{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:38:02Z","timestamp":1792629482823,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010618","name":"Guangzhou University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010618","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jep.2025.120681","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T06:14:05Z","timestamp":1759558445000},"page":"120681","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"PB","title":["Cistanche deserticola Y.C.Ma protects rats against osteoporotic osteoarthritis by inhibiting the phosphatidylinositol 3-kinase\/serine-threonine protein kinase B\/hypoxia-inducible factor 1 alpha signaling pathway"],"prefix":"10.1016","volume":"355","author":[{"given":"Fan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YiZhou","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiAo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiaMing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YiFeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4032-0522","authenticated-orcid":false,"given":"Yang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZiYun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120681_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155516","article-title":"Luteolin rescues postmenopausal osteoporosis elicited by OVX through alleviating osteoblast pyroptosis via activating PI3K-AKT signaling","volume":"128","author":"Chai","year":"2024","journal-title":"Phytomedicine"},{"issue":"18","key":"10.1016\/j.jep.2025.120681_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/nu16183130","article-title":"Effects and mechanisms of polyunsaturated fatty acids on age-related musculoskeletal diseases: sarcopenia, osteoporosis, and Osteoarthritis-A narrative review","volume":"16","author":"Chen","year":"2024","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jep.2025.120681_bib3","doi-asserted-by":"crossref","first-page":"ITC1","DOI":"10.7326\/AITC202401160","article-title":"Osteoporosis","volume":"177","author":"Ensrud","year":"2024","journal-title":"Ann. Intern. Med."},{"issue":"3","key":"10.1016\/j.jep.2025.120681_bib4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s40265-024-02138-w","article-title":"Treatment of osteoporosis and osteoarthritis in the oldest old","volume":"85","author":"Fuggle","year":"2025","journal-title":"Drugs"},{"issue":"6","key":"10.1016\/j.jep.2025.120681_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13807","article-title":"The gut microbiota metabolite capsiate regulate SLC2A1 expression by targeting HIF-1\u03b1 to inhibit knee osteoarthritis-induced ferroptosis","volume":"22","author":"Guan","year":"2023","journal-title":"Aging Cell"},{"issue":"10","key":"10.1016\/j.jep.2025.120681_bib6","doi-asserted-by":"crossref","first-page":"16640","DOI":"10.3390\/molecules191016640","article-title":"Influence of sulfur fumigation on the chemical constituents and antioxidant activity of buds of Lonicera japonica","volume":"19","author":"Guo","year":"2014","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.jep.2025.120681_bib7","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nrrheum.2013.113","article-title":"Osteoarthritis: osteoporotic OA: a reasonable target for bone-acting agents","volume":"9","author":"Herrero-Beaumont","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2025.120681_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2024.112614","article-title":"The interplay between osteoarthritis and osteoporosis: mechanisms, implications, and treatment considerations - a narrative review","volume":"197","author":"Huang","year":"2024","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.jep.2025.120681_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1077796","article-title":"Mechanisms by which kidney-tonifying Chinese herbs inhibit osteoclastogenesis: emphasis on immune cells","volume":"14","author":"Jiao","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.jep.2025.120681_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12040968","article-title":"Protective effect of Lonicera japonica on PM2.5-Induced pulmonary damage in BALB\/c mice via the TGF-\u03b2 and NF-\u03baB pathway","volume":"12","author":"Lee","year":"2023","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.jep.2025.120681_bib11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.joca.2021.05.007","article-title":"The burden of OA-health services and economics","volume":"30","author":"Leifer","year":"2022","journal-title":"Osteoarthr. Cartil."},{"issue":"6","key":"10.1016\/j.jep.2025.120681_bib12","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.phymed.2013.01.001","article-title":"Antiosteoporotic activity of echinacoside in ovariectomized rats","volume":"20","author":"Li","year":"2013","journal-title":"Phytomedicine"},{"issue":"9","key":"10.1016\/j.jep.2025.120681_bib13","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0024-3205(03)00383-7","article-title":"The ethanol metabolite, linolenic acid ethyl ester, stimulates mitogen-activated protein kinase and cyclin signaling in hepatic stellate cells","volume":"73","author":"Li","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2025.120681_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117570","article-title":"Cistanche deserticola improves ovariectomized-induced osteoporosis mainly by regulating lipid metabolism: insights from serum metabolomics using UPLC\/Q-TOF-MS","volume":"322","author":"Li","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120681_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109365","article-title":"The ameliorative effects and mechanisms of abscisic acid on learning and memory","volume":"224","author":"Liao","year":"2023","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jep.2025.120681_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119455","article-title":"Zuogui pills alleviate iron overload-induced osteoporosis by attenuating ROS-Mediated osteoblast apoptosis via the PI3K-AKT pathway and mitigating mitochondrial damage","volume":"344","author":"Lin","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120681_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.110897","article-title":"Casticin ameliorates osteoarthritic cartilage damage in rats through PI3K\/AKT\/HIF-1\u03b1 signaling","volume":"391","author":"Liu","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2025.120681_bib18","doi-asserted-by":"crossref","first-page":"540","DOI":"10.34133\/research.0540","article-title":"Palladium-based nanocomposites remodel osteoporotic microenvironment by bone-targeted hydrogen enrichment and zincum repletion","volume":"7","author":"Liu","year":"2024","journal-title":"Research"},{"issue":"9","key":"10.1016\/j.jep.2025.120681_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/nu17091501","article-title":"Bioactive components, pharmacological properties, and applications of Cistanche deserticola Y. C. Ma: a comprehensive review","volume":"17","author":"Liu","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2025.120681_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1060721","article-title":"Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K\/AKT\/mTOR signaling pathway and enhancement of autophagy","volume":"13","author":"Lu","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2025.120681_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.905507","article-title":"GCTOF-MS combined LC-QTRAP-MS\/MS reveals metabolic difference between osteoarthritis and osteoporotic osteoarthritis and the intervention effect of erxian decoction","volume":"13","author":"Ma","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.jep.2025.120681_bib22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthr. Cartil."},{"issue":"6","key":"10.1016\/j.jep.2025.120681_bib23","first-page":"1242","article-title":"[osteoporosis]. No shinkei geka","volume":"52","author":"Saito","year":"2024","journal-title":"Neurolog. Surg."},{"issue":"29","key":"10.1016\/j.jep.2025.120681_bib24","doi-asserted-by":"crossref","first-page":"43732","DOI":"10.1007\/s11356-022-20137-w","article-title":"Multiple health benefits of curcumin and its therapeutic potential","volume":"29","author":"Shah","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.jep.2025.120681_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155702","article-title":"Androsin alleviates non-alcoholic fatty liver disease by activating autophagy and attenuating de novo lipogenesis","volume":"129","author":"Singh","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2025.120681_bib26","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13020-023-00788-8","article-title":"Effects of genus epimedium in the treatment of osteoarthritis and relevant signaling pathways","volume":"18","author":"Tong","year":"2023","journal-title":"Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2025.120681_bib27","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1186\/s12967-023-04771-7","article-title":"Cucurbitacin E reduces IL-1\u03b2-induced inflammation and cartilage degeneration by inhibiting the PI3K\/Akt pathway in osteoarthritic chondrocytes","volume":"21","author":"Wang","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jep.2025.120681_bib28","article-title":"Tanshinone ameliorates glucocorticoid-induced bone loss via activation of AKT1 signaling pathway","volume":"10","author":"Wang","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.jep.2025.120681_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12040843","article-title":"Osteoporosis, osteoarthritis, and subchondral insufficiency fracture: recent insights","volume":"12","author":"Yokota","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.jep.2025.120681_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154018","article-title":"Pharmacokinetics and anti-liver fibrosis characteristics of amygdalin: key role of the deglycosylated metabolite prunasin","volume":"99","author":"Zhang","year":"2022","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2025.120681_bib31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12974-022-02495-x","article-title":"DKK3 ameliorates neuropathic pain via inhibiting ASK-1\/JNK\/p-38-mediated microglia polarization and neuroinflammation","volume":"19","author":"Zhang","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2025.120681_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155808","article-title":"Chemical composition, pharmacological effects, and parasitic mechanisms of cistanche deserticola: an update","volume":"132","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.jep.2025.120681_bib33","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1096\/fj.201902117R","article-title":"Knee loading repairs osteoporotic osteoarthritis by relieving abnormal remodeling of subchondral bone via Wnt\/\u03b2-catenin signaling","volume":"34","author":"Zheng","year":"2020","journal-title":"FASEB J."},{"issue":"Pt 2","key":"10.1016\/j.jep.2025.120681_bib34","article-title":"Modulation of gut microbiota by crude mulberry polysaccharide attenuates knee osteoarthritis progression in rats","volume":"262","author":"Zheng","year":"2024","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412501373X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412501373X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T03:36:12Z","timestamp":1764041772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412501373X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":34,"alternative-id":["S037887412501373X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120681","relation":{"is-supplemented-by":[{"id-type":"uri","id":"https:\/\/data.mendeley.com\/preview\/3wjdptkswb?a=01e2cbf5-724e-4666-a269-874cd3853547","asserted-by":"subject"}]},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cistanche deserticola Y.C.Ma protects rats against osteoporotic osteoarthritis by inhibiting the phosphatidylinositol 3-kinase\/serine-threonine protein kinase B\/hypoxia-inducible factor 1 alpha signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120681","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120681"}}