{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T11:29:37Z","timestamp":1776511777412,"version":"3.51.2"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jep.2025.120621","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T18:04:15Z","timestamp":1758132255000},"page":"120621","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"PA","title":["Reinwardtia indica Dumort. protects against ponatinib-induced cerebral ischemia in adult zebrafish via attenuation of oxidative stress, neuroinflammation, mitochondrial dysfunction, and neurotransmitter dysregulation: A multi-target therapeutic strategy"],"prefix":"10.1016","volume":"355","author":[{"given":"Karan","family":"Wadhwa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Payal","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7906-5744","authenticated-orcid":false,"given":"Govind","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120621_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jep.2025.120621_bib2","doi-asserted-by":"crossref","first-page":"31958","DOI":"10.18632\/oncotarget.24110","article-title":"Ponatinib exerts anti-angiogenic effects in the zebrafish and human umbilical vein endothelial cells via blocking VEGFR signaling pathway","volume":"9","author":"Ai","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.jep.2025.120621_bib3","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s11910-023-01282-2","article-title":"Neuroinflammation in acute ischemic and hemorrhagic stroke","volume":"23","author":"Alsbrook","year":"2023","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.jep.2025.120621_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/9780470110218.ch1","article-title":"Assay methods for cholinesterases","volume":"5","author":"Augustinsson","year":"1957","journal-title":"Methods Biochem. Anal."},{"key":"10.1016\/j.jep.2025.120621_bib5","article-title":"Ponatinib-induced cerebrovascular accident (CVA)","volume":"14","author":"Azad","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.jep.2025.120621_bib6","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/BF00974874","article-title":"Cerebral ischemia: changes in brain choline, acetylcholine, and other monoamines as related to energy metabolism","volume":"16","author":"Beley","year":"1991","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jep.2025.120621_bib7","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1046\/j.1471-4159.1999.0731127.x","article-title":"Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease","volume":"73","author":"Berman","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jep.2025.120621_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1746-4269-9-1","article-title":"Ecological status and traditional knowledge of medicinal plants in Kedarnath wildlife sanctuary of Garhwal Himalaya, India","volume":"9","author":"Bhat","year":"2013","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"10.1016\/j.jep.2025.120621_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/03670240802034996","article-title":"Wild edible plants used by the people of manang district, central Nepal","volume":"48","author":"Bhattarai","year":"2009","journal-title":"Ecol. Food Nutr."},{"key":"10.1016\/j.jep.2025.120621_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2024.109871","article-title":"Intermittent fasting along with hydroalcoholic extract of Centella asiatica ameliorates sub-acute hypoxia-induced ischemic stroke in adult zebrafish","volume":"279","author":"Bindal","year":"2024","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.jep.2025.120621_bib11","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bbr.2013.07.019","article-title":"Evaluation of spontaneous recovery of behavioral and brain injury profiles in zebrafish after hypoxia","volume":"253","author":"Braga","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jep.2025.120621_bib12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/cns.12189","article-title":"Quercetin improves behavioral deficiencies, restores astrocytes and microglia, and reduces serotonin metabolism in 3-nitropropionic acid-induced rat model of Huntington's disease","volume":"20","author":"Chakraborty","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jep.2025.120621_bib13","first-page":"154","article-title":"Diverse models in Alzheimer's research: exploring alternative approaches beyond traditional rodent frameworks","volume":"6","author":"Chauhan","year":"2024","journal-title":"Aging Pathobiol. Ther."},{"key":"10.1016\/j.jep.2025.120621_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2025.111404","article-title":"Vitexin alleviates cerebral ischemia\/reperfusion injury by regulating mitophagy via the SIRT1\/PINK1\/Parkin pathway","volume":"227","author":"Chen","year":"2025","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jep.2025.120621_bib15","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1089\/ars.2010.3576","article-title":"Oxidative stress in ischemic brain damage: mechanisms of cell death and potential molecular targets for neuroprotection","volume":"14","author":"Chen","year":"2011","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.jep.2025.120621_bib16","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s12975-021-00907-3","article-title":"Zebrafish as a model for in-depth mechanistic study for stroke","volume":"12","author":"Chen","year":"2021","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.jep.2025.120621_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134492","article-title":"Revealing sex-specific molecular changes in hypoxia-ischemia induced neural damage and subsequent recovery using zebrafish model","volume":"712","author":"Das","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jep.2025.120621_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.01181","article-title":"Vitexin possesses anticonvulsant and anxiolytic-like effects in murine animal models","volume":"11","author":"de Oliveira","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120621_bib19","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/s12870-025-06290-7","article-title":"Altitudinal impacts on phytochemical composition and mycorrhizal diversity of Reinwardtia indica Dumort, a medicinally valuable herb","volume":"25","author":"Dhiman","year":"2025","journal-title":"BMC Plant Biol."},{"key":"10.1016\/j.jep.2025.120621_bib20","doi-asserted-by":"crossref","first-page":"596","DOI":"10.2174\/1570159X18666200114160844","article-title":"Pre-clinical to clinical translational failures and current status of clinical trials in stroke therapy: a brief review","volume":"18","author":"Dhir","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.jep.2025.120621_bib21","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jep.2025.120621_bib22","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2025.120621_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41983-020-00206-y","article-title":"The relationship between oxidative stress and acute ischemic stroke severity and functional outcome","volume":"56","author":"Elsayed","year":"2020","journal-title":"Egypt. J. Neurol. Psychiat. Neurosurg."},{"key":"10.1016\/j.jep.2025.120621_bib24","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s11033-021-06145-y","article-title":"Rutin improves glutamate uptake and inhibits glutamate excitotoxicity in rat brain slices","volume":"48","author":"Ferreira","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jep.2025.120621_bib25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jep.2025.120621_bib26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1432-1033.1974.tb03608.x","article-title":"Studies on energy\u2010linked reactions: modified mitochondrial ATPase of oligomycin\u2010resistant mutants of Saccharomyces cerevisiae","volume":"46","author":"Griffiths","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jep.2025.120621_bib27","doi-asserted-by":"crossref","first-page":"24","DOI":"10.14715\/cmb\/2021.67.1.4","article-title":"Reinwardtia indica: phytochemical screening and evaluation of wound healing activity of the extracts in experimental model rats","volume":"67","author":"Gurung","year":"2021","journal-title":"Cell. Mol. Biol."},{"key":"10.1016\/j.jep.2025.120621_bib28","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1055\/s-0039-1688787","article-title":"Ponatinib tyrosine kinase inhibitor induces a thromboinflammatory response","volume":"119","author":"Hamadi","year":"2019","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.jep.2025.120621_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/ene.16481","article-title":"Global, regional, and national epidemiology of ischemic stroke from 1990 to 2021","volume":"31","author":"Hou","year":"2024","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.jep.2025.120621_bib30","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.reth.2021.09.009","article-title":"Current status of ischemic stroke treatment: from thrombolysis to potential regenerative medicine","volume":"18","author":"Hurd","year":"2021","journal-title":"Regen. Ther."},{"key":"10.1016\/j.jep.2025.120621_bib31","first-page":"763","article-title":"Indigenous uses of economically important flora of Margallah Hills National Park, Islamabad, Pakistan","volume":"8","author":"Jabeen","year":"2009","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.jep.2025.120621_bib32","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12974-019-1516-2","article-title":"Neuroinflammation: friend and foe for ischemic stroke","volume":"16","author":"Jayaraj","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2025.120621_bib33","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.4142\/jvs.21273","article-title":"Quercetin ameliorates glutamate toxicity-induced neuronal cell death by controlling calcium-binding protein parvalbumin","volume":"23","author":"Kang","year":"2022","journal-title":"J. Vet. Sci."},{"key":"10.1016\/j.jep.2025.120621_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2025.115177","article-title":"Advances in brain ischemia mechanisms and treatment approaches: recent insights and inflammation-driven risks","volume":"386","author":"Kim","year":"2025","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jep.2025.120621_bib35","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/0076-6879(67)10061-X","article-title":"Preparation of succinate dehydrogenase and reconstitution of succinate oxidase","volume":"10","author":"King","year":"1967","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jep.2025.120621_bib36","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0076-6879(67)10055-4","article-title":"Preparations and properties of soluble NADH dehydrogenases from cardiac muscle","volume":"10","author":"King","year":"1967","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jep.2025.120621_bib37","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0003-9861(78)90479-4","article-title":"Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase","volume":"186","author":"Kono","year":"1978","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jep.2025.120621_bib38","doi-asserted-by":"crossref","first-page":"373","DOI":"10.4103\/1673-5374.228711","article-title":"Cerebral ischemia and neuroregeneration","volume":"13","author":"Lee","year":"2018","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.jep.2025.120621_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102758","article-title":"Global, regional, and national burden of ischemic stroke, 1990\u20132021: an analysis of data from the global burden of disease study 2021","volume":"75","author":"Li","year":"2024","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.jep.2025.120621_bib40","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1161\/CIRCRESAHA.124.324164","article-title":"Ponatinib-induced cardiomyocyte toxicity: dark side of the integrated stress response","volume":"134","author":"Liang","year":"2024","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2025.120621_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116397","article-title":"Qilong capsule alleviates ponatinib-induced ischemic stroke in a zebrafish model by regulating coagulation, inflammation and apoptosis","volume":"314","author":"Lin","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120621_bib42","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.2174\/1570159X21666230717144752","article-title":"Neuroprotective strategies for stroke by natural products: advances and perspectives","volume":"21","author":"Liu","year":"2023","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.jep.2025.120621_bib43","doi-asserted-by":"crossref","first-page":"924","DOI":"10.14336\/AD.2017.1126","article-title":"Mitochondria in ischemic stroke: new insight and implications","volume":"9","author":"Liu","year":"2018","journal-title":"Aging Dis"},{"key":"10.1016\/j.jep.2025.120621_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s43856-025-00939-y","article-title":"Epidemiology and future trend predictions of ischemic stroke based on the global burden of disease study 1990\u20132021","volume":"5","author":"Liu","year":"2025","journal-title":"Commun. Med."},{"key":"10.1016\/j.jep.2025.120621_bib45","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2025.120621_bib46","doi-asserted-by":"crossref","first-page":"95","DOI":"10.5897\/JMPR2013.5228","article-title":"Medico-ethnobotanical investigations in Parbat district of Western Nepal","volume":"8","author":"Malla","year":"2014","journal-title":"J. Med. Plants Res."},{"key":"10.1016\/j.jep.2025.120621_bib47","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuropharm.2017.11.050","article-title":"Neurotransmitters in the mediation of cerebral ischemic injury","volume":"134","author":"Mayor","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jep.2025.120621_bib48","first-page":"523","article-title":"Phytochemical screening and TLC profiling of various extracts of Reinwardtia indica","volume":"9","author":"Mehta","year":"2017","journal-title":"Int. J. Pharmacogn. Phytochem. Res."},{"key":"10.1016\/j.jep.2025.120621_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s42826-024-00232-4","article-title":"Drug screening for ischemic stroke using larvae and adult zebrafish model: a review","volume":"41","author":"Nayaka","year":"2025","journal-title":"Lab Anim. Res."},{"key":"10.1016\/j.jep.2025.120621_bib50","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jep.2025.120621_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fnsys.2021.806544","article-title":"Excitatory-inhibitory homeostasis and diaschisis: tying the local and global scales in the post-stroke cortex","volume":"15","author":"P\u00e1scoa dos Santos","year":"2022","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.jep.2025.120621_bib52","first-page":"1453","article-title":"Medicinal plants used in the health care system practiced by traditional Vaidyas in Alaknanda Catchment of Uttarakhand, India","volume":"13","author":"Phondani","year":"2009","journal-title":"Ethnobotanical Leaflets"},{"key":"10.1016\/j.jep.2025.120621_bib53","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0165-0270(99)00146-6","article-title":"Spectrophotometric measurement of experimental brain injury","volume":"94","author":"Preston","year":"2000","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jep.2025.120621_bib54","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.biopha.2018.05.003","article-title":"Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK\/SIRT1 signaling pathway in OA rats","volume":"103","author":"Qiu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.120621_bib55","doi-asserted-by":"crossref","first-page":"409","DOI":"10.31254\/phyto.2021.10521","article-title":"Expanding the TLC studies on the unexplored medicinal plant Reinwartdtia indica","volume":"10","author":"Saklani","year":"2021","journal-title":"J. Phytopharmacol."},{"key":"10.1016\/j.jep.2025.120621_bib56","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3390\/biom14030305","article-title":"Understanding the pathophysiology of ischemic stroke: the basis of current therapies and opportunity for new pnes","volume":"14","author":"Salaudeen","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.jep.2025.120621_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110610","article-title":"Dopaminergic modulation by quercetin: in silico and in vivo evidence using Caenorhabditis elegans as a model","volume":"382","author":"Salgueiro","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2025.120621_bib58","first-page":"716","article-title":"Development and validation of a HPTLC method for simultaneous estimation of L-glutamic acid and \u03b3-aminobutyric acid in mice brain","volume":"75","author":"Sancheti","year":"2013","journal-title":"Indian J. Pharmaceut. Sci."},{"key":"10.1016\/j.jep.2025.120621_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12883-024-04006-2","article-title":"Cerebrovascular stenosis related to tyrosine kinase inhibitor for chronic myeloid leukemia: two illustrative cases","volume":"25","author":"Sasaki","year":"2025","journal-title":"BMC Neurol."},{"key":"10.1016\/j.jep.2025.120621_bib60","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1016\/0006-2952(74)90235-4","article-title":"A fluorometric micromethod for the simultaneous determination of serotonin, noradrenaline and dopamine in milligram amounts of brain tissue","volume":"23","author":"Schlumpf","year":"1974","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2025.120621_bib61","first-page":"248","article-title":"Evaluation of in vitro antimicrobial activity, qualitative and quantitative phytochemical, proximate composition of leaf and stem of Reinwardtia indica dumort: a comparative study","volume":"8","author":"Shukla","year":"2017","journal-title":"Indian J. Nat. Prod. Resour."},{"key":"10.1016\/j.jep.2025.120621_bib62","first-page":"365","article-title":"Importance of local names of some useful plants in ethnobotanical study","volume":"7","author":"Singh","year":"2008","journal-title":"Indian J. Tradit. Knowl."},{"key":"10.1016\/j.jep.2025.120621_bib63","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1007\/s11033-022-07161-2","article-title":"Quercetin ameliorates lipopolysaccharide-induced neuroinflammation and oxidative stress in adult zebrafish","volume":"49","author":"Singh","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jep.2025.120621_bib64","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1083\/jcb.32.2.415","article-title":"An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study","volume":"32","author":"Sottocasa","year":"1967","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jep.2025.120621_bib65","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0043-1354(71)90171-0","article-title":"Measurement of pollutant toxicity to fish\u2014Iii: sublethal effects and \u201csafe\u201d concentrations","volume":"5","author":"Sprague","year":"1971","journal-title":"Water Res."},{"key":"10.1016\/j.jep.2025.120621_bib66","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.micpath.2018.12.024","article-title":"Evaluation of antioxidant and antimicrobial potential of a novel Himalayan plant Reinwardtia indica dumort: scientifically unexplored","volume":"127","author":"Upadhyay","year":"2019","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.jep.2025.120621_bib67","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/01480545.2018.1488859","article-title":"Antioxidant, antimicrobial and cytotoxic potential of silver nanoparticles synthesized using flavonoid rich alcoholic leaves extract of Reinwardtia indica","volume":"42","author":"Upadhyay","year":"2019","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.jep.2025.120621_bib68","article-title":"Pharmacognostic standardization of Asian folk medicinal plant Reinwardtia indica Dumort","volume":"12","author":"Upadhyay","year":"2018","journal-title":"Int. J. Green Pharm."},{"key":"10.1016\/j.jep.2025.120621_bib69","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s11011-019-00479-0","article-title":"Neuroprotective effect of Reinwardtia indica against scopolamine induced memory-impairment in rat by attenuating oxidative stress","volume":"35","author":"Upadhyay","year":"2020","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.jep.2025.120621_bib70","first-page":"494","article-title":"Indigenous medicinal plants knowledge of Kunihar forest division, district Solan","volume":"6","author":"Verma","year":"2007","journal-title":"Indian J. Tradit. Knowl."},{"key":"10.1016\/j.jep.2025.120621_bib71","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.3390\/antiox10091384","article-title":"The alterations in mitochondrial dynamics following cerebral ischemia\/reperfusion injury","volume":"10","author":"Vongsfak","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2025.120621_bib72","first-page":"9646","article-title":"Pharmacognostical characterization, phytochemical screening, and HPTLC fingerprinting profile of major flavonoids in the leaf extract of Reinwardtia indica Dumort","volume":"6","author":"Wadhwa","year":"2024","journal-title":"African J. Biol. Sci."},{"key":"10.1016\/j.jep.2025.120621_bib73","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/jcbfm.2014.27","article-title":"Zebrafish models of cerebrovascular disease","volume":"34","author":"Walcott","year":"2014","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.jep.2025.120621_bib74","series-title":"Gastritis - New Approaches and Treatments","article-title":"Gastritis treated by chinese medicine","author":"Wang","year":"2019"},{"key":"10.1016\/j.jep.2025.120621_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113744","article-title":"Discovery of anti-stroke active substances in Guhong injection based on multi-phenotypic screening of zebrafish","volume":"155","author":"Wang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.120621_bib76","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3965376","article-title":"Acute toxicity of leaf extracts of Enydra fluctuans Lour in zebrafish (Danio rerio Hamilton)","author":"Xavier","year":"2020","journal-title":"Scientifica (Cairo)"},{"key":"10.1016\/j.jep.2025.120621_bib77","first-page":"88","article-title":"Zebrafish as an alternative model for hypoxic-ischemic brain damage","volume":"3","author":"Yu","year":"2011","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"10.1016\/j.jep.2025.120621_bib78","first-page":"195","article-title":"Quercetin exerts a neuroprotective effect through inhibition of the iNOS\/NO system and pro-inflammation gene expression in PC12 cells and in zebrafish","volume":"27","author":"Zhang","year":"2011","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jep.2025.120621_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116275","article-title":"Determining the chemical profile of Caragana jubata (Pall.) Poir. by UPLC\u2013QTOF\u2013MS analysis and evaluating its anti-ischemic stroke effects","volume":"309","author":"Zhao","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120621_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173292","article-title":"Ponatinib-induced ischemic stroke in larval zebrafish for drug screening","volume":"889","author":"Zhu","year":"2020","journal-title":"Eur. J. Pharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125013133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125013133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:10:36Z","timestamp":1761696636000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125013133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":80,"alternative-id":["S0378874125013133"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120621","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reinwardtia indica Dumort. protects against ponatinib-induced cerebral ischemia in adult zebrafish via attenuation of oxidative stress, neuroinflammation, mitochondrial dysfunction, and neurotransmitter dysregulation: A multi-target therapeutic strategy","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120621","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120621"}}