{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:44:04Z","timestamp":1786992244320,"version":"build-2736575974"},"reference-count":114,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination for the improvement of Higher Education Personnel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jep.2025.120588","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T08:39:10Z","timestamp":1757493550000},"page":"120588","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"PA","title":["Syagrus vagans (Bondar) Hawkes seed oil has a safe use, provides a protective effect against methyl methanesulfonate-induced DNA damage, and alleviates pain and inflammation in mice"],"prefix":"10.1016","volume":"355","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7051-1592","authenticated-orcid":false,"given":"Jeanderson Marcelino","family":"da Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesly Mikael","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meykson Alexandre","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Rivaldo","family":"de Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson Correia","family":"de Lima J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonata Henrique","family":"de Santana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Pinheiro","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresinha Gon\u00e7alves","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano Aparecido","family":"Chagas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Carlos Amanaj\u00e1s","family":"de Aguiar J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Maria do Amaral","family":"Ferraz Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Henrique","family":"Galdino dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Victor","family":"de Oliveira Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Vanusa","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Tereza dos Santos","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120588_bib1","first-page":"121","volume":"105","author":"Aebi","year":"1984"},{"key":"10.1016\/j.jep.2025.120588_bib2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.ejmhg.2013.07.002","article-title":"Antigenotoxic and anticlastogenic potential of Agaricus bisporus against MMS induced toxicity in human lymphocyte cultures and in bone marrow cells of mice","volume":"14","author":"Ahmad","year":"2013","journal-title":"Egypt. J. Med. Hum. Genet."},{"key":"10.1016\/j.jep.2025.120588_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117157","article-title":"Cold pressed Pinus halepensis mill. seed oil for potential health applications: analgesic, anti-inflammatory effects, and assessment of inflammatory mediators by RT-qPCR in skin wound healing","volume":"319","author":"Ait Atmane","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120588_bib4","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.14013","article-title":"Myristic acid reduces skin inflammation and nociception","volume":"46","author":"Alonso\u2010Castro","year":"2022","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.jep.2025.120588_bib5","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1007\/s10787-024-01548-2","article-title":"Fixed oil from the Caatinga palm Syagrus coronata with effect on complete Freund's adjuvant (CFA)-Induced arthritis","volume":"32","author":"Alves","year":"2024","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jep.2025.120588_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2023.116558","article-title":"Lauric acid improves hormonal profiles, antioxidant properties, sperm quality and histomorphometric changes in testis and epididymis of streptozotocin-induced diabetic infertility rats","volume":"470","author":"Anuar","year":"2023","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2025.120588_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118283","article-title":"Almond fixed oil from Syagrus coronata (Mart.) Becc. has antinociceptive and anti-inflammatory potential, without showing oral toxicity in mice","volume":"331","author":"Barbosa","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120588_bib9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12944-016-0237-0","article-title":"Oil from pumpkin (Cucurbita pepo L.) seeds: evaluation of its functional properties on wound healing in rats","volume":"15","author":"Bardaa","year":"2016","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.jep.2025.120588_bib10","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/eji.201545520","article-title":"Carrageenan\u2010induced inflammation promotes ROS generation and neutrophil extracellular trap formation in a mouse model of peritonitis","volume":"46","author":"Barth","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jep.2025.120588_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e03962","article-title":"In vivo and in silico evaluation of antinociceptive activities of seed extract from the Holarrhena antidysenterica plant","volume":"6","author":"Bhuiyan","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2025.120588_bib12","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jep.2025.120588_bib13","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/bcpt.12054","article-title":"Genotoxicity and carcinogenicity studies of bronchodilators and AntiAsthma drugs","volume":"112","author":"Brambilla","year":"2013","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.jep.2025.120588_bib14","first-page":"302","author":"Buege","year":"1978"},{"key":"10.1016\/j.jep.2025.120588_bib15","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1016\/j.ejphar.2011.05.085","article-title":"Fatty acids and inflammation: the cutting edge between food and pharma","volume":"668","author":"Calder","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.120588_bib16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3390\/toxics11030231","article-title":"Spleen toxicity of organophosphorus flame retardant TDCPP in mice and the related mechanisms","volume":"11","author":"Cao","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.jep.2025.120588_bib17","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1016\/j.clnu.2022.09.007","article-title":"Fish consumption, omega-3 fatty acid intake, and risk of pain: the Seniors-ENRICA-1 cohort","volume":"41","author":"Carballo-Casla","year":"2022","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.jep.2025.120588_bib18","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.3390\/life13061273","article-title":"Aptasensors are conjectured as promising ALT and AST diagnostic tools for the early diagnosis of acute liver injury","volume":"13","author":"Chinnappan","year":"2023","journal-title":"Life"},{"key":"10.1016\/j.jep.2025.120588_bib19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/mutage\/gem051","article-title":"The comet assay: topical issues","volume":"23","author":"Collins","year":"2008","journal-title":"Mutagenesis"},{"key":"10.1016\/j.jep.2025.120588_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/5580126","article-title":"Biological potential of products obtained from palm trees of the genus syagrus","volume":"2021","author":"Coriolano","year":"2021","journal-title":"Evidence-Based Complement. Altern. Med."},{"key":"10.1016\/j.jep.2025.120588_bib21","doi-asserted-by":"crossref","DOI":"10.15517\/rbt.v67i6.33883","article-title":"Antimutagenic activity and identification of antioxidant compounds in the plant Poincianella bracteosa (Fabaceae)","volume":"67","author":"Couto","year":"2019","journal-title":"Rev. Biol. Trop."},{"key":"10.1016\/j.jep.2025.120588_bib22","first-page":"43","article-title":"Syagrus coronata and Syagrus vagans: traditional exploitation in Bahia, Brazi","volume":"48","author":"Crepaldi","year":"2004","journal-title":"Palms"},{"key":"10.1016\/j.jep.2025.120588_bib108","doi-asserted-by":"crossref","DOI":"10.20900\/immunometab20200008","article-title":"Impact of dietary fatty acids on macrophage lipid metabolism, signaling and function","volume":"2","author":"Davanso","year":"2020","journal-title":"Immunometabolism"},{"key":"10.1016\/j.jep.2025.120588_bib23","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1163\/15685403-00003242","article-title":"Methyl esters from the copepod Tisbe biminiensis assayed by two transesterification methods","volume":"86","author":"de Lima","year":"2013","journal-title":"Crustaceana"},{"key":"10.1016\/j.jep.2025.120588_bib24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.yrtph.2018.04.004","article-title":"Saline extract of Pilosocereus gounellei stem has antinociceptive effect in mice without showing acute toxicity and altering motor coordination","volume":"95","author":"de Oliveira","year":"2018","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.jep.2025.120588_bib110","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.foodchem.2018.04.040","article-title":"Inhibition of the essential oil from Chenopodium ambrosioides L. and \u03b1-terpinene on the NorA efflux-pump of Staphylococcus aureus","volume":"262","author":"de Morais Oliveira-Tintino","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2025.120588_bib25","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jep.2015.08.017","article-title":"Antinociceptive and anti-inflammatory effects of Caryocar coriaceum Wittm fruit pulp fixed ethyl acetate extract on zymosan-induced arthritis in rats","volume":"174","author":"de Oliveira","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120588_bib26","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1182\/blood-2010-07-273417","article-title":"Interleukin-1 in the pathogenesis and treatment of inflammatory diseases","volume":"117","author":"Dinarello","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jep.2025.120588_bib27","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/15287394.2024.2338431","article-title":"Syagrus coronata fixed oil prevents rotenone-induced movement disorders and oxidative stress in Drosophila melanogaster","volume":"87","author":"dos Santos Nunes","year":"2024","journal-title":"J. Toxicol. Environ. Health, Part A"},{"key":"10.1016\/j.jep.2025.120588_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113941","article-title":"Biological safety of Syagrus coronata (Mart.) Becc. Fixed oil: cytotoxicity, acute oral toxicity, and genotoxicity studies","volume":"272","author":"dos Santos Souza","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120588_bib29","doi-asserted-by":"crossref","first-page":"292","DOI":"10.4103\/2221-1691.235324","article-title":"Coriandrum sativum grown under organic or chemical fertilizer effectively prevents DNA damage: preliminary phytochemical screening, flavonoid content, ESI (-) FT-ICR MS, in vitro antioxidant and in vivo (mice bone marrow) antimutagenic activity against cy","volume":"8","author":"dos Santos","year":"2018","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.jep.2025.120588_bib30","doi-asserted-by":"crossref","DOI":"10.1093\/qjmed\/hcae070.198","article-title":"Assessment of the role of Keratin 18 and high mobility group box 1 biomarkers for early prediction of drugs and chemicals induced hepatotoxicity A prospective study in the poison control center of Ain shams university hospitals (PCC-ASUH)","volume":"117","author":"Ebeid","year":"2024","journal-title":"QJM An Int. J. Med."},{"key":"10.1016\/j.jep.2025.120588_bib31","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3109\/13880209.2011.600318","article-title":"Antinociceptive and anti-inflammatory effects of olive oil (olea europeae L.) in mice","volume":"50","author":"Eidi","year":"2012","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2025.120588_bib32","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/em.20146","article-title":"Involvement of oxygen free radicals in the serum\u2010mediated increase of benzoquinone genotoxicity","volume":"46","author":"Fabiani","year":"2005","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.jep.2025.120588_bib111","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1159\/000356067","article-title":"Induction of apoptosis by the medium-chain length fatty acid lauric acid in colon cancer cells due to induction of oxidative stress","volume":"59","author":"Fauser","year":"2013","journal-title":"Chemotherapy"},{"key":"10.1016\/j.jep.2025.120588_bib33","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.pain.2013.11.015","article-title":"The interphase of the formalin test","volume":"155","author":"Fischer","year":"2014","journal-title":"Pain"},{"key":"10.1016\/j.jep.2025.120588_bib34","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1016\/j.bbagen.2012.10.020","article-title":"The fairytale of the GSSG\/GSH redox potential","volume":"1830","author":"Floh\u00e9","year":"2013","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.jep.2025.120588_bib35","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1007\/s10787-022-01046-3","article-title":"Tumor necrosis factor alpha (TNF-\u03b1) blockage reduces acute inflammation and delayed wound healing in oral ulcer of rats","volume":"30","author":"Freitas","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jep.2025.120588_bib36","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.3390\/molecules28052036","article-title":"BDE-47 induces immunotoxicity in RAW264.7 macrophages through the reactive oxygen species-mediated mitochondrial apoptotic pathway","volume":"28","author":"Gao","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.120588_bib37","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1055\/s-0033-1351138","article-title":"Postoperative pain control","volume":"26","author":"Garimella","year":"2013","journal-title":"Clin. Colon Rectal Surg."},{"key":"10.1016\/j.jep.2025.120588_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2024.1406322","article-title":"Fasting triglyceride concentrations are associated with markers of lipid metabolism and glucose homeostasis in healthy, non-obese dogs in lean and overweight condition","volume":"11","author":"Gomez-Fernandez-Blanco","year":"2024","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.jep.2025.120588_bib40","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/FTD.0000000000000589","article-title":"Biomarkers of drug-induced kidney toxicity","volume":"41","author":"Griffin","year":"2019","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.jep.2025.120588_bib41","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases. The first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2025.120588_bib42","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1074\/jbc.R118.003214","article-title":"Adipose oxidative stress and protein carbonylation","volume":"294","author":"Hauck","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2025.120588_bib43","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0165-7992(90)90153-B","article-title":"The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides","volume":"245","author":"Hayashi","year":"1990","journal-title":"Mutat. Res. Lett."},{"key":"10.1016\/j.jep.2025.120588_bib44","article-title":"Palmitic acid accelerates endothelial cell injury and cardiovascular dysfunction via palmitoylation of PKM2","volume":"12","author":"He","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jep.2025.120588_bib112","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/ejp.1327","article-title":"The analgesic efficacy of morphine varies with rat strain and experimental pain model: implications for target validation efforts in pain drug discovery","volume":"23","author":"Hestehave","year":"2019","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.jep.2025.120588_bib45","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0003-2697(76)90326-2","article-title":"A fluorometric method for determination of oxidized and reduced glutathione in tissues","volume":"74","author":"Hissin","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jep.2025.120588_bib46","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/895857","article-title":"Antinociceptive activities and the mechanisms of anti\u2010inflammation of asiatic acid in mice","volume":"2011","author":"Huang","year":"2011","journal-title":"Evidence-Based Complement. Altern. Med."},{"key":"10.1016\/j.jep.2025.120588_bib47","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jdermsci.2013.10.010","article-title":"Anti-bacterial and anti-inflammatory properties of capric acid against propionibacterium acnes: a comparative study with lauric acid","volume":"73","author":"Huang","year":"2014","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jep.2025.120588_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119382","article-title":"Behavioral assessment to evaluate the analgesic and anti-inflammatory effects of Fagonia bruguieri var. laxa boiss by targeting pro-inflammatory cytokines and prostaglandin pathways","volume":"342","author":"Javaid","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120588_bib50","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.8805","article-title":"Food additive \u201clauric acid\u201d possess non-toxic profile on biochemical, haematological and histopathological studies in female sprague dawley (SD) rats","volume":"8","author":"Khan","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.jep.2025.120588_bib52","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/15287394.2021.1969305","article-title":"Using intracellular metabolic profiling to identify novel biomarkers of cisplatin-induced acute kidney injury in NRK-52E cells","volume":"85","author":"Kim","year":"2022","journal-title":"J. Toxicol. Environ. Health, Part A"},{"key":"10.1016\/j.jep.2025.120588_bib53","first-page":"155","article-title":"In vivo rodent micronucleus assay: protocol, conduct and data interpretation","volume":"455","author":"Krishna","year":"2000","journal-title":"Mutat. Res. Mol. Mech. Mutagen."},{"key":"10.1016\/j.jep.2025.120588_bib54","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13002-022-00520-0","article-title":"Ethnomedicinal study of medicinal plants used by mizo tribes in champhai district of Mizoram, India","volume":"18","author":"Laldingliani","year":"2022","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"10.1016\/j.jep.2025.120588_bib55","volume":"vol. 144","author":"Lapa","year":"2008"},{"key":"10.1016\/j.jep.2025.120588_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081930","article-title":"TNF\u03b1 signals via p66Shc to induce E-Selectin, promote leukocyte transmigration and enhance permeability in human endothelial cells","volume":"8","author":"Laviola","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2025.120588_bib57","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.mpaic.2021.05.003","article-title":"Renal physiology: blood flow, glomerular filtration and plasma clearance","volume":"22","author":"Leatherby","year":"2021","journal-title":"Anaesth. Intensive Care Med."},{"key":"10.1016\/j.jep.2025.120588_bib58","first-page":"464","author":"Levine","year":"1990"},{"key":"10.1016\/j.jep.2025.120588_bib59","first-page":"2185","article-title":"Heterogeneity and function of kupffer cells in liver injury","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.120588_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/5702159","article-title":"Acute and subacute toxicity of methanol extract of Syzygium guineense leaves on the histology of the liver and kidney and biochemical compositions of blood in rats","volume":"2019","author":"Loha","year":"2019","journal-title":"Evidence-Based Complement. Altern. Med."},{"key":"10.1016\/j.jep.2025.120588_bib61","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1080\/1061186X.2018.1547733","article-title":"Drug delivery to tumours using a novel 5-FU derivative encapsulated into lipid nanocapsules","volume":"27","author":"Lollo","year":"2019","journal-title":"J. Drug Target."},{"key":"10.1016\/j.jep.2025.120588_bib62","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1080\/09553002.2022.2121873","article-title":"Genomic DNA damage induced by co-exposure to DNA damaging agents and pulsed magnetic field","volume":"99","author":"L\u00f3pez-D\u00edaz","year":"2023","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.jep.2025.120588_bib63","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1182\/blood.2021012295","article-title":"Neutrophils in acute inflammation: current concepts and translational implications","volume":"139","author":"Margraf","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.jep.2025.120588_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/6501046","article-title":"Measurement and clinical significance of biomarkers of oxidative stress in humans","volume":"2017","author":"Marrocco","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2025.120588_bib65","doi-asserted-by":"crossref","first-page":"13525","DOI":"10.1073\/pnas.0705924104","article-title":"TRPA1 mediates formalin-induced pain","volume":"104","author":"McNamara","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jep.2025.120588_bib66","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2025.120588_bib67","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jep.2025.120588_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.131743","article-title":"Characterization of structural, genotoxic, and immunological effects of methyl methanesulfonate (MMS) induced DNA modifications: implications for inflammation-driven carcinogenesis","volume":"268","author":"Mustafa","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2025.120588_bib113","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.3390\/ijms16035014","article-title":"Anticarcinogenic properties of medium chain fatty acids on human colorectal, skin and breast cancer cells in vitro","volume":"16","author":"Narayanan","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.120588_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116908","article-title":"Essential oil from leaves of Croton blanchetianus Baill does not present acute oral toxicity, has antigenotoxic action and reduces neurogenic and inflammatory nociception in mice","volume":"318","author":"Nascimento","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120588_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.11646\/phytotaxa.294.1.1","article-title":"A revision of the genus syagrus (Arecaceae)","volume":"294","author":"Noblick","year":"2017","journal-title":"Phytotaxa"},{"key":"10.1016\/j.jep.2025.120588_bib71","year":"2002"},{"key":"10.1016\/j.jep.2025.120588_bib72","article-title":"Test No. 489: in vivo mammalian alkaline comet assay","volume":"vol. 4","year":"2016"},{"key":"10.1016\/j.jep.2025.120588_bib73","series-title":"OECD Guidelines for the Testing of Chemicals, Section 4","article-title":"Test no. 474: mammalian erythrocyte micronucleus test","year":"2016"},{"key":"10.1016\/j.jep.2025.120588_bib105","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jep.2016.09.004","article-title":"Evaluation of acute toxicity, genotoxicity and inhibitory effect on acute inflammation of an ethanol extract of Morus alba L. (Moraceae) in mice","volume":"194","author":"Oliveira","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120588_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117716","article-title":"Chemical profile and evaluation of the pharmacological activity of the dry extract and fraction of ethyl acetate obtained from the leaves of Mimosa caesalpiniifolia","volume":"323","author":"Oliveira","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120588_bib75","first-page":"269","author":"Owen","year":"2010"},{"key":"10.1016\/j.jep.2025.120588_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113598","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs): a current insight into its molecular mechanism eliciting organ toxicities","volume":"172","author":"Panchal","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2025.120588_bib114","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbrc.2015.08.120","article-title":"Concerted action of p62 and Nrf2 protects cells from palmitic acid-induced lipotoxicity","volume":"466","author":"Park","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2025.120588_bib77","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1177\/07482337221122482","article-title":"Comparison of the genotoxicity of two commercial pesticides by their micro and nano size capsules","volume":"38","author":"Paz-Trejo","year":"2022","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.jep.2025.120588_bib78","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1080\/10520295.2020.1719197","article-title":"Evaluation of effects of poincianella bracteosa (Tul.) L.P. Queiroz leaves in Allium cepa and Mus musculus","volume":"95","author":"Pereira","year":"2020","journal-title":"Biotech. Histochem."},{"key":"10.1016\/j.jep.2025.120588_bib79","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/s41467-024-45439-0","article-title":"Heterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage","volume":"15","author":"Ruz-Maldonado","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2025.120588_bib80","doi-asserted-by":"crossref","DOI":"10.3390\/app132413196","article-title":"New insights into bioactive compounds of wild-growing medicinal plants","volume":"13","author":"Salem","year":"2023","journal-title":"Appl. Sci."},{"key":"10.1016\/j.jep.2025.120588_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2023.106147","article-title":"Chemical composition and antimicrobial potential of Acrocomia aculeata (Jacq.) Lodd. ex Mart. and Syagrus cearensis noblick (Arecaceae)","volume":"180","author":"Sampaio","year":"2023","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.jep.2025.120588_bib82","first-page":"4827","article-title":"Evaluation of a soluble tetrazolium\/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines","volume":"48","author":"Scudiero","year":"1988","journal-title":"Cancer Res."},{"key":"10.1016\/j.jep.2025.120588_bib83","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1039161","article-title":"Functional identification of the zebrafish Interleukin-1 receptor in an embryonic model of Il-1\u03b2-induced systemic inflammation","volume":"13","author":"Sebo","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.120588_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175990","article-title":"Lauric acid provides neuroprotection against oxidative stress in mouse model of hyperglycaemic stroke","volume":"956","author":"Shaheryar","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.120588_bib115","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.1007\/s13197-014-1543-z","article-title":"In vitro antioxidant assay of medium chain fatty acid rich rice bran oil in comparison to native rice bran oil","volume":"52","author":"Sengupta","year":"2015","journal-title":"J. Food Sci. Technol."},{"key":"10.1016\/j.jep.2025.120588_bib85","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.3390\/biomedicines11123342","article-title":"Natural fatty acid guards against brain endothelial cell death and microvascular pathology following ischemic insult in the presence of acute hyperglycemia","volume":"11","author":"Shaheryar","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.jep.2025.120588_bib109","doi-asserted-by":"crossref","first-page":"654","DOI":"10.4236\/jbise.2013.66080","article-title":"Effects of oleic acid on murine macrophage dysfunction","volume":"06","author":"Shiomi","year":"2013","journal-title":"J. Biomed. Sci. Eng."},{"key":"10.1016\/j.jep.2025.120588_bib86","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.toxicon.2020.07.006","article-title":"Tityus stigmurus venom causes genetic damage in blood and testicular cells and affects the number and morphology of gametogenic lineage cells in mice","volume":"185","author":"Silva","year":"2020","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2025.120588_bib87","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4103\/aam.aam_56_18","article-title":"Inflammation and cancer","volume":"18","author":"Singh","year":"2019","journal-title":"Ann. Afr. Med."},{"key":"10.1016\/j.jep.2025.120588_bib116","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1015200","article-title":"Therapeutic drug monitoring for cytotoxic anticancer drugs: Principles and evidence-based practices","volume":"12","author":"Smita","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jep.2025.120588_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117707","article-title":"The annonalide diterpene extracted from Casimirella ampla (Miers) reduces inflammatory and antinociceptive events in general models of inflammation","volume":"324","author":"Sousa","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120588_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156364","article-title":"Anti-inflammatory activity of essential oil from medicinal plants: an insight into molecular mechanism, in-silico studies and signaling pathways","volume":"138","author":"Subudhi","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120588_bib90","article-title":"Toxicogenetic evaluation of Smallanthus sonchifolius (yacon) as a herbal medicine","volume":"257","author":"Szokalo","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120588_bib117","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/jcp.22740","article-title":"Activation of survival and apoptotic signaling pathways in lymphocytes exposed to palmitic acid","volume":"227","author":"Takahashi","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jep.2025.120588_bib91","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J","article-title":"Single cell gel\/comet assay: guidelines for in vitro and in vivo genetic toxicology testing","volume":"35","author":"Tice","year":"2000","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.jep.2025.120588_bib92","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jep.2025.120588_bib93","doi-asserted-by":"crossref","first-page":"834","DOI":"10.2174\/1871520620666200310091719","article-title":"Lauric acid modulates cancer-associated microRNA expression and inhibits the growth of the cancer cell","volume":"20","author":"Verma","year":"2020","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.jep.2025.120588_bib118","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41387-020-0108-7","article-title":"Toxicity of fatty acid profiles of popular edible oils in human EndoC-\u03b2H1 beta-cells","volume":"10","author":"Von Hanstein","year":"2020","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.jep.2025.120588_bib94","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.intimp.2018.03.014","article-title":"Blend of organic acids and medium chain fatty acids prevents the inflammatory response and intestinal barrier dysfunction in mice challenged with enterohemorrhagic Escherichia coli O157:H7","volume":"58","author":"Wang","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.120588_bib95","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jep.2011.02.010","article-title":"In vitro and in vivo evaluation of the wound healing properties of Siegesbeckia pubescens","volume":"134","author":"Wang","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120588_bib96","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156387","article-title":"Serum fatty acids are correlated with inflammatory cytokines in ulcerative colitis","volume":"11","author":"Wiese","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2025.120588_bib97","unstructured":"World Health Organization (WHO), 2025. Available in: <https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cancer>."},{"key":"10.1016\/j.jep.2025.120588_bib98","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s12088-020-00896-1","article-title":"In vitro cytotoxicity study of cyclophosphamide, etoposide and paclitaxel on monocyte macrophage cell line raw 264.7","volume":"60","author":"Yadav","year":"2020","journal-title":"Indian J. Microbiol."},{"key":"10.1016\/j.jep.2025.120588_bib99","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.02635","article-title":"Lauric acid is an inhibitor of Clostridium difficile growth in vitro and reduces inflammation in a mouse infection model","volume":"8","author":"Yang","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jep.2025.120588_bib107","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1080\/15548627.2024.2394308","article-title":"TRIM21-mediated ubiquitination of SQSTM1\/p62 abolishes its Ser403 phosphorylation and enhances palmitic acid cytotoxicity","volume":"21","author":"Yang","year":"2025","journal-title":"Autophagy"},{"key":"10.1016\/j.jep.2025.120588_bib106","doi-asserted-by":"crossref","first-page":"572","DOI":"10.2174\/1566524020666200128155115","article-title":"The effects of lauric acid on IPEC-J2 cell differentiation, proliferation, and death","volume":"20","author":"Yang","year":"2020","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.jep.2025.120588_bib100","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/bmc.1641","article-title":"Determination of ipriflavone in human plasma by LC\u2010MS and its application in a pharmacokinetic study","volume":"26","author":"Yun","year":"2012","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jep.2025.120588_bib101","article-title":"Comparison of lauric acid and 12-hydroxylauric acid in the alleviation of drought stress in peach (Prunus persica (L.) Batsch)","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.jep.2025.120588_bib102","doi-asserted-by":"crossref","first-page":"381","DOI":"10.33549\/physiolres.935201","article-title":"Linoleic acid alleviates lipopolysaccharide induced acute liver injury via activation of Nrf2","author":"Zhang","year":"2024","journal-title":"Physiol. Res."},{"key":"10.1016\/j.jep.2025.120588_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.impact.2021.100338","article-title":"Intracellular GSH\/GST antioxidants system change as an earlier biomarker for toxicity evaluation of iron oxide nanoparticles","volume":"23","author":"Zhang","year":"2021","journal-title":"NanoImpact"},{"issue":"5","key":"10.1016\/j.jep.2025.120588_bib104","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3390\/biom14050601","article-title":"Palmitic acid inhibits cell proliferation and tumor growth of endometrial cancer in vitro and in vivo","volume":"14","author":"Zhao","year":"2024","journal-title":"Biomolecules"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125012802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125012802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:30:22Z","timestamp":1773286222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125012802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":114,"alternative-id":["S0378874125012802"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120588","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Syagrus vagans (Bondar) Hawkes seed oil has a safe use, provides a protective effect against methyl methanesulfonate-induced DNA damage, and alleviates pain and inflammation in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120588","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120588"}}