{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T05:27:45Z","timestamp":1764048465599,"version":"3.45.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Chongqing Natural Science Foundation","doi-asserted-by":"publisher","award":["CSTB2023NSCQLZX0093","cstc2021jcyj-msxmX0409"],"award-info":[{"award-number":["CSTB2023NSCQLZX0093","cstc2021jcyj-msxmX0409"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074256"],"award-info":[{"award-number":["82074256"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013160","name":"Venture and Innovation Support Program for Chongqing Overseas Returnees","doi-asserted-by":"publisher","award":["CQTCM202233"],"award-info":[{"award-number":["CQTCM202233"]}],"id":[{"id":"10.13039\/501100013160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jep.2025.120725","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T22:20:01Z","timestamp":1760048401000},"page":"120725","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PB","title":["Integrated proteomics and bioinformatics reveal the pharmacological mechanism of Shenqi Yanshen granule in chronic kidney disease-mineral and bone disorder (CKD-MBD)"],"prefix":"10.1016","volume":"355","author":[{"given":"Qiang","family":"Ran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jep.2025.120725_bib1","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1007\/s00198-022-06462-3","article-title":"Management of osteoporosis in patients with chronic kidney disease","volume":"33","author":"Abdalbary","year":"2022","journal-title":"Osteoporos. Int."},{"issue":"1","key":"10.1016\/j.jep.2025.120725_bib2","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1186\/s12882-020-01999-z","article-title":"Impact of physical activity and exercise on bone health in patients with chronic kidney disease: a systematic review of observational and experimental studies","volume":"21","author":"Cardoso","year":"2020","journal-title":"BMC Nephrol."},{"issue":"4","key":"10.1016\/j.jep.2025.120725_bib3","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/jcb.21114","article-title":"Apoptotic signaling in methylglyoxal-treated human osteoblasts involves oxidative stress, c-Jun N-terminal kinase, caspase-3, and p21-activated kinase 2","volume":"100","author":"Chan","year":"2007","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.jep.2025.120725_bib4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jcb.22763","article-title":"Profiling the changes in signaling pathways in ascorbic acid\/\u03b2-glycerophosphate-induced osteoblastic differentiation","volume":"112","author":"Chaves Neto","year":"2011","journal-title":"J. Cell. Biochem."},{"issue":"12","key":"10.1016\/j.jep.2025.120725_bib5","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1007\/s11255-018-1995-6","article-title":"Effects of parathyroidectomy on blood bone markers and heart rate variability in patients with stage 5 chronic kidney disease","volume":"50","author":"Chen","year":"2018","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.jep.2025.120725_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152917","article-title":"The antifibrotic and anti-inflammatory effects of icariin on the kidney in a unilateral ureteral obstruction mouse model","volume":"59","author":"Chen","year":"2019","journal-title":"Phytomedicine"},{"year":"2022","series-title":"Clinical Study of Shenqi Yanshen Granule on Delaying 3-5 Stages of Chronic Kidney Disease","author":"Cheng","key":"10.1016\/j.jep.2025.120725_bib7"},{"issue":"4","key":"10.1016\/j.jep.2025.120725_bib8","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3892\/mmr.2022.12642","article-title":"Icariin attenuates thioacetamide-induced bone loss via the RANKL-p38\/ERK-NFAT signaling pathway","volume":"25","author":"Cheng","year":"2022","journal-title":"Mol. Med. Rep."},{"issue":"4","key":"10.1016\/j.jep.2025.120725_bib9","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/ndt\/gfac212","article-title":"CKD-MBD biomarkers and CKD progression: an analysis by the joint model","volume":"38","author":"D'Arrigo","year":"2023","journal-title":"Nephrol. Dial. Transplant."},{"issue":"9","key":"10.1016\/j.jep.2025.120725_bib10","doi-asserted-by":"crossref","first-page":"8317","DOI":"10.1007\/s11033-022-07645-1","article-title":"Icariin protects bone marrow mesenchymal stem cells in aplastic anemia by targeting MAPK pathway","volume":"49","author":"Deng","year":"2022","journal-title":"Mol. Biol. Rep."},{"issue":"3","key":"10.1016\/j.jep.2025.120725_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/cbf.4005","article-title":"Icariin alleviates renal inflammation and tubulointerstitial fibrosis via Nrf2-mediated attenuation of mitochondrial damage","volume":"42","author":"Ding","year":"2024","journal-title":"Cell Biochem. Funct."},{"issue":"4","key":"10.1016\/j.jep.2025.120725_bib12","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s00223-021-00838-z","article-title":"The role of bone biopsy in the management of CKD-MBD","volume":"108","author":"Ferreira","year":"2021","journal-title":"Calcif. Tissue Int."},{"issue":"3","key":"10.1016\/j.jep.2025.120725_bib14","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1053\/j.ajkd.2021.06.031","article-title":"Diagnosis and management of osteoporosis in advanced kidney disease: a review","volume":"79","author":"Ginsberg","year":"2022","journal-title":"Am. J. Kidney Dis."},{"issue":"10","key":"10.1016\/j.jep.2025.120725_bib16","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.3390\/nu14102124","article-title":"Alkaline phosphatase: an old friend as treatment target for cardiovascular and mineral bone disorders in chronic kidney disease","volume":"14","author":"Haarhaus","year":"2022","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jep.2025.120725_bib17","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/ndt\/gfr317","article-title":"Diagnostic usefulness of bone mineral density and biochemical markers of bone turnover in predicting fracture in CKD stage 5D patients: a single-center cohort study","volume":"27","author":"Iimori","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"issue":"6","key":"10.1016\/j.jep.2025.120725_bib18","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1053\/j.ajkd.2017.07.019","article-title":"KDOQI US commentary on the 2017 KDIGO Clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD)","volume":"70","author":"Isakova","year":"2017","journal-title":"Am. J. Kidney Dis."},{"issue":"1","key":"10.1016\/j.jep.2025.120725_bib19","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s13018-025-05697-0","article-title":"Icariin promotes osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by activating PI3K-AKT-UTX\/EZH2 signaling in steroid-induced femoral head osteonecrosis","volume":"20","author":"Ji","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"issue":"1","key":"10.1016\/j.jep.2025.120725_bib20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.kint.2017.04.006","article-title":"Executive summary of the 2017 KDIGO chronic kidney disease-mineral and bone disorder (CKD-MBD) guideline update: what's changed and why it matters","volume":"92","author":"Ketteler","year":"2017","journal-title":"Kidney Int."},{"issue":"9","key":"10.1016\/j.jep.2025.120725_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0314-3","article-title":"Adaptor protein CrkII negatively regulates osteoblast differentiation and function through JNK phosphorylation","volume":"51","author":"Kim","year":"2019","journal-title":"Exp. Mol. Med."},{"issue":"13","key":"10.1016\/j.jep.2025.120725_bib22","doi-asserted-by":"crossref","first-page":"7007","DOI":"10.3390\/ijms22137007","article-title":"Bifunctional role of CrkL during bone remodeling","volume":"22","author":"Kim","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.jep.2025.120725_bib23","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/jcb.24749","article-title":"Crk at the quarter century mark: perspectives in signaling and cancer","volume":"115","author":"Kumar","year":"2014","journal-title":"J. Cell. Biochem."},{"issue":"21","key":"10.1016\/j.jep.2025.120725_bib24","doi-asserted-by":"crossref","first-page":"11828","DOI":"10.1080\/07391102.2023.2265488","volume":"42","author":"Laeliocattleya","year":"2024","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"25","key":"10.1016\/j.jep.2025.120725_bib25","doi-asserted-by":"crossref","first-page":"13642","DOI":"10.1073\/pnas.94.25.13642","article-title":"Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis","volume":"94","author":"Lee","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.jep.2025.120725_bib26","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/s12276-020-0406-0","article-title":"The dynactin subunit DCTN1 controls osteoclastogenesis via the Cdc42\/PAK2 pathway","volume":"52","author":"Lee","year":"2020","journal-title":"Exp. Mol. Med."},{"issue":"6","key":"10.1016\/j.jep.2025.120725_bib27","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1302\/2046-3758.126.BJR-2022-0324.R1","article-title":"LncRNA PCBP1-AS1 induces osteoporosis by sponging miR-126-5p\/PAK2 axis","volume":"12","author":"Li","year":"2023","journal-title":"Bone Joint Res"},{"year":"2024","series-title":"Study on the Mechanism of Promoting Bone Formation by the Clinically Experienced Formula Shenqi Yanshen Recipe","author":"Li","key":"10.1016\/j.jep.2025.120725_bib28"},{"issue":"13","key":"10.1016\/j.jep.2025.120725_bib29","first-page":"1","article-title":"Clinical efficacy observation of shenqi yanshen formula in the treatment of chronic kidney disease stages 3-5","volume":"17","author":"Li","year":"2019","journal-title":"Guide of China Medicine"},{"key":"10.1016\/j.jep.2025.120725_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7978258","article-title":"Investigating the mechanism of rhizoma Coptidis-Eupatorium fortunei medicine in the treatment of type 2 diabetes based on network pharmacology and molecular docking","volume":"2022","author":"Li","year":"2022","journal-title":"BioMed Res. Int."},{"issue":"2","key":"10.1016\/j.jep.2025.120725_bib31","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1432-1033.1996.0171r.x","article-title":"Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways","volume":"242","author":"Lim","year":"1996","journal-title":"Eur. J. Biochem."},{"issue":"5","key":"10.1016\/j.jep.2025.120725_bib32","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3390\/ijms9050698","article-title":"Caffeine induces cell death via activation of apoptotic signal and inactivation of survival signal in human osteoblasts","volume":"9","author":"Lu","year":"2008","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.jep.2025.120725_bib33","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1074\/jbc.R110.200329","article-title":"Signaling role of Cdc42 in regulating mammalian physiology","volume":"286","author":"Melendez","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.jep.2025.120725_bib34","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1002\/jcb.20891","article-title":"Modulation of mouse RANKL gene expression by Runx2 and PKA pathway","volume":"98","author":"Mori","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jep.2025.120725_bib35","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02270","article-title":"Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation","volume":"3","author":"Phee","year":"2014","journal-title":"eLife"},{"issue":"11","key":"10.1016\/j.jep.2025.120725_bib36","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.3390\/diagnostics12112828","article-title":"The effect of Vitamin D level on parathyroid hormone and alkaline phosphatase","volume":"12","author":"Rajab","year":"2022","journal-title":"Diagnostics"},{"key":"10.1016\/j.jep.2025.120725_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.dib.2022.108765","article-title":"Multiomics data analysis workflow to assess severity in longitudinal plasma samples of COVID-19 patients","volume":"46","author":"Rajoria","year":"2023","journal-title":"Data Brief"},{"key":"10.1016\/j.jep.2025.120725_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.119308","article-title":"Integrated bioinformatics and multi-omics to investigate the mechanism of Rhododendron molle Flos-induced hepatotoxicity","volume":"341","author":"Ran","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120725_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106840","article-title":"Mechanisms of polydatin against spinal cord ischemia-reperfusion injury based on network pharmacology, molecular docking and molecular dynamics simulation","volume":"140","author":"Sun","year":"2023","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.jep.2025.120725_bib40","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00467-022-05552-y","article-title":"Improved equations to estimate GFR in Chinese children with chronic kidney disease","volume":"38","author":"Tang","year":"2023","journal-title":"Pediatr. Nephrol."},{"issue":"2","key":"10.1016\/j.jep.2025.120725_bib41","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s11255-022-03328-9","article-title":"Investigation on maintenance hemodialysis patients with mineral and bone disorder in Anhui province, China","volume":"55","author":"Tao","year":"2023","journal-title":"Int. Urol. Nephrol."},{"issue":"2","key":"10.1016\/j.jep.2025.120725_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2022.113085","article-title":"Icariin triggers osteogenic differentiation of bone marrow stem cells by up-regulating miR-335-5p","volume":"414","author":"Teng","year":"2022","journal-title":"Exp. Cell Res."},{"year":"2020","series-title":"Clinical Observation of Shenqi Yanshen Granule in Treating 3-4 Stages of Chronic Kidney Disease","author":"Wang","key":"10.1016\/j.jep.2025.120725_bib43"},{"issue":"6","key":"10.1016\/j.jep.2025.120725_bib44","doi-asserted-by":"crossref","first-page":"8307","DOI":"10.3892\/mmr.2017.7610","article-title":"Anti-osteoporotic effects of tetramethylpyrazine via promoting osteogenic differentiation and inhibiting osteoclast formation","volume":"16","author":"Wang","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.jep.2025.120725_bib45","article-title":"Evaluation of bone metabolism biomarkers in Paget's disease of bone","volume":"11","author":"Werner de Castro","year":"2019","journal-title":"Cureus"},{"issue":"6","key":"10.1016\/j.jep.2025.120725_bib46","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000024445","article-title":"Effects of tonifying kidney and strengthen bone therapy on non-dialysis patients with chronic kidney disease-mineral and bone disorder: a protocol for the systematic review and meta-analysis of randomized controlled trials","volume":"100","author":"Wu","year":"2021","journal-title":"Medicine"},{"key":"10.1016\/j.jep.2025.120725_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2023.117518","article-title":"The levels of bone turnover markers and parathyroid hormone and their relationship in chronic kidney disease","volume":"548","author":"Xie","year":"2023","journal-title":"Clin. Chim. Acta"},{"issue":"5","key":"10.1016\/j.jep.2025.120725_bib48","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1681\/ASN.2021101327","article-title":"Interventions to attenuate vascular calcification progression in chronic kidney disease: a systematic review of clinical trials","volume":"33","author":"Xu","year":"2022","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jep.2025.120725_bib49","article-title":"Potential efficacy and mechanisms of icariin for the animal model of osteonecrosis of the femoral head","volume":"16","author":"Xu","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"20","key":"10.1016\/j.jep.2025.120725_bib50","first-page":"4027","article-title":"Regression analysis of serum bone metabolic markers and traditional Chinese medicine syndromes in patients with CKD-MBD","volume":"42","author":"Yang","year":"2017","journal-title":"Zhongguo Zhongyao Zazhi"},{"issue":"7","key":"10.1016\/j.jep.2025.120725_bib51","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.2215\/CJN.12871211","article-title":"Bone mineral density and fracture risk in older individuals with CKD","volume":"7","author":"Yenchek","year":"2012","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"19","key":"10.1016\/j.jep.2025.120725_bib52","article-title":"Factors influencing the efficacy of shenqi Yanshen Granule in ameliorating early proteinuria among patients with nephrotic syndrome: a logistic analysis","volume":"7","author":"Yu","year":"2024","journal-title":"Altern Ther Health Med"},{"issue":"7","key":"10.1016\/j.jep.2025.120725_bib53","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.3390\/molecules23071656","article-title":"Comparison of the active compositions between raw and processed Epimedium from different species","volume":"23","author":"Zhang","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.120725_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2019.115139","article-title":"MicroRNA-429 inhibits bone metastasis in breast cancer by regulating CrkL and MMP-9","volume":"130","author":"Zhang","year":"2020","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.jep.2025.120725_bib55","doi-asserted-by":"crossref","first-page":"5625","DOI":"10.1080\/21655979.2021.2023789","article-title":"Shenqi Yanshen Formula (SQYSF) protects against chronic kidney disease by modulating gut microbiota","volume":"13","author":"Zhang","year":"2022","journal-title":"Bioengineered"},{"issue":"1","key":"10.1016\/j.jep.2025.120725_bib56","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbad518","article-title":"Network pharmacology: towards the artificial intelligence-based precision traditional Chinese medicine","volume":"25","author":"Zhang","year":"2023","journal-title":"Brief Bioinform"},{"issue":"17","key":"10.1016\/j.jep.2025.120725_bib57","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.2174\/0113892010276372231129105022","article-title":"Icariin attenuates human renal tubular epithelial cell senescence by targeting PAK2 via miR-23b-3p","volume":"25","author":"Zhang","year":"2024","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.jep.2025.120725_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116543","article-title":"Icariin, the main prenylflavonoid of Epimedii Folium, ameliorated chronic kidney disease by modulating energy metabolism via AMPK activation","volume":"312","author":"Zhao","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120725_bib59","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jocn.2022.03.020","article-title":"Bone metabolic indices: promising predictors for assessing acromegaly","volume":"99","author":"Zhu","year":"2022","journal-title":"J. Clin. Neurosci."},{"issue":"6","key":"10.1016\/j.jep.2025.120725_bib60","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.jpha.2019.11.001","article-title":"Offline two-dimensional liquid chromatography coupled with ion mobility-quadrupole time-of-flight mass spectrometry enabling four-dimensional separation and characterization of the multicomponents from white ginseng and red ginseng","volume":"10","author":"Zuo","year":"2020","journal-title":"J. Pharm. Anal."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125014175?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125014175?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T03:30:02Z","timestamp":1764041402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125014175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":58,"alternative-id":["S0378874125014175"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120725","relation":{},"ISSN":["0378-8741"],"issn-type":[{"type":"print","value":"0378-8741"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated proteomics and bioinformatics reveal the pharmacological mechanism of Shenqi Yanshen granule in chronic kidney disease-mineral and bone disorder (CKD-MBD)","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120725","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120725"}}