{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:46:56Z","timestamp":1787795216607,"version":"build-2784847793"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y2023206"],"award-info":[{"award-number":["Y2023206"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["KYYW202406"],"award-info":[{"award-number":["KYYW202406"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["QTJ23033"],"award-info":[{"award-number":["QTJ23033"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404862"],"award-info":[{"award-number":["82404862"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204608"],"award-info":[{"award-number":["82204608"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jep.2025.120825","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:56:12Z","timestamp":1761785772000},"page":"120825","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Acori Tatarinowii Rhizoma-Curcumae Radix Herbal pair ameliorates depression by regulating microglia M1\/M2 polarization via TLR4\/MyD88\/NF-\u03baB pathway"],"prefix":"10.1016","volume":"356","author":[{"given":"Jianwei","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yewen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoxi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangxiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongcheng","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoru","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120825_bib1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.immuni.2016.02.013","article-title":"Microglial physiology and pathophysiology: insights from genome-wide transcriptional profiling","volume":"44","author":"Andrea","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.jep.2025.120825_bib2","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/jpp\/rgab126","article-title":"Curcumae radix: a review of its botany, traditional uses, phytochemistry, pharmacology and toxicology","volume":"74","author":"Ao","year":"2022","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2025.120825_bib3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jpsychires.2021.02.006","article-title":"The effectiveness of continuous and interval exercise preconditioning against chronic unpredictable stress: involvement of hippocampal PGC-1\u03b1\/FNDC5\/BDNF pathway","volume":"136","author":"Babaei","year":"2021","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jep.2025.120825_bib4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3390\/antiox11020281","article-title":"Molecular mechanisms and therapeutic potential of \u03b1- and \u03b2-Asarone in the treatment of neurological disorders","volume":"11","author":"Balakrishnan","year":"2022","journal-title":"Antioxidants-Basel"},{"key":"10.1016\/j.jep.2025.120825_bib5","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1126\/science.1120972","article-title":"Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress","volume":"311","author":"Berton","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jep.2025.120825_bib6","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/824919","article-title":"CD14 mediates binding of high doses of LPS but is dispensable for TNF-\u03b1 production","volume":"2013","author":"Borz\u0119cka","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jep.2025.120825_bib7","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1177\/1352458520979304","article-title":"Depression in multiple sclerosis across the adult lifespan","volume":"27","author":"Chan","year":"2021","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jep.2025.120825_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107843","article-title":"Alpha-asarone improves cognitive function of aged rats by alleviating neuronal excitotoxicity via GABA receptors","volume":"162","author":"Chen","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jep.2025.120825_bib9","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00018-020-03656-y","article-title":"TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling","volume":"78","author":"Ciesielska","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jep.2025.120825_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155726","article-title":"\u03b2-Caryophyllene promotes the survival of random skin flaps by upregulating the PI3K\/AKT signaling pathway","volume":"130","author":"Deng","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2025.120825_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-020-0808-8","article-title":"Reduction of depression-like behavior in rat model induced by ShRNA targeting norepinephrine transporter in locus coeruleus","volume":"10","author":"Du","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jep.2025.120825_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154363","article-title":"Alpha-asarone ameliorates neurological deterioration of intracerebral hemorrhagic rats by alleviating secondary brain injury via anti-excitotoxicity pathways","volume":"105","author":"Gao","year":"2022","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.jep.2025.120825_bib13","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/acel.12322","article-title":"Relation between TLR4\/NF-\u03baB signaling pathway activation by 27-hydroxycholesterol and 4-hydroxynonenal, and atherosclerotic plaque instability","volume":"14","author":"Gargiulo","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.jep.2025.120825_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.690371","article-title":"Hydrogen sulfide ameliorates angiotensin II-Induced atrial fibrosis progression to atrial fibrillation through inhibition of the warburg effect and endoplasmic reticulum stress","volume":"12","author":"Hu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120825_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119705","article-title":"Inhalation of Acori Tatarinowii Rhizoma essential oil alleviates dyskinesia in Parkinson\u2019s disease rats through the regulation of neuroinflammation","volume":"348","author":"Hu","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2025.120825_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2025.153118","article-title":"Changpu Yujin Tang mitigates Tourette syndrome by enhancing mitophagy and suppressing NLRP3 inflammasome-mediated pyroptosis","volume":"230","author":"Huang","year":"2025","journal-title":"Immunobiology"},{"issue":"1","key":"10.1016\/j.jep.2025.120825_bib17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s40744-017-0058-2","article-title":"Depression risk in patients with rheumatoid arthritis in the United Kingdom","volume":"4","author":"Jacob","year":"2017","journal-title":"Rheumatol. Ther."},{"issue":"1","key":"10.1016\/j.jep.2025.120825_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11481-025-10202-9","article-title":"(+)-Catechin alleviates CCI-induced neuropathic pain by modulating Microglia M1 and M2 polarization via the TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"20","author":"Jing","year":"2025","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.jep.2025.120825_bib19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13020-016-0113-x","article-title":"Authentication of Acori Tatarinowii Rhizoma (Shi Chang Pu) and its adulterants by morphological distinction, chemical composition and ITS sequencing","volume":"11","author":"Lam","year":"2016","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2025.120825_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155635","article-title":"Curcumin-primed olfactory mucosa-derived mesenchymal stem cells mitigate cerebral ischemia\/reperfusion injury-induced neuronal PANoptosis by modulating microglial polarization","volume":"129","author":"Lan","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2025.120825_bib21","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12974-017-0964-9","article-title":"Lentivirus-mediated interleukin-1beta (IL-1beta) knock-down in the hippocampus alleviates lipopolysaccharide (LPS)-induced memory deficits and anxiety- and depression-like behaviors in mice","volume":"14","author":"Li","year":"2017","journal-title":"J. Neuroinflammation"},{"issue":"9","key":"10.1016\/j.jep.2025.120825_bib22","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.3390\/ijms26093964","article-title":"Paeonol relieves chronic neuropathic pain by reducing communication between schwann cells and macrophages in the dorsal root ganglia after injury","volume":"26","author":"Li","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"9524","key":"10.1016\/j.jep.2025.120825_bib23","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/S0140-6736(06)68770-9","article-title":"Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data","volume":"367","author":"Lopez","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2025.120825_bib24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.pneurobio.2016.01.005","article-title":"The biphasic function of microglia in ischemic stroke","volume":"157","author":"Ma","year":"2017","journal-title":"Prog. Neurobiol."},{"issue":"5","key":"10.1016\/j.jep.2025.120825_bib25","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/acel.12356","article-title":"A herbal medicine for Alzheimer\u2019s disease and its active constituents promote neural progenitor proliferation","volume":"14","author":"Mao","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.jep.2025.120825_bib26","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1146\/annurev-clinpsy-072220-021440","article-title":"Major depression and its recurrences: life course matters","volume":"18","author":"Monroe","year":"2022","journal-title":"Annu. Rev. Clin. Psychol."},{"issue":"12","key":"10.1016\/j.jep.2025.120825_bib27","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.3390\/ph7121028","article-title":"Role of microglial M1\/M2 polarization in relapse and remission of psychiatric disorders and diseases","volume":"7","author":"Nakagawa","year":"2014","journal-title":"Pharmaceuticals"},{"issue":"7","key":"10.1016\/j.jep.2025.120825_bib28","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.cell.2013.11.030","article-title":"Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor","volume":"155","author":"Parkhurst","year":"2013","journal-title":"Cell"},{"issue":"23","key":"10.1016\/j.jep.2025.120825_bib29","first-page":"2279","article-title":"Depression in the primary care setting","volume":"380","author":"Pies","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2025.120825_bib30","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev-immunol-093019-110159","article-title":"Microglia and central nervous system-associated macrophages-from origin to disease modulation","volume":"39","author":"Prinz","year":"2021","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jep.2025.120825_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156482","article-title":"Curcuma wenyujin extract alleviates cognitive deficits and restrains pyroptosis through PINK1\/Parkin mediated autophagy in Alzheimer\u2019s disease","volume":"139","author":"Qi","year":"2025","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.jep.2025.120825_bib32","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1001\/jamapsychiatry.2014.2427","article-title":"Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes","volume":"72","author":"Setiawan","year":"2015","journal-title":"JAMA Psychiatry"},{"issue":"7526","key":"10.1016\/j.jep.2025.120825_bib33","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/515180a","article-title":"Mental health: a world of depression","volume":"515","author":"Smith","year":"2014","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.jep.2025.120825_bib34","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jpsychires.2006.10.013","article-title":"Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide","volume":"42","author":"Steiner","year":"2008","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.jep.2025.120825_bib35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bbi.2014.05.007","article-title":"Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides","volume":"42","author":"Torres-Platas","year":"2014","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.jep.2025.120825_bib36","doi-asserted-by":"crossref","DOI":"10.1111\/ejn.14720","article-title":"Neuroinflammation and depression: a review","author":"Troubat","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.jep.2025.120825_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155929","article-title":"Schisandra chinensis lignans regulate and cooperate with endogenous cannabinoid systems to ameliorate intestinal barrier injury associated with depression","volume":"133","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120825_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122282","article-title":"TrkB\/BDNF signaling pathway and its small molecular agonists in CNS injury","volume":"336","author":"Wang","year":"2024","journal-title":"Life Sci."},{"issue":"8","key":"10.1016\/j.jep.2025.120825_bib39","doi-asserted-by":"crossref","first-page":"43","DOI":"10.53388\/TMR20230116001","article-title":"Kai-Xin-San regulates synaptic plasticity through calcium signaling to alleviate symptoms of depression-like behavioral disorders in mice","volume":"8","author":"Wu","year":"2023","journal-title":"Trad. Med. Res."},{"key":"10.1016\/j.jep.2025.120825_bib40","article-title":"TLR4 cross-talk with NLRP3 inflammasome and complement signaling pathways in Alzheimer\u2019s Disease","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.jep.2025.120825_bib41","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.tins.2015.08.001","article-title":"Depression as a microglial disease","volume":"38","author":"Yirmiya","year":"2015","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jep.2025.120825_bib42","article-title":"Danggui Sini Decoction normalizes the intestinal microbiota and serum metabolite levels to treat sciatica","volume":"132","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2025.120825_bib43","article-title":"Germacrone protects against oxygen-glucose deprivation\/reperfusion injury by inhibiting autophagy processes in PC12 cells","volume":"20","author":"Zhang","year":"2020","journal-title":"Bmc Compl. Med."},{"issue":"8","key":"10.1016\/j.jep.2025.120825_bib44","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyv006","article-title":"NLRP3 inflammasome mediates chronic mild stress-induced depression in mice via neuroinflammation","volume":"18","author":"Zhang","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412501517X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412501517X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T23:32:18Z","timestamp":1776123138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412501517X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":44,"alternative-id":["S037887412501517X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120825","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acori Tatarinowii Rhizoma-Curcumae Radix Herbal pair ameliorates depression by regulating microglia M1\/M2 polarization via TLR4\/MyD88\/NF-\u03baB pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120825","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120825"}}