{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:54:48Z","timestamp":1791608088527,"version":"4.3.4"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374176"],"award-info":[{"award-number":["82374176"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jep.2025.120758","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:44:54Z","timestamp":1760661894000},"page":"120758","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Er-Chen decoction alleviates spermatogenic dysfunction in obese mice by tuning the SIRT1\/p53 axis"],"prefix":"10.1016","volume":"356","author":[{"given":"Maohui","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiexin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangsen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingmiao","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peihai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanju","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4933-7347","authenticated-orcid":false,"given":"Weijun","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jep.2025.120758_bib1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/toxres\/tfab049","article-title":"The modulatory impacts of Glycyrrhiza glabra extract against methotrexate-induced testicular dysfunction and oxidative stress","volume":"10","author":"Aldhahrani","year":"2021","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.jep.2025.120758_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115095","article-title":"Fenofibrate and diosmetin in a rat model of testicular toxicity: new insight on their protective mechanism through PPAR-\u03b1\/NRF-2\/HO-1 signaling pathway","volume":"165","author":"Alqahtani","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.120758_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2025.152032","article-title":"Ameliorating monosodium glutamate-induced testicular dysfunction by modulating steroidogenesis, oxidative stress, inflammation, and apoptosis: therapeutic role of hesperidin","volume":"771","author":"Askar","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7","key":"10.1016\/j.jep.2025.120758_bib4","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1007\/s00394-022-02917-9","article-title":"Ameliorating high-fat diet-induced sperm and testicular oxidative damage by micronutrient-based antioxidant intervention in rats","volume":"61","author":"Billah","year":"2022","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.jep.2025.120758_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2024.101273","article-title":"Obesity and male fertility disorders","volume":"97","author":"Cannarella","year":"2024","journal-title":"Mol. Aspect. Med."},{"issue":"3\u201304","key":"10.1016\/j.jep.2025.120758_bib6","first-page":"70","article-title":"Obesity and Male infertility: true, true, and unrelated?","volume":"41","author":"Ceraolo","year":"2023","journal-title":"Semin. Reprod. Med."},{"key":"10.1016\/j.jep.2025.120758_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154808","article-title":"Erchen decoction to reduce oxidative stress in dyslipidemia phlegm-dampness retention syndrome mice: in vivo mechanism revealed by metabolomics (liquid chromatography-mass spectrometry)","volume":"115","author":"Chen","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120758_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120218","article-title":"Erchen decoction alleviates anxiety and depression-like behaviors in high-fat diet-induced obesity mice via the Adipose-Brain axis","volume":"352","author":"Chen","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120758_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116333","article-title":"Qingdai Decoction suppresses prostate cancer growth in lethal-stage prostate cancer models","volume":"308","author":"Chen","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120758_bib10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1124\/pr.110.002790","article-title":"The blood-testis barrier and its implications for male contraception","volume":"64","author":"Cheng","year":"2012","journal-title":"Pharmacol. Rev."},{"issue":"Pt 3","key":"10.1016\/j.jep.2025.120758_bib11","article-title":"Erchen decoction alleviates the progression of NAFLD by inhibiting lipid accumulation and iron overload through Caveolin-1 signaling","volume":"319","author":"Deng","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2025.120758_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23335","article-title":"Naringenin alleviate reproductive toxicity evoked by lead acetate via attenuation of sperm profile and biochemical alterations in male Wistar rat: involvement of TGF\u03b2\/AKT\/mTOR pathway","volume":"37","author":"Elhemiely","year":"2023","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.jep.2025.120758_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1274035","article-title":"A short-term high-fat diet alters rat testicular activity and blood-testis barrier integrity through the SIRT1\/NRF2\/MAPKs signaling pathways","volume":"14","author":"Falvo","year":"2023","journal-title":"Front. Endocrinol."},{"issue":"4","key":"10.1016\/j.jep.2025.120758_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120775","article-title":"Diet-induced obesity in male C57BL\/6 mice decreases fertility as a consequence of disrupted blood-testis barrier","volume":"10","author":"Fan","year":"2015","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.jep.2025.120758_bib15","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.1096\/fj.12-224048","article-title":"Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content","volume":"27","author":"Fullston","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.jep.2025.120758_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115386","article-title":"Electroacupuncture activates angiogenesis by regulating the PI3K\/Pten\/Thbs1 signaling pathway to promote the browning of adipose tissue in HFD-induced obese mice","volume":"166","author":"Gao","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.jep.2025.120758_bib17","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12958-018-0416-0","article-title":"Rosiglitazone ameliorates palmitic acid-induced cytotoxicity in TM4 Sertoli cells","volume":"16","author":"Ge","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"1","key":"10.1016\/j.jep.2025.120758_bib18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2478\/enr-2020-0004","article-title":"Possible ameliorating effects of Glycyrrhiza Glabra (Licorice) on the sperm parameters in rats under high fat diet","volume":"54","author":"Ghorbanlou","year":"2020","journal-title":"Endocr. Regul."},{"issue":"10","key":"10.1016\/j.jep.2025.120758_bib19","doi-asserted-by":"crossref","first-page":"6896","DOI":"10.1002\/jcp.26581","article-title":"Testicular germ cell apoptosis and sperm defects in mice upon long-term high fat diet feeding","volume":"233","author":"Ghosh","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jep.2025.120758_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/srep18193","article-title":"RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders","volume":"5","author":"Grandjean","year":"2015","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.jep.2025.120758_bib21","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.fertnstert.2008.08.026","article-title":"Impact of male obesity on infertility: a critical review of the current literature","volume":"90","author":"Hammoud","year":"2008","journal-title":"Fertil. Steril."},{"issue":"1","key":"10.1016\/j.jep.2025.120758_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1530\/REP-23-0097","article-title":"Obesity induces male mice infertility via oxidative stress, apoptosis, and glycolysis","volume":"166","author":"Han","year":"2023","journal-title":"Reproduction"},{"issue":"3","key":"10.1016\/j.jep.2025.120758_bib23","first-page":"253","article-title":"Voluntary exercise improves sperm parameters in high fat diet receiving rats through alteration in testicular oxidative stress, mir-34a\/SIRT1\/p53 and apoptosis","volume":"42","author":"Heydari","year":"2021","journal-title":"Horm. Mol. Biol. Clin. Invest."},{"issue":"3","key":"10.1016\/j.jep.2025.120758_bib24","first-page":"555","article-title":"Clinical observation on the efficacy of modified Er-chen decoction in treating seminal fluid non-liquefaction with phlegm-damp obstruction pattern","volume":"40","author":"Huang","year":"2024","journal-title":"J. Pract.Traditi. Chin. Med."},{"issue":"3","key":"10.1016\/j.jep.2025.120758_bib25","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1177\/0960327120950007","article-title":"Nobiletin ameliorates nonylphenol-induced testicular damage by improving biochemical, steroidogenic, hormonal, spermatogenic, apoptotic and histological profile","volume":"40","author":"Ijaz","year":"2021","journal-title":"Hum. Exp. Toxicol."},{"issue":"9","key":"10.1016\/j.jep.2025.120758_bib26","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1038\/s41366-020-0595-6","article-title":"High fat diet causes distinct aberrations in the testicular proteome","volume":"44","author":"Jarvis","year":"2020","journal-title":"Int. J. Obes."},{"issue":"D1","key":"10.1016\/j.jep.2025.120758_bib27","doi-asserted-by":"crossref","first-page":"D1670","DOI":"10.1093\/nar\/gkae973","article-title":"Generic Diagramming Platform (GDP): a comprehensive database of high-quality biomedical graphics","volume":"53","author":"Jiang","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.jep.2025.120758_bib28","first-page":"9","article-title":"Enhanced Er-chen decoction for the treatment of seminal Non-Liquefaction: a Study of 82 cases","volume":"31","author":"Ke","year":"2012","journal-title":"Inner Mongolia J. Tradit. Chin."},{"issue":"2","key":"10.1016\/j.jep.2025.120758_bib29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/humupd\/dmac035","article-title":"Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries","volume":"29","author":"Levine","year":"2023","journal-title":"Hum. Reprod. Update"},{"issue":"13","key":"10.1016\/j.jep.2025.120758_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202200524","article-title":"Icariin ameliorates spermatogenesis disorder in Obese mice induced by high-fat diet through regulating the glycolytic pathway","volume":"67","author":"Luo","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"issue":"4","key":"10.1016\/j.jep.2025.120758_bib31","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1071\/RD15351","article-title":"Body mass index and human sperm quality: neither one extreme nor the other","volume":"29","author":"Luque","year":"2017","journal-title":"Reprod. Fertil. Dev."},{"issue":"21","key":"10.1016\/j.jep.2025.120758_bib32","doi-asserted-by":"crossref","first-page":"16202","DOI":"10.1074\/jbc.275.21.16202","article-title":"Death signal-induced localization of p53 protein to Mitochondria: a potential role IN apoptotic signaling","volume":"275","author":"Marchenko","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"10113","key":"10.1016\/j.jep.2025.120758_bib33","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1016\/S0140-6736(17)32129-3","article-title":"Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128\u00b79 million children, adolescents, and adults","volume":"390","year":"2017","journal-title":"Lancet"},{"issue":"Pt A","key":"10.1016\/j.jep.2025.120758_bib34","article-title":"Zhuling Yanzong formula ameliorates obesity-induced oligoasthenozoospermia via regulating HSL\/StAR and HSL\/TIMP-1","volume":"353","author":"Pan","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120758_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.839034","article-title":"Restoring impaired fertility through diet: observations of switching from high-fat diet during puberty to normal diet in adulthood among obese Male mice","volume":"13","author":"Qi","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"6","key":"10.1016\/j.jep.2025.120758_bib36","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/MED.0000000000000883","article-title":"Male infertility and obesity","volume":"31","author":"Rasouli","year":"2024","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"issue":"3","key":"10.1016\/j.jep.2025.120758_bib37","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/20905998.2025.2473219","article-title":"Obesity and male infertility - a tenuous relationship: facts discerned for the busy clinicians","volume":"23","author":"Rocco","year":"2025","journal-title":"Arab. J. Urol."},{"issue":"6","key":"10.1016\/j.jep.2025.120758_bib38","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/advances\/nmy057","article-title":"The effect of nutrients and dietary supplements on sperm quality parameters: a systematic review and meta-analysis of randomized clinical trials","volume":"9","author":"Salas-Huetos","year":"2018","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.jep.2025.120758_bib39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.reprotox.2020.05.009","article-title":"Obesity-induced testicular oxidative stress, inflammation and apoptosis: protective and therapeutic effects of orlistat","volume":"95","author":"Suleiman","year":"2020","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.jep.2025.120758_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102334","article-title":"Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death","volume":"53","author":"Sun","year":"2022","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.jep.2025.120758_bib41","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1210\/en.2014-1720","article-title":"EB1 regulates tubulin and actin cytoskeletal networks at the sertoli cell blood-testis barrier in male rats: an in vitro study","volume":"156","author":"Tang","year":"2015","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.jep.2025.120758_bib42","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1186\/s12967-023-04440-9","article-title":"SIRT1 activation promotes energy homeostasis and reprograms liver cancer metabolism","volume":"21","author":"Varghese","year":"2023","journal-title":"J. Transl. Med."},{"issue":"5","key":"10.1016\/j.jep.2025.120758_bib43","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bbabio.2008.10.005","article-title":"The mitochondrial p53 pathway","volume":"1787","author":"Vaseva","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.jep.2025.120758_bib44","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s00018-022-04142-3","article-title":"LncRNA Tug1 maintains blood-testis barrier integrity by modulating Ccl2 expression in high-fat diet mice","volume":"79","author":"Wang","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"issue":"34","key":"10.1016\/j.jep.2025.120758_bib45","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.3748\/wjg.v28.i34.5007","article-title":"Ji-Chuan decoction ameliorates slow transit constipation via regulation of intestinal glial cell apoptosis","volume":"28","author":"Wang","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2025.120758_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144059","article-title":"Bisphenol S perturbs Sertoli cell junctions in male rats via alterations in cytoskeletal organization mediated by an imbalance between mTORC1 and mTORC2","volume":"762","author":"Wu","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.jep.2025.120758_bib47","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12690","article-title":"Melatonin protects mouse testes from palmitic acid-induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1-dependent manner","volume":"69","author":"Xu","year":"2020","journal-title":"J. Pineal Res."},{"issue":"6","key":"10.1016\/j.jep.2025.120758_bib48","first-page":"561","article-title":"Guo Jun's experience in treating idiopathic asthenozoospermia based on the theory of Phlegm-Dampness","volume":"38","author":"Yan","year":"2019","journal-title":"Beijing J. Tradit. Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2025.120758_bib49","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1159\/000489918","article-title":"Proteomics analysis of testis of rats fed a high-fat diet","volume":"47","author":"Yang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.jep.2025.120758_bib50","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9151067","article-title":"Metformin improves fertility in Obese males by alleviating oxidative stress-induced blood-testis barrier damage","volume":"2019","author":"Ye","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2025.120758_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155533","article-title":"Dihydroquercetin improves experimental acute liver failure by targeting ferroptosis and mitochondria-mediated apoptosis through the SIRT1\/p53 axis","volume":"128","author":"Zeng","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120758_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116811","article-title":"Erchen Decoction alleviates obesity-related hepatic steatosis via modulating gut microbiota-drived butyric acid contents and promoting fatty acid \u03b2-oxidation","volume":"317","author":"Zhang","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.jep.2025.120758_bib53","doi-asserted-by":"crossref","DOI":"10.1002\/fsn3.70592","article-title":"Erchen decoction offers health benefits in regulating obesity: component analysis, network pharmacology, and experiment verification","volume":"13","author":"Zhang","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.jep.2025.120758_bib54","article-title":"Shuxie-1 decoction alleviated CUMS -Induced liver injury via IL-6\/JAK2\/STAT3 signaling","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."}],"updated-by":[{"DOI":"10.1016\/j.jep.2026.121730","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000}},{"DOI":"10.1016\/j.jep.2026.121730","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000}},{"DOI":"10.1016\/j.jep.2026.122362","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000}}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125014503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125014503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:42:47Z","timestamp":1763703767000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125014503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":54,"alternative-id":["S0378874125014503"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120758","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Er-Chen decoction alleviates spermatogenic dysfunction in obese mice by tuning the SIRT1\/p53 axis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120758","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120758"}}