{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:08:15Z","timestamp":1780600095698,"version":"3.54.1"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1-027-3(2024)"],"award-info":[{"award-number":["2021-I2M-1-027-3(2024)"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22207127"],"award-info":[{"award-number":["22207127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jep.2025.120769","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T23:00:38Z","timestamp":1761433238000},"page":"120769","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Exploring the mechanism of BuNao AnShen Capsules in the treatment of insomnia based on network pharmacology and experimental validation"],"prefix":"10.1016","volume":"356","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8908-7604","authenticated-orcid":false,"given":"Yang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Wei","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Nan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Bao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120769_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"issue":"2","key":"10.1016\/j.jep.2025.120769_bib2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41583-018-0098-9","article-title":"Exploring phylogeny to find the function of sleep","volume":"20","author":"Anafi","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.jep.2025.120769_bib3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1124\/pr.117.014381","article-title":"Drugs for insomnia beyond benzodiazepines: pharmacology, clinical applications, and discovery","volume":"70","author":"Atkin","year":"2018","journal-title":"Pharmacol. Rev."},{"issue":"9","key":"10.1016\/j.jep.2025.120769_bib4","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1037\/bul0000053","article-title":"Sleep and mental disorders: a meta-analysis of polysomnographic research","volume":"142","author":"Baglioni","year":"2016","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.jep.2025.120769_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.752211","article-title":"Mechanisms underlying the action of Ziziphi Spinosae Semen in the treatment of insomnia: a Study involving network pharmacology and experimental validation","volume":"12","author":"Bian","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.120769_bib6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.4103\/0974-8490.157957","article-title":"Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds","volume":"7","author":"Bounda","year":"2015","journal-title":"Pharmacogn. Res."},{"issue":"2","key":"10.1016\/j.jep.2025.120769_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/nu13020530","article-title":"Herbal remedies and their possible effect on the GABAergic system and sleep","volume":"13","author":"Bruni","year":"2021","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.jep.2025.120769_bib8","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/ijc.33552","article-title":"Chronic restraint stress promotes the mobilization and recruitment of Myeloid-Derived suppressor cells through \u03b2-adrenergic-activated CXCL5-CXCR2-Erk signaling cascades","volume":"149","author":"Cao","year":"2021","journal-title":"Int. J. Cancer"},{"issue":"3","key":"10.1016\/j.jep.2025.120769_bib9","first-page":"174","article-title":"Review about the mechanism of insomnia","volume":"3","author":"Cheng","year":"2016","journal-title":"World J. Sleep Med."},{"issue":"1","key":"10.1016\/j.jep.2025.120769_bib10","article-title":"The interaction of Suk-Saiyasna remedy with GABAA and CB1 receptor-targeting drugs: enhancing hypnotic and sedative effects in in vivo models","volume":"15","author":"Damjuti","year":"2024","journal-title":"J. Adv. Pharm. Technol. Research (JAPTR)\\\""},{"issue":"5","key":"10.1016\/j.jep.2025.120769_bib11","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.sleep.2010.02.002","article-title":"Cellular and chemical neuroscience of mammalian sleep","volume":"11","author":"Datta","year":"2010","journal-title":"Sleep Med."},{"issue":"3","key":"10.1016\/j.jep.2025.120769_bib12","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3390\/molecules24030418","article-title":"Quercetin and related chromenone derivatives as monoamine oxidase inhibitors: targeting neurological and mental disorders","volume":"24","author":"Dhiman","year":"2019","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.jep.2025.120769_bib13","first-page":"168","article-title":"Self-administered Phyto-acupressure for sleep disorders: a pilot study","volume":"11","author":"Doan","year":"2018","journal-title":"Int. J. Complement Alt. Med."},{"key":"10.1016\/j.jep.2025.120769_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112141","article-title":"Soporific effect of modified Suanzaoren Decoction on mice models of insomnia by regulating Orexin-A and HPA axis homeostasis","volume":"143","author":"Dong","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"8","key":"10.1016\/j.jep.2025.120769_bib15","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and Python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"issue":"7","key":"10.1016\/j.jep.2025.120769_bib16","first-page":"1440","article-title":"Research progress on the pharmacological mechanism of Semen ziziphi spinosae and its extract in treating insomnia","volume":"17","author":"Fang","year":"2024","journal-title":"Global Tradi. Chinese Med."},{"key":"10.1016\/j.jep.2025.120769_bib17","first-page":"1","article-title":"A network-based method for mechanistic investigation of Shexiang Baoxin Pill's treatment of cardiovascular diseases","volume":"7","author":"Fang","year":"2017","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.jep.2025.120769_bib18","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1002\/jcc.21478","volume":"31","author":"Fuhrmann","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jep.2025.120769_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2019.101215","article-title":"Insomnia and risk of mortality from all-cause, cardiovascular disease, and cancer: systematic review and meta-analysis of prospective cohort studies","volume":"48","author":"Ge","year":"2019","journal-title":"Sleep Med. Rev."},{"issue":"18","key":"10.1016\/j.jep.2025.120769_bib20","first-page":"1581","article-title":"A clinical observation on Danggui Liuhuang Decoction for 32 cases of menopausal insomnia","volume":"55","author":"Geng","year":"2014","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2025.120769_bib21","doi-asserted-by":"crossref","first-page":"7778","DOI":"10.1021\/jm100856p","article-title":"Novel spirotetracyclic zwitterionic dual H the treatment of sleep disorders","volume":"53","author":"Gianotti","year":"2010","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.jep.2025.120769_bib22","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s41398-019-0677-1","article-title":"A computationally inspired in-vivo approach identifies a link between amygdalar transcriptional heterogeneity, socialization and anxiety","volume":"9","author":"Goldman","year":"2019","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.jep.2025.120769_bib23","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41386-019-0431-7","article-title":"Sleep in the United States military","volume":"45","author":"Good","year":"2020","journal-title":"Neuropsychopharmacology"},{"issue":"6567","key":"10.1016\/j.jep.2025.120769_bib24","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1126\/science.abj8188","article-title":"The translational neuroscience of sleep: a contextual framework","volume":"374","author":"Grandner","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.jep.2025.120769_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2019.01185","article-title":"Integrating network pharmacology and pharmacological evaluation for deciphering the action mechanism of herbal formula Zuojin Pill in suppressing hepatocellular carcinoma","volume":"10","author":"Guo","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.jep.2025.120769_bib26","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.3390\/nu11081719","article-title":"Efficacy of Polygonatum sibiricum on mild insomnia: a randomized placebo-controlled trial","volume":"11","author":"Ha","year":"2019","journal-title":"Nutrients"},{"issue":"21","key":"10.1016\/j.jep.2025.120769_bib27","doi-asserted-by":"crossref","first-page":"10589","DOI":"10.1039\/D1FO01178B","article-title":"Targets and underlying mechanisms related to the sedative and hypnotic activities of saponins from Rhodiola rosea L. (Crassulaceae)","volume":"12","author":"Hao","year":"2021","journal-title":"Food Funct."},{"issue":"7","key":"10.1016\/j.jep.2025.120769_bib28","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.3390\/molecules25071587","article-title":"Sedative effects of latexes obtained from some Lactuca L. Species growing in Turkey","volume":"25","author":"Ilg\u00fcn","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.120769_bib29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nrn2576","article-title":"How (and why) the immune system makes us sleep","volume":"10","author":"Imeri","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jep.2025.120769_bib30","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ejphar.2015.06.037","article-title":"Ursolic acid enhances pentobarbital-induced sleeping behaviors via GABAergic neurotransmission in mice","volume":"762","author":"Jeon","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.120769_bib31","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5428\/pcar20110311","article-title":"Advances in research on pharmacological effects and clinical application of Ligustri Lucidi Fructus","volume":"11","author":"Jin","year":"2011","journal-title":"Pharmaceut. Care Res."},{"issue":"1","key":"10.1016\/j.jep.2025.120769_bib32","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s11325-020-02071-8","article-title":"Insomnia and type 2 diabetes mellitus: a risk assessment","volume":"25","author":"Kawada","year":"2021","journal-title":"Sleep Breath."},{"issue":"5","key":"10.1016\/j.jep.2025.120769_bib33","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1089\/jmf.2017.4064","article-title":"Natural products from single plants as sleep aids: a systematic review","volume":"21","author":"Kim","year":"2018","journal-title":"J. Med. Food"},{"issue":"11","key":"10.1016\/j.jep.2025.120769_bib34","doi-asserted-by":"crossref","first-page":"6629","DOI":"10.3390\/ijerph19116629","article-title":"The positive effects of Poria cocos extract on quality of sleep in Insomnia rat models","volume":"19","author":"Kim","year":"2022","journal-title":"Int. J. Environ. Res. Publ. Health"},{"issue":"32","key":"10.1016\/j.jep.2025.120769_bib35","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.2174\/138161208786549281","article-title":"The role of cytokines in sleep regulation","volume":"14","author":"Krueger","year":"2008","journal-title":"Curr. Pharm. Des."},{"issue":"1","key":"10.1016\/j.jep.2025.120769_bib36","doi-asserted-by":"crossref","first-page":"7427","DOI":"10.1038\/s41598-020-64218-7","article-title":"The effects of presleep slow breathing and music listening on polysomnographic sleep measures-a pilot trial","volume":"10","author":"Kuula","year":"2020","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.jep.2025.120769_bib37","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1111\/j.1471-4159.2005.03274.x","article-title":"Kainic acid-induced status epilepticus alters GABA receptor subunit mRNA and protein expression in the developing rat hippocampus","volume":"94","author":"Laur\u00e9n","year":"2005","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.jep.2025.120769_bib38","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.2217\/14622416.8.8.1063","article-title":"Characterization of the drugged human genome","volume":"8","author":"Lauss","year":"2007","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.jep.2025.120769_bib39","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.30640","article-title":"AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity","volume":"6","author":"Levenga","year":"2017","journal-title":"eLife"},{"issue":"8","key":"10.1016\/j.jep.2025.120769_bib40","first-page":"1193","article-title":"Research overview on chemical constituents and pharmacological effects of Eclipta prostrata","volume":"13","author":"Li","year":"2010","journal-title":"China Pharm."},{"key":"10.1016\/j.jep.2025.120769_bib41","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.176329","article-title":"Distinct glutamatergic projections of the posteroventral medial amygdala play different roles in arousal and anxiety","volume":"9","author":"Li","year":"2024","journal-title":"JCI Insight"},{"issue":"5","key":"10.1016\/j.jep.2025.120769_bib42","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyu110","article-title":"PI3K\/AKT\/mTOR signaling-mediated neuropeptide VGF in the hippocampus of mice is involved in the rapid onset antidepressant-like effects of GLYX-13","volume":"18","author":"Lu","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120769_bib43","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12906-020-03000-8","article-title":"Revealing the sedative-hypnotic effect of the extracts of herb pair Semen Ziziphi spinosae and Radix Polygalae and related mechanisms through experiments and metabolomics approach","volume":"20","author":"Luo","year":"2020","journal-title":"BMC Complement. Med. Ther."},{"issue":"14","key":"10.1016\/j.jep.2025.120769_bib44","first-page":"3952","article-title":"Evidence mapping of clinical studies on 23 commonly used Chinese patent medicines for treating insomnia","volume":"49","author":"Ma","year":"2024"},{"issue":"8","key":"10.1016\/j.jep.2025.120769_bib45","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/acs.jctc.5b00255","article-title":"ff14SB: improving the accuracy of protein side chain and backbone parameters from ff99SB","volume":"11","author":"Maier","year":"2015","journal-title":"J. Chem. Theor. Comput."},{"issue":"2","key":"10.1016\/j.jep.2025.120769_bib46","first-page":"264","article-title":"Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAA and GABA\u03c1 receptors","volume":"171","author":"Manuel","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2025.120769_bib47","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2174\/157340911795677602","article-title":"Molecular docking: a powerful approach for structure-based drug discovery","volume":"7","author":"Meng","year":"2011","journal-title":"Curr. Comput. Aided Drug Des."},{"key":"10.1016\/j.jep.2025.120769_bib48","first-page":"6611338","article-title":"Magnitude of poor sleep hygiene practice and associated factors among medical students in Ethiopia: a cross-sectional Study","volume":"15","author":"Molla","year":"2021","journal-title":"Sleep Disord"},{"key":"10.1016\/j.jep.2025.120769_bib49","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.smrv.2010.11.003","article-title":"Serotonin control of sleep-wake behavior","volume":"15","author":"Monti","year":"2011","journal-title":"Sleep Med. Rev."},{"issue":"2","key":"10.1016\/j.jep.2025.120769_bib50","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12160-011-9280-2","article-title":"Sleep and inflammation: psychoneuroimmunology in the context of cardiovascular disease","volume":"42","author":"Motivala","year":"2011","journal-title":"Ann. Behav. Med."},{"issue":"2","key":"10.1016\/j.jep.2025.120769_bib51","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0006-8993(71)90028-X","article-title":"The central metabolism of serotonin in the cat during insomnia. A neurophysiological and biochemical study after administration of P-chlorophenylalanine or destruction of the raphe system","volume":"29","author":"Pujol","year":"1971","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.jep.2025.120769_bib52","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s11655-020-3087-6","article-title":"Sedative and hypnotic effects and transcriptome analysis of Polygala tenuifolia in aged insomnia rats","volume":"26","author":"Ren","year":"2020","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2025.120769_bib53","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1177\/1753425910385962","article-title":"Immune alterations after selective rapid eye movement or total sleep deprivation in healthy male volunteers","volume":"18","author":"Ruiz","year":"2012","journal-title":"Innate Immun."},{"issue":"25","key":"10.1016\/j.jep.2025.120769_bib54","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1016\/j.cell.2023.10.025","article-title":"Prolonged sleep deprivation induces a cytokine storm-like syndrome in mammals","volume":"186","author":"Sang","year":"2023","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jep.2025.120769_bib55","first-page":"57","article-title":"Python: a programming Language for software integration and development","volume":"17","author":"Sanner","year":"1999","journal-title":"J. Mol. Graph. Model."},{"issue":"7063","key":"10.1016\/j.jep.2025.120769_bib56","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/nature04284","article-title":"Hypothalamic regulation of sleep and circadian rhythms","volume":"437","author":"Saper","year":"2005","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.jep.2025.120769_bib57","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1080\/07420528.2019.1647436","article-title":"Lipid peroxidation depends on the clock 3111T\/C gene polymorphism in menopausal women with Insomnia","volume":"36","author":"Semenova","year":"2019","journal-title":"Chronobiol. Int."},{"issue":"1","key":"10.1016\/j.jep.2025.120769_bib58","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jep.2009.02.027","article-title":"Transcriptomic analysis of EGb 761-regulated neuroactive receptor pathway in vivo","volume":"123","author":"Su","year":"2009","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2025.120769_bib59","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s11011-019-00499-w","article-title":"Shuangxia decoction alleviates p-chlorophenylalanine induced insomnia through the modification of serotonergic and immune system","volume":"35","author":"Sun","year":"2020","journal-title":"Metab. Brain Dis."},{"issue":"3","key":"10.1016\/j.jep.2025.120769_bib60","doi-asserted-by":"crossref","first-page":"Itc33","DOI":"10.7326\/AITC202103160","article-title":"Insomnia","volume":"174","author":"Sutton","year":"2021","journal-title":"Ann. Intern. Med."},{"issue":"2","key":"10.1016\/j.jep.2025.120769_bib62","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"9","key":"10.1016\/j.jep.2025.120769_bib63","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/jcc.20035","article-title":"Development and testing of a general amber force field","volume":"25","author":"Wang","year":"2004","journal-title":"J. Comput. Chem."},{"issue":"12","key":"10.1016\/j.jep.2025.120769_bib64","first-page":"93","article-title":"Study on the origin, evolution and modern pharmacological research of traditional Chinese medicine Compound Erzhi pill","volume":"19","author":"Wang","year":"2017","journal-title":"J. Liaoning Univ. TCM."},{"key":"10.1016\/j.jep.2025.120769_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/1418634","article-title":"Network pharmacology-based strategy to investigate pharmacological mechanisms of qiaoshao formula for treatment of premature ejaculation","volume":"2020","author":"Wang","year":"2020","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.jep.2025.120769_bib66","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1007\/s11325-020-02244-5","article-title":"Hypnotic activities of Zao Ren an Shen capsule, a traditional Chinese medicine, in an anxiety-like mouse model","volume":"25","author":"Wang","year":"2021","journal-title":"Sleep Breath."},{"issue":"17","key":"10.1016\/j.jep.2025.120769_bib67","first-page":"147","article-title":"Clinical effect of modified Suanzaoren decoction in the treatment of insomnia","volume":"7","author":"Wang","year":"2022","journal-title":"Clin. Res. Pract."},{"issue":"5","key":"10.1016\/j.jep.2025.120769_bib68","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/bcpt.13452","article-title":"Antidepressant effects of 3-(3,4-Methylenedioxy-5-Trifluoromethyl Phenyl)-2e-Propenoic acid isobutyl amide involve TSPO-Mediated mitophagy signalling pathway","volume":"127","author":"Wei","year":"2020","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"18","key":"10.1016\/j.jep.2025.120769_bib69","first-page":"44","article-title":"Experimental study on the sedative and hypnotic effects of Bunao Anshen capsule","volume":"3","author":"Xu","year":"2011","journal-title":"Clin. J. Chinese Med."},{"key":"10.1016\/j.jep.2025.120769_bib70","article-title":"Tian Wang Bu Xin Dan for insomnia: a systematic review of efficacy and safety","author":"Yang","year":"2019","journal-title":"Evid. Bas. Complement Alternat Med."},{"issue":"7","key":"10.1016\/j.jep.2025.120769_bib71","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3109\/13880200903280042","article-title":"Anxiolytic and sedative-hypnotic activities of polygalasaponins from Polygala tenuifolia in mice","volume":"48","author":"Yao","year":"2010","journal-title":"Pharm. Biol."},{"issue":"1","key":"10.1016\/j.jep.2025.120769_bib72","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-92913-6","article-title":"Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice","volume":"11","author":"Yao","year":"2021","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.jep.2025.120769_bib73","first-page":"15","article-title":"Study on sedative-hypnotic effect of Poria Cocos and Fushen water decoction","volume":"15","author":"You","year":"2013","journal-title":"J. Hubei Univ. Chin. Med."},{"key":"10.1016\/j.jep.2025.120769_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112212","article-title":"Improvement in mitochondrial function underlies the effects of ANNAO tablets on attenuating cerebral ischemia-reperfusion injuries","volume":"246","author":"Zhang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120769_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2019.104580","article-title":"Inhibition of JNK ameliorates depressive-like behaviors and reduces the activation of pro-inflammatory cytokines and the phosphorylation of glucocorticoid receptors at serine 246 induced by neuroinflammation","volume":"113","author":"Zhang","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jep.2025.120769_bib76","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.nbd.2014.04.008","article-title":"Maternal sleep deprivation inhibits hippocampal neurogenesis associated with inflammatory response in young offspring rats","volume":"68","author":"Zhao","year":"2014","journal-title":"Neurobiol. Dis."},{"issue":"11","key":"10.1016\/j.jep.2025.120769_bib77","first-page":"147","article-title":"Regulatory effect of Polygala tenuifolia and licorice-simmered P. tenuifolia on learning and memory, HPA axis function and neurotransmitters in rats with heart-kidney imbalance insomnia","volume":"27","author":"Zhao","year":"2021","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"18","key":"10.1016\/j.jep.2025.120769_bib78","first-page":"2295","article-title":"Research progress of the classic prescription Tianwang buxin dan in the treatment of insomnia","volume":"33","author":"Zhao","year":"2022","journal-title":"China Pharm."},{"key":"10.1016\/j.jep.2025.120769_bib79","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/s12906-019-2732-0","article-title":"Sedative and hypnotic effects of compound Anshen essential oil inhalation for insomnia","volume":"19","author":"Zhong","year":"2019","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2025.120769_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113627","article-title":"Sedative and hypnotic effects of Perilla frutescens essential oil through GABAergic system pathway","volume":"279","author":"Zhong","year":"2021","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125014618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125014618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:43:09Z","timestamp":1763703789000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125014618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":79,"alternative-id":["S0378874125014618"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120769","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the mechanism of BuNao AnShen Capsules in the treatment of insomnia based on network pharmacology and experimental validation","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120769","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120769"}}