{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T14:26:57Z","timestamp":1793629617174,"version":"4.5.1"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2023A03J0345"],"award-info":[{"award-number":["2023A03J0345"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574773"],"award-info":[{"award-number":["82574773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010842","name":"Guangzhou Municipal Health Commission","doi-asserted-by":"publisher","award":["20222A010043"],"award-info":[{"award-number":["20222A010043"]}],"id":[{"id":"10.13039\/501100010842","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010842","name":"Guangzhou Municipal Health Commission","doi-asserted-by":"publisher","award":["2023\\u30112318"],"award-info":[{"award-number":["2023\\u30112318"]}],"id":[{"id":"10.13039\/501100010842","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jep.2025.120855","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:45:58Z","timestamp":1762253158000},"page":"120855","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Lifei Qingchang Granules alleviate airway inflammation in a mouse model of bronchiectasis by inhibiting neutrophil extracellular traps"],"prefix":"10.1016","volume":"356","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0534-4112","authenticated-orcid":false,"given":"Hu","family":"Yuanlong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"wanyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng","family":"Jiamin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao","family":"Shangke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du","family":"Yingsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Shiting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Zhiming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Qifen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Zhijuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Xinghua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Shouxie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhenqiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Dapeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wenju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Zhimin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120855_bib1","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.chest.2016.10.055","article-title":"Adult patients with bronchiectasis: a first look at the US bronchiectasis research registry","volume":"151","author":"Aksamit","year":"2017","journal-title":"Chest"},{"key":"10.1016\/j.jep.2025.120855_bib2","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.chest.2016.10.055","article-title":"Adult patients with bronchiectasis: a first look at the US bronchiectasis research registry","volume":"151","author":"Aksamit","year":"2017","journal-title":"Chest"},{"key":"10.1016\/j.jep.2025.120855_bib3","doi-asserted-by":"crossref","first-page":"5180","DOI":"10.1021\/acs.jafc.4c06704","article-title":"Luteolin mitigates acute lung injury through immune modulation and antinecroptosis effects by targeting the BTK and FLT3 signaling pathways","volume":"73","author":"Cao","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2025.120855_bib4","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1182\/blood-2018-11-844530","article-title":"Neutrophils and NETs in modulating acute and chronic inflammation","volume":"133","author":"Castanheira","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.jep.2025.120855_bib5","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01126-2025","article-title":"European respiratory society clinical practice guideline for the management of adult bronchiectasis","author":"Chalmers","year":"2025","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jep.2025.120855_bib6","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S2213-2600(23)00093-0","article-title":"Bronchiectasis in Europe: data on disease characteristics from the European bronchiectasis registry (EMBARC)","volume":"11","author":"Chalmers","year":"2023","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.jep.2025.120855_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154057","article-title":"Treatment with JianPiYiFei II granules for patients with moderate to very severe chronic obstructive pulmonary disease: a 52-week randomised, double-blinded, placebo-controlled, multicentre trial","volume":"100","author":"Chen","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120855_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156283","article-title":"Qingke Pingchuan granules alleviate airway inflammation in COPD exacerbation by inhibiting neutrophil extracellular traps in mice","volume":"136","author":"Cheng","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120855_bib9","doi-asserted-by":"crossref","first-page":"W357","DOI":"10.1093\/nar\/gkz382","article-title":"SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2025.120855_bib10","doi-asserted-by":"crossref","first-page":"13384","DOI":"10.3390\/molecules200713384","article-title":"Molecular docking and structure-based drug design strategies","volume":"20","author":"Ferreira","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.120855_bib11","series-title":"Ferritin-mediated neutrophil extracellular traps formation and cytokine storm via macrophage scavenger receptor in sepsis-associated lung injury","year":"2024"},{"key":"10.1016\/j.jep.2025.120855_bib12","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1513\/AnnalsATS.201506-333OC","article-title":"A comprehensive analysis of the impact of Pseudomonas aeruginosa colonization on prognosis in adult bronchiectasis","volume":"12","author":"Finch","year":"2015","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.jep.2025.120855_bib13","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S0140-6736(18)31767-7","article-title":"Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity","volume":"392","author":"Flume","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2025.120855_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156663","article-title":"Luteolin inhibits inflammation and M1 macrophage polarization in the treatment of pseudomonas aeruginosa-induced acute pneumonia through suppressing EGFR\/PI3K\/AKT\/NF-\u03baB and EGFR\/ERK\/AP-1 signaling pathways","volume":"141","author":"Gu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120855_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/1759-7714.70040","article-title":"Diosmetin inhibits NETs formation in neutrophils through regulating Nrf2 signaling","volume":"16","author":"Guo","year":"2025","journal-title":"Thorac. Cancer"},{"key":"10.1016\/j.jep.2025.120855_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114654","article-title":"Luteolin attenuates lipopolysaccharide-induced acute lung injury\/acute respiratory distress syndrome by activating alveolar epithelial sodium channels via cGMP\/PI3K pathway","volume":"282","author":"Hou","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120855_bib17","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.1016\/j.apsb.2021.10.008","article-title":"Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation","volume":"12","author":"Hu","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jep.2025.120855_bib18","first-page":"1","article-title":"Lifei Qingchang Tang attenuates acute lung injury via the NF-\u03baB and MAPK signaling pathways","author":"Huang","year":"2025","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.jep.2025.120855_bib19","first-page":"1","article-title":"Lifei Qingchang Tang attenuates acute lung injury via the NF-\u03baB and MAPK signaling pathways","author":"Huang","year":"2025","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.jep.2025.120855_bib20","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0241-2021","article-title":"Neutrophil extracellular traps in chronic lung disease: implications for pathogenesis and therapy","volume":"31","author":"Keir","year":"2022","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.jep.2025.120855_bib21","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S2213-2600(20)30504-X","article-title":"Neutrophil extracellular traps, disease severity, and antibiotic response in bronchiectasis: an international, observational, multicohort study","volume":"9","author":"Keir","year":"2021","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.jep.2025.120855_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22020559","article-title":"Neutrophil extracellular traps and their implications in cardiovascular and inflammatory disease","volume":"22","author":"Klopf","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.120855_bib23","doi-asserted-by":"crossref","first-page":"5190","DOI":"10.21037\/jtd-24-573","article-title":"Correlation of sputum inflammatory markers with severity and blood inflammatory markers in bronchiectasis","volume":"16","author":"Kwok","year":"2024","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.jep.2025.120855_bib24","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1002\/ptr.6324","article-title":"Curcuminoids: implication for inflammation and oxidative stress in cardiovascular diseases","volume":"33","author":"Li","year":"2019","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2025.120855_bib25","article-title":"Could Chinese herbs accelerate the resolution of reversible bronchiectasis in adults?: a case report","volume":"96","author":"Li","year":"2017","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.jep.2025.120855_bib26","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0891-5849(02)01325-4","article-title":"DPI induces mitochondrial superoxide-mediated apoptosis","volume":"34","author":"Li","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2025.120855_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.743030","article-title":"NOX2-Deficient neutrophils facilitate joint inflammation through higher pro-inflammatory and weakened immune checkpoint activities","volume":"12","author":"Liao","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.120855_bib28","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.2147\/JIR.S465413","article-title":"IL-6 and TIMP-1 correlated to airway pathogen colonization and predict disease severity in patients with non-cystic fibrosis bronchiectasis","volume":"17","author":"Lin","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.jep.2025.120855_bib29","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1513\/AnnalsATS.201511-740PS","article-title":"Bronchiectasis in China","volume":"13","author":"Lin","year":"2016","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.jep.2025.120855_bib30","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.biopha.2018.07.094","article-title":"Luteolin alleviates LPS-induced bronchopneumonia injury in vitro and in vivo by down-regulating microRNA-132 expression","volume":"106","author":"Liu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.120855_bib31","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s10753-021-01581-1","article-title":"Emodin attenuates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-dependent pyroptosis signaling pathway in vitro and in vivo","volume":"45","author":"Liu","year":"2022","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2025.120855_bib32","series-title":"Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice","year":"2014"},{"key":"10.1016\/j.jep.2025.120855_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1535555","article-title":"Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases","volume":"16","author":"Lv","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120855_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1276420","article-title":"In vivo MRI and PET imaging in a translational ILD mouse model expressing non-resolving fibrosis and bronchiectasis-like pathology after repeated systemic exposure to bleomycin","volume":"11","author":"Mahmutovic Persson","year":"2024","journal-title":"Front. Med."},{"key":"10.1016\/j.jep.2025.120855_bib35","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1165\/ajrcmb.24.5.4315","article-title":"Airway inflammation and bronchial hyperresponsiveness after Mycoplasma pneumoniae infection in a murine model","volume":"24","author":"Martin","year":"2001","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.jep.2025.120855_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/ph17101403","article-title":"Discovery and development of caffeic acid analogs as versatile therapeutic agents","volume":"17","author":"Mou","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jep.2025.120855_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.jep.2025.120855_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1017540","article-title":"Mice with lung airway ciliopathy develop persistent Mycobacterium abscessus lung infection and have a proinflammatory lung phenotype associated with decreased T regulatory cells","volume":"13","author":"Nava","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.120855_bib39","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1056\/NEJMra2202819","article-title":"Bronchiectasis - A clinical review","volume":"387","author":"O'Donnell","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2025.120855_bib40","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1056\/NEJMra2202819","article-title":"Bronchiectasis - A clinical review","volume":"387","author":"O'Donnell","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2025.120855_bib41","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2025.120855_bib42","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1083\/jcb.201006052","article-title":"Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps","volume":"191","author":"Papayannopoulos","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jep.2025.120855_bib43","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01966-2023","article-title":"Airway IL-1\u03b2 is related to disease severity and mucociliary function in bronchiectasis","volume":"64","author":"Perea","year":"2024","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jep.2025.120855_bib44","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3389\/fimmu.2016.00484","article-title":"Neutrophils discriminate between lipopolysaccharides of different bacterial sources and selectively release neutrophil extracellular traps","volume":"7","author":"Pieterse","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.120855_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1342227","article-title":"NOX2 and NOX4 expression in monocytes and macrophages-extracellular vesicles in signalling and therapeutics","volume":"12","author":"Rathi","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jep.2025.120855_bib46","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jep.2017.03.042","article-title":"Rapid antidepressant effects of Yueju: a new look at the function and mechanism of an old herbal medicine","volume":"203","author":"Ren","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120855_bib47","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3389\/fimmu.2012.00360","article-title":"Activation of PAD4 in NET formation","volume":"3","author":"Rohrbach","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.120855_bib48","doi-asserted-by":"crossref","first-page":"L466","DOI":"10.1152\/ajplung.00513.2018","article-title":"Role of TRPP2 in mouse airway smooth muscle tension and respiration","volume":"317","author":"Sang","year":"2019","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.jep.2025.120855_bib49","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.3389\/fphar.2019.01600","article-title":"Rhein suppresses lung inflammatory injury induced by human respiratory syncytial virus through inhibiting NLRP3 inflammasome activation via NF-\u03baB pathway in mice","volume":"10","author":"Shen","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120855_bib50","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/jcpe.13962","article-title":"Computational analysis of curcumin-mediated alleviation of inflammation in periodontitis patients with experimental validation in mice","volume":"51","author":"Shen","year":"2024","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.jep.2025.120855_bib51","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2025.120855_bib52","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s12931-019-1243-3","article-title":"Mortality risk and causes of death in patients with non-cystic fibrosis bronchiectasis","volume":"20","author":"Sin","year":"2019","journal-title":"Respir. Res."},{"key":"10.1016\/j.jep.2025.120855_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1233101","article-title":"Severe chronic non-bacterial osteomyelitis in combination with total MPO deficiency and responsiveness to TNF\u03b1 inhibition","volume":"14","author":"Sundqvist","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.120855_bib54","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2025.120855_bib55","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1152\/japplphysiol.01322.2009","article-title":"Lung structure phenotype variation in inbred mouse strains revealed through in vivo micro-CT imaging","volume":"109","author":"Thiesse","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.jep.2025.120855_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047403","article-title":"Oroxylin-A rescues LPS-induced acute lung injury via regulation of NF-\u03baB signaling pathway in rodents","volume":"7","author":"Tseng","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2025.120855_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0288704","article-title":"Microbiology sampling in non-cystic fibrosis bronchiectasis cases from northern Alberta","volume":"18","author":"Wagner","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2025.120855_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109537","article-title":"Inhibition of neutrophil elastase prevents cigarette smoke exposure-induced formation of neutrophil extracellular traps and improves lung function in a mouse model of chronic obstructive pulmonary disease","volume":"114","author":"Wang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.120855_bib59","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adq4409","article-title":"A gut Eggerthella lenta-derived metabolite impairs neutrophil function to aggravate bacterial lung infection","volume":"17","author":"Wang","year":"2025","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jep.2025.120855_bib60","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1146\/annurev-biochem-060815-014442","article-title":"Reactive oxygen species and neutrophil function","volume":"85","author":"Winterbourn","year":"2016","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jep.2025.120855_bib61","article-title":"Identification of inhibitors from a functional food-based plant Perillae Folium against hyperuricemia via metabolomics profiling, network pharmacology and all-atom molecular dynamics simulations","volume":"15","author":"Wu","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2025.120855_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1047367","article-title":"Identification of renal ischemia reperfusion injury subtypes and predictive strategies for delayed graft function and graft survival based on neutrophil extracellular trap-related genes","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.120855_bib63","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1007\/s10787-023-01228-7","article-title":"Diosmetin alleviates acute lung injury caused by lipopolysaccharide by targeting barrier function","volume":"31","author":"Xia","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jep.2025.120855_bib64","first-page":"587","article-title":"Experience of professor Zhang Zhimin in the treatment of bronchiectasis with Lifei Qingchang Decoction","author":"Yang","year":"2022","journal-title":"Guangming Journal of Chinese Medicine"},{"key":"10.1016\/j.jep.2025.120855_bib65","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2147\/DDDT.S495225","article-title":"Exploring the Anti-PANoptosis mechanism of dachaihu decoction against sepsis-induced acute lung injury: network pharmacology, bioinformatics, and experimental validation","volume":"19","author":"Yang","year":"2025","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.jep.2025.120855_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154646","article-title":"Apigenin ameliorates non-eosinophilic inflammation, dysregulated immune homeostasis and mitochondria-mediated airway epithelial cell apoptosis in chronic obese asthma via the ROS-ASK1-MAPK pathway","volume":"111","author":"Yu","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120855_bib67","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofad425","article-title":"The utility of metagenomic next-generation sequencing (mNGS) in the management of patients with bronchiectasis: a single-center retrospective study of 93 cases","volume":"10","author":"Zhang","year":"2023","journal-title":"Open Forum Infect. Dis."},{"key":"10.1016\/j.jep.2025.120855_bib68","article-title":"The impact of tanreqing injection on mucus hypersecretion and cough in bronchiectasis: a meta-analysis of randomized controlled trials","volume":"103","author":"Zhang","year":"2024","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.jep.2025.120855_bib69","first-page":"152","article-title":"[Annual review of bronchiectasis research in 2023]","volume":"47","author":"Zhang","year":"2024","journal-title":"Zhonghua Jiehe He Huxi Zazhi"},{"key":"10.1016\/j.jep.2025.120855_bib70","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1080\/14656566.2023.2210763","article-title":"Advances in pharmacotherapy for bronchiectasis in adults","volume":"24","author":"Zhang","year":"2023","journal-title":"Expet Opin. Pharmacother."},{"key":"10.1016\/j.jep.2025.120855_bib71","doi-asserted-by":"crossref","first-page":"E884","DOI":"10.21037\/jtd.2017.08.170","article-title":"Symptom-based treatment with traditional Chinese medicine in bronchiectasis patients with hemoptysis","volume":"9","author":"Zhang","year":"2017","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.jep.2025.120855_bib72","first-page":"E115","article-title":"Personalized alternative therapy of intractable bronchiectasis-induced hemoptysis in a patient: syndrome differentiation and treatment according to individual physique category","volume":"5","author":"Zhang","year":"2013","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.jep.2025.120855_bib73","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1111\/cea.14140","article-title":"Bronchial inflammation biomarker patterns link humoral immunodeficiency with bronchiectasis-related small airway dysfunction","volume":"52","author":"Zissler","year":"2022","journal-title":"Clin. Exp. Allergy"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125015478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125015478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T23:07:00Z","timestamp":1773875220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125015478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":73,"alternative-id":["S0378874125015478"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120855","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lifei Qingchang Granules alleviate airway inflammation in a mouse model of bronchiectasis by inhibiting neutrophil extracellular traps","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120855","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120855"}}