{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:26:37Z","timestamp":1793467597924,"version":"4.5.0"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LYY21H300001"],"award-info":[{"award-number":["LYY21H300001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jep.2025.120607","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T16:26:29Z","timestamp":1757607989000},"page":"120607","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"PA","title":["Dictamnine inhibited keratinocyte hyperproliferation and alleviated psoriasis-like dermatitis via blocking HIF1A-mediated ferroptotic pathway"],"prefix":"10.1016","volume":"355","author":[{"given":"W\u0113i","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7115-1996","authenticated-orcid":false,"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-Lin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Min","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Li","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Chang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0542-9362","authenticated-orcid":false,"given":"Chen-Huan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W\u00e9i","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jep.2025.120607_bib1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/15321819.2018.1472605","article-title":"Immunohistochemical expression HIF1\u03b1 in chronic plaque psoriasis, an association with angiogenesis and proliferation","volume":"39","author":"Abdou","year":"2018","journal-title":"J. Immunoassay Immunochem."},{"issue":"4","key":"10.1016\/j.jep.2025.120607_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.humimm.2024.110814","article-title":"Cytokines in psoriasis: From pathogenesis to targeted therapy","volume":"85","author":"Alsabbagh","year":"2024","journal-title":"Hum. Immunol."},{"issue":"7","key":"10.1016\/j.jep.2025.120607_bib3","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1016\/j.jid.2021.09.039","article-title":"Defining psoriasis remission based on histopathologic and molecular criteria: a systematic literature review","volume":"142","author":"Balak","year":"2022","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.jep.2025.120607_bib4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s40257-024-00857-0","article-title":"Managing the patient with psoriasis and metabolic comorbidities","volume":"25","author":"Bellinato","year":"2024","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.jep.2025.120607_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1186455","article-title":"Revisiting the interleukin 17 family of cytokines in psoriasis: pathogenesis and potential targets for innovative therapies","volume":"14","author":"Brembilla","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.120607_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155041","article-title":"Phytochemicals: targeting autophagy to treat psoriasis","volume":"120","author":"Chen","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120607_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124758","article-title":"Gypenoside A-loaded mPEG-PLGA nanoparticles ameliorate high-glucose-induced retinal microvasculopathy by inhibiting ferroptosis","volume":"666","author":"Chen","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.jep.2025.120607_bib8","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1007\/s00210-024-03461-5","article-title":"The molecular mechanism of berberine affecting psoriasis skin inflammation by regulating keratinocyte pyroptosis via the p38 MAPK\/NF-\u03baB pathway","volume":"398","author":"Chen","year":"2025","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.jep.2025.120607_bib9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fchem.2020.00073","article-title":"Anti-inflammatory limonoids from cortex dictamni","volume":"8","author":"Chen","year":"2020","journal-title":"Front. Chem."},{"key":"10.1016\/j.jep.2025.120607_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153453","article-title":"Anti-atopic dermatitis effects of dictamni cortex: studies on in vitro and in vivo experimental models","volume":"82","author":"Chen","year":"2021","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2025.120607_bib11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1186\/s12906-019-2767-2","article-title":"Anti-inflammatory effects of a methanol extract of Dictamnus dasycarpus Turcz. root bark on imiquimod-induced psoriasis","volume":"19","author":"Choi","year":"2019","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2025.120607_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113486","article-title":"Topical delivery of bioactive compounds from Cortex Dictamni alleviates atopic dermatitis-like lesion by inhibiting the activation of keratinocytes, macrophages, and basophils: dictamnine versus fraxinellone","volume":"143","author":"Chou","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2025.120607_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.3854","article-title":"A novel UPLC-MS\/MS method for simultaneous determination of 10 effective constituents in the Jixingshizhen preparation","volume":"31","author":"Cui","year":"2017","journal-title":"Biomed. Chromatogr."},{"issue":"2","key":"10.1016\/j.jep.2025.120607_bib14","doi-asserted-by":"crossref","first-page":"302","DOI":"10.4049\/jimmunol.2300319","article-title":"IL-17A orchestrates reactive oxygen species\/HIF1\u03b1-mediated metabolic reprogramming in psoriasis","volume":"212","author":"Dhamija","year":"2024","journal-title":"J. Immunol."},{"key":"10.1016\/j.jep.2025.120607_bib15","article-title":"T cells promote distinct transcriptional programs of cutaneous inflammatory disease in keratinocytes and dermal fibroblasts","volume":"9","author":"DeBerg","year":"2025","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jep.2025.120607_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2025.120607_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117431","article-title":"GPR97 depletion aggravates imiquimod-induced psoriasis pathogenesis via amplifying IL-23\/IL-17 axis signal pathway","volume":"179","author":"Gao","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.120607_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.121963","article-title":"Structural elucidation and anti-psoriasis activity of a novel polysaccharide from Saussurea Costus","volume":"333","author":"Gong","year":"2024","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"10.1016\/j.jep.2025.120607_bib19","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41392-023-01655-6","article-title":"Signaling pathways and targeted therapies for psoriasis","volume":"8","author":"Guo","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"5","key":"10.1016\/j.jep.2025.120607_bib20","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1007\/s10787-024-01519-7","article-title":"Nrf2-mediated ferroptosis inhibition: a novel approach for managing inflammatory diseases","volume":"32","author":"Han","year":"2024","journal-title":"Inflammopharmacology"},{"issue":"1","key":"10.1016\/j.jep.2025.120607_bib21","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3390\/molecules26010124","article-title":"Chemical composition of a novel distillate from fermented mixture of nine anti-inflammatory herbs and its UVB-protective efficacy in mouse dorsal skin via attenuating collagen disruption and inflammation","volume":"26","author":"Her","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.120607_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123120","article-title":"An approach for psoriasis of microneedle patch simultaneously targeting multiple inflammatory cytokines and relapse related T cells","volume":"318","author":"Huang","year":"2025","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.jep.2025.120607_bib23","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.chroma.2006.01.077","article-title":"Pressurized liquid extraction followed by high-performance liquid chromatography for determination of seven active compounds in Cortex Dictamni","volume":"1108","author":"Jiang","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jep.2025.120607_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.749626","article-title":"A traditional Chinese medicine formula danshen baibixiao ameliorates imiquimod-induced psoriasis-like inflammation in mice","volume":"12","author":"Jin","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"16","key":"10.1016\/j.jep.2025.120607_bib84","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.3390\/nu16162690","article-title":"Efficacy and Safety of Orally Administered East Asian Herbal Medicine Combined with Narrowband Ultraviolet B against Psoriasis: A Bayesian Network Meta-Analysis and Network Analysis","volume":"16","author":"Jo","year":"2024","journal-title":"Nutrients"},{"issue":"46","key":"10.1016\/j.jep.2025.120607_bib25","article-title":"New and old topical treatments for psoriasis","volume":"186","author":"Kofoed","year":"2024","journal-title":"Ugeskr Laeger"},{"key":"10.1016\/j.jep.2025.120607_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1094375","article-title":"Narciclasine inhibits phospholipase A2 and regulates phospholipid metabolism to ameliorate psoriasis-like dermatitis","volume":"13","author":"Kong","year":"2023","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.jep.2025.120607_bib27","doi-asserted-by":"crossref","first-page":"552","DOI":"10.5114\/ada.2024.143428","article-title":"The IL-23\/Th17 pathway inhibitors in the treatment of psoriasis and the risk of skin malignancies: a review","volume":"41","author":"Krzysztofik","year":"2024","journal-title":"Postepy Dermatol Alergol"},{"issue":"10","key":"10.1016\/j.jep.2025.120607_bib28","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1055\/a-1152-8169","article-title":"In vitro and in vivo metabolic activation of obacunone, A bioactive and potentially hepatotoxic constituent of dictamni cortex","volume":"86","author":"Lang","year":"2020","journal-title":"Planta Med."},{"issue":"Pt A","key":"10.1016\/j.jep.2025.120607_bib29","article-title":"An alkaloid-rich phytopharmaceutical prepared from Qing Dai against IL-17A-induced psoriasis","volume":"318","author":"Lee","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120607_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1386783","article-title":"Promising strategies in natural products treatments of psoriasis-update","volume":"11","author":"Le","year":"2024","journal-title":"Front. Med."},{"key":"10.1016\/j.jep.2025.120607_bib31","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.jconrel.2023.12.009","article-title":"Transdermal delivery of Fn14 siRNA using a novel composite ionic liquid for treatment of psoriasis-like skin lesions","volume":"365","author":"Li","year":"2024","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.jep.2025.120607_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119680","article-title":"Integrating transcriptomics and network pharmacology to reveal the effect and mechanism of Bai-Jie-Jing-Xie ointment on improving skin inflammation of psoriasis","volume":"346","author":"Lin","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.jep.2025.120607_bib33","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3390\/antiox14050555","article-title":"Oxidative stress and skin diseases: the role of lipid peroxidation","volume":"14","author":"Li Pomi","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2025.120607_bib34","article-title":"Caffeic acid reduces ferroptosis to dampen inflammation of keratinocytes in psoriasis by inhibiting EGR1-induced transcription activation of CHAC1","author":"Li","year":"2024","journal-title":"Curr. Mol. Med."},{"issue":"6","key":"10.1016\/j.jep.2025.120607_bib35","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1002\/ptr.7007","article-title":"Dictamnine is an effective anti-anaphylactoid compound acting via the MrgX2 receptor located on mast cells","volume":"35","author":"Liu","year":"2021","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2025.120607_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.123777","article-title":"Delivery of penetration-enhancing antioxidant polyphenol nanoparticles with Codonopsis pilosula polysaccharide microneedles for synergistic treatment of psoriasis","volume":"363","author":"Liu","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2025.120607_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110221","article-title":"Piperine ameliorates psoriatic skin inflammation by inhibiting the phosphorylation of STAT3","volume":"119","author":"Lu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.120607_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.138537","article-title":"Role of miRNA regulation in IGFBP-2 overexpression and neuronal ferroptosis: insights into the Nrf2\/SLC7A11\/GPX4 pathway in Alzheimer's disease","volume":"287","author":"Luo","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2025.120607_bib39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.molimm.2025.02.013","article-title":"Andrographolide represses HIF-1\u03b1 and VEGFA expression, thus inhibiting hypoxia-induced proliferation, oxidative stress, and inflammatory cytokine secretion in human keratinocytes","volume":"180","author":"Ma","year":"2025","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jep.2025.120607_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117856","article-title":"Evaluating the efficacy and mechanisms of Hua-Zhuo-Ning-Fu-Decoction on psoriasis using integrated bioinformatics analysis and metabolomics","volume":"325","author":"Man","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.jep.2025.120607_bib41","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s12325-020-01346-6","article-title":"Psoriasis and cardiovascular risk: a comprehensive review","volume":"37","author":"Masson","year":"2020","journal-title":"Adv. Ther."},{"issue":"9","key":"10.1016\/j.jep.2025.120607_bib42","doi-asserted-by":"crossref","DOI":"10.1111\/dth.15685","article-title":"The role of lifestyle and nutrition in psoriasis: current status of knowledge and interventions","volume":"35","author":"Musumeci","year":"2022","journal-title":"Dermatol. Ther."},{"issue":"2","key":"10.1016\/j.jep.2025.120607_bib43","first-page":"2207","article-title":"Inhibitory effects of TGP on KGF-induced hyperproliferation of HaCaT cells via suppression of the p38 MAPK\/NF-\u03baB p65 pathway","volume":"18","author":"Pang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2025.120607_bib44","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2147\/CCID.S462797","article-title":"The role of interleukin 23\/17 Axis in psoriasis management: a comprehensive review of clinical trials","volume":"17","author":"Potestio","year":"2024","journal-title":"Clin. Cosmet. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.jep.2025.120607_bib45","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/jdv.18720","article-title":"Prevalence, comorbidities and mortality of generalized pustular psoriasis: a literature review","volume":"37","author":"Prinz","year":"2023","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.jep.2025.120607_bib46","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.freeradbiomed.2024.09.010","article-title":"Novel therapeutic approach for psoriasis: upregulating FcRn to inhibit ferroptosis and alleviate lesional skin","volume":"224","author":"Qian","year":"2024","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.jep.2025.120607_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/biof.70013","article-title":"The role of NRF2 transcription factor in inflammatory skin diseases","volume":"51","author":"Salman","year":"2025","journal-title":"Biofactors"},{"issue":"2","key":"10.1016\/j.jep.2025.120607_bib48","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s12016-024-08991-7","article-title":"The immunology of psoriasis-current concepts in pathogenesis","volume":"66","author":"Sieminska","year":"2024","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jep.2025.120607_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122768","article-title":"Reactive oxygen species-sensitive fenofibrate-loaded dextran nanoparticles in alleviation of osteoarthritis","volume":"347","author":"Sheng","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2025.120607_bib50","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.taap.2018.12.012","article-title":"Dictamnine-induced hepatotoxicity in mice: the role of metabolic activation of furan","volume":"364","author":"Shi","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"11","key":"10.1016\/j.jep.2025.120607_bib51","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/s41419-021-04284-5","article-title":"Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation","volume":"12","author":"Shou","year":"2021","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.jep.2025.120607_bib52","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1177\/039463200601900405","article-title":"VEGF is likely a key factor in the link between inflammation and angiogenesis in psoriasis: results of an immunohistochemical study","volume":"19","author":"Simonetti","year":"2006","journal-title":"Int. J. Immunopathol. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.120607_bib53","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.det.2024.02.007","article-title":"Psoriasis comorbidities and their treatment impact","volume":"42","author":"Taliercio","year":"2024","journal-title":"Dermatol. Clin."},{"key":"10.1016\/j.jep.2025.120607_bib54","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/607363","article-title":"Cross talk between proliferative, angiogenic, and cellular mechanisms orchestred by HIF-1\u03b1 in psoriasis","volume":"2015","author":"Torales-Carde\u00f1a","year":"2015","journal-title":"Mediat. Inflamm."},{"issue":"16","key":"10.1016\/j.jep.2025.120607_bib55","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.3390\/molecules24162880","article-title":"High-throughput immunological analysis of dictamni cortex: implication in the quality control of herbal medicine","volume":"24","author":"Tsang","year":"2019","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jep.2025.120607_bib56","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cyto.2013.02.029","article-title":"High serum levels of HIF-1\u03b1 in psoriatic patients correlate with an over-expression of IL-6","volume":"62","author":"Vasilopoulos","year":"2013","journal-title":"Cytokine"},{"issue":"2","key":"10.1016\/j.jep.2025.120607_bib57","doi-asserted-by":"crossref","DOI":"10.1172\/JCI183219","article-title":"Ferroptosis of select skin epithelial cells initiates and maintains chronic systemic immune-mediated psoriatic disease","volume":"135","author":"Vats","year":"2024","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jep.2025.120607_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118059","article-title":"Qinzhuliangxue mixture ameliorates psoriasis by restraining apoptosis in psoriasis via downregulating the MDA-5 pathway","volume":"328","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120607_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.140523","article-title":"Cross-talks of GSH, mitochondria, RNA m6A modification, NRF2, and p53 between ferroptosis and cuproptosis in HCC: a review","volume":"302","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.jep.2025.120607_bib60","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12951-019-0514-y","article-title":"Nano-drug delivery systems in wound treatment and skin regeneration","volume":"17","author":"Wang","year":"2019","journal-title":"J. Nanobiotechnol."},{"issue":"Pt A","key":"10.1016\/j.jep.2025.120607_bib61","article-title":"Rutin attenuates inflammation by downregulating AGE-RAGE signaling pathway in psoriasis: network pharmacology analysis and experimental evidence","volume":"125","author":"Wang","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120607_bib62","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12951-020-00635-0","article-title":"Flexible liposomal gel dual-loaded with all-trans retinoic acid and betamethasone for enhanced therapeutic efficiency of psoriasis","volume":"18","author":"Wang","year":"2020","journal-title":"J. Nanobiotechnol."},{"issue":"5","key":"10.1016\/j.jep.2025.120607_bib63","article-title":"Nano transdermal system combining mitochondria-targeting cerium oxide nanoparticles with all-trans retinoic acid for psoriasis","volume":"18","author":"Wang","year":"2023","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.jep.2025.120607_bib64","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jchromb.2013.03.018","article-title":"Simultaneous determination of limonin, dictamnine, obacunone and fraxinellone in rat plasma by a validated UHPLC-MS\/MS and its application to a pharmacokinetic study after oral administration of Cortex Dictamni extract","volume":"928","author":"Wang","year":"2013","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jep.2025.120607_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biopha.2018.03.039","article-title":"Cortex Dictamni extracts inhibit over-proliferation and migration of rat airway smooth muscle cells via FAK\/p38\/Bcl-2 signaling pathway","volume":"102","author":"Wei","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.120607_bib66","article-title":"Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice","volume":"2023","author":"Weng","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2025.120607_bib67","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.2147\/CCID.S457958","article-title":"Identification of potential ferroptosis biomarkers and analysis of immune cell infiltration in psoriasis using machine learning","volume":"17","author":"Wu","year":"2024","journal-title":"Clin. Cosmet. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.jep.2025.120607_bib68","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jep.2011.03.010","article-title":"Cortex Dictamni extract induces apoptosis of activated hepatic stellate cells via STAT1 and attenuates liver fibrosis in mice","volume":"135","author":"Wu","year":"2011","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.120607_bib69","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s13105-023-00966-0","article-title":"HIF-1 signaling: an emerging mechanism for mitochondrial dynamics","volume":"79","author":"Xin","year":"2023","journal-title":"J. Physiol. Biochem."},{"issue":"7","key":"10.1016\/j.jep.2025.120607_bib70","article-title":"Effect of fire needle combined with traditional Chinese medicine on psoriasis: a systematic review and meta-analysis","volume":"103","author":"Xu","year":"2024","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.jep.2025.120607_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154925","article-title":"Jingfang granules exert anti-psoriasis effect by targeting MAPK-mediated dendritic cell maturation and PPAR\u03b3-mediated keratinocytes cell cycle progression in vitro and in vivo","volume":"117","author":"Xu","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120607_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118704","article-title":"Diosmetin-7-O-\u03b2-D-glucopyranoside from Pogostemonis Herba alleviated SARS-CoV-2-induced pneumonia by reshaping macrophage polarization and limiting viral replication","volume":"336","author":"Xu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120607_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112183","article-title":"Cornuside alleviates psoriasis-like skin lesions in mice by relieving inflammatory effects","volume":"134","author":"Yan","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.120607_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115368","article-title":"Dictamnine ameliorates chronic itch in DNFB-induced atopic dermatitis mice via inhibiting MrgprA3","volume":"208","author":"Yang","year":"2023","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.120607_bib75","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s11655-022-3683-8","article-title":"Chinese medicine as supporting therapy for psoriasis: past, present, and future","volume":"29","author":"Yang","year":"2023","journal-title":"Chin. J. Integr. Med."},{"issue":"1","key":"10.1016\/j.jep.2025.120607_bib76","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00403-024-03669-8","article-title":"MiR-128-3p promotes hyperproliferation of keratinocytes and psoriasis-like inflammation by targeting SIRT1\/HIF-1\u03b1","volume":"317","author":"You","year":"2025","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jep.2025.120607_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2022.102916","article-title":"Pathogenesis, multi-omics research, and clinical treatment of psoriasis","volume":"133","author":"Yu","year":"2022","journal-title":"J. Autoimmun."},{"issue":"4","key":"10.1016\/j.jep.2025.120607_bib78","doi-asserted-by":"crossref","first-page":"520","DOI":"10.4103\/mgr.MEDGASRES-D-24-00144","article-title":"Nitric oxide: a gas transmitter in healthy and diseased skin","volume":"15","author":"Zaborova","year":"2025","journal-title":"Med. Gas Res."},{"key":"10.1016\/j.jep.2025.120607_bib79","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jep.2016.05.030","article-title":"Effects of Viola yedoensis Makino anti-itching compound on degranulation and cytokine generation in RBL-2H3 mast cells","volume":"189","author":"Zeng","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120607_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114454","article-title":"A TCM formula VYAC ameliorates DNCB-induced atopic dermatitis via blocking mast cell degranulation and suppressing NF-\u03baB pathway","volume":"280","author":"Zeng","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120607_bib81","doi-asserted-by":"crossref","first-page":"26","DOI":"10.4103\/mgr.MEDGASRES-D-24-00148","article-title":"Mechanism by which hydrogen-rich water mitigates exercise-induced fatigue: activation of the immunoresponsive gene 1-itaconate\/nuclear factor erythroid 2-related factor 2\/heme oxygenase-1 pathway","volume":"16","author":"Zhang","year":"2026","journal-title":"Med. Gas Res."},{"key":"10.1016\/j.jep.2025.120607_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106689","article-title":"Hypoxia-inducible factor-1: a potential pharmacological target to manage psoriasis","volume":"86","author":"Zhu","year":"2020","journal-title":"Int. Immunopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125012991?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125012991?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:46:32Z","timestamp":1773099992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125012991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":83,"alternative-id":["S0378874125012991"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120607","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dictamnine inhibited keratinocyte hyperproliferation and alleviated psoriasis-like dermatitis via blocking HIF1A-mediated ferroptotic pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120607","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120607"}}