{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:06:15Z","timestamp":1793995575121,"version":"4.8.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Jilin Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["20220202076NC"],"award-info":[{"award-number":["20220202076NC"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jep.2025.120511","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T15:33:23Z","timestamp":1756740803000},"page":"120511","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Effectiveness and mechanisms of curcumin for colorectal cancer in preclinical models:A systematic review and\u2002meta-analysis"],"prefix":"10.1016","volume":"354","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9511-3811","authenticated-orcid":false,"given":"Yongheng","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiming","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglong","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuedong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jep.2025.120511_bib1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/ptr.7305","article-title":"Curcumin and its derivatives in cancer therapy: potentiating antitumor activity of cisplatin and reducing side effects","volume":"36","author":"Abadi","year":"2022","journal-title":"Phytother Res."},{"issue":"12","key":"10.1016\/j.jep.2025.120511_bib2","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/labinvest.2008.90","article-title":"Long-term use of an antiinflammatory, curcumin, suppressed type 1 immunity and exacerbated visceral leishmaniasis in a chronic experimental model","volume":"88","author":"Adapala","year":"2008","journal-title":"Lab. Invest."},{"issue":"9","key":"10.1016\/j.jep.2025.120511_bib5","doi-asserted-by":"crossref","first-page":"998","DOI":"10.2174\/18735592MTEx9NTk2y","article-title":"Colorectal cancer epidemiology: recent trends and impact on outcomes","volume":"22","author":"Baidoun","year":"2021","journal-title":"Curr. Drug Targets"},{"issue":"2","key":"10.1016\/j.jep.2025.120511_bib6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3390\/ph17020164","article-title":"Bioavailability of oral curcumin in systematic reviews: a methodological study","volume":"17","author":"Bu\u010devi\u0107 Popovi\u0107","year":"2024","journal-title":"Pharmaceuticals"},{"issue":"2","key":"10.1016\/j.jep.2025.120511_bib7","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s10856-019-6351-6","article-title":"Skin permeation and thermodynamic features of curcumin-loaded liposomes","volume":"31","author":"Campani","year":"2020","journal-title":"J. Mater. Sci. Med"},{"issue":"13","key":"10.1016\/j.jep.2025.120511_bib8","first-page":"2161","article-title":"Effect of curcumin combined with 5-Fluorouracil on the growth of colorectal cancer mice transplanted tumor","volume":"39","author":"Cao","year":"2023","journal-title":"Modern Med. Health"},{"key":"10.1016\/j.jep.2025.120511_bib9","article-title":"Curcumin suppresses metastasis via Sp-1, FAK inhibition, and E-Cadherin upregulation in colorectal cancer","volume":"2013","author":"Chen","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"issue":"2","key":"10.1016\/j.jep.2025.120511_bib10","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1080\/01635581.2022.2139398","article-title":"Curcumin represses colorectal cancer cell proliferation by triggering ferroptosis via PI3K\/Akt\/mTOR signaling","volume":"75","author":"Chen","year":"2023","journal-title":"Nutr. Cancer"},{"issue":"3","key":"10.1016\/j.jep.2025.120511_bib11","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/19390211.2021.2021344","article-title":"Fish oil, plant polyphenols, and their combinations have no tumor growth promoting effects on human lung and Colon carcinoma xenograft mice","volume":"20","author":"Das","year":"2023","journal-title":"J. Diet. Suppl."},{"issue":"1","key":"10.1016\/j.jep.2025.120511_bib12","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1186\/s12885-024-12898-z","article-title":"Curcumin suppresses colorectal tumorigenesis through restoring the gut microbiota and metabolites","volume":"24","author":"Deng","year":"2024","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jep.2025.120511_bib13","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3389\/fphar.2017.00877","article-title":"Curcumin suppresses the Colon cancer proliferation by inhibiting Wnt\/\u03b2-Catenin pathways via miR-130a","volume":"8","author":"Dou","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120511_bib14","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.2147\/IJN.S132434","article-title":"Liposomal curcumin and its application in cancer","volume":"12","author":"Feng","year":"2017","journal-title":"Int. J. Nanomed."},{"issue":"12","key":"10.1016\/j.jep.2025.120511_bib15","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.3390\/genes13122182","article-title":"Efficacy of wholistic turmeric supplement on adenomatous polyps in patients with familial adenomatous Polyposis-A randomized, double-blinded, placebo-controlled study","volume":"13","author":"Gilad","year":"2022","journal-title":"Genes"},{"issue":"23","key":"10.1016\/j.jep.2025.120511_bib16","doi-asserted-by":"crossref","first-page":"7787","DOI":"10.3390\/molecules28237787","article-title":"Tetrahydrocurcumin derivatives enhanced the anti-inflammatory activity of curcumin: synthesis, biological evaluation, and structure-activity relationship analysis","volume":"28","author":"Gonz\u00e1lez","year":"2023","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.jep.2025.120511_bib17","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1039\/c0nr00758g","article-title":"Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo","volume":"3","author":"Gou","year":"2011","journal-title":"Nanoscale"},{"issue":"6","key":"10.1016\/j.jep.2025.120511_bib18","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s00018-022-04311-4","article-title":"Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer","volume":"79","author":"Gu\u00e9guinou","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"issue":"16","key":"10.1016\/j.jep.2025.120511_bib19","first-page":"2261","article-title":"Antitumor effects of curcumin and oxaliplatin combination on xenografts of human colon cancer LoVo cells in nude mice","volume":"44","author":"Guo","year":"2013","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"3","key":"10.1016\/j.jep.2025.120511_bib20","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/ptr.5257","article-title":"Curcumin combined with oxaliplatin effectively suppress colorectal carcinoma in vivo through inducing apoptosis","volume":"29","author":"Guo","year":"2015","journal-title":"Phytother Res."},{"issue":"1","key":"10.1016\/j.jep.2025.120511_bib21","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1208\/s12248-012-9432-8","article-title":"Therapeutic roles of curcumin: lessons learned from clinical trials","volume":"15","author":"Gupta","year":"2013","journal-title":"AAPS J."},{"issue":"9","key":"10.1016\/j.jep.2025.120511_bib22","article-title":"Synthesis of a smart pH sensitive micelle containing hyaluronic acid-curcumin bioconjugate against colorectal cancer","volume":"15","author":"Hazrati","year":"2025","journal-title":"BioNanoScience"},{"issue":"5","key":"10.1016\/j.jep.2025.120511_bib23","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s11095-023-03500-5","article-title":"Cationic ester prodrugs of curcumin with N,N-dimethyl amino acid promoieties improved poor water solubility and intestinal absorption","volume":"40","author":"Hirano-Kusuda","year":"2023","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jep.2025.120511_bib24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2288-14-43","article-title":"SYRCLE's risk of bias tool for animal studies","volume":"14","author":"Hooijmans","year":"2014","journal-title":"BMC Med. Res. Methodol."},{"issue":"2","key":"10.1016\/j.jep.2025.120511_bib25","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/ijc.25670","article-title":"Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo","volume":"129","author":"Howells","year":"2011","journal-title":"Int. J. Cancer"},{"issue":"2","key":"10.1016\/j.jep.2025.120511_bib26","first-page":"149","article-title":"Curcum enhances anti-tum or effectof oxaliplatin on colorectal cancer cell xenograft","author":"Hu","year":"2013","journal-title":"Chin J Surg Integr Tradit West Med"},{"issue":"1","key":"10.1016\/j.jep.2025.120511_bib27","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s12951-021-00981-7","article-title":"Self-assembled fluorescent hybrid nanoparticles-mediated collaborative lncRNA CCAT1 silencing and curcumin delivery for synchronous colorectal cancer theranostics","volume":"19","author":"Jia","year":"2021","journal-title":"J. Nanobiotechnol."},{"issue":"9","key":"10.1016\/j.jep.2025.120511_bib28","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1158\/0008-5472.CAN-13-3536","article-title":"Curcumin promotes autophagic survival of a subset of Colon cancer stem cells, which are ablated by DCLK1-siRNA","volume":"74","author":"Kantara","year":"2014","journal-title":"Cancer Res."},{"issue":"13","key":"10.1016\/j.jep.2025.120511_bib29","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1080\/10408398.2015.1077195","article-title":"Curcumin, an active component of turmeric (Curcuma longa), and its effects on health","volume":"57","author":"Kocaadam","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"4","key":"10.1016\/j.jep.2025.120511_bib30","doi-asserted-by":"crossref","first-page":"495","DOI":"10.4240\/wjgs.v15.i4.495","article-title":"Current and emerging therapeutic approaches for colorectal cancer: a comprehensive review","volume":"15","author":"Kumar","year":"2023","journal-title":"World J. Gastrointest. Surg."},{"issue":"4","key":"10.1016\/j.jep.2025.120511_bib32","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1158\/1940-6207.CAPR-13-0387","article-title":"Curcumin suppresses proliferation of colon cancer cells by targeting CDK2","volume":"7","author":"Lim","year":"2014","journal-title":"Cancer Prev. Res."},{"issue":"3","key":"10.1016\/j.jep.2025.120511_bib33","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.nano.2011.06.011","article-title":"A Lipo-PEG-PEI complex for encapsulating curcumin that enhances its antitumor effects on Curcumin-sensitive and Curcumin-resistance cells","volume":"8","author":"Lin","year":"2012","journal-title":"Nanomedicine"},{"issue":"7","key":"10.1016\/j.jep.2025.120511_bib34","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1038\/s41418-023-01178-1","article-title":"Curcumin activates a ROS\/KEAP1\/NRF2\/miR-34a\/b\/c cascade to suppress colorectal cancer metastasis","volume":"30","author":"Liu","year":"2023","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.jep.2025.120511_bib35","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00210-023-02584-5","article-title":"Curcumin targets miR-134-5p to suppress the progression of colorectal cancer through regulating the CDCA3\/CDK1 pathway","volume":"397","author":"Liu","year":"2024","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"issue":"5","key":"10.1016\/j.jep.2025.120511_bib36","doi-asserted-by":"crossref","first-page":"694","DOI":"10.6061\/clinics\/2013(05)18","article-title":"Effect of curcumin on human colon cancer multidrug resistance in vitro and in vivo","volume":"68","author":"Lu","year":"2013","journal-title":"Clinics"},{"issue":"000","key":"10.1016\/j.jep.2025.120511_bib37","first-page":"10","article-title":"Effects of curcumin on 5-fluorouracil resistance of colon cancer cells through the pi3k\/akt\/mtor pathway via macc1","volume":"56","author":"Ma","year":"2022","journal-title":"Eur J Integr Med"},{"issue":"4","key":"10.1016\/j.jep.2025.120511_bib38","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1080\/01635580902752262","article-title":"Curcumin synergizes with resveratrol to inhibit colon cancer","volume":"61","author":"Majumdar","year":"2009","journal-title":"Nutr. Cancer"},{"issue":"3","key":"10.1016\/j.jep.2025.120511_bib39","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1002\/ptr.7389","article-title":"Curcumin nanoformulations: beneficial nanomedicine against cancer","volume":"36","author":"Maleki Dizaj","year":"2022","journal-title":"Phytother Res."},{"issue":"11","key":"10.1016\/j.jep.2025.120511_bib40","doi-asserted-by":"crossref","first-page":"9552","DOI":"10.1002\/jcb.27273","article-title":"The efficacy of curcuminoids in improvement of ulcerative colitis symptoms and patients' self-reported well-being: a randomized double-blind controlled trial","volume":"119","author":"Masoodi","year":"2018","journal-title":"J. Cell. Biochem."},{"issue":"6","key":"10.1016\/j.jep.2025.120511_bib41","doi-asserted-by":"crossref","first-page":"604","DOI":"10.4103\/1735-5362.389948","article-title":"Antinociceptive and anti-inflammatory actions of curcumin and nano curcumin: a comparative study","volume":"18","author":"Mohammadi","year":"2023","journal-title":"Res. Pharm. Sci."},{"key":"10.1016\/j.jep.2025.120511_bib42","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.semcancer.2019.05.001","article-title":"Risk of colorectal cancer in inflammatory bowel diseases","volume":"64","author":"Nadeem","year":"2020","journal-title":"Semin. Cancer Biol."},{"issue":"5","key":"10.1016\/j.jep.2025.120511_bib43","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1111\/cas.14383","article-title":"Curcumin \u03b2-D-glucuronide exhibits anti-tumor effects on oxaliplatin-resistant colon cancer with less toxicity in vivo","volume":"111","author":"Ozawa-Umeta","year":"2020","journal-title":"Cancer Sci."},{"issue":"4","key":"10.1016\/j.jep.2025.120511_bib44","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/08923973.2018.1474921","article-title":"Curcumin reduces the expression of interleukin 1\u03b2 and the production of interleukin 6 and tumor necrosis factor alpha by M1 macrophages from patients with behcet's disease","volume":"40","author":"Palizgir","year":"2018","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.jep.2025.120511_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-030-73234-9_1","article-title":"Effects of curcuminoids on systemic inflammation and quality of life in patients with colorectal cancer undergoing chemotherapy: a randomized controlled trial","volume":"1328","author":"Panahi","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"issue":"7","key":"10.1016\/j.jep.2025.120511_bib46","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.3390\/ijms21072364","article-title":"Curcumin and colorectal cancer: from basic to clinical evidences","volume":"21","author":"Pricci","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jep.2025.120511_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-32267-8","article-title":"A combination of curcumin and oligomeric proanthocyanidins offer superior anti-tumorigenic properties in colorectal cancer","volume":"8","author":"Ravindranathan","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2025.120511_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.01021","article-title":"Turmeric and its major compound curcumin on health: bioactive effects and safety profiles for food, pharmaceutical, biotechnological and medicinal applications","volume":"11","author":"Sharifi-Rad","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120511_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112442","article-title":"Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms","volume":"146","author":"Slika","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.jep.2025.120511_bib50","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1158\/1940-6207.CAPR-14-0354","article-title":"Novel evidence for curcumin and boswellic acid-induced chemoprevention through regulation of miR-34a and miR-27a in colorectal cancer","volume":"8","author":"Toden","year":"2015","journal-title":"Cancer Prev. Res."},{"issue":"6","key":"10.1016\/j.jep.2025.120511_bib51","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1158\/1055-9965.EPI-07-2693","article-title":"Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects","volume":"17","author":"Vareed","year":"2008","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"3","key":"10.1016\/j.jep.2025.120511_bib52","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1007\/s00210-023-02721-0","article-title":"Curcumin inhibits the development of colorectal cancer via regulating the USP4\/LAMP3 pathway","volume":"397","author":"Wei","year":"2024","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.jep.2025.120511_bib53","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.semcancer.2020.02.011","article-title":"Curcumin and colorectal cancer: an update and current perspective on this natural medicine","volume":"80","author":"Weng","year":"2022","journal-title":"Semin. Cancer Biol."},{"issue":"1","key":"10.1016\/j.jep.2025.120511_bib54","doi-asserted-by":"crossref","first-page":"18","DOI":"10.15430\/JCP.2018.23.1.18","article-title":"Comparative effects of curcumin and TetrahydroCurcumin on dextran sulfate sodium-induced colitis and inflammatory signaling in mice","volume":"23","author":"Yang","year":"2018","journal-title":"J. Cancer Prev."},{"key":"10.1016\/j.jep.2025.120511_bib55","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.2147\/OTT.S199601","article-title":"Curcumin reverses oxaliplatin resistance in human colorectal cancer via regulation of TGF-\u03b2\/Smad2\/3 signaling pathway","volume":"12","author":"Yin","year":"2019","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.jep.2025.120511_bib56","article-title":"Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa","volume":"138","author":"Yue","year":"2020","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.jep.2025.120511_bib57","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41698-023-00353-4","article-title":"Survival improvement for patients with metastatic colorectal cancer over twenty years","volume":"7","author":"Zeineddine","year":"2023","journal-title":"npj Precis. Oncol."},{"key":"10.1016\/j.jep.2025.120511_bib58","first-page":"2021","article-title":"Combined anti-cancer effects of curcumin and oxaliplatin on Colon carcinoma colo205 cells using transplanted nude mice","volume":"34","author":"Zhang","year":"2021","journal-title":"Pak. J. Pharm. Sci."},{"issue":"8","key":"10.1016\/j.jep.2025.120511_bib59","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3390\/nu8080495","article-title":"Spices for prevention and treatment of cancers","volume":"8","author":"Zheng","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2025.120511_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153547","article-title":"Low Curcumin concentration enhances the anticancer effect of 5-fluorouracil against colorectal cancer","volume":"85","author":"Zheng","year":"2021","journal-title":"Phytomedicine"},{"issue":"8","key":"10.1016\/j.jep.2025.120511_bib61","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3390\/nu8080515","article-title":"Natural polyphenols for prevention and treatment of cancer","volume":"8","author":"Zhou","year":"2021","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.jep.2025.120511_bib62","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000518121","article-title":"Curcumin suppresses the progression of colorectal cancer by improving immunogenic cell death caused by irinotecan","volume":"67","author":"Zhu","year":"2022","journal-title":"Chemotherapy"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125012036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125012036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T20:29:23Z","timestamp":1772828963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125012036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":59,"alternative-id":["S0378874125012036"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120511","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness and mechanisms of curcumin for colorectal cancer in preclinical models:A systematic review and\u2002meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120511","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120511"}}