{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:07:10Z","timestamp":1767665230261,"version":"3.45.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100025324","name":"\u0130zmir K\u00e2tip \u00c7elebi University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100025324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jep.2025.120689","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:37:11Z","timestamp":1759538231000},"page":"120689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"PB","title":["LC-MS\/MS based phytochemical composition profiling and the development of hemostatic in situ gel formulation of Teucrium polium L."],"prefix":"10.1016","volume":"355","author":[{"given":"Miray","family":"Ilhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mert","family":"Ilhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazal Ezgi","family":"Gultekin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Senyigit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muge","family":"Kilicarslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jep.2025.120689_bib1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.33808\/marusbed.767312","article-title":"The effect of algan hemostatic agent (AHA) on wound healing","volume":"10","author":"Aksoy","year":"2020","journal-title":"Clin. Exp. Health Sci."},{"issue":"9","key":"10.1016\/j.jep.2025.120689_bib2","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1007\/s10904-022-02388-9","article-title":"Nanoarchitectonics: porous hydrogel as bio-sorbent for effective remediation of hazardous contaminants","volume":"32","author":"Ali","year":"2022","journal-title":"J. Inorg. Organomet. Polym. Mater."},{"issue":"6","key":"10.1016\/j.jep.2025.120689_bib3","first-page":"499","article-title":"The effect of Teucrium polium honey on the wound healing and tensile strength in rat. Iran","volume":"14","author":"Alizadeh","year":"2011","journal-title":"J. Basic Med. Sci."},{"key":"10.1016\/j.jep.2025.120689_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemphyslip.2020.104889","article-title":"SLN enriched hydrogels for dermal application: full factorial design study to estimate the relationship between composition and mechanical properties","volume":"228","author":"Amasya","year":"2020","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.jep.2025.120689_bib5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.biomaterials.2017.05.011","article-title":"Engineering a sprayable and elastic hydrogel adhesive with antimicrobial properties for wound healing","volume":"139","author":"Annabi","year":"2017","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.jep.2025.120689_bib6","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jobcr.2017.12.005","article-title":"Periodontal thermoresponsive, mucoadhesive dual antimicrobial loaded in-situ gel for the treatment of periodontal disease: preparation, in-vitro characterization and antimicrobial study","volume":"8","author":"Bansal","year":"2018","journal-title":"J. Oral Biol. Craniofac. Res."},{"key":"10.1016\/j.jep.2025.120689_bib7","series-title":"Developing Solid Oral Dosage Forms","first-page":"181","article-title":"Polymer properties and characterization","author":"Brady","year":"2017"},{"key":"10.1016\/j.jep.2025.120689_bib8","series-title":"Comprehensive Biomaterials","first-page":"529","article-title":"Encapsulation of cells (Cellular Delivery) using sol\u2013gel systems","author":"Braun","year":"2011"},{"key":"10.1016\/j.jep.2025.120689_bib9","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.sajb.2020.10.017","article-title":"Teucrium polium-wound healing potential, toxicity and polyphenolic profile","volume":"137","author":"Chabane","year":"2021","journal-title":"South Afr. J. Bot."},{"key":"10.1016\/j.jep.2025.120689_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/280928","article-title":"Preparation and evaluation of novel in situ gels containing acyclovir for the treatment of oral Herpes simplex virus infections","volume":"2014","author":"Chaudhary","year":"2014","journal-title":"Sci. World J."},{"issue":"16","key":"10.1016\/j.jep.2025.120689_bib11","doi-asserted-by":"crossref","first-page":"4522","DOI":"10.3390\/ma14164522","article-title":"An overview on thermosensitive oral gel based on poloxamer 407","volume":"14","author":"Chen","year":"2021","journal-title":"Materials"},{"key":"10.1016\/j.jep.2025.120689_bib12","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ijbiomac.2020.02.097","article-title":"Polysaccharide as renewable responsive biopolymer for in situ gel in the delivery of drug through ocular route","volume":"150","author":"Chowhan","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.jep.2025.120689_bib13","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.drudis.2016.12.008","article-title":"In vitro and in vivo evaluation of in situ gelling systems for sustained topical ophthalmic delivery: state of the art and beyond","volume":"22","author":"Destruel","year":"2017","journal-title":"Drug Discov. Today"},{"issue":"2","key":"10.1016\/j.jep.2025.120689_bib14","first-page":"75","article-title":"Traditional medicine in Turkey. VI. Folk medicine in west Anatolia: afyon, Kutahya, Denizli, Mugla, Aydin provinces","volume":"53","author":"Honda","year":"1996","journal-title":"J. Ethnopharmacol."},{"issue":"Pt 1","key":"10.1016\/j.jep.2025.120689_bib15","article-title":"Natural polymer-based bioadhesives as hemostatic platforms for wound healing","volume":"256","author":"Huang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2025.120689_bib16","series-title":"Teucrium Species: Biology and Applications","first-page":"111","article-title":"Ethnobotanical features of Teucrium species","author":"Jari\u0107","year":"2020"},{"issue":"1","key":"10.1016\/j.jep.2025.120689_bib17","first-page":"1","article-title":"Review on Teucrium polium biological activities and medical characteristics against different pathologic situations","volume":"4","author":"Khazaei","year":"2018","journal-title":"J. Contemp. Med. Sci."},{"issue":"1","key":"10.1016\/j.jep.2025.120689_bib18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12951-023-02261-y","article-title":"New insights into nanotherapeutics for periodontitis: a triple concerto of antimicrobial activity, immunomodulation and periodontium regeneration","volume":"22","author":"Li","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jep.2025.120689_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119238","article-title":"Mucoadhesive in situ forming gel for oral mucositis pain control","volume":"580","author":"Li","year":"2020","journal-title":"Int. J. Pharm."},{"issue":"9","key":"10.1016\/j.jep.2025.120689_bib20","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1016\/j.actbio.2012.05.001","article-title":"Rapidly curable chitosan-PEG hydrogels as tissue adhesives for hemostasis and wound healing","volume":"8","author":"Lih","year":"2012","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jep.2025.120689_bib21","series-title":"Comprehensive Biomaterials II","first-page":"430","article-title":"Polymers in oral drug delivery","author":"Mastropietro","year":"2017"},{"issue":"3","key":"10.1016\/j.jep.2025.120689_bib22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/mabi.201200332","article-title":"Design strategies and applications of tissue bioadhesives","volume":"13","author":"Mehdizadeh","year":"2013","journal-title":"Macromol. Biosci."},{"issue":"2","key":"10.1016\/j.jep.2025.120689_bib23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/15583724.2015.1114493","article-title":"Nano\/Biomimetic tissue adhesives development: from research to clinical application","volume":"56","author":"Modaresifar","year":"2016","journal-title":"Polym. Rev."},{"key":"10.1016\/j.jep.2025.120689_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2023.213670","article-title":"In situ generated hemostatic adhesives: from mechanisms of action to recent advances and applications","volume":"155","author":"Monteiro","year":"2023","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.jep.2025.120689_bib25","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1007\/s00289-019-03013-5","article-title":"Graft copolymer of PVP\u2014A sutureless, haemostatic bioadhesive for wound healing application","volume":"77","author":"Pal","year":"2019","journal-title":"Polym. Bull."},{"issue":"1\u20132","key":"10.1016\/j.jep.2025.120689_bib26","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ijpharm.2006.12.038","article-title":"Development of a poloxamer analogs\/carbopol-based in situ gelling and mucoadhesive ophthalmic delivery system for puerarin","volume":"337","author":"Qi","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jep.2025.120689_bib27","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ijpharm.2018.11.016","article-title":"Optimization of a novel in situ gel for sustained ocular drug delivery using Box-Behnken design: in vitro, ex vivo, in vivo and human studies","volume":"554","author":"Ranch","year":"2019","journal-title":"Int. J. Pharm."},{"issue":"1\u20132","key":"10.1016\/j.jep.2025.120689_bib28","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijpharm.2011.03.042","article-title":"Comparison of ion-activated in situ gelling systems for ocular drug delivery. Part 1: physicochemical characterisation and in vitro release","volume":"411","author":"Rupenthal","year":"2011","journal-title":"Int. J. Pharm."},{"issue":"3","key":"10.1016\/j.jep.2025.120689_bib29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4103\/2231-4040.85541","article-title":"Qualitative analysis of controlled release ciprofloxacin\/carbopol 934 mucoadhesive suspension","volume":"2","author":"Sahoo","year":"2011","journal-title":"\\\"J. Adv. Pharm. Technol. Research\\\"\\\" (JAPTR)\\\""},{"issue":"1","key":"10.1016\/j.jep.2025.120689_bib30","first-page":"37","article-title":"Effect of hydroalcoholic extract of Teucrium polium on the process of wound healing in diabetic rats","volume":"2","author":"Salih","year":"2020","journal-title":"Passer J. Basic Appl. Sci."},{"issue":"3","key":"10.1016\/j.jep.2025.120689_bib31","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF02862090","article-title":"Traditional medicine in Turkey VIII. folk medicine in east Anatolia; Erzurum, Erz\u00edncan, A\u011fri, Kars, I\u011fdir provinces","volume":"51","author":"Sezik","year":"1997","journal-title":"Econ. Bot."},{"key":"10.1016\/j.jep.2025.120689_bib32","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.polymer.2018.01.080","article-title":"Chemical and microstructural controls on viscoplasticity in Carbopol hydrogel","volume":"139","author":"Shafiei","year":"2018","journal-title":"Polymer"},{"issue":"5","key":"10.1016\/j.jep.2025.120689_bib33","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.3390\/molecules27051561","article-title":"Teucrium polium L.: phytochemical screening and biological activities at different phenological stages","volume":"27","author":"Sharifi-Rad","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.120689_bib34","series-title":"Neutron Scattering - Applications in Biology, Chemistry, and Materials Science","first-page":"459","article-title":"Soft condensed matter","author":"Shibayama","year":"2017"},{"key":"10.1016\/j.jep.2025.120689_bib35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5344\/ajev.1977.28.1.49","article-title":"Total phenol analysis: automation and comparison with manual methods","volume":"28","author":"Slinkard","year":"1977","journal-title":"Am. J. Enol. Vitic."},{"issue":"8","key":"10.1016\/j.jep.2025.120689_bib36","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.drudis.2019.05.036","article-title":"Poloxamer-based in situ gelling thermoresponsive systems for ocular drug delivery applications","volume":"24","author":"Soliman","year":"2019","journal-title":"Drug Discov. Today"},{"issue":"9","key":"10.1016\/j.jep.2025.120689_bib37","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s10856-021-06573-z","article-title":"Comparative analysis of the hemostatic, analgesic and healing effects of cyanoacrylate on free gingival graft surgical wounds in donor and recipient areas: a systematic review","volume":"32","author":"Verissimo","year":"2021","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.jep.2025.120689_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114688","article-title":"Smart stimuli-responsive hydrogels for drug delivery in periodontitis treatment","volume":"162","author":"Wang","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.jep.2025.120689_bib39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0378-8741(93)90048-A","article-title":"Traditional medicine in Turkey. IV. Folk medicine in the Mediterranean subdivision","volume":"39","author":"Yesilada","year":"1993","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120689_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2020.112347","article-title":"Simultaneous quantitative screening of 53 phytochemicals in 33 species of medicinal and aromatic plants: a detailed, robust and comprehensive LC\u2013MS\/MS method validation","volume":"149","author":"Yilmaz","year":"2020","journal-title":"Ind. Crops Prod."},{"issue":"Pt 1","key":"10.1016\/j.jep.2025.120689_bib41","article-title":"Advances of biological macromolecules hemostatic materials: a review","volume":"269","author":"Zhang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2025.120689_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2018.04.034","article-title":"Bioadhesives for internal medical applications: a review","volume":"74","author":"Zhu","year":"2018","journal-title":"Acta Biomater."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125013819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125013819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T03:27:06Z","timestamp":1764041226000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125013819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":42,"alternative-id":["S0378874125013819"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120689","relation":{},"ISSN":["0378-8741"],"issn-type":[{"type":"print","value":"0378-8741"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LC-MS\/MS based phytochemical composition profiling and the development of hemostatic in situ gel formulation of Teucrium polium L.","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120689","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120689"}}