{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:04:20Z","timestamp":1785161060525,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A04J5398"],"award-info":[{"award-number":["2025A04J5398"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jep.2025.120772","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:46:20Z","timestamp":1761201980000},"page":"120772","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Qizhiweitong granule alleviates diarrhea-predominant irritable bowel syndrome via inhibition of the IL-6\/Src\/STAT3 feedback loop"],"prefix":"10.1016","volume":"356","author":[{"given":"Qing","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangyu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zerong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5565-9214","authenticated-orcid":false,"given":"Tao","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqiu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jep.2025.120772_bib1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4314\/ajtcam.v11i4.7","article-title":"Laxative activities of Cassia sieberiana and Senna obtusifolia","volume":"11","author":"Ajayi","year":"2014","journal-title":"Afr. J. Tradit., Complementary Altern. Med."},{"issue":"5","key":"10.1016\/j.jep.2025.120772_bib2","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1053\/gast.2000.19576","article-title":"A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development","volume":"119","author":"Al-Chaer","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2025.120772_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109130","article-title":"Interleukin-6 cytokine: an overview of the immune regulation, immune dysregulation, and therapeutic approach","volume":"111","author":"Aliyu","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.jep.2025.120772_bib4","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1111\/jgh.13642","article-title":"Comparison of the Rome IV and Rome III criteria for IBS diagnosis: a cross-sectional survey","volume":"32","author":"Bai","year":"2017","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2025.120772_bib5","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.ijbiomac.2022.11.243","article-title":"Soluble dietary fiber and cellulose from Saccharina japonica by-product ameliorate Loperamide-induced constipation via modulating enteric neurotransmitters, short-chain fatty acids and gut microbiota","volume":"226","author":"Cao","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"Pt 3","key":"10.1016\/j.jep.2025.120772_bib6","article-title":"Qi-Zhi-Wei-Tong granules alleviates chronic non-atrophic gastritis in mice by altering the gut microbiota and bile acid metabolism","volume":"319","author":"Chen","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120772_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119337","article-title":"Glycyrrhizic acid reduces neutrophil extracellular trap formation to ameliorate colitis-associated colorectal cancer by inhibiting peptidylarginine deiminase 4","volume":"341","author":"Chen","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120772_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2024.117852","article-title":"Artificial intelligence in metabolomics: a Current review","volume":"178","author":"Chi","year":"2024","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.jep.2025.120772_bib9","article-title":"Research progress of Chaihu Shugan powder in gastrointestinal diseases","volume":"16","author":"Chun","year":"2024","journal-title":"Clin. J. Chin. Med."},{"issue":"13","key":"10.1016\/j.jep.2025.120772_bib10","doi-asserted-by":"crossref","first-page":"8884","DOI":"10.1021\/acs.jmedchem.1c00629","article-title":"Recent update on development of small-molecule STAT3 inhibitors for cancer therapy: from phosphorylation inhibition to protein degradation","volume":"64","author":"Dong","year":"2021","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.jep.2025.120772_bib11","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s00795-013-0055-7","article-title":"Diamine oxidase as a marker of intestinal mucosal injury and the effect of soluble dietary fiber on gastrointestinal tract toxicity after intravenous 5-fluorouracil treatment in rats","volume":"47","author":"Fukudome","year":"2014","journal-title":"Med. Mol. Morphol."},{"issue":"20","key":"10.1016\/j.jep.2025.120772_bib12","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1038\/sj.onc.1204349","article-title":"Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells","volume":"20","author":"Garcia","year":"2001","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.jep.2025.120772_bib13","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.3390\/biomedicines9081016","article-title":"Targeting STAT3 signaling pathway in colorectal cancer","volume":"9","author":"Gargalionis","year":"2021","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.jep.2025.120772_bib14","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1053\/j.gastro.2006.11.002","article-title":"The serotonin signaling system: from basic understanding to drug development for functional GI disorders","volume":"132","author":"Gershon","year":"2007","journal-title":"Gastroenterology"},{"issue":"26","key":"10.1016\/j.jep.2025.120772_bib15","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.3748\/wjg.v29.i26.4120","article-title":"Irritable bowel syndrome: epidemiology, overlap disorders, pathophysiology and treatment","volume":"29","author":"Huang","year":"2023","journal-title":"World J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.jep.2025.120772_bib16","doi-asserted-by":"crossref","first-page":"163","DOI":"10.5056\/jnm16043","article-title":"Irritable bowel syndrome: is it really a functional disorder? A new perspective on alteration of enteric nervous System","volume":"22","author":"Jahng","year":"2016","journal-title":"J. Neurogastroenterol Motil."},{"issue":"8","key":"10.1016\/j.jep.2025.120772_bib17","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/apt.14948","article-title":"Review article: an analysis of safety profiles of treatments for diarrhoea-predominant irritable bowel syndrome","volume":"48","author":"Lacy","year":"2018","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"10","key":"10.1016\/j.jep.2025.120772_bib18","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1111\/jgh.15981","article-title":"Ameliorating effects of electroacupuncture on the low-grade intestinal inflammation in rat model of diarrhea-predominant irritable bowel syndrome","volume":"37","author":"Li","year":"2022","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"8","key":"10.1016\/j.jep.2025.120772_bib19","first-page":"66","article-title":"Clinical observation of 40 cases of irritable bowel syndrome treated with Qizhiweitong granule","volume":"24","author":"Liu","year":"2015","journal-title":"Chin. J. Ethnomed. Ethnopharmacy"},{"issue":"3","key":"10.1016\/j.jep.2025.120772_bib20","first-page":"257","article-title":"Understanding traditional Chinese medicine therapeutics: an overview of the basics and clinical applications","volume":"9","author":"Matos","year":"2021","journal-title":"Health Care"},{"issue":"Suppl. 1: s3\u2013105","key":"10.1016\/j.jep.2025.120772_bib21","first-page":"s15","article-title":"The role of the gut Microbiota in bile acid metabolism","volume":"16","author":"Ram\u00edrez-P\u00e9rez","year":"2017","journal-title":"Ann. Hepatol."},{"issue":"4","key":"10.1016\/j.jep.2025.120772_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70152","article-title":"STAT3 signaling pathway in health and disease","volume":"6","author":"Samad","year":"2025","journal-title":"MedComm"},{"issue":"2","key":"10.1016\/j.jep.2025.120772_bib23","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3390\/biomedicines10020289","article-title":"Implication of intestinal barrier dysfunction in gut dysbiosis and diseases","volume":"10","author":"Stolfi","year":"2022","journal-title":"Biomedicines"},{"issue":"13","key":"10.1016\/j.jep.2025.120772_bib24","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.4103\/0366-6999.235118","article-title":"A randomized, Double-Blind, multicenter, placebo-controlled trial of qi-zhi-wei-tong granules on postprandial distress syndrome-predominant functional dyspepsia","volume":"131","author":"Su","year":"2018","journal-title":"Chin. Med. J. (Engl)"},{"key":"10.1016\/j.jep.2025.120772_bib25","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6679348","article-title":"Tongxie anchang decoction relieves visceral hypersensitivity in diarrhea-predominant irritable bowel syndrome rats by regulating the NGF\/TrkA signaling pathway","volume":"2021","author":"Tan","year":"2021","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"10.1016\/j.jep.2025.120772_bib26","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.csbj.2020.02.018","article-title":"Neuropeptides in gut-brain axis and their influence on host immunity and stress","volume":"18","author":"Wei","year":"2020","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"10","key":"10.1016\/j.jep.2025.120772_bib27","first-page":"1513","article-title":"Clinical observation of 40 cases of irritable bowel syndrome treated with Qizhiweitong granules","volume":"38","author":"Yao","year":"2013","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2025.120772_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118236","article-title":"Chang-Kang-Fang alleviates diarrhea predominant irritable bowel syndrome (IBS-D) through inhibiting TLR4\/NF-\u03baB\/NLRP3 pathway","volume":"330","author":"Zhang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120772_bib30","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.neuroscience.2019.07.020","article-title":"Colivelin rescues ischemic Neuron and axons involving JAK\/STAT3 signaling pathway","volume":"416","author":"Zhao","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.jep.2025.120772_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115601","article-title":"Co-existing polysaccharides affect the systemic exposure of major bioactive ingredients in Chang-Kang-Fang, a multi-herb prescription for treatment of irritable bowel syndrome","volume":"298","author":"Zhong","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120772_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119457","article-title":"Anti-inflammatory and immunomodulatory effects of Glycyrrhiza uralensis fisch. On ulcerative colitis in rats: role of nucleotide-binding oligomerization domain 2\/receptor-interacting protein 2\/nuclear factor-kappa B signaling pathway","volume":"344","author":"Zhong","year":"2025","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125014643?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125014643?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:51:31Z","timestamp":1773870691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125014643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":31,"alternative-id":["S0378874125014643"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120772","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Qizhiweitong granule alleviates diarrhea-predominant irritable bowel syndrome via inhibition of the IL-6\/Src\/STAT3 feedback loop","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120772","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120772"}}