{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:08:13Z","timestamp":1789412893878,"version":"build-2803163510"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018531","name":"Major Science and Technology Projects in Yunnan Province","doi-asserted-by":"publisher","award":["202302AA310013"],"award-info":[{"award-number":["202302AA310013"]}],"id":[{"id":"10.13039\/501100018531","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jep.2025.120664","type":"journal-article","created":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T15:14:37Z","timestamp":1759072477000},"page":"120664","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"PA","title":["Crotalaria assamica Benth alleviated acetaminophen-induced liver injury through the upregulation of Nrf2 pathway"],"prefix":"10.1016","volume":"355","author":[{"given":"Yan-Ling","family":"Qian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bang-Yin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Shi","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Run","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo-Qi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Li","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Dong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jep.2025.120664_bib1","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1007\/s00204-024-03725-2","article-title":"The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice","volume":"98","author":"Adelusi","year":"2024","journal-title":"Arch. Toxicol."},{"issue":"4","key":"10.1016\/j.jep.2025.120664_bib2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/ame2.12452","volume":"7","author":"Ahmed","year":"2024","journal-title":"Anim. Model. Exp. Med."},{"issue":"1","key":"10.1016\/j.jep.2025.120664_bib3","doi-asserted-by":"crossref","DOI":"10.1515\/chem-2024-0029","article-title":"Hepatoprotective effects of safranal on acetaminophen-induced hepatotoxicity in rats","volume":"22","author":"Alayunt","year":"2024","journal-title":"Open Chem."},{"key":"10.1016\/j.jep.2025.120664_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110029","article-title":"Abietic acid inhibits acetaminophen-induced liver injury by alleviating inflammation and ferroptosis through regulating Nrf2\/HO-1 axis","volume":"118","author":"An","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2025.120664_bib5","article-title":"Biochemical markers of in vivo hepatotoxicity","volume":"6","author":"Arika","year":"2016","journal-title":"Clin. Toxicol."},{"issue":"8","key":"10.1016\/j.jep.2025.120664_bib6","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0031-9422(99)00503-8","article-title":"Triterpene saponins from the fruits of Hedera helix","volume":"53","author":"Bedir","year":"2000","journal-title":"Phytochemistry"},{"issue":"4","key":"10.1016\/j.jep.2025.120664_bib7","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.ajpath.2018.12.006","article-title":"Liver regeneration after acetaminophen hepatotoxicity","volume":"189","author":"Bhushan","year":"2019","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.jep.2025.120664_bib8","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3390\/livers3020021","article-title":"Regeneration and recovery after acetaminophen hepatotoxicity","volume":"3","author":"Bhushan","year":"2023","journal-title":"Livers"},{"key":"10.1016\/j.jep.2025.120664_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155221","article-title":"Protective effect of tibetan medicine qiwei tiexie pills on liver injury induced by acetaminophen overdose: an integrated strategy of network pharmacology, metabolomics and transcriptomics","volume":"123","author":"Bian","year":"2024","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.jep.2025.120664_bib10","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1136\/flgastro-2021-101886","article-title":"Guideline review: EASL clinical practice guidelines: drug-induced liver injury (DILI)","volume":"13","author":"Brennan","year":"2022","journal-title":"Frontline Gastroenterol."},{"issue":"7","key":"10.1016\/j.jep.2025.120664_bib11","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/ejp.621","article-title":"Acetaminophen\/paracetamol: a history of errors, failures and false decisions","volume":"19","author":"Brune","year":"2014","journal-title":"Eur. J. Pain"},{"issue":"1","key":"10.1016\/j.jep.2025.120664_bib12","doi-asserted-by":"crossref","DOI":"10.1080\/15384047.2023.2184150","article-title":"Daucosterol combined with umbilical cord mesenchymal stem cell-derived exosomes can alleviate liver damage in liver failure mice by regulating the IL-6\/STAT3 signaling pathway","volume":"24","author":"Deng","year":"2023","journal-title":"Cancer Biol. Ther."},{"issue":"2","key":"10.1016\/j.jep.2025.120664_bib13","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1021\/acs.molpharmaceut.2c00881","article-title":"Pterostilbene-loaded soluplus\/poloxamer 188 mixed micelles for protection against acetaminophen-induced acute liver injury","volume":"20","author":"Dong","year":"2023","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jep.2025.120664_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120407","article-title":"Anti-breast cancer effects of Pterocarpus soyauxii Taub aqueous extract and its compounds by integrating ADMET, network pharmacology, molecular docking, dynamic simulation, CLC-Pred and pdCSM-Cancer\/PPI approaches, and in vitro validation","volume":"353","author":"Emmanuel","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.jep.2025.120664_bib15","doi-asserted-by":"crossref","first-page":"8468","DOI":"10.1021\/acsanm.3c00763","article-title":"Antioxidation and anti-inflammatory activity of prussian blue nanozymes to alleviate acetaminophen-induced acute liver injury","volume":"6","author":"Feng","year":"2023","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.jep.2025.120664_bib16","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3390\/ani14030373","article-title":"The antioxidant and hepatoprotective potential of berberine and silymarin on acetaminophen induced toxicity in cyprinus carpio L","volume":"14","author":"Gr\u0103dinariu","year":"2024","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.jep.2025.120664_bib17","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.bbrc.2003.12.096","article-title":"IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system","volume":"314","author":"Hagihara","year":"2004","journal-title":"Biochem. Bioph. Res. Co."},{"key":"10.1016\/j.jep.2025.120664_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117740","article-title":"Network pharmacology and experimental validation of effects of total saponins extracted from abrus cantoniensis Hance on acetaminophen-induced liver injury","volume":"324","author":"He","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.jep.2025.120664_bib19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3892\/ijmm.2022.5123","article-title":"FTY720 attenuates APAP-induced liver injury via the JAK2\/STAT3 signaling pathway","volume":"49","author":"He","year":"2022","journal-title":"Int. J. Mol. Med."},{"issue":"10","key":"10.1016\/j.jep.2025.120664_bib20","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3390\/molecules22101617","article-title":"A network pharmacology-based study on the hepatoprotective effect of fructus schisandrae","volume":"22","author":"Hong","year":"2017","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.jep.2025.120664_bib21","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1002\/jcp.27262","article-title":"PI3k\/AKT signaling pathway: erythropoiesis and beyond","volume":"234","author":"Jafari","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jep.2025.120664_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2024.106297","article-title":"Kakuol and asarinin protecting liver injury via HSP90AA1\/CDK2\/mTOR signaling pathway","volume":"180","author":"Jiang","year":"2025","journal-title":"Fitoterapia"},{"issue":"11","key":"10.1016\/j.jep.2025.120664_bib23","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1002\/jcc.20945","article-title":"CHARMM-GUI: a web-based graphical user interface for CHARMM","volume":"29","author":"Jo","year":"2008","journal-title":"J. Comput. Chem."},{"issue":"1","key":"10.1016\/j.jep.2025.120664_bib24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/his.13082","article-title":"The histopathological evaluation of drug\u2010induced liver injury","volume":"70","author":"Kleiner","year":"2016","journal-title":"Histopathology"},{"key":"10.1016\/j.jep.2025.120664_bib25","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1248\/bpb.22.203","article-title":"Study of structure-hepatoprotective relationships of oleanene-type triterpenoidal glucuronides obtained from several fabaceous plants on rat primary hepatocyte cultures","volume":"22","author":"Kinjo","year":"1999","journal-title":"Biol. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.jep.2025.120664_bib26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/00498250802512830","article-title":"Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes","volume":"39","author":"Laine","year":"2009","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jep.2025.120664_bib27","doi-asserted-by":"crossref","DOI":"10.7573\/dic.2023-2-11","article-title":"Hepatoprotective effects of silymarin in management of liver injury caused by tuberculosis treatment","volume":"12","author":"Lee","year":"2023","journal-title":"Drugs in Context."},{"issue":"4","key":"10.1016\/j.jep.2025.120664_bib28","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1039\/D2FO02716J","article-title":"Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation","volume":"14","author":"Li","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2025.120664_bib29","article-title":"Multi-omics reveals inhibitory effect of baicalein on non-alcoholic fatty liver disease in mice","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"27","key":"10.1016\/j.jep.2025.120664_bib30","doi-asserted-by":"crossref","first-page":"4920","DOI":"10.3748\/wjg.v23.i27.4920","article-title":"Anti-oxidant and anti-inflammatory effects of hydrogen-rich water alleviate ethanol-induced fatty liver in mice","volume":"23","author":"Lin","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2025.120664_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112580","article-title":"Taraxasterol protects against acetaminophen-induced hepatotoxicity by reducing liver inflammatory response and ameliorating oxidative stress in mice","volume":"138","author":"Lin","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.120664_bib32","article-title":"Modulation of HMGB1 release in APAP-induced liver injury: a possible strategy of chikusetsusaponin V targeting NETs formation","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"43","key":"10.1016\/j.jep.2025.120664_bib33","doi-asserted-by":"crossref","first-page":"9954","DOI":"10.1021\/jp003020w","article-title":"Structure and dynamics of the TIP3P, SPC, and SPC\/E water models at 298 K","volume":"105","author":"Mark","year":"2001","journal-title":"J. Phys. Chem. C"},{"issue":"1","key":"10.1016\/j.jep.2025.120664_bib34","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0022-3565(25)29663-X","article-title":"Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism","volume":"187","author":"Mitchell","year":"1973","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"9","key":"10.1016\/j.jep.2025.120664_bib35","doi-asserted-by":"crossref","first-page":"e3377","DOI":"10.1093\/cid\/ciaa1255","article-title":"A randomized controlled trial of intravenous N-acetylcysteine in the management of anti-tuberculosis drug\u2013induced liver injury","volume":"73","author":"Moosa","year":"2021","journal-title":"Clin.l Infect. Dis."},{"issue":"8","key":"10.1016\/j.jep.2025.120664_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202100938","article-title":"In silico analysis identifies the anti\u2010liver injury targets of diammonium glycyrrhizinate: validated in perfluorooctanoic acid\u2010lesioned mouse model","volume":"19","author":"Qin","year":"2022","journal-title":"Chem. Biodivers."},{"issue":"1","key":"10.1016\/j.jep.2025.120664_bib37","doi-asserted-by":"crossref","DOI":"10.1186\/s13578-023-01184-3","article-title":"Knocking out Fkbp51 decreases CCl4-induced liver injury through enhancement of mitochondrial function and Parkin activity","volume":"14","author":"Qiu","year":"2024","journal-title":"Cell Biosci."},{"issue":"2","key":"10.1016\/j.jep.2025.120664_bib38","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1055\/s-0039-1679919","article-title":"Acetaminophen hepatotoxicity","volume":"39","author":"Ramachandran","year":"2019","journal-title":"Semin. Liver Dis."},{"issue":"1","key":"10.1016\/j.jep.2025.120664_bib39","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4103\/1735-5362.394823","article-title":"Ameliorative effects of umbelliferone against acetaminophen-induced hepatic oxidative stress and inflammation in mice","volume":"19","author":"Sadeghinejad","year":"2024","journal-title":"Res. Pharm. Sci."},{"key":"10.1016\/j.jep.2025.120664_bib40","doi-asserted-by":"crossref","DOI":"10.1007\/s00210-025-03869-7","article-title":"Quinic acid alleviates liver toxicity induced by acetaminophen in mice via anti-oxidative and anti-inflammatory effects","author":"Shariati","year":"2025","journal-title":"N-S. Arch Pharmacol"},{"issue":"24","key":"10.1016\/j.jep.2025.120664_bib41","doi-asserted-by":"crossref","first-page":"9682","DOI":"10.3390\/ijms21249682","article-title":"Cell death in liver diseases: a review","volume":"21","author":"Shojaie","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.jep.2025.120664_bib42","article-title":"Mechanism and clinical significance of IL-6 combined with TNF-\u03b1 or IL-1 for the induction of acute phase proteins SAA and CRP in chronic inflammatory diseases","volume":"4","author":"Song","year":"2016","journal-title":"J. Alcohol. Drug Depend."},{"key":"10.1016\/j.jep.2025.120664_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102852","article-title":"Remote ischemic conditioning attenuates oxidative stress and inflammation via the Nrf2\/HO-1 pathway in MCAO mice","volume":"66","author":"Sun","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2025.120664_bib44","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btae416","article-title":"ADMET-AI: a machine learning ADMET platform for evaluation of large-scale chemical libraries","volume":"40","author":"Swanson","year":"2024","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jep.2025.120664_bib45","first-page":"67","article-title":"Quality standard of yao medicine Crotalaria Assamica","volume":"31","author":"Tang","year":"2022","journal-title":"China Pharm."},{"key":"10.1016\/j.jep.2025.120664_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118590","article-title":"Liver injury protection of Artemisia stechmanniana besser through PI3K\/AKT pathway","volume":"334","author":"Tian","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120664_bib47","article-title":"Smilax China L. polysaccharide alleviates oxidative stress and protects from acetaminophen-induced hepatotoxicity via activating the Nrf2-ARE pathway","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120664_bib48","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s11033-024-09806-w","article-title":"Glucocorticoid efficacy and treatment strategies for drug-induced liver injury: a literature review","volume":"51","author":"Wang","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jep.2025.120664_bib49","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bbrc.2023.02.043","article-title":"Piezo1 alleviates acetaminophen-induced acute liver injury by activating Nrf2 and reducing mitochondrial reactive oxygen species","volume":"652","author":"Wang","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2025.120664_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2025.107238","article-title":"Innovative strategy for full-scale polar components explicition and ultrasonic-assisted optimization of Astragalus membranaceus flower","volume":"114","author":"Wang","year":"2025","journal-title":"Ultrason. Sonochem."},{"issue":"1","key":"10.1016\/j.jep.2025.120664_bib51","first-page":"Si1","article-title":"Acetaminophen toxicity","volume":"10","author":"Whittaker","year":"2025","journal-title":"J. Educ. Teach. Emerg. Med."},{"issue":"1","key":"10.1016\/j.jep.2025.120664_bib52","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.livres.2023.03.001","article-title":"A dual role of inflammation in acetaminophen-induced liver injury","volume":"7","author":"Xu","year":"2023","journal-title":"Liver Res."},{"key":"10.1016\/j.jep.2025.120664_bib53","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.redox.2018.04.019","article-title":"Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions","volume":"17","author":"Yan","year":"2018","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.jep.2025.120664_bib54","first-page":"131","article-title":"Acetaminophen-induced hepatotoxicity: a comprehensive update","volume":"4","author":"Yoon","year":"2016","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.jep.2025.120664_bib55","series-title":"Yunnan Provincial Standard for Chinese Materia Medica 2005 (5)","first-page":"15","year":"2005"},{"issue":"1","key":"10.1016\/j.jep.2025.120664_bib56","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3390\/cimb46010019","article-title":"Integrating metabolomics and network pharmacology to decipher the hepatoprotective effect mechanisms of magnesium isoglycyrrhizinate injection","volume":"46","author":"Zhang","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"issue":"2","key":"10.1016\/j.jep.2025.120664_bib57","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1177\/09731296231220116","article-title":"Anwulignan alleviates the acute liver injury induced by acetaminophen in mice","volume":"20","author":"Zhao","year":"2024","journal-title":"Pharmacogn. Mag."},{"key":"10.1016\/j.jep.2025.120664_bib58","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.toxlet.2020.08.007","article-title":"Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice","volume":"333","author":"Zhao","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jep.2025.120664_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112949","article-title":"Indole alkaloids from leaves of Alstonia scholaris (L.) R. Br. protect against emphysema in mice","volume":"259","author":"Zhao","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2025.120664_bib60","article-title":"Integrated spatial transcriptome and metabolism study reveals metabolic heterogeneity in human injured brain","volume":"4","author":"Zheng","year":"2023","journal-title":"Cell Rep. Med."},{"issue":"20","key":"10.1016\/j.jep.2025.120664_bib61","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.3390\/nu15204349","article-title":"Eriodictyol alleviated LPS\/D-GalN-induced acute liver injury by inhibiting oxidative stress and cell apoptosis via PI3K\/AKT signaling pathway","volume":"15","author":"Zheng","year":"2023","journal-title":"Nutrients"},{"issue":"26","key":"10.1016\/j.jep.2025.120664_bib62","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.1016\/j.cell.2023.11.003","article-title":"Mapping the transcriptome: realizing the full potential of spatial data analysis","volume":"186","author":"Zormpas","year":"2023","journal-title":"Cell"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412501356X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412501356X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:33:46Z","timestamp":1778538826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412501356X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":62,"alternative-id":["S037887412501356X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120664","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crotalaria assamica Benth alleviated acetaminophen-induced liver injury through the upregulation of Nrf2 pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120664","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120664"}}