{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:37:44Z","timestamp":1781624264393,"version":"3.54.5"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010618","name":"Guangzhou University of Chinese Medicine","doi-asserted-by":"publisher","award":["GZYFT2024G07"],"award-info":[{"award-number":["GZYFT2024G07"]}],"id":[{"id":"10.13039\/501100010618","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2023B1212060063"],"award-info":[{"award-number":["2023B1212060063"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374101"],"award-info":[{"award-number":["82374101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074082"],"award-info":[{"award-number":["82074082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374097"],"award-info":[{"award-number":["82374097"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104472"],"award-info":[{"award-number":["82104472"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515110954"],"award-info":[{"award-number":["2022A1515110954"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515011706"],"award-info":[{"award-number":["2022A1515011706"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515011014"],"award-info":[{"award-number":["2023A1515011014"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515030157"],"award-info":[{"award-number":["2023A1515030157"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["202201005"],"award-info":[{"award-number":["202201005"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jep.2025.120713","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:17:39Z","timestamp":1760001459000},"page":"120713","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"PB","title":["Coptidis Rhizome alleviates dexamethasone- and fructose-induced metabolic disorder in rats as an inducer of HO-1 agonist via erythrocyte metabolism"],"prefix":"10.1016","volume":"355","author":[{"given":"Xiaolin","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haikang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixuan","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiannan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziren","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengquan","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120713_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tips.2015.09.003","article-title":"Translational significance of heme oxygenase in obesity and metabolic syndrome","volume":"37","author":"Abraham","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"issue":"3","key":"10.1016\/j.jep.2025.120713_bib2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.fshw.2019.07.004","article-title":"Antioxidant activity and total phenolic content of essential oils and extracts of sweet basil (Ocimum basilicum L.) plants","volume":"8","author":"Ahmed","year":"2019","journal-title":"Food Sci. Hum. Wellness"},{"key":"10.1016\/j.jep.2025.120713_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113215","article-title":"Oxyberberine, a novel HO-1 agonist, effectively ameliorates oxidative stress and inflammatory response in LPS\/D-GalN induced acute liver injury mice via coactivating erythrocyte metabolism and Nrf2 signaling pathway","volume":"166","author":"Ai","year":"2022","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.jep.2025.120713_bib71","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2337\/diaspect.17.3.183","article-title":"Glucose metabolism and regulation: beyond insulin and glucagon","volume":"17","author":"Aronoff","year":"2004","journal-title":"Diabetes Spectr."},{"key":"10.1016\/j.jep.2025.120713_bib4","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.2337\/dc20-S002","article-title":"2. Classification and diagnosis of diabetes: standards of medical care in Diabetes\u20142020","volume":"43","author":"Association","year":"2019","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.jep.2025.120713_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0026-0495(00)80077-3","article-title":"What is oxidative stress?","volume":"49","author":"Betteridge","year":"2000","journal-title":"Metabolism"},{"issue":"8","key":"10.1016\/j.jep.2025.120713_bib6","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1063\/1.448118","article-title":"Molecular dynamics with coupling to an external Bath","volume":"81","author":"Berendsen","year":"1984","journal-title":"J. Chem. Phys."},{"issue":"8\u20139","key":"10.1016\/j.jep.2025.120713_bib7","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.phymed.2012.03.011","article-title":"Hypocholesterolemia of Rhizoma Coptidis alkaloids is related to the bile acid by up-regulated CYP7A1 in hyperlipidemic rats","volume":"19","author":"Cao","year":"2012","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.jep.2025.120713_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201600753","article-title":"Effects of ferric citrate supplementation on advanced glycation end products in a rat model of streptozotocin\/nicotinamide\u2010induced diabetes","volume":"61","author":"Chao","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.jep.2025.120713_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2019.103470","article-title":"Polysaccharides from the flowers of tea (Camellia sinensis L.) modulate gut health and ameliorate cyclophosphamide-induced immunosuppression","volume":"61","author":"Chen","year":"2019","journal-title":"J. Funct.Foods"},{"key":"10.1016\/j.jep.2025.120713_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2021.114032","article-title":"A comparative investigation of the interaction and pharmacokinetics of hemoglobin with berberine and its oxymetabolite","volume":"199","author":"Chen","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2025.120713_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175234","article-title":"Metformin alleviates long-term high-fructose diet-induced skeletal muscle insulin resistance in rats by regulating purine nucleotide cycle","volume":"933","author":"Cheng","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.120713_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117361","article-title":"Berberine alleviates fructose-induced hepatic injury via ADK\/AMPK\/Nrf2 pathway: a novel insight","volume":"179","author":"Cheng","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"9","key":"10.1016\/j.jep.2025.120713_bib13","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1161\/01.CIR.91.9.2306","article-title":"Vascular smooth muscle cell heme oxygenases generate guanylyl cyclase-stimulatory carbon monoxide","volume":"91","author":"Christodoulides","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2025.120713_bib14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.diabres.2017.05.024","article-title":"Effects of medicinal food plants on impaired glucose tolerance: a systematic review of randomized controlled trials","volume":"131","author":"Demmers","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.jep.2025.120713_bib15","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ijbiomac.2020.05.042","article-title":"Effects of Nigella sativa seed polysaccharides on type 2 diabetic mice and gut microbiota","volume":"159","author":"Dong","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2025.120713_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154135","article-title":"In vitro and in vivo hypoglycemia effect of oxyberberine, a novel HO-1 agonist: a renewed evidence linking HO-1 to diabetes mellitus","volume":"101","author":"Dou","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120713_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111312","article-title":"Oxyberberine, an absorbed metabolite of berberine, possess superior hypoglycemic effect via regulating the PI3K\/Akt and Nrf2 signaling pathways","volume":"137","author":"Dou","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.jep.2025.120713_bib18","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jep.2006.07.013","article-title":"Differential effect of Rhizoma coptidis and its main alkaloid compound berberine on TNF-\u03b1 induced NF\u03baB translocation in human keratinocytes","volume":"109","author":"Enk","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120713_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1380163","article-title":"Association between heme oxygenase-1 and hyperlipidemia in pre-diabetic patients: a cross-sectional study","volume":"15","author":"Fan","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2025.120713_bib20","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.colsurfb.2012.03.006","article-title":"Erythrocytes load of low molecular weight chitosan nanoparticles as a potential vascular drug delivery system","volume":"95","author":"Fan","year":"2012","journal-title":"Colloids Surf., B"},{"key":"10.1016\/j.jep.2025.120713_bib21","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.3389\/fimmu.2020.01467","article-title":"Naturally derived heme-oxygenase 1 inducers and their therapeutic application to immune-mediated diseases","volume":"11","author":"Funes","year":"2020","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2025.120713_bib22","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s12906-023-04033-5","article-title":"Stevia (Stevia rebaudiana) extract ameliorates insulin resistance by regulating mitochondrial function and oxidative stress in the skeletal muscle of db\/db mice","volume":"23","author":"Han","year":"2023","journal-title":"BMC Complementary Med. Ther"},{"key":"10.1016\/j.jep.2025.120713_bib23","article-title":"Co-Crystal of rosiglitazone with berberine ameliorates hyperglycemia and insulin resistance through the PI3K\/AKT\/TXNIP pathway in vivo and in vitro","volume":"13","author":"He","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120713_bib24","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2174\/138161208783330772","article-title":"Drug loaded erythrocytes: as novel drug delivery system","volume":"14","author":"Hirlekar","year":"2008","journal-title":"Curr. Pharm. Des."},{"issue":"7086","key":"10.1016\/j.jep.2025.120713_bib25","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nature04634","article-title":"Reactive oxygen species have a causal role in multiple forms of insulin resistance","volume":"440","author":"Houstis","year":"2006","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.jep.2025.120713_bib26","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/ijc.11452","article-title":"Identification of common or distinct genes related to antitumor activities of a medicinal herb and its major component by oligonucleotide microarray","volume":"107","author":"Iizuka","year":"2003","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.jep.2025.120713_bib27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cell.2014.04.043","article-title":"Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man","volume":"158","author":"Jais","year":"2014","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jep.2025.120713_bib28","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12906-021-03382-3","article-title":"Obese rats intervened with Rhizoma coptidis revealed differential gene expression and microbiota by serum metabolomics","volume":"21","author":"Ji","year":"2021","journal-title":"BMC Complementary Med. Ther."},{"key":"10.1016\/j.jep.2025.120713_bib29","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8601028","article-title":"Combination of diet quality Score, plasma carotenoids, and lipid peroxidation to monitor oxidative stress","author":"Kim","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2025.120713_bib30","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.lfs.2016.02.046","article-title":"Synergetic cholesterol-lowering effects of main alkaloids from Rhizoma Coptidis in HepG2 cells and hypercholesterolemia hamsters","volume":"151","author":"Kou","year":"2016","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.jep.2025.120713_bib31","first-page":"305","article-title":"Comparison of Helicobacter pylori urease inhibition by Rhizoma Coptidis, Cortex Phellodendri and berberine: Mechanisms of interaction with the sulfhydryl group","volume":"82","author":"Li","year":"2016","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2025.120713_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117600","article-title":"Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis","volume":"322","author":"Li","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.jep.2025.120713_bib33","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1142\/S0192415X25500752","article-title":"Advancing traditional Chinese medicine research through network pharmacology: strategies for target identification, mechanism elucidation and innovative therapeutic applications","volume":"53","author":"Li","year":"2025","journal-title":"Am. J. Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2025.120713_bib34","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12967-023-04802-3","article-title":"Impact of NQO1 dysregulation in CNS disorders","volume":"22","author":"Li","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jep.2025.120713_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121202","article-title":"Clinical progress and advanced research of red blood cells based drug delivery system","volume":"279","author":"Li","year":"2021","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.jep.2025.120713_bib36","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1142\/S0192415X25500648","article-title":"A comprehensive review on botany, ethnopharmacology, phytochemistry, biosynthesis, pharmacology, toxicity, quality control and metabolomics of Coptidis rhizome","volume":"53","author":"Liao","year":"2025","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2025.120713_bib37","article-title":"An inhibitory effect of Berberine from herbal Coptis chinensis Franch on rat detrusor contraction in benign prostatic hyperplasia associated with lower urinary tract symptoms","volume":"268","author":"Lin","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2025.120713_bib38","first-page":"41","article-title":"Discussion of formula and medicinals with Rhizoma coptidis to treat Xiaokezheng","volume":"28","author":"Liu","year":"2010","journal-title":"Si Chuan Zhong Yi Yao Za Zhi. ."},{"key":"10.1016\/j.jep.2025.120713_bib39","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.fitote.2019.03.003","article-title":"The anti-hyperglycemia effects of Rhizoma Coptidis alkaloids: a systematic review of modern pharmacological studies of the traditional herbal medicine","volume":"134","author":"Ma","year":"2019","journal-title":"Fitoterapia"},{"issue":"5083","key":"10.1016\/j.jep.2025.120713_bib40","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1126\/science.1439783","article-title":"What if Minkowski had been ageusic? An alternative angle on diabetes","volume":"258","author":"McGarry","year":"1992","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jep.2025.120713_bib41","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2337\/db17-0367","article-title":"Uncoupling exercise bioenergetics from systemic metabolic homeostasis by conditional inactivation of Baf60 in skeletal muscle","volume":"67","author":"Meng","year":"2017","journal-title":"Diabetes"},{"issue":"10","key":"10.1016\/j.jep.2025.120713_bib42","doi-asserted-by":"crossref","first-page":"732","DOI":"10.3390\/toxins13100732","article-title":"The protective effect of heme Oxygenase-1 on liver injury caused by DON-induced oxidative stress and cytotoxicity","volume":"13","author":"Meng","year":"2021","journal-title":"Toxins"},{"issue":"131","key":"10.1016\/j.jep.2025.120713_bib43","article-title":"Study of in vivo glucose metabolism in high-fat diet-fed mice using oral glucose tolerance test (OGTT) and insulin tolerance test (ITT)","author":"Nagy","year":"2018","journal-title":"JoVE J."},{"issue":"4","key":"10.1016\/j.jep.2025.120713_bib70","doi-asserted-by":"crossref","first-page":"297","DOI":"10.32598\/IJT.16.4.975.1","article-title":"Dexamethasone Promotes the Risk of Cardiovascular Disease in High Fructose-exposed Wistar Rats","volume":"16","author":"Olaitan","year":"2022","journal-title":"Iran. J. Toxicol."},{"key":"10.1016\/j.jep.2025.120713_bib44","article-title":"Effect of Rhizoma coptidis (Huang Lian) on treating diabetes mellitus","author":"Pang","year":"2015","journal-title":"eCAM"},{"key":"10.1016\/j.jep.2025.120713_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109046","article-title":"Differential gene expression and network-based analyses of the placental transcriptome reveal distinct potential biomarkers for gestational diabetes mellitus","volume":"180","author":"Pineda-Cortel","year":"2021","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.jep.2025.120713_bib46","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.ijbiomac.2014.09.060","article-title":"A polysaccharide extract of mulberry leaf ameliorates hepatic glucose metabolism and insulin signaling in rats with type 2 diabetes induced by high fat-diet and streptozotocin","volume":"72","author":"Ren","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"issue":"9","key":"10.1016\/j.jep.2025.120713_bib47","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.metabol.2007.04.021","article-title":"Effect of chromium on carbohydrate and lipid metabolism in a rat model of type 2 diabetes mellitus: the fat-fed, streptozotocin-treated rat","volume":"56","author":"Sahin","year":"2007","journal-title":"Metabolism"},{"key":"10.1016\/j.jep.2025.120713_bib48","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jff.2019.02.035","article-title":"Natural product puerarin activates Akt and ameliorates glucose and lipid metabolism dysfunction in hepatic cells","volume":"55","author":"Shen","year":"2019","journal-title":"J. Funct.Foods"},{"issue":"4","key":"10.1016\/j.jep.2025.120713_bib49","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1620\/tjem.200.167","article-title":"The heme oxygenase dilemma in cellular homeostasis: new insights for the feedback regulation of heme catabolism","volume":"200","author":"Shibahara","year":"2003","journal-title":"Tohoku J. Exp. Med."},{"issue":"000","key":"10.1016\/j.jep.2025.120713_bib50","article-title":"Unveiling the therapeutic potential of traditional Chinese medicine Rhizome Coptidis: a comprehensive review","volume":"13","author":"Singh","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2025.120713_bib51","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/639541","article-title":"Therapeutic roles of heme oxygenase\u20101 in metabolic diseases: curcumin and resveratrol analogues as possible inducers of heme oxygenase\u20101","volume":"2013","author":"Son","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"5","key":"10.1016\/j.jep.2025.120713_bib73","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.fshw.2022.04.029","article-title":"Gypenoside ameliorates insulin resistance and hyperglycemia via the AMPK-mediated signaling pathways in the liver of type 2 diabetes mellitus mice","volume":"11","author":"Song","year":"2022","journal-title":"Food Science and Human Wellness"},{"issue":"1","key":"10.1016\/j.jep.2025.120713_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167552","article-title":"The relevance of the heme oxygenase system in alleviating diabetes-related hormonal and metabolic disorders","volume":"1871","author":"Szkudelski","year":"2024","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"issue":"2","key":"10.1016\/j.jep.2025.120713_bib62","first-page":"208","article-title":"Extraction and purification process of total alkaloids in rhizome coptidis","volume":"23","author":"Tu","year":"2012","journal-title":"Tradit. Chin. Drug Res. Clin. Pharmacol."},{"issue":"7","key":"10.1016\/j.jep.2025.120713_bib53","doi-asserted-by":"crossref","first-page":"973","DOI":"10.3390\/biology12070973","article-title":"Berberine and its study as an antidiabetic compound","volume":"12","author":"Utami","year":"2023","journal-title":"Biology"},{"key":"10.1016\/j.jep.2025.120713_bib54","article-title":"The antihyperglycemic effects of Rhizoma Coptidis and mechanism of actions: a review of systematic reviews and pharmacological research","author":"Wang","year":"2014","journal-title":"BioMed Res. Int."},{"issue":"1","key":"10.1016\/j.jep.2025.120713_bib55","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/13880209.2019.1577466","article-title":"Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology","volume":"57","author":"Wang","year":"2019","journal-title":"Pharm. Biol."},{"issue":"1","key":"10.1016\/j.jep.2025.120713_bib56","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s42003-024-06243-0","article-title":"Activation of Nrf2\/HO-1 signaling pathway exacerbates cholestatic liver injury","volume":"7","author":"Wang","year":"2024","journal-title":"Commun. Biol."},{"issue":"3","key":"10.1016\/j.jep.2025.120713_bib57","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ijbiomac.2007.02.011","article-title":"Studies of the interaction between paraquat and bovine hemoglobin","volume":"41","author":"Wang","year":"2007","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2025.120713_bib58","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6435861","article-title":"Oxidant\/antioxidant imbalance in Alzheimer's disease: therapeutic and diagnostic prospects","volume":"2018","author":"Wojsiat","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2025.120713_bib59","article-title":"Modulation of aging diseases via RAGE targets: a dietary intervention review","author":"Wu","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.jep.2025.120713_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113806","article-title":"An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy","volume":"270","author":"Xiao","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120713_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113995","article-title":"Berberis kansuensis extract alleviates type 2 diabetes in rats by regulating gut microbiota composition","volume":"273","author":"Xu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120713_bib63","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9570616","article-title":"Advanced glycation end products: potential mechanism and therapeutic target in cardiovascular complications under diabetes","volume":"2019","author":"Yang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.jep.2025.120713_bib64","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1080\/10717544.2022.2036870","article-title":"The discovery of berberine erythrocyte-hemoglobin self-assembly delivery system: a neglected carrier underlying its pharmacokinetics","volume":"29","author":"Yu","year":"2022","journal-title":"Drug Deliv."},{"issue":"15","key":"10.1016\/j.jep.2025.120713_bib65","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.3390\/molecules27154922","article-title":"Receptor for advanced glycation end products (RAGE): a pivotal hub in immune diseases","volume":"27","author":"Yue","year":"2022","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.jep.2025.120713_bib66","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.cmet.2009.03.012","article-title":"AMPK: an emerging drug target for diabetes and the metabolic syndrome","volume":"9","author":"Zhang","year":"2009","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.jep.2025.120713_bib67","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41420-024-02205-x","article-title":"Effective protective mechanisms of HO-1 in diabetic complications: a narrative review","volume":"10","author":"Zhang","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.jep.2025.120713_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.933211","article-title":"Emerging trends and hot spots in hepatic glycolipid metabolism research from 2002 to 2021: a bibliometric analysis","volume":"9","author":"Zhou","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jep.2025.120713_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.metop.2024.100303","article-title":"Coffee pulp improves glucose and lipid metabolism disorder in high-fat diet-induced diabetic mice","volume":"23","author":"Zhu","year":"2024","journal-title":"Metabol Open"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125014059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125014059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:13:58Z","timestamp":1778692438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125014059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":72,"alternative-id":["S0378874125014059"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120713","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coptidis Rhizome alleviates dexamethasone- and fructose-induced metabolic disorder in rats as an inducer of HO-1 agonist via erythrocyte metabolism","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120713","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120713"}}