{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:06:54Z","timestamp":1791356814706,"version":"4.3.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009108","name":"Shandong University","doi-asserted-by":"publisher","award":["YJSTZCX2025002"],"award-info":[{"award-number":["YJSTZCX2025002"]}],"id":[{"id":"10.13039\/100009108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jep.2025.120570","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T08:38:54Z","timestamp":1757493534000},"page":"120570","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"PA","title":["Combining metabolomics and network pharmacology to clarify the mechanism of Angelica sinensis-Sophora flavescens pills in treating atopic dermatitis through the sweet-bitter harmonization theory"],"prefix":"10.1016","volume":"355","author":[{"given":"Peng","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangfeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4361-032X","authenticated-orcid":false,"given":"Jiafeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoshuang","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120570_bib1","article-title":"Temporal dissociation of COX-2-dependent arachidonic acid and 2-arachidonoylglycerol metabolism in RAW264.7 macrophages","volume":"65","author":"Aleem","year":"2024","journal-title":"JLR (J. Lipid Res.)"},{"key":"10.1016\/j.jep.2025.120570_bib2","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-002319","article-title":"p38 MAPK signaling in M1 macrophages results in selective elimination of M2 macrophages by MEK inhibition","volume":"9","author":"Baumann","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.jep.2025.120570_bib3","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20220979","article-title":"Dominant negative variants in ITPR3 impair T cell Ca2+ dynamics causing combined immunodeficiency","volume":"222","author":"Blanco","year":"2025","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jep.2025.120570_bib4","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1038\/sj.jid.5700913","article-title":"Stratum Corneum acidification is impaired in moderately aged human and Murine skin","volume":"127","author":"Choi","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jep.2025.120570_bib5","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1111\/bjd.15641","article-title":"Severity strata for eczema area and severity index (EASI), modifiedEASI, scoring atopic dermatitis (SCORAD), objectiveSCORAD, atopic dermatitis severity index and body surface area in adolescents and adults with atopic dermatitis","volume":"177","author":"Chopra","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jep.2025.120570_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.apsb.2016.11.001","article-title":"Targeting calcium signaling in cancer therapy","volume":"7","author":"Cui","year":"2017","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jep.2025.120570_bib7","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1152\/jn.00129.2012","article-title":"Changes in taste receptor cell [Ca2+]i modulate chorda tympani responses to bitter, sweet, and umami taste stimuli","volume":"108","author":"DeSimone","year":"2012","journal-title":"J. Neurophysiol."},{"issue":"6","key":"10.1016\/j.jep.2025.120570_bib8","first-page":"29","article-title":"Treatment of 30 cases of scrotal eczema with antipruritic lotion combined with Danggui Kushen pills","volume":"2004","author":"Du","year":"2004","journal-title":"Chin F Ther"},{"key":"10.1016\/j.jep.2025.120570_bib9","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/chemse\/bjt115","article-title":"Differential effects of bitter compounds on the taste transduction channels TRPM5 and IP3 receptor type 3","volume":"39","author":"Gees","year":"2014","journal-title":"Chem. Senses"},{"key":"10.1016\/j.jep.2025.120570_bib10","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0140-6736(24)02519-4","article-title":"Atopic dermatitis","volume":"405","author":"Guttman-Yassky","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2025.120570_bib11","doi-asserted-by":"crossref","first-page":"D1670","DOI":"10.1093\/nar\/gkae973","article-title":"Generic Diagramming Platform (GDP): a comprehensive database of high-quality biomedical graphics","volume":"53","author":"Jiang","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2025.120570_bib12","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nrm.2016.25","article-title":"Metabolomics: beyond biomarkers and towards mechanisms","volume":"17","author":"Johnson","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jep.2025.120570_bib13","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1111\/j.1440-1746.2010.06312.x","article-title":"Attenuation of warm ischemia\u2013reperfusion injury in the liver by bucillamine through decreased neutrophil activation and Bax\/Bcl\u20102 modulation","volume":"25","author":"Junnarkar","year":"2010","journal-title":"J of Gastro and Hepatol"},{"key":"10.1016\/j.jep.2025.120570_bib14","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1172\/JCI115617","article-title":"Calcium and potassium are important regulators of barrier homeostasis in murine epidermis","volume":"89","author":"Lee","year":"1992","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jep.2025.120570_bib15","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3390\/nu12020411","article-title":"Inhibitory effect of Centella asiatica extract on DNCB-Induced atopic dermatitis in HaCaT cells and BALB\/c mice","volume":"12","author":"Lee","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2025.120570_bib17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1085\/jgp.201611637","article-title":"Extraoral bitter taste receptors in health and disease","volume":"149","author":"Lu","year":"2017","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.jep.2025.120570_bib18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4140\/TCP.n.2025.123","article-title":"Atopic dermatitis in adults: focus on topical therapy","volume":"40","author":"Marshall","year":"2025","journal-title":"sr care pharm"},{"key":"10.1016\/j.jep.2025.120570_bib19","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.jaci.2025.01.013","article-title":"Update on atopic dermatitis","volume":"155","author":"Meledathu","year":"2025","journal-title":"J. Allergy Clin. Immunol."},{"issue":"4","key":"10.1016\/j.jep.2025.120570_bib20","first-page":"165","article-title":"Clinical observation of Danggui Kushen Pill combined with mizolastine tablets in the treatment of chronic eczema","volume":"8","author":"Pei","year":"2011","journal-title":"J chang Uni Nat Sci Edi"},{"key":"10.1016\/j.jep.2025.120570_bib21","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/0006-2952(75)90018-0","article-title":"Effects of 5,6-dihydroxytryptamine on tyrosine-hydroxylase activity in central catecholaminergic neurons of the rat","volume":"24","author":"Renaud","year":"1975","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2025.120570_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/science.aba6500","article-title":"Developmental cell programs are co-opted in inflammatory skin disease","volume":"371","author":"Reynolds","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.jep.2025.120570_bib23","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev-physiol-020911-153318","article-title":"The calcium-sensing receptor beyond extracellular calcium homeostasis: conception, development, adult physiology, and disease","volume":"74","author":"Riccardi","year":"2012","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jep.2025.120570_bib24","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev-immunol-101320-031555","article-title":"Functional hallmarks of healthy macrophage responses: their regulatory basis and disease relevance","volume":"40","author":"Sheu","year":"2022","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jep.2025.120570_bib25","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1161\/CIRCULATIONAHA.118.034621","article-title":"Inflammation and NLRP3 inflammasome activation initiated in response to pressure overload by Ca2+\/Calmodulin-Dependent protein kinase II \u03b4 signaling in cardiomyocytes are essential for adverse cardiac remodeling","volume":"138","author":"Suetomi","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2025.120570_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117626","article-title":"Sophora flavescens-Angelica sinensis in the treatment of eczema by inhibiting TLR4\/MyD88\/NF-\u03baB pathway","volume":"322","author":"Sun","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120570_bib27","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1136\/gut.28.7.822","article-title":"Development of phospholipase A2 and lysophosphatidylcholine metabolising enzyme activities in the neonatal rat intestine","volume":"28","author":"Tagesson","year":"1987","journal-title":"Gut"},{"key":"10.1016\/j.jep.2025.120570_bib28","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/nn.2379","article-title":"Nicotine activates the chemosensory cation channel TRPA1","volume":"12","author":"Talavera","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jep.2025.120570_bib29","article-title":"An update on extra-oral bitter taste receptors","volume":"19","author":"Tuzim","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jep.2025.120570_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmgh.2024.05.002","article-title":"SIRT1 stabilizes \u03b2-TrCP1 to inhibit Snail1 expression in maintaining intestinal epithelial integrity to alleviate colitis","volume":"18","author":"Wang","year":"2024","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2025.120570_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118520","article-title":"Investigation into the anti-inflammatory mechanism of Pothos chinensis (Raf.) Merr. By regulating TLR4\/MyD88\/NF-\u03baB pathway: integrated network pharmacology, serum pharmacochemistry, and metabolomics","volume":"334","author":"Xiao","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.120570_bib32","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.jep.2011.08.031","article-title":"The synergistic anti-inflammatory effect of the combination of sodium ferulate and oxymatrine and its modulation on inflammation-associated mediators in RAW 264.7 cells","volume":"137","author":"Yuan","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120570_bib33","doi-asserted-by":"crossref","DOI":"10.1172\/JCI170706","article-title":"GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing","volume":"133","author":"Yu","year":"2023","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jep.2025.120570_bib34","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbad518","article-title":"Network pharmacology: towards the artificial intelligence-based precision traditional Chinese medicine","volume":"25","author":"Zhang","year":"2023","journal-title":"Briefings Bioinf."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125012620?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125012620?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:18:45Z","timestamp":1761697125000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125012620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":33,"alternative-id":["S0378874125012620"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120570","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combining metabolomics and network pharmacology to clarify the mechanism of Angelica sinensis-Sophora flavescens pills in treating atopic dermatitis through the sweet-bitter harmonization theory","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120570","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120570"}}