{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:15:55Z","timestamp":1790093755756,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jep.2025.120845","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T16:01:23Z","timestamp":1762012883000},"page":"120845","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Anti-metastatic and anti-tumor effects of the ethyl acetate fraction of Ajwa dates (Phoenix dactylifera L.) in prostate cancer models and its UPLC-based phytochemical profiling"],"prefix":"10.1016","volume":"356","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3335-5794","authenticated-orcid":false,"given":"Mirza Muqtadir","family":"Baig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Fareeduddin","family":"Quadri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulkadir Kurban","family":"Nur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furkhan Ahmed","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syeda Hajera","family":"Begum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heeba Mohammed","family":"Shafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huda Mohammad","family":"Shafiuddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman I.","family":"Elkady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleem Ahmed","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120845_bib1","first-page":"689","article-title":"Traditional medicinal plants research in Egypt: studies of antioxidant and anticancer activities","volume":"6","author":"Aboul-Enein","year":"2012","journal-title":"J. Med. Plants Res."},{"key":"10.1016\/j.jep.2025.120845_bib2","first-page":"205","article-title":"Knowledge, attitude, and practice toward prostate cancer and its screening methods in qassim region","volume":"363","author":"Altwairgi","year":"2025","journal-title":"Georgian Med. News"},{"key":"10.1016\/j.jep.2025.120845_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2014.00020","article-title":"Cancer wars: natural products strike back","author":"Basmadjian","year":"2014","journal-title":"Front. Chem."},{"key":"10.1016\/j.jep.2025.120845_bib4","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.4161\/cc.9.14.12371","article-title":"Mammosphere-forming cells from breast cancer cell lines as a tool for the identification of CSC-like- and early progenitor-targeting drugs","volume":"9","author":"Cioce","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jep.2025.120845_bib5","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1016\/j.bbagen.2013.02.008","article-title":"Natural products: a continuing source of novel","volume":"1830","author":"Cragg","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.jep.2025.120845_bib6","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.coph.2010.06.012","article-title":"The challenge of selecting the 'right' in vivo oncology pharmacology model","volume":"10","author":"Firestone","year":"2010","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.jep.2025.120845_bib7","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.2147\/DDDT.S138320","article-title":"Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition","volume":"11","author":"Gao","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.jep.2025.120845_bib8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/mc.22260","article-title":"Morusin inhibits glioblastoma stem cell growth in vitro and in vivo through stemness attenuation, adipocyte transdifferentiation, and apoptosis induction","volume":"55","author":"Guo","year":"2016","journal-title":"Mol. Carcinog."},{"issue":"4","key":"10.1016\/j.jep.2025.120845_bib9","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.dental.2015.01.007","article-title":"Cytotoxicity of dimethyl sulfoxide (DMSO) in direct contact with odontoblast-like cells","volume":"31","author":"Hebling","year":"2015","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jep.2025.120845_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10051076","article-title":"Potential and therapeutic roles of diosmin in human diseases","author":"Huwait","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.jep.2025.120845_bib11","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/emmm.201202367","article-title":"Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2\/CCR2-induced STAT3 activation","volume":"5","author":"Izumi","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.jep.2025.120845_bib12","first-page":"7177","article-title":"An improved and versatile immunosuppression protocol for the development of tumor xenograft in mice","volume":"34","author":"Jivrajani","year":"2014","journal-title":"Anticancer Res."},{"key":"10.1016\/j.jep.2025.120845_bib13","article-title":"AC SC","author":"Khalid","year":"2017","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.jep.2025.120845_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2015.06.013","article-title":"Cancer stem cells: a challenging paradigm for designing targeted drug therapies","author":"Khan","year":"2015","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jep.2025.120845_bib15","article-title":"Tumorsphere as an effective in vitro platform for screening anticancer stem cell drugs","volume":"7","author":"Lee","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jep.2025.120845_bib16","series-title":"Dates: Production, Processing, Food, and Medicinal Values","author":"Manickavasagan","year":"2012"},{"key":"10.1016\/j.jep.2025.120845_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/nature17038","article-title":"Metastatic colonization by circulating tumour cells","author":"Massagu\u00e9","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jep.2025.120845_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/stem.774","article-title":"Concise review: cancer stem cells: in vitro models","author":"Mather","year":"2012","journal-title":"Stem Cell."},{"key":"10.1016\/j.jep.2025.120845_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2018.02.030","article-title":"Induction of apoptosis and cell cycle arrest by ethyl acetate fraction of phoenix dactylifera L. (Ajwa dates) in prostate cancer cells","author":"Mirza","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120845_bib20","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nprot.2007.25","article-title":"Establishment of human tumor xenografts in immunodeficient mice","volume":"2","author":"Morton","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jep.2025.120845_bib21","doi-asserted-by":"crossref","DOI":"10.1021\/np200906s","article-title":"Natural products as sources of new drugs over the 30 years from 1981 to 2010","author":"Newman","year":"2012","journal-title":"J. Nat. Prod."},{"issue":"43","key":"10.1016\/j.jep.2025.120845_bib22","doi-asserted-by":"crossref","first-page":"36529","DOI":"10.1074\/jbc.M503111200","article-title":"RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo","volume":"280","author":"Pulukuri","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2025.120845_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2012.03.009","article-title":"The PSA-\/lo prostate cancer cell population harbors self-renewing long-term tumor-propagating cells that resist castration","volume":"10","author":"Qin","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jep.2025.120845_bib24","first-page":"483","article-title":"Therapeutic effects of date fruits (Phoenix dactylifera) in the prevention of diseases via modulation of anti-inflammatory, anti-oxidant and anti-tumour activity","volume":"7","author":"Rahmani","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.jep.2025.120845_bib25","article-title":"Anticancer properties of hydroxycinnamic acids -A review","volume":"1","author":"Rocha","year":"2012","journal-title":"Cancer Clin. Oncol."},{"key":"10.1016\/j.jep.2025.120845_bib36","series-title":"World\u202fChecklist\u202fof\u202fSelected\u202fPlant\u202fFamilies (WCSP)","year":"2012"},{"key":"10.1016\/j.jep.2025.120845_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.semcancer.2017.03.009","article-title":"Cellular determinants and microenvironmental regulation of prostate cancer metastasis","author":"Rycaj","year":"2017","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.jep.2025.120845_bib27","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3892\/ol.2012.1090","article-title":"Isolation and enrichment of PC-3 prostate cancer stem-like cells using MACS and serum-free medium","volume":"5","author":"Sheng","year":"2013","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jep.2025.120845_bib28","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jep.2025.120845_bib29","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ymeth.2005.08.001","article-title":"Cell migration and invasion assays","volume":"37","author":"Valster","year":"2005","journal-title":"Methods"},{"key":"10.1016\/j.jep.2025.120845_bib30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-1-61779-080-5_20","article-title":"Cell sensitivity assays: the MTT assay","volume":"731","author":"Van Meerloo","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jep.2025.120845_bib31","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11010-013-1621-y","article-title":"Morusin inhibits human cervical cancer stem cell growth and migration through attenuation of NF-\u03baB activity and apoptosis induction","volume":"379","author":"Wang","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.jep.2025.120845_bib32","article-title":"Structures, sources, identification\/quantification methods, health benefits, bioaccessibility, and products of Isorhamnetin glycosides as phytonutrients","volume":"15","author":"Wang","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2025.120845_bib33","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrc4016","article-title":"Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer","volume":"15","author":"Watson","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jep.2025.120845_bib34","first-page":"1","article-title":"Doxycycline induces apoptosis and inhibits proliferation and invasion of human cervical carcinoma stem cells","volume":"10","author":"Yang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2025.120845_bib35","article-title":"The therapeutic potential of epigallocatechin-3-gallate against human oral squamous cell carcinoma through inhibition of cell proliferation and induction of apoptosis: in vitro and in vivo murine xenograft study","volume":"20","author":"Yoshimura","year":"2019","journal-title":"Mol. Med. Rep."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125015375?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125015375?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:46:57Z","timestamp":1763704017000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125015375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":36,"alternative-id":["S0378874125015375"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120845","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-metastatic and anti-tumor effects of the ethyl acetate fraction of Ajwa dates (Phoenix dactylifera L.) in prostate cancer models and its UPLC-based phytochemical profiling","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120845","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120845"}}