{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T09:15:01Z","timestamp":1776503701473,"version":"3.51.2"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008868","name":"Jiangsu Province Department of Science and Technology","doi-asserted-by":"publisher","award":["BK20241733"],"award-info":[{"award-number":["BK20241733"]}],"id":[{"id":"10.13039\/501100008868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jep.2025.120726","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:11:39Z","timestamp":1760145099000},"page":"120726","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"PB","title":["HuangLong oral liquid alleviates cough variant asthma in mice via inhibiting M2 macrophage chemotaxis and polarization by regulating the PI3K\/AKT\/ERK pathway"],"prefix":"10.1016","volume":"355","author":[{"given":"Xixi","family":"Ji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhui","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xudong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weina","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"19","key":"10.1016\/j.jep.2025.120726_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27196704","article-title":"Quercetin and resveratrol differentially decrease expression of the high-affinity IgE receptor (Fc\u03b5RI) by human and mouse mast cells","volume":"27","author":"Alam","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.120726_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.805770","article-title":"The ability of resveratrol to attenuate ovalbumin-mediated allergic asthma is associated with changes in microbiota involving the gut-lung axis, enhanced barrier function and decreased inflammation in the lungs","volume":"13","author":"Alharris","year":"2022","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.jep.2025.120726_bib3","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.tips.2022.02.009","article-title":"Chemokine receptor CCR1: new target for asthma therapy","volume":"43","author":"Barnes","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"issue":"13","key":"10.1016\/j.jep.2025.120726_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310451","article-title":"Macrophages orchestrate airway inflammation, remodeling, and resolution in asthma","volume":"24","author":"Britt","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jep.2025.120726_bib5","first-page":"17","article-title":"Phytochemistry, pharmacology, and clinical trials of Morus alba","volume":"14","author":"Chan","year":"2016","journal-title":"Chin. J. Nat. Med."},{"issue":"4","key":"10.1016\/j.jep.2025.120726_bib6","doi-asserted-by":"crossref","DOI":"10.1111\/liv.16131","article-title":"Osteopontin promotes cholangiocyte secretion of chemokines to support macrophage recruitment and fibrosis in MASH","volume":"45","author":"Coombes","year":"2025","journal-title":"Liver Int."},{"issue":"1","key":"10.1016\/j.jep.2025.120726_bib7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41392-021-00482-x","article-title":"Eosinophil-derived chemokine (hCCL15\/23, mCCL6) interacts with CCR1 to promote eosinophilic airway inflammation","volume":"6","author":"Du","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"13","key":"10.1016\/j.jep.2025.120726_bib8","doi-asserted-by":"crossref","first-page":"7187","DOI":"10.1021\/acs.jafc.3c09601","article-title":"Puerarin induces macrophage M2 polarization to exert antinonalcoholic steatohepatitis pharmacological activity via the activation of autophagy","volume":"72","author":"Fang","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.jep.2025.120726_bib9","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/exd.14718","article-title":"CCL6 promotes M2 polarization and inhibits macrophage autophagy by activating PI3-kinase\/Akt signalling pathway during skin wound healing","volume":"32","author":"Feng","year":"2023","journal-title":"Exp. Dermatol."},{"issue":"6","key":"10.1016\/j.jep.2025.120726_bib10","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.jaci.2023.08.010","article-title":"Functional immunophenotyping of blood neutrophils identifies novel endotypes of viral response in preschool children with recurrent wheezing","volume":"152","author":"Fitzpatrick","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jep.2025.120726_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122218","article-title":"Eupatilin inhibits pulmonary fibrosis by activating Sestrin2\/PI3K\/Akt\/mTOR dependent autophagy pathway","volume":"334","author":"Gong","year":"2023","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.jep.2025.120726_bib12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/imm.13574","article-title":"Ectopic endometriotic stromal cells-derived lactate induces M2 macrophage polarization via Mettl3\/Trib1\/ERK\/STAT3 signalling pathway in endometriosis","volume":"168","author":"Gou","year":"2023","journal-title":"Immunology"},{"issue":"22","key":"10.1016\/j.jep.2025.120726_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27227683","article-title":"Integrating multi-type component determination and Anti-Oxidant\/-Inflammatory assay to evaluate the impact of pre-molting washing on the quality and bioactivity of cicadae periostracum","volume":"27","author":"Guo","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.120726_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.952509","article-title":"M2 macrophages promote IL-33 expression, ILC2 expansion and mucous metaplasia in response to early life rhinovirus infections","volume":"13","author":"Han","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2025.120726_bib15","doi-asserted-by":"crossref","first-page":"7328","DOI":"10.1038\/s41467-023-43219-w","article-title":"RNA m(6)A methylation modulates airway inflammation in allergic asthma via PTX3-dependent macrophage homeostasis","volume":"14","author":"Han","year":"2023","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.jep.2025.120726_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.modpat.2023.100197","article-title":"Multiplex immunohistochemistry and immunofluorescence: a practical update for pathologists","volume":"36","author":"Harms","year":"2023","journal-title":"Mod. Pathol."},{"issue":"5","key":"10.1016\/j.jep.2025.120726_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109955","article-title":"Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors","volume":"37","author":"He","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.jep.2025.120726_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106423","article-title":"A network pharmacology-based strategy for predicting anti-inflammatory targets of ephedra in treating asthma","volume":"83","author":"Huang","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2025.120726_bib19","article-title":"Study on mechanism and huanglong mixture in the treatment of children with cough variant asthma and experimental verification based on network pharmacologic analysis","volume":"46","author":"Ji","year":"2024","journal-title":"Int J of Tradit Chin Med"},{"issue":"8","key":"10.1016\/j.jep.2025.120726_bib20","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s12272-019-01174-5","article-title":"Hesperetin inhibits neuroinflammation on microglia by suppressing inflammatory cytokines and MAPK pathways","volume":"42","author":"Jo","year":"2019","journal-title":"Arch Pharm. Res. (Seoul)"},{"issue":"16","key":"10.1016\/j.jep.2025.120726_bib21","doi-asserted-by":"crossref","first-page":"5275","DOI":"10.7150\/ijbs.86701","article-title":"Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization","volume":"19","author":"Ko","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jep.2025.120726_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2021.100995","article-title":"Cellular and molecular mechanisms of allergic asthma","volume":"85","author":"Koml\u00f3si","year":"2022","journal-title":"Mol. Aspect. Med."},{"issue":"5","key":"10.1016\/j.jep.2025.120726_bib23","first-page":"661","article-title":"Effectiveness and safety of traditional Chinese herbs in children with cough variant asthma: a systematic review and Meta-analysi","volume":"41","author":"Kyou-Hwan","year":"2021","journal-title":"J. Tradit. Chin. Med."},{"issue":"Pt A","key":"10.1016\/j.jep.2025.120726_bib24","article-title":"Protective effects of Angelica decursiva franchet & savatier on allergic responses through enhancement of Nrf2 and suppression of NF-kB\/MMP-9 in ovalbumin-exposed mice","volume":"318","author":"Lee","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120726_bib25","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12964-024-01578-x","article-title":"VDR promotes pancreatic cancer progression in vivo by activating CCL20-mediated M2 polarization of tumor associated macrophage","volume":"22","author":"Li","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.jep.2025.120726_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118504","article-title":"Shegan-mahuang decoction ameliorates cold-induced asthma via regulating the proliferation and apoptosis of airway smooth muscle cells through TAS2R10: an in vivo and in vitro study","volume":"334","author":"Li","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120726_bib27","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.ijbiomac.2019.09.189","article-title":"Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation","volume":"145","author":"Li","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2025.120726_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107266","article-title":"STAT6 up-regulation amplifies M2 macrophage anti-inflammatory capacity through mesenchymal stem cells","volume":"91","author":"Li","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"9","key":"10.1016\/j.jep.2025.120726_bib29","first-page":"630","article-title":"Progress on the changing trend of etiological component ratio of chronic cough in children","volume":"50","author":"Li","year":"2023","journal-title":"Int. J. Pediatr."},{"key":"10.1016\/j.jep.2025.120726_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.116022","article-title":"A comprehensive review of the botany, ethnopharmacology, phytochemistry, pharmacology, toxicity and quality control of perillae fructus","volume":"304","author":"Liu","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120726_bib31","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12964-024-01489-x","article-title":"MyD88 in myofibroblasts enhances nonalcoholic fatty liver disease-related hepatocarcinogenesis via promoting macrophage M2 polarization","volume":"22","author":"Liu","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.jep.2025.120726_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113726","article-title":"Simultaneous determination of nine constituents by validated UFLC-MS\/MS in the plasma of cough variant asthma rats and its application to pharmacokinetic study after oral administration of huanglong cough oral liquid","volume":"193","author":"Liu","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"6","key":"10.1016\/j.jep.2025.120726_bib33","first-page":"27","article-title":"The clinic observation of huanglong mixture on infantile cough variant asthma with wind-heat phlegm syndrome and its influence on the lung function and T cell subsets","volume":"11","author":"Long","year":"2015","journal-title":"J Pediat of Traditi Chin Med"},{"issue":"2","key":"10.1016\/j.jep.2025.120726_bib34","first-page":"103","article-title":"Clinical observation on huanglong oral liquid in treating cough variant asthma","volume":"45","author":"Long","year":"2017","journal-title":"Acta Chin Med and Pharma"},{"issue":"8","key":"10.1016\/j.jep.2025.120726_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.1357","article-title":"Retrospective, observational study of different medication regimens and outcome in children with cough variant asthma","volume":"12","author":"Lou","year":"2024","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.jep.2025.120726_bib36","article-title":"An ApoA-I mimic peptide of 4F promotes SDF-1\u03b1 expression in endothelial cells through PI3K\/Akt\/ERK\/HIF-1\u03b1 signaling pathway","volume":"12","author":"Lv","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.jep.2025.120726_bib37","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.jaci.2021.10.001","article-title":"Advances in asthma: new understandings of asthma's natural history, risk factors, underlying mechanisms, and clinical management","volume":"148","author":"Miller","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"issue":"8","key":"10.1016\/j.jep.2025.120726_bib38","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/ddr.21461","article-title":"Dose translation between laboratory animals and human in preclinical and clinical phases of drug development","volume":"79","author":"Nair","year":"2018","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.jep.2025.120726_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2024.101103","article-title":"Tumor-associated macrophages promote bladder cancer metastasis through the CCL20-CCR6 axis","volume":"60","author":"Nakagawa","year":"2025","journal-title":"Neoplasia"},{"key":"10.1016\/j.jep.2025.120726_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116637","article-title":"Zi-su-zi decoction improves airway hyperresponsiveness in cough-variant asthma rat model through PI3K\/AKT1\/mTOR, JAK2\/STAT3 and HIF-1\u03b1\/NF-\u03baB signaling pathways","volume":"314","author":"Nguyen","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120726_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115120","article-title":"Quercetin attenuates the progression of chronic rhinosinusitis with nasal polyps by regulating macrophage M2 polarization and remodeling of nasal mucosa","volume":"162","author":"Qu","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120726_bib42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12950-025-00444-y","article-title":"Exosomes derived from M2 macrophages regulate airway inflammation by modulating epithelial cell proliferation and apoptosis","volume":"22","author":"Ren","year":"2025","journal-title":"J. Inflamm."},{"issue":"5","key":"10.1016\/j.jep.2025.120726_bib43","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/cmi.2010.31","article-title":"Murine lung eosinophil activation and chemokine production in allergic airway inflammation","volume":"7","author":"Rose","year":"2010","journal-title":"Cell. Mol. Immunol."},{"issue":"9","key":"10.1016\/j.jep.2025.120726_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/nu13093152","article-title":"Ferulic acid metabolites attenuate LPS-induced inflammatory response in enterocyte-like cells","volume":"13","author":"Serreli","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2025.120726_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157203","article-title":"Jiawei yanghe decoction alleviates osteoporotic osteoarthritis by promoting MSC osteogenic differentiation and homing via ITGB6\/TGF-\u03b2\/CXCR4 pathway","volume":"147","author":"Sheng","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120726_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phymed.2017.08.027","article-title":"Eupatilin suppresses the allergic inflammatory response in vitro and in vivo","volume":"42","author":"Song","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120726_bib47","article-title":"Armeniacae semen amarum: a review on its botany, phytochemistry, pharmacology, clinical application, toxicology and pharmacokinetics","volume":"15","author":"Tang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120726_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118542","article-title":"Ethnobotany, phytochemistry, pharmacology and quality control of Peucedanum decursivum (miq.) maxim: a critical review","volume":"334","author":"Tao","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120726_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113911","article-title":"Unveiling the substantial role of rutin in the management of drug-induced nephropathy using network pharmacology and molecular docking","volume":"146","author":"Thakur","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2025.120726_bib50","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/pca.3117","article-title":"From metabolomic analysis to quality assessment and biosynthetic insight in traditional Chinese medicine: mulberry tree as a case study","volume":"33","author":"Tian","year":"2022","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.jep.2025.120726_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113894","article-title":"Vitex negundo linn. extract alleviates inflammatory aggravation and lung injury by modulating AMPK\/PI3K\/Akt\/p38-NF-\u03baB and TGF-\u03b2\/Smad\/Bcl2\/caspase\/LC3 cascade and macrophages activation in murine model of OVA-LPS induced allergic asthma","volume":"271","author":"Tirpude","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"13","key":"10.1016\/j.jep.2025.120726_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310829","article-title":"A2BAR antagonism decreases the glomerular expression and secretion of chemoattractants for monocytes and the pro-fibrotic M2 macrophages polarization during diabetic nephropathy","volume":"24","author":"Torres-Ar\u00e9valo","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.jep.2025.120726_bib53","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.4049\/jimmunol.1601515","article-title":"Akt signaling pathway in macrophage activation and M1\/M2 polarization","volume":"198","author":"Vergadi","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.jep.2025.120726_bib54","doi-asserted-by":"crossref","DOI":"10.1097\/HEP.0000000000001393","article-title":"Hepatocyte-specific C-C motif chemokine ligand 9 signaling promotes liver fibrosis progression in mice","author":"Wang","year":"2025","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.jep.2025.120726_bib55","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.221","article-title":"Cell-type-specific expression analysis of liver transcriptomics with clinical parameters to decipher the cause of intrahepatic inflammation in chronic hepatitis B","volume":"3","author":"Wang","year":"2024","journal-title":"Imeta"},{"issue":"25","key":"10.1016\/j.jep.2025.120726_bib56","doi-asserted-by":"crossref","first-page":"11535","DOI":"10.7150\/thno.45261","article-title":"FOXO1 promotes tumor progression by increased M2 macrophage infiltration in esophageal squamous cell carcinoma","volume":"10","author":"Wang","year":"2020","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/j.jep.2025.120726_bib57","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s10565-022-09767-5","article-title":"CCL24\/CCR3 axis plays a central role in angiotensin II-induced heart failure by stimulating M2 macrophage polarization and fibroblast activation","volume":"39","author":"Wang","year":"2023","journal-title":"Cell Biol. Toxicol."},{"issue":"2","key":"10.1016\/j.jep.2025.120726_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2021.112575","article-title":"PD-L1 induces macrophage polarization toward the M2 phenotype via erk\/akt\/mTOR","volume":"402","author":"Wei","year":"2021","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jep.2025.120726_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116171","article-title":"Modified dingchuan decoction treats cough-variant asthma by suppressing lung inflammation and regulating the lung microbiota","volume":"306","author":"Wen","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.jep.2025.120726_bib60","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1002\/ptr.8146","article-title":"Cucurbitacin B modulates M2 macrophage differentiation and attenuates osteosarcoma progression via PI3K\/AKT pathway","volume":"38","author":"Wu","year":"2024","journal-title":"Phytother Res."},{"issue":"3","key":"10.1016\/j.jep.2025.120726_bib61","doi-asserted-by":"crossref","first-page":"968","DOI":"10.7150\/ijbs.90808","article-title":"SGK1 aggravates idiopathic pulmonary fibrosis by triggering H3k27ac-mediated macrophage reprogramming and disturbing immune homeostasis","volume":"20","author":"Wu","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jep.2025.120726_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156220","article-title":"The inhibition of rutin on src kinase blocks high glucose-induced EGFR\/ERK transactivation in diabetic nephropathy by integrative approach of network pharmacology and experimental verification","volume":"135","author":"Wu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120726_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117565","article-title":"Baiheqingjin formula reduces inflammation in mice with asthma by inhibiting the PI3K\/AKT\/NF-\u03bab signaling pathway","volume":"321","author":"Yan","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2025.120726_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24065136","article-title":"The chemokine receptor CCR1 mediates microglia stimulated glioma invasion","volume":"24","author":"Zeren","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jep.2025.120726_bib65","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41467-023-44168-0","article-title":"Cullin5 drives experimental asthma exacerbations by modulating alveolar macrophage antiviral immunity","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jep.2025.120726_bib66","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s12890-025-03627-8","article-title":"Airway inflammation, bronchial hyperresponsiveness, and anti-asthma therapy responses in cough variant asthma and classic asthma with FEV(1)% \u226580% predicted","volume":"25","author":"Zhang","year":"2025","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.jep.2025.120726_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116153","article-title":"Ephedrae herba: a comprehensive review of its traditional uses, phytochemistry, pharmacology, and toxicology","volume":"307","author":"Zheng","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"10.1016\/j.jep.2025.120726_bib68","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.7150\/thno.82535","article-title":"The HDAC10 instructs macrophage M2 program via deacetylation of STAT3 and promotes allergic airway inflammation","volume":"13","author":"Zhong","year":"2023","journal-title":"Theranostics"},{"issue":"7","key":"10.1016\/j.jep.2025.120726_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/jcm7070174","article-title":"Pattern of response to bronchial challenge with histamine in patients with non-atopic cough-variant and classic asthma","volume":"7","author":"Zugic","year":"2018","journal-title":"J. Clin. Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125014187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125014187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T03:27:30Z","timestamp":1764041250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125014187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":69,"alternative-id":["S0378874125014187"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120726","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HuangLong oral liquid alleviates cough variant asthma in mice via inhibiting M2 macrophage chemotaxis and polarization by regulating the PI3K\/AKT\/ERK pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120726","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120726"}}