decoction in 20 cases of Sj\u00f6gren\u2019s syndrome","author":"Yan","year":"2008","journal-title":"J. Nanjing Univ. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2025.120470_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155888","article-title":"Revitalizing gut health: liangxue guyuan yishen decoction promotes akkermansia muciniphila-induced intestinal stem cell recovery post-radiation in mice","volume":"132","author":"Yan","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120470_bib30","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jtos.2023.09.012","article-title":"Genomic DNA activates the AIM2 inflammasome and STING pathways to induce inflammation in lacrimal gland myoepithelial cells","volume":"30","author":"Yang","year":"2023","journal-title":"Ocul. Surf."},{"issue":"9","key":"10.1016\/j.jep.2025.120470_bib31","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1080\/15548627.2021.2024702","article-title":"Negative feedback system to maintain cell ROS homeostasis: KEAP1-PGAM5 complex senses mitochondrially generated ROS to induce mitophagy","volume":"18","author":"Zeb","year":"2022","journal-title":"Autophagy"},{"issue":"12","key":"10.1016\/j.jep.2025.120470_bib32","first-page":"3235","article-title":"[Research progress in treatment of Sj\u00f6gren's syndrome by traditional Chinese medicine]","volume":"48","author":"Zhang","year":"2023","journal-title":"Zhongguo Zhongyao Zazhi"},{"issue":"21","key":"10.1016\/j.jep.2025.120470_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e38421","article-title":"Maidong Dishao Decoction mitigates submandibular gland injury in NOD mice through modulation of gut microbiota and restoration of Th17\/Treg immune balance","volume":"10","author":"Zhang","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2025.120470_bib34","article-title":"Mitochondrial displacement loop Region SNPs modify Sj\u00f6gren's Syndrome development by regulating cytokines expression in female patients","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Genet."},{"issue":"2","key":"10.1016\/j.jep.2025.120470_bib35","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s10787-023-01393-9","article-title":"Rapamycin can alleviate the submandibular gland pathology of Sj\u00f6gren's syndrome by limiting the activation of cGAS-STING signaling pathway","volume":"32","author":"Zhu","year":"2024","journal-title":"Inflammopharmacology"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125011626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125011626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:50:23Z","timestamp":1772819423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125011626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":35,"alternative-id":["S0378874125011626"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120470","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maidong Dishao Decoction can inhibit the activation of the cGAS-STING signaling pathway of Sj\u00f6gren's syndrome by reducing oxidative stress in salivary gland epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120470","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120470"}}