{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:09:05Z","timestamp":1792804145351,"version":"4.5.0"},"reference-count":111,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374119"],"award-info":[{"award-number":["82374119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574783"],"award-info":[{"award-number":["82574783"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jep.2025.120759","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T22:20:16Z","timestamp":1760998816000},"page":"120759","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Polygalae Radix extracts show anti-Parkinson's disease effects and reduce depression-like symptoms by modulating energy metabolism"],"prefix":"10.1016","volume":"356","author":[{"given":"Shouqing","family":"Jiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruidie","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rostyslav","family":"Stoika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Sik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuna","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1525-0876","authenticated-orcid":false,"given":"Meng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"15","key":"10.1016\/j.jep.2025.120759_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23158350","article-title":"Implication of melanocortin receptor genes in the familial comorbidity of type 2 diabetes and depression","volume":"23","author":"Amin","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.120759_bib2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.brainresbull.2017.03.009","article-title":"Metabolic dysfunction in Parkinson's disease: bioenergetics, redox homeostasis and central carbon metabolism","volume":"133","author":"Anandhan","year":"2017","journal-title":"Brain Res. Bull."},{"issue":"11","key":"10.1016\/j.jep.2025.120759_bib3","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1007\/s11064-024-04223-8","article-title":"Intranasal adiporon mitigated anxiety and depression-like behaviors in 6-OHDA-induced Parkinson 's disease rat model: going beyond motor symptoms","volume":"49","author":"Azizifar","year":"2024","journal-title":"Neurochem. Res."},{"issue":"2","key":"10.1016\/j.jep.2025.120759_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/toxics10020069","article-title":"MPTP-treated zebrafish recapitulate \u2018late-stage\u2019 parkinson\u2019s-like cognitive decline","volume":"10","author":"Bashirzade","year":"2022","journal-title":"Toxics"},{"issue":"4","key":"10.1016\/j.jep.2025.120759_bib5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0166-2236(93)90117-5","article-title":"Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?","volume":"16","author":"Beal","year":"1993","journal-title":"Trends Neurosci."},{"issue":"8","key":"10.1016\/j.jep.2025.120759_bib6","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.modgep.2006.04.006","article-title":"GFAP transgenic zebrafish","volume":"6","author":"Bernardos","year":"2006","journal-title":"Gene Expr. Patterns : GEP"},{"key":"10.1016\/j.jep.2025.120759_bib7","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neuint.2018.04.003","article-title":"Restorative effect of l-Dopa treatment against ochratoxin a induced neurotoxicity","volume":"118","author":"Bhat","year":"2018","journal-title":"Neurochem. Int."},{"issue":"5","key":"10.1016\/j.jep.2025.120759_bib8","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.physbeh.2011.07.029","article-title":"Stimuli affecting zebrafish (Danio rerio) behavior in the light\/dark preference test","volume":"104","author":"Blaser","year":"2011","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.jep.2025.120759_bib9","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3389\/fnagi.2018.00301","article-title":"The emerging role of energy metabolism and neuroprotective strategies in Parkinson's Disease","volume":"10","author":"B\u0142aszczyk","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.jep.2025.120759_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111357","article-title":"Therapeutic efficacy of 3,4-Diaminopyridine phosphate on neuromuscular junction in Pompe disease","volume":"137","author":"Bragato","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"1 Suppl. 1","key":"10.1016\/j.jep.2025.120759_bib11","first-page":"S39","article-title":"Safety and tolerability of COMT inhibitors","volume":"62","author":"Brooks","year":"2004","journal-title":"Neurology"},{"issue":"20","key":"10.1016\/j.jep.2025.120759_bib12","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.156222","article-title":"Dichloroacetate and thiamine improve survival and mitochondrial stress in a C. elegans model of dihydrolipoamide dehydrogenase deficiency","volume":"7","author":"Broxton","year":"2022","journal-title":"JCI Insight"},{"issue":"20","key":"10.1016\/j.jep.2025.120759_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/cells11203267","article-title":"MAOA uVNTR genetic variant and major depressive disorder: a systematic review","volume":"11","author":"Castro Gon\u00e7alves","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.jep.2025.120759_bib14","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a040568","article-title":"Carbohydrate metabolism","volume":"13","author":"Chandel","year":"2021","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.jep.2025.120759_bib15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pneurobio.2013.06.004","article-title":"Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies","volume":"108","author":"Chen","year":"2013","journal-title":"Prog. Neurobiol."},{"issue":"3","key":"10.1016\/j.jep.2025.120759_bib16","doi-asserted-by":"crossref","first-page":"775","DOI":"10.3233\/JPD-191900","article-title":"The association between type 2 diabetes mellitus and Parkinson's disease","volume":"10","author":"Cheong","year":"2020","journal-title":"J. Parkinsons Dis."},{"issue":"3","key":"10.1016\/j.jep.2025.120759_bib17","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2174\/1871527321666211231100255","article-title":"The role of monoamine oxidase B inhibitors in the treatment of Parkinson's disease - an update","volume":"22","author":"Chew","year":"2023","journal-title":"CNS Neurol. Disord.: Drug Targets"},{"issue":"1","key":"10.1016\/j.jep.2025.120759_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-12457-6","article-title":"Separate neural representations of depression, anxiety and apathy in Parkinson's disease","volume":"7","author":"Dan","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.jep.2025.120759_bib19","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1177\/0269881108097817","article-title":"Association of HPA axis genes with suicidal behaviour in schizophrenia","volume":"24","author":"De Luca","year":"2010","journal-title":"J. Psychopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120759_bib20","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1080\/13880209.2020.1758732","article-title":"Polygala tenuifolia: a source for anti-alzheimer's disease drugs","volume":"58","author":"Deng","year":"2020","journal-title":"Pharm. Biol."},{"issue":"13","key":"10.1016\/j.jep.2025.120759_bib21","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1021\/acschemneuro.2c00089","article-title":"Characterization of developmental neurobehavioral toxicity in a zebrafish MPTP-induced model: a novel mechanism involving anemia","volume":"13","author":"Dong","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.jep.2025.120759_bib22","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3389\/fnmol.2018.00257","article-title":"Integrated analysis reveals altered lipid and glucose metabolism and identifies NOTCH2 as a biomarker for Parkinson's disease related depression","volume":"11","author":"Dong","year":"2018","journal-title":"Front. Mol. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.jep.2025.120759_bib23","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jns.2012.07.015","article-title":"The role of the dopaminergic system in mood, motivation and cognition in Parkinson's disease: a double blind randomized placebo-controlled experimental challenge with pramipexole and methylphenidate","volume":"320","author":"Drijgers","year":"2012","journal-title":"J. Neurol. Sci."},{"issue":"5","key":"10.1016\/j.jep.2025.120759_bib24","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.neurobiolaging.2013.11.001","article-title":"Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease","volume":"35","author":"Dunn","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"11","key":"10.1016\/j.jep.2025.120759_bib25","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1093\/hmg\/ddx076","article-title":"Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function","volume":"26","author":"Eachus","year":"2017","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"10.1016\/j.jep.2025.120759_bib26","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3390\/neurolint13030038","article-title":"Selective serotonin reuptake inhibitors and adverse effects: a narrative review","volume":"13","author":"Edinoff","year":"2021","journal-title":"Neurol. Int."},{"issue":"1","key":"10.1016\/j.jep.2025.120759_bib27","article-title":"A zebrafish model of acmsd deficiency does not support a prominent role for ACMSD in Parkinson's disease","volume":"11","author":"Fargher","year":"2025","journal-title":"npj Parkinson's Dis."},{"issue":"3","key":"10.1016\/j.jep.2025.120759_bib28","first-page":"414","article-title":"Metabolomics investigation on antiobesity effects of Corydalis bungeana on high-fat high-sugar diet-induced obese rats","volume":"14","author":"Fu","year":"2022","journal-title":"Chin. Herb. Med."},{"issue":"2","key":"10.1016\/j.jep.2025.120759_bib29","first-page":"310","article-title":"De novo transcriptome assembly and metabolomic analysis of three tissue types in Cinnamomum cassia","volume":"15","author":"Gao","year":"2023","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.jep.2025.120759_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175950","article-title":"Neuroprotective effect of chlorogenic acid on Parkinson's disease like symptoms through boosting the autophagy in zebrafish","volume":"956","author":"Gao","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.jep.2025.120759_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10123005","article-title":"Plasma metabolic disturbances in Parkinson's disease patients","volume":"10","author":"G\u0105tarek","year":"2022","journal-title":"Biomedicines"},{"issue":"17","key":"10.1016\/j.jep.2025.120759_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179248","article-title":"The PPARg system in major depression: pathophysiologic and therapeutic implications","volume":"22","author":"Gold","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.jep.2025.120759_bib33","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1006\/dbio.1999.9204","article-title":"Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons","volume":"208","author":"Guo","year":"1999","journal-title":"Dev. Biol."},{"issue":"4","key":"10.1016\/j.jep.2025.120759_bib34","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1021\/acs.jproteome.9b00861","article-title":"Oxidative damage to the TCA cycle enzyme MDH1 dysregulates bioenergetic enzymatic activity in the aged murine brain","volume":"19","author":"Guo","year":"2020","journal-title":"J. Proteome Res."},{"issue":"1","key":"10.1016\/j.jep.2025.120759_bib35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0169-328X(95)00278-Z","article-title":"Dopamine transporter (Dat) and synaptic vesicle amine transporter (VMAT2) gene expression in the substantia nigra of control and Parkinson's disease","volume":"36","author":"Harrington","year":"1996","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"4","key":"10.1016\/j.jep.2025.120759_bib36","doi-asserted-by":"crossref","first-page":"842","DOI":"10.2337\/dc06-2011","article-title":"Type 2 diabetes and the risk of Parkinson's disease","volume":"30","author":"Hu","year":"2007","journal-title":"Diabetes Care"},{"issue":"12","key":"10.1016\/j.jep.2025.120759_bib37","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1038\/s42255-022-00707-5","article-title":"Dual roles of hexokinase 2 in shaping microglial function by gating glycolytic flux and mitochondrial activity","volume":"4","author":"Hu","year":"2022","journal-title":"Nat. Metab."},{"issue":"3","key":"10.1016\/j.jep.2025.120759_bib38","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s11239-019-01945-3","article-title":"Interactions between clopidogrel and traditional Chinese medicine","volume":"48","author":"Hu","year":"2019","journal-title":"J. Thromb. Thrombolysis"},{"issue":"2","key":"10.1016\/j.jep.2025.120759_bib39","first-page":"201","article-title":"Molecular basis and mechanism of action of Albizia julibrissin in depression treatment and clinical application of its formulae","volume":"15","author":"Huang","year":"2023","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.jep.2025.120759_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajp.2021.102691","article-title":"The role of pramipexole in the treatment of patients with depression and Parkinson's disease: a meta-analysis of randomized controlled trials","volume":"61","author":"Jiang","year":"2021","journal-title":"Asian J. Psychiatr."},{"key":"10.1016\/j.jep.2025.120759_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2021.688703","article-title":"Protective effects and mechanism of Radix Polygalae against neurological diseases as well as effective substance","volume":"12","author":"Jiang","year":"2021","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.jep.2025.120759_bib42","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.ecoenv.2019.01.104","article-title":"Synergistic effects of Pb and repeated heat pulse on developmental neurotoxicity in zebrafish","volume":"172","author":"Jin","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jep.2025.120759_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.718244","article-title":"Cerebroventricular microinjections of MPTP on adult zebrafish induces dopaminergic neuronal death, mitochondrial fragmentation, and sensorimotor impairments","volume":"15","author":"Kalyn","year":"2021","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.jep.2025.120759_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8010001","article-title":"Comprehensive analysis of neurotoxin-induced ablation of dopaminergic neurons in zebrafish larvae","volume":"8","author":"Kalyn","year":"2019","journal-title":"Biomedicines"},{"issue":"12","key":"10.1016\/j.jep.2025.120759_bib45","doi-asserted-by":"crossref","first-page":"6461","DOI":"10.1093\/nar\/gkad440","article-title":"Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce translational stalling","volume":"51","author":"Kejiou","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"1\u20133","key":"10.1016\/j.jep.2025.120759_bib46","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ejphar.2013.09.026","article-title":"The inhibition of JNK MAPK and NF-\u03baB signaling by tenuifoliside A isolated from Polygala tenuifolia in lipopolysaccharide-induced macrophages is associated with its anti-inflammatory effect","volume":"721","author":"Kim","year":"2013","journal-title":"Eur. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.jep.2025.120759_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027395","article-title":"Cerebroventricular microinjection (CVMI) into adult zebrafish brain is an efficient misexpression method for forebrain ventricular cells","volume":"6","author":"Kizil","year":"2011","journal-title":"PLoS One"},{"issue":"4\u20135","key":"10.1016\/j.jep.2025.120759_bib48","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S1566-2772(03)00085-9","article-title":"HAB\/LAB rats: an animal model of extremes in trait anxiety and depression","volume":"3","author":"Landgraf","year":"2003","journal-title":"Clin. Neurosci. Res."},{"issue":"8","key":"10.1016\/j.jep.2025.120759_bib49","doi-asserted-by":"crossref","first-page":"734","DOI":"10.14348\/molcells.2015.0131","article-title":"Tricyclic antidepressants amitriptyline and desipramine induced neurotoxicity associated with Parkinson's disease","volume":"38","author":"Lee","year":"2015","journal-title":"Mol. Cells"},{"issue":"1\u20132","key":"10.1016\/j.jep.2025.120759_bib50","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jns.2006.05.024","article-title":"Effects of the dopamine agonist pramipexole on depression, anhedonia and motor functioning in Parkinson's disease","volume":"248","author":"Lemke","year":"2006","journal-title":"J. Neurol. Sci."},{"issue":"31","key":"10.1016\/j.jep.2025.120759_bib51","doi-asserted-by":"crossref","first-page":"8307","DOI":"10.1021\/acs.jafc.8b02607","article-title":"Pinostrobin Exerts Neuroprotective actions in neurotoxin-induced Parkinson's disease models through Nrf2 induction","volume":"66","author":"Li","year":"2018","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.jep.2025.120759_bib52","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14411","article-title":"The potential role of glucose metabolism, lipid metabolism, and amino acid metabolism in the treatment of Parkinson's disease","volume":"30","author":"Li","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jep.2025.120759_bib53","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.chemosphere.2019.02.174","article-title":"Zebrafish behavioral phenomics applied for phenotyping aquatic neurotoxicity induced by lead contaminants of environmentally relevant level","volume":"224","author":"Li","year":"2019","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.jep.2025.120759_bib54","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.jep.2011.01.040","article-title":"Protective effect of zhen-wu-tang (ZWT) through keeping DA stable and VMAT 2\/DAT mRNA in balance in rats with striatal lesions induced by MPTP","volume":"134","author":"Li","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120759_bib55","article-title":"Botulinum neurotoxin a ameliorates depressive-like behavior in a reserpine-induced Parkinson's disease mouse model via suppressing hippocampal microglial engulfment and neuroinflammation","author":"Li","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2025.120759_bib56","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jare.2024.08.016","article-title":"Impaired microglial glycolysis promotes inflammatory responses after intracerebral haemorrhage via HK2-dependent mitochondrial dysfunction","volume":"73","author":"Li","year":"2025","journal-title":"J. Adv. Res."},{"issue":"8","key":"10.1016\/j.jep.2025.120759_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23084150","article-title":"Cerebroventricular injection of Pgk1 attenuates MPTP-induced neuronal toxicity in dopaminergic cells in zebrafish brain in a glycolysis-independent manner","volume":"23","author":"Lin","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jep.2025.120759_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9010037","article-title":"Celastrol inhibits dopaminergic neuronal death of Parkinson's disease through activating mitophagy","volume":"9","author":"Lin","year":"2019","journal-title":"Antioxidants"},{"issue":"8","key":"10.1016\/j.jep.2025.120759_bib59","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.14336\/AD.2021.0422","article-title":"Potential crosstalk between Parkinson's Disease and energy metabolism","volume":"12","author":"Liu","year":"2021","journal-title":"Aging dis"},{"key":"10.1016\/j.jep.2025.120759_bib60","article-title":"Polygalae Radix: review of metabolites, pharmacological activities and toxicology","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120759_bib61","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ntt.2015.11.008","article-title":"Effects of diphenylhydantoin on locomotion and thigmotaxis of larval zebrafish","volume":"53","author":"Liu","year":"2016","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.jep.2025.120759_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111118","article-title":"Nicotinamide riboside ameliorates survival time and motor dysfunction in an MPTP-induced Parkinson's disease zebrafish model through effects on glucose metabolism and endoplasmic reticulum stress","volume":"399","author":"Luo","year":"2024","journal-title":"Chem. Biol. Interact."},{"issue":"5","key":"10.1016\/j.jep.2025.120759_bib63","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s12032-023-02008-7","article-title":"ErbB2-upregulated HK1 and HK2 promote breast cancer cell proliferation, migration and invasion","volume":"40","author":"Ma","year":"2023","journal-title":"Med. Oncol."},{"key":"10.1016\/j.jep.2025.120759_bib64","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1016\/j.biopha.2018.11.063","article-title":"Anti-Parkinson activity of bioactive substances extracted from Holothuria leucospilota","volume":"109","author":"Malaiwong","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"12","key":"10.1016\/j.jep.2025.120759_bib65","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s11910-013-0409-5","article-title":"Depression and Parkinson's disease: current knowledge","volume":"13","author":"Marsh","year":"2013","journal-title":"Curr. Neurol. Neurosci. Rep."},{"issue":"1","key":"10.1016\/j.jep.2025.120759_bib66","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/ana.410280111","article-title":"Selective hypometabolism in the inferior frontal lobe in depressed patients with Parkinson's disease","volume":"28","author":"Mayberg","year":"1990","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.jep.2025.120759_bib67","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/cdd.2009.200","article-title":"The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy","volume":"17","author":"Michiorri","year":"2010","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.jep.2025.120759_bib68","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00702-017-1709-8","article-title":"Type a monoamine oxidase and serotonin are coordinately involved in depressive disorders: from neurotransmitter imbalance to impaired neurogenesis","volume":"125","author":"Naoi","year":"2018","journal-title":"J. Neural Transm."},{"issue":"10","key":"10.1016\/j.jep.2025.120759_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/biom13101435","article-title":"Autophagy in Parkinson's disease","volume":"13","author":"Nechushtai","year":"2023","journal-title":"Biomolecules"},{"issue":"10","key":"10.1016\/j.jep.2025.120759_bib70","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s00702-023-02658-x","article-title":"Sex- and age-specific prevalence and risk factors of depressive symptoms in Parkinson's disease","volume":"130","author":"Niu","year":"2023","journal-title":"J. Neural Transm."},{"issue":"3","key":"10.1016\/j.jep.2025.120759_bib71","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1582-4934.2006.tb00423.x","article-title":"In vivo models of angiogenesis","volume":"10","author":"Norrby","year":"2006","journal-title":"J. Cell Mol. Med."},{"issue":"4","key":"10.1016\/j.jep.2025.120759_bib72","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/ana.24014","article-title":"Energy failure: does it contribute to neurodegeneration?","volume":"74","author":"Pathak","year":"2013","journal-title":"Ann. Neurol."},{"issue":"8","key":"10.1016\/j.jep.2025.120759_bib73","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41573-021-00210-8","article-title":"Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials","volume":"20","author":"Patton","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"4","key":"10.1016\/j.jep.2025.120759_bib74","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/bph.14110","article-title":"Achyranthes bidentata polypeptide protects dopaminergic neurons from apoptosis in Parkinson's disease models both in vitro and in vivo","volume":"175","author":"Peng","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.120759_bib75","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.crvi.2018.01.007","article-title":"Genetic diversity and population structure of a protected species: Polygala tenuifolia willd","volume":"341","author":"Peng","year":"2018","journal-title":"C. R. Biol."},{"issue":"12","key":"10.1016\/j.jep.2025.120759_bib76","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1007\/s11064-014-1443-7","article-title":"Withania somnifera alleviates parkinsonian phenotypes by inhibiting apoptotic pathways in dopaminergic neurons","volume":"39","author":"Prakash","year":"2014","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jep.2025.120759_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117387","article-title":"Transcriptome analysis reveals the anti-parkinson's activity of mangiferin in zebrafish","volume":"179","author":"Qin","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.120759_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115234","article-title":"Co-treatment with natural HMGB1 inhibitor glycyrrhizin exerts neuroprotection and reverses Parkinson's disease like pathology in zebrafish","volume":"292","author":"Ren","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120759_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112629","article-title":"Neuroprotective effect of YIAEDAER peptide against Parkinson's disease like pathology in zebrafish","volume":"147","author":"Ren","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.jep.2025.120759_bib80","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12868-020-00607-y","article-title":"Knockout of the circadian gene, Per2, disrupts corticosterone secretion and results in depressive-like behaviors and deficits in startle responses","volume":"22","author":"Russell","year":"2021","journal-title":"BMC Neurosci."},{"issue":"1","key":"10.1016\/j.jep.2025.120759_bib81","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.nbd.2010.06.001","article-title":"Dopaminergic cell damage and vulnerability to MPTP in Pink1 knockdown zebrafish","volume":"40","author":"Sallinen","year":"2010","journal-title":"Neurobiol. Dis."},{"issue":"10","key":"10.1016\/j.jep.2025.120759_bib82","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.044925","article-title":"The SDHB Arg230His mutation causing familial paraganglioma alters glycolysis in a new caenorhabditis elegans model","volume":"13","author":"Sask\u0151i","year":"2020","journal-title":"Dis. Model. Mech."},{"issue":"2","key":"10.1016\/j.jep.2025.120759_bib83","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.bbr.2011.12.016","article-title":"Measuring thigmotaxis in larval zebrafish","volume":"228","author":"Schn\u00f6rr","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jep.2025.120759_bib84","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jneumeth.2019.03.008","article-title":"A simple method to study motor and non-motor behaviors in adult zebrafish","volume":"320","author":"Selvaraj","year":"2019","journal-title":"J. Neurosci. Methods"},{"issue":"10","key":"10.1016\/j.jep.2025.120759_bib85","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1007\/s10072-014-1891-5","article-title":"The benefits of pramipexole selection in the treatment of Parkinson's disease","volume":"35","author":"Silindir","year":"2014","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.jep.2025.120759_bib86","article-title":"A chronic immobilization stress protocol for inducing depression-like behavior in mice","volume":"147","author":"Son","year":"2019","journal-title":"J. Vis. Exp."},{"issue":"2","key":"10.1016\/j.jep.2025.120759_bib87","doi-asserted-by":"crossref","DOI":"10.3390\/neurosci6020028","article-title":"Reserpine causes neuroendocrine toxicity, inducing impairments in cognition via disturbing hypothalamic\u2013pituitary\u2013thyroid axis in zebrafish","volume":"6","author":"Sun","year":"2025","journal-title":"NeuroSci"},{"issue":"10","key":"10.1016\/j.jep.2025.120759_bib88","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/s41593-018-0234-x","article-title":"The role of brain vasculature in neurodegenerative disorders","volume":"21","author":"Sweeney","year":"2018","journal-title":"Nat. Neurosci."},{"issue":"0","key":"10.1016\/j.jep.2025.120759_bib89","doi-asserted-by":"crossref","DOI":"10.5455\/njppp.2023.13.11551202204122022","article-title":"Adverse drug reaction profile of patients taking amantadine for traumatic brain injury in a tertiary care hospital","author":"Thaha","year":"2022","journal-title":"Natl. J. Physiol. Pharm. Pharmacol."},{"issue":"5","key":"10.1016\/j.jep.2025.120759_bib90","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1474-4422(21)00030-2","article-title":"Challenges in the diagnosis of Parkinson's disease","volume":"20","author":"Tolosa","year":"2021","journal-title":"Lancet Neurol."},{"issue":"6","key":"10.1016\/j.jep.2025.120759_bib91","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13031","article-title":"Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease","volume":"18","author":"Trist","year":"2019","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.jep.2025.120759_bib92","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0165-2478(94)00183-R","article-title":"Glycyrrhizin (20 beta-carboxy-11-oxo-30-norolean-12-en-3 beta-yl-2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid) improves the resistance of thermally injured mice to opportunistic infection of herpes simplex virus type 1","volume":"44","author":"Utsunomiya","year":"1995","journal-title":"Immunol. Lett."},{"issue":"18","key":"10.1016\/j.jep.2025.120759_bib93","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2221097120","article-title":"High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation","volume":"120","author":"Wang","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA."},{"issue":"10","key":"10.1016\/j.jep.2025.120759_bib94","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1038\/s41380-023-02098-9","article-title":"Targeting PDK2 rescues stress-induced impaired brain energy metabolism","volume":"28","author":"Wang","year":"2023","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.jep.2025.120759_bib95","article-title":"The alleviative effect of Calendula officinalis L. extract against Parkinson's disease-like pathology in zebrafish via the involvement of autophagy activation","volume":"17","author":"Wang","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jep.2025.120759_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.141682","article-title":"Endocrine disrupting effects of parabens in zebrafish (Danio rerio): new insights from transcriptomics, metabolomics, and molecular dynamics simulation","volume":"354","author":"Wei","year":"2024","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.jep.2025.120759_bib97","first-page":"298","article-title":"Combined analysis of transcriptomics and metabolomics revealed complex metabolic genes for diterpenoids biosynthesis in different organs of Anoectochilus roxburghii","volume":"15","author":"Wei","year":"2023","journal-title":"Chin. Herb. Med."},{"issue":"6","key":"10.1016\/j.jep.2025.120759_bib98","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.psyneuen.2012.09.011","article-title":"Mineralocorticoid receptor antagonist spironolactone prevents chronic corticosterone induced depression-like behavior","volume":"38","author":"Wu","year":"2013","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"10.1016\/j.jep.2025.120759_bib99","first-page":"422","article-title":"Metabonomics study of liver and kidney subacute toxicity induced by garidi-5 in rats","volume":"14","author":"Wurihan","year":"2022","journal-title":"Chin. Herb. Med."},{"issue":"1","key":"10.1016\/j.jep.2025.120759_bib100","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41422-024-01022-2","article-title":"\u03b1-Synuclein amyloid fibril directly binds to LC3B and suppresses SQSTM1\/p62-mediated selective autophagy","volume":"35","author":"Xu","year":"2025","journal-title":"Cell Res."},{"issue":"1","key":"10.1016\/j.jep.2025.120759_bib101","article-title":"Investigation of radix achyranthis bidentatae phytochemistry and pharmacology","volume":"5","author":"Yang","year":"2019","journal-title":"World J. Tradit. Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2025.120759_bib102","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/s41467-023-36209-5","article-title":"Astrocytic lactate dehydrogenase a regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice","volume":"14","author":"Yao","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2025.120759_bib103","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9923331","article-title":"The positive role and mechanism of herbal medicine in Parkinson's disease","author":"Yin","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"9","key":"10.1016\/j.jep.2025.120759_bib104","first-page":"3339","article-title":"The role of mineralocorticoid receptors in hypothalamic-pituitary-adrenal axis regulation in humans","volume":"83","author":"Young","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.jep.2025.120759_bib105","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1001\/archpsyc.60.1.24","article-title":"Mineralocorticoid receptor function in major depression","volume":"60","author":"Young","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"issue":"2","key":"10.1016\/j.jep.2025.120759_bib106","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1039\/C9FO02288K","article-title":"Anti-Parkinson's disease activity of phenolic acids from Eucommia ulmoides Oliver leaf extracts and their autophagy activation mechanism","volume":"11","author":"Zhang","year":"2020","journal-title":"Food Funct."},{"issue":"13","key":"10.1016\/j.jep.2025.120759_bib107","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1097\/WNR.0000000000001494","article-title":"miR-132-5p regulates apoptosis and autophagy in MPTP model of Parkinson's disease by targeting ULK1","volume":"31","author":"Zhao","year":"2020","journal-title":"Neuroreport"},{"key":"10.1016\/j.jep.2025.120759_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2020.104759","article-title":"Polygalae Radix: a review of its traditional uses, phytochemistry, pharmacology, toxicology, and pharmacokinetics","volume":"147","author":"Zhao","year":"2020","journal-title":"Fitoterapia"},{"issue":"11","key":"10.1016\/j.jep.2025.120759_bib109","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1089\/acm.2009.0101","article-title":"Therapeutic history of Parkinson's disease in Chinese medical treatises","volume":"15","author":"Zheng","year":"2009","journal-title":"J. Alternative Compl. Med."},{"key":"10.1016\/j.jep.2025.120759_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105197","article-title":"miR-103a-3p regulates mitophagy in Parkinson's disease through Parkin\/Ambra1 signaling","volume":"160","author":"Zhou","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"8","key":"10.1016\/j.jep.2025.120759_bib111","doi-asserted-by":"crossref","DOI":"10.3390\/cells8080911","article-title":"The therapeutic implications of tea polyphenols against dopamine (DA) neuron degeneration in Parkinson's disease (PD)","volume":"8","author":"Zhou","year":"2019","journal-title":"Cells"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125014515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125014515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:52:26Z","timestamp":1763704346000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125014515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":111,"alternative-id":["S0378874125014515"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120759","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polygalae Radix extracts show anti-Parkinson's disease effects and reduce depression-like symptoms by modulating energy metabolism","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120759","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120759"}}