{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:36:40Z","timestamp":1777873000024,"version":"3.51.4"},"reference-count":104,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jep.2025.120879","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:21:12Z","timestamp":1763641272000},"page":"120879","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Cyathulae radix: A comprehensive review of botany, ethnopharmacology, phytochemistry, pharmacological effects, pharmacokinetics, safety and toxicity, processing methods, analysis methods, and quality control"],"prefix":"10.1016","volume":"357","author":[{"given":"Zhibo","family":"You","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiwen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhao","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqing","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruifeng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixue","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2722-3330","authenticated-orcid":false,"given":"Hai","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120879_bib1","author":"Bin"},{"key":"10.1016\/j.jep.2025.120879_bib2","series-title":"Study on the Quality Analysis of Index Components and Blood-Activating Active Fractions of Cyathula officinalis Kuan","author":"Cao","year":"2017"},{"issue":"52","key":"10.1016\/j.jep.2025.120879_bib3","doi-asserted-by":"crossref","first-page":"693","DOI":"10.4103\/pm.pm_560_16","article-title":"Therapeutic effects of Cyathula officinalis kuan and its active fraction on acute blood stasis rat model and identification constituents by HPLC-QTOF\/MS\/MS","volume":"13","author":"Cao","year":"2017","journal-title":"Pharmacogn. Mag."},{"key":"10.1016\/j.jep.2025.120879_bib4","series-title":"Research on the Chemical Composition of Cyathulae Radix and Preliminary Exploration of its Preparation Process of Health Wine","author":"Chen","year":"2023"},{"issue":"1","key":"10.1016\/j.jep.2025.120879_bib5","first-page":"49","article-title":"Preliminary study on anti-tumor effect of Cyathula Radix. polysaccharide","volume":"2001","author":"Chen","year":"2001","journal-title":"J. Chengdu Univ. Tradit. Chin. Med."},{"issue":"11","key":"10.1016\/j.jep.2025.120879_bib6","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/S0008-6215(03)00073-9","article-title":"Structural elucidation and antitumor activity of a fructan from Cyathula officinalis Kuan","volume":"338","author":"Chen","year":"2003","journal-title":"Carbohydr. Res."},{"issue":"4","key":"10.1016\/j.jep.2025.120879_bib7","first-page":"234","article-title":"RP-HPLC determination of cyasterone in Radix Cyathulae","volume":"20","author":"Chen","year":"2000","journal-title":"Chin J Pharm Anal"},{"issue":"4","key":"10.1016\/j.jep.2025.120879_bib8","first-page":"4","article-title":"The identification of Chuanniuxi and adulterants Maniuxi based on ITS sequence analysis","volume":"5","author":"Chen","year":"2014","journal-title":"Chin Med Clin"},{"issue":"3","key":"10.1016\/j.jep.2025.120879_bib9","first-page":"756","article-title":"To investigate the efficacy and mechanism of Sanbi decoction combined with methotrexate and leflunomide in the treatment of rheumatoid arthritis with wind-cold-damp syndrome","volume":"47","author":"Chen","year":"2024","journal-title":"J. Chin. Med. Mater."},{"issue":"2","key":"10.1016\/j.jep.2025.120879_bib10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.15212\/AMM-2024-0015","article-title":"Pristimerin inhibits thioredoxin reductase in the treatment of non-small cell lung cancer","volume":"3","author":"Chu","year":"2024","journal-title":"Acta Materia Medica"},{"key":"10.1016\/j.jep.2025.120879_bib11","series-title":"Pharmacopoeia I of the People's Republic of China","author":"Committee","year":"2025"},{"issue":"5","key":"10.1016\/j.jep.2025.120879_bib12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1001\/jama.2022.24140","article-title":"Management of menopausal symptoms: a review","volume":"329","author":"Crandall","year":"2023","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.jep.2025.120879_bib13","first-page":"1312","article-title":"Isolation and structure identification of ecdysterones from Cyathula officinalis","volume":"42","author":"Cui","year":"2019","journal-title":"Chin. Tradit. Pat. Med."},{"issue":"2","key":"10.1016\/j.jep.2025.120879_bib15","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jep.2014.02.005","article-title":"Comparative pharmacokinetics of rhein and chrysophanol after oral administration of Quyu Qingre granules in normal and acute blood stasis rabbits","volume":"153","author":"Dai","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120879_bib16","first-page":"195","article-title":"Clinical application of bloodletting effect of achyrantheson hypertension","volume":"47","author":"Deng","year":"2020","journal-title":"Liaoning J. Tradit. Chin. Med."},{"issue":"90","key":"10.1016\/j.jep.2025.120879_bib17","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/bs.afnr.2019.02.004","article-title":"Phytoestrogens, phytosteroids and saponins in vegetables: biosynthesis, functions, health effects and practical applications","volume":"2019","author":"Di Gioia","year":"2019","journal-title":"Adv. Food Nutr. Res."},{"issue":"2","key":"10.1016\/j.jep.2025.120879_bib18","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/ame2.12224","article-title":"Classic mechanisms and experimental models for the anti-inflammatory effect of traditional Chinese medicine","volume":"5","author":"Du","year":"2022","journal-title":"Animal Model Exp Med"},{"key":"10.1016\/j.jep.2025.120879_bib19","series-title":"Flora of China","year":"2004"},{"issue":"65","key":"10.1016\/j.jep.2025.120879_bib20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ijbiomac.2014.01.017","article-title":"Novel polysaccharide from Radix Cyathulae officinalis Kuan can improve immune response to ovalbumin in mice","author":"Feng","year":"2014","journal-title":"Int J Biol Macromol Apr"},{"issue":"3","key":"10.1016\/j.jep.2025.120879_bib21","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3109\/08820139.2015.1009546","article-title":"SulfatedRadix Cyathulae officinalisPolysaccharides Act as adjuvant via promoting the dendritic cell maturation and suppressing treg frequency","volume":"44","author":"Feng","year":"2015","journal-title":"Immunol. Investig."},{"issue":"22","key":"10.1016\/j.jep.2025.120879_bib22","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.3390\/molecules24224150","article-title":"Immunomodulatory effects of phosphorylated Radix Cyathulae officinalis polysaccharides in immunosuppressed mice","volume":"15","author":"Feng","year":"2019","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.jep.2025.120879_bib23","first-page":"2118","article-title":"Identification of the roots of Cyathula officinalisand its Adulterant based on Saponins","volume":"43","author":"Gao","year":"2020","journal-title":"J. Chin. Med. Mater."},{"issue":"1","key":"10.1016\/j.jep.2025.120879_bib24","first-page":"192","article-title":"Research progress on antitumor effects of plant polysaccharides","volume":"10","author":"Ge","year":"2024","journal-title":"Biol. Chem. Eng."},{"issue":"6","key":"10.1016\/j.jep.2025.120879_bib25","first-page":"75","article-title":"Cellulase-assisted extraction of polysaccharide from Cyathula officinalis Kuan","volume":"13","author":"Gu","year":"2015","journal-title":"Chin J Bioproc Eng"},{"key":"10.1016\/j.jep.2025.120879_bib26","series-title":"Experimental Study on the Effect of Ethanol Extract of Cyathula Radix on Plasma TXA2 Concentration in SHR Rats","author":"Guo","year":"2008"},{"issue":"10","key":"10.1016\/j.jep.2025.120879_bib27","article-title":"Enzyme-assisted extraction, characterization, and in vitro antioxidant activity of polysaccharides from Potentilla anserina L","volume":"17","author":"Guo","year":"2023","journal-title":"Front. Nutr."},{"issue":"72","key":"10.1016\/j.jep.2025.120879_bib28","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.ijbiomac.2014.09.007","article-title":"Characterization and antioxidant activities of the polysaccharides from Radix Cyathulae officinalis Kuan","author":"Han","year":"2015","journal-title":"Int J Biol Macromol Jan"},{"issue":"11","key":"10.1016\/j.jep.2025.120879_bib29","first-page":"192","article-title":"Inhibitory effect of Cyathula officinalis Kuan. polysaccharide combined with vitamin C on activity of Hepg-2 tumor cells in vitro","volume":"48","author":"Hao","year":"2020","journal-title":"iangsu Agric. Sci."},{"issue":"1","key":"10.1016\/j.jep.2025.120879_bib30","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4103\/wjtcm.wjtcm_55_21","article-title":"Ultra-performance liquid Chromatography-Quadrupole\/Time-of-Flight mass spectrometry based bile and urine metabonomics Study on the ameliorative effects of curcuma wenyujin rhizoma on acute blood stasis in rats","volume":"8","author":"Hao","year":"2022","journal-title":"World J Tradit Chin Med"},{"issue":"10","key":"10.1016\/j.jep.2025.120879_bib31","first-page":"2336","article-title":"Comparison of the effects of Cyathula Radix and its confusion on promoting blood circulation and removing blood stasis","volume":"26","author":"He","year":"2015","journal-title":"LMMMR"},{"key":"10.1016\/j.jep.2025.120879_bib32","author":"Hu"},{"key":"10.1016\/j.jep.2025.120879_bib33","series-title":"Research on the Mechanism of Anti-rheumatoidarthritis Ofecdysteroids Isolated from Cyathulaofficinalis K.C.Kuan","author":"Huang","year":"2024"},{"issue":"1","key":"10.1016\/j.jep.2025.120879_bib34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13020-019-0237-x","article-title":"Review of traditional uses, botany, chemistry, pharmacology, pharmacokinetics, and toxicology of Radix Cyathulae","volume":"14","author":"Huang","year":"2019","journal-title":"Chin. Med."},{"issue":"2","key":"10.1016\/j.jep.2025.120879_bib35","first-page":"224","article-title":"Study on the mechanism of action of chuanniuxi in the treatment of secondary amenorrhea based on network pharmacology and molecular docking","volume":"44","author":"Huang","year":"2024","journal-title":"Henan J Tradit Chin Med"},{"issue":"2","key":"10.1016\/j.jep.2025.120879_bib36","article-title":"The application of traditional Chinese medicine polysaccharides in wound healing: a review","volume":"304","author":"Ji","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2025.120879_bib37","unstructured":"Jia, S.X., 2015 edition. Yao Pin Hua Yi. China Traditional Chinese Medicine Press, Beijing.https:\/\/www.junshilei.cn\/n\/dsrqw\/book\/base\/14091273\/05e665f8af6a4a8f971e615910dfb857\/1acd08c063526da44dc6831b5426adb6.shtml?dm=-339430255&dxid=000016240894&tp=dsrquanwen&uf=1&userid=7556&bt=qw&pagetype=6&sKey=%E8%8D%AF%E5%93%81%E5%8C%96%E4%B9%89&sch=%E3%80%8A%E8%8D%AF%E5%93%81%E5%8C%96%E4%B9%89%E3%80%8B&searchtype=qw&sourceurl=43d26d1f384904422c3b78c07dc074f3ee866465eb801e9ae02205beb091265309be6624587199f26b0b22de804c317a999fec4ef642780dba391b1bb10c62fa83b8b315929339988daf79e0baf722b6bad6da8a2e54ff97d7f859ad8b1bfcdcf4bae6e3628b00e48f037e271c857f5d07973b614613b606674a9d96c8f96c1c&template=dsrquanwen&zjid=000016240894_37."},{"issue":"6","key":"10.1016\/j.jep.2025.120879_bib38","first-page":"463","article-title":"Triterpenoid saponins from the roots of Cyathula officinalis and their inhibitory effects on nitric oxide production","volume":"15","author":"Jiang","year":"2017","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2025.120879_bib39","unstructured":"Li, S.Z., 2017 edition. Ben Cao Gang Mu. 21st Century Publishing House; National top 100 publishing House, Nanchang.https:\/\/www.jingjilei.cn\/n\/dsrqw\/book\/base\/15263177\/77dde3d24f084e8491f2c1f2baef6b0a\/09a97cfda205cfaf050f2ea862bac416.shtml?dm=-845579977&dxid=000019714707&tp=dsrquanwen&uf=1&userid=7556&bt=qw&pagetype=6&sKey=%E6%9C%AC%E8%8D%89%E7%BA%B2%E7%9B%AE&sch=%E6%9C%AC%E8%8D%89%E7%BA%B2%E7%9B%AE&searchtype=qw&sourceurl=43d26d1f384904422c3b78c07dc074f3ee866465eb801e9ae02205beb091265309be6624587199f26b0b22de804c317a999fec4ef642780dba391b1bb10c62fa557a7c097534688af1bbe5963a14e625662137fb7ac4561cddae5bb98ba51a99827c8f9fb180eb086295647cc93f0822f419ef099a0647f1dfff2b46145f9627&template=dsrquanwen&zjid=000019714707_147."},{"issue":"4","key":"10.1016\/j.jep.2025.120879_bib40","first-page":"54","article-title":"Study on processing technology of cyathula of ficinalis with orthogonal experimental design","author":"Li","year":"2005","journal-title":"Res. Pract. Chin. Med."},{"issue":"11","key":"10.1016\/j.jep.2025.120879_bib41","first-page":"1992","article-title":"Comparison of ferulic acid contents in Cyathula officinalis Kuan beforeand after being processed","volume":"25","author":"Li","year":"2010","journal-title":"GJCM"},{"issue":"7","key":"10.1016\/j.jep.2025.120879_bib42","first-page":"553","article-title":"Effects of polysaccharides from the roots of Radix Cyathulae officinalisKuan on in vivo antioxidant capacities of D-galactose-induced aging mouse model","volume":"39","author":"Li","year":"2014","journal-title":"Chin. J. Antibiot."},{"issue":"272","key":"10.1016\/j.jep.2025.120879_bib43","article-title":"A novel LC-MS\/MS method for complete composition analysis of polysaccharides by aldononitrile acetate and multiple reaction monitoring","volume":"15","author":"Li","year":"2021","journal-title":"Carbohydr. Polym."},{"issue":"6","key":"10.1016\/j.jep.2025.120879_bib44","first-page":"171","article-title":"Network pharmacology-based approach to Study the mechanism of Cyathula Officinalis kuan in the treatment of hypertension","volume":"53","author":"Liang","year":"2024","journal-title":"Shandong Chem. Ind."},{"key":"10.1016\/j.jep.2025.120879_bib45","unstructured":"Lin, D.R., 2006 edition. Xian Shou Li Shang Xu Duan Mi Fang. People's Medical Publishing House, Beijing.https:\/\/www.zhengzhifl.cn\/n\/dsrqw\/book\/base\/15005542\/267f9b9ca0084ad3a3e2dcd3099eac4a\/fbc53336d007517ac8854886ae909b0b.shtml?dm=-1805745327&dxid=000030525007&tp=dsrquanwen&uf=1&userid=7556&bt=qw&pagetype=6&sKey=%E4%BB%99%E6%8E%88%E7%90%86%E4%BC%A4%E7%BB%AD%E6%96%AD%E7%A7%98%E6%96%B9&sch=%E3%80%8A%E4%BB%99%E6%8E%88%E7%90%86%E4%BC%A4%E7%BB%AD%E6%96%AD%E7%A7%98%E6%96%B9%E3%80%8B&searchtype=qw&sourceurl=43d26d1f384904422c3b78c07dc074f3ee866465eb801e9ae02205beb091265309be6624587199f26b0b22de804c317a999fec4ef642780dba391b1bb10c62fa1c83eeab76ff9a6f49888dfa1a32d8d2adecf5baeb81258fcefeced37336dd15d60f6c42ac5d730bccc3d486b322eb69473fd7a517e011916e7f9b74d5f84b8f&template=dsrquanwen&zjid=000030525007_3."},{"issue":"2","key":"10.1016\/j.jep.2025.120879_bib46","first-page":"141","article-title":"Isolation, purification and monosaccharide composition of polysaccharide from cyathula officinalis kuan","volume":"9","author":"Liu","year":"2003","journal-title":"J Appl Environ Biol"},{"issue":"22","key":"10.1016\/j.jep.2025.120879_bib47","first-page":"6199","article-title":"Mechanism of Cyathulae Radix in treatment of knee osteoarthritis based on metabolomics","volume":"47","author":"Liu","year":"2022","journal-title":"CJOCMM"},{"issue":"13","key":"10.1016\/j.jep.2025.120879_bib48","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.3390\/molecules29133019","article-title":"Integrating UPLC-Q-TOF-MS and network pharmacology to explore the potential mechanisms of Paeonia lactiflora pall. in the treatment of blood stasis syndrome","volume":"29","author":"Ma","year":"2024","journal-title":"Molecules"},{"issue":"19","key":"10.1016\/j.jep.2025.120879_bib49","first-page":"145","article-title":"Exploration on diagnosis and treatment of refractory hypertension based on theory of \"Liver Qi Dysregulation Predominates in Disorders of the Five Zang Organs\"","volume":"57","author":"Ma","year":"2025","journal-title":"N Chin Med"},{"issue":"2","key":"10.1016\/j.jep.2025.120879_bib50","first-page":"6","article-title":"Active anticogulants in vivo of different ingredients extracted from Radix Cyathulae","volume":"35","author":"Meng","year":"2018","journal-title":"TCMINFO"},{"issue":"7","key":"10.1016\/j.jep.2025.120879_bib51","first-page":"1872","article-title":"Active constituents of essential oil from Curcuma phaeocaulis for treatment of dysmenorrhea","volume":"49","author":"Mi","year":"2024","journal-title":"Chin. J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2025.120879_bib52","unstructured":"Miao, X.Y., 2013 edition. Shen Nong Ben Cao Jing Shu. Shanxi Science and Technology Press, Taiyuan.https:\/\/www.junshilei.cn\/n\/dsrqw\/book\/base\/15208851\/7472a335e2844aeb9828fb47b5344a14\/4f3bb45e162221a612c2465b59cd38db.shtml?dm=-339430255&dxid=000030576311&tp=dsrquanwen&uf=1&userid=7556&bt=qw&pagetype=6&sKey=%E7%A5%9E%E5%86%9C%E6%9C%AC%E8%8D%89%E7%BB%8F%E7%96%8F&sch=%E3%80%8A%E7%A5%9E%E5%86%9C%E6%9C%AC%E8%8D%89%E7%BB%8F%E7%96%8F%E3%80%8B%E9%80%89%E5%BD%95&searchtype=qw&sourceurl=43d26d1f384904422c3b78c07dc074f3ee866465eb801e9ae02205beb091265309be6624587199f26b0b22de804c317a999fec4ef642780dba391b1bb10c62fab91e07f3560e3b043b086b78e6754b097ae6fcaaf7cb2f0c97472b5b0535d0fb4b716db4f4ab258ac7037bc37a495ea9ec0a755e51ee993870811a3c2793a7ef&template=dsrquanwen&zjid=000030576311_94."},{"issue":"1","key":"10.1016\/j.jep.2025.120879_bib53","first-page":"51","article-title":"New generation estrogen receptor-targeted agents in breast cancer: present situation and future prospectives","volume":"3","author":"Min","year":"2024","journal-title":"Acta Mater Med"},{"issue":"10","key":"10.1016\/j.jep.2025.120879_bib54","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s11655-021-3492-5","article-title":"Inokosterone is A potential drug target of Estrogen receptor 1 in rheumatoid arthritis patients: analysis from active ingredient of Cyathula Officinalis","volume":"27","author":"Mo","year":"2021","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2025.120879_bib55","series-title":"Blood Stas","first-page":"37","article-title":"Chapter 5 - traditional diagnosis and syndrome differentiation of Blood stasis","author":"Neeb","year":"2007"},{"issue":"269","key":"10.1016\/j.jep.2025.120879_bib56","article-title":"Chemical composition and uterine smooth muscle relaxant activity of essential oils from 10 kinds of blood-activating and stasis-resolving Chinese medicinal herbs","volume":"6","author":"Ni","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"13","key":"10.1016\/j.jep.2025.120879_bib57","first-page":"292","article-title":"Progress in research on the antithrombotic mechanism of food-derived organic acids and their derivatives","volume":"43","author":"Ning","year":"2022","journal-title":"Food Sci. (N. Y.)"},{"issue":"7","key":"10.1016\/j.jep.2025.120879_bib58","first-page":"657","article-title":"HPLC method for the determination of blood drug level of cyasterone","volume":"19","author":"Pan","year":"2010","journal-title":"Chin. J. Convalescent Med."},{"issue":"7","key":"10.1016\/j.jep.2025.120879_bib59","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1002\/ptr.7861","article-title":"A review on phytoestrogens: current status and future direction","volume":"37","author":"Patra","year":"2023","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2025.120879_bib60","series-title":"Experimental Study on the Mechanism of Antihypertensive Action of Ethanol Extract of Cyathula officinalis Kuan","author":"Qu","year":"2008"},{"issue":"15","key":"10.1016\/j.jep.2025.120879_bib61","first-page":"4839","article-title":"Exploring quantitative relationship and standardization research of wine stir-fry industrial technology of Cyathulae Radix based on \u201cfire heat\u201d","volume":"54","author":"Shi","year":"2023","journal-title":"CHIN HERB MED"},{"issue":"15","key":"10.1016\/j.jep.2025.120879_bib62","first-page":"4839","article-title":"Exploring quantitative relationship and standardization research of wine stir-fry industrial technology of Cyathulae Radix based on \u201cfire heat\u201d","volume":"54","author":"Shi","year":"2023","journal-title":"CHIN HERB MED"},{"issue":"3","key":"10.1016\/j.jep.2025.120879_bib63","first-page":"212","article-title":"Ethanol extract of Cyathulae Radix inhibits osteoclast differentiation and bone loss","volume":"22","author":"Shi","year":"2024","journal-title":"Chin. J. Nat. Med."},{"issue":"227","key":"10.1016\/j.jep.2025.120879_bib64","article-title":"Characterization and comparison of polysaccharides from Achyranthes bidentata, Cyathula officinalis and Achyranthes aspera by saccharides mapping","volume":"1","author":"Si","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2025.120879_bib65","first-page":"40","article-title":"Experimental Study on the effect of Cyathula Radix decoction on mouse pregnancy","author":"Song","year":"1994","journal-title":"China J. Chin. Mater. Med."},{"issue":"36","key":"10.1016\/j.jep.2025.120879_bib66","first-page":"96","article-title":"A brief study of ZHANG Jiebin's theory of true-yin from Zuogui pills and Yougui pills","volume":"16","author":"Song","year":"2024","journal-title":"Clin J Chin Med"},{"issue":"3","key":"10.1016\/j.jep.2025.120879_bib67","first-page":"19","article-title":"Inhibitory effect of polysaccharides from Cyathula officinalisKuan on mouse hepatoma H22 cells","volume":"2001","author":"Song","year":"2001","journal-title":"Pharmacol. Clin. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2025.120879_bib68","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.ijbiomac.2018.05.132","article-title":"Enzyme-assisted extraction, chemical characteristics, and immunostimulatory activity of polysaccharides from Korean ginseng (Panax ginseng Meyer)","volume":"116","author":"Song","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.jep.2025.120879_bib69","doi-asserted-by":"crossref","first-page":"495","DOI":"10.4103\/wjtcm.wjtcm_69_24","article-title":"Arctiin protects chondrocytes from Interleukin-1\u03b2-Induced Inflammation and Apoptosis by RNA Sequence in vivo and in vitro","volume":"10","author":"Song","year":"2024","journal-title":"World J Tradit Chin Med"},{"key":"10.1016\/j.jep.2025.120879_bib70","series-title":"Studies on Nature and Flavor of Cyathula officinalis Kuan","author":"Sun","year":"2016"},{"issue":"8","key":"10.1016\/j.jep.2025.120879_bib71","first-page":"2709","article-title":"Pharmacological substance basis of Sanmiao Pills in intervening damp-heat type gout based on chinmedomics","volume":"56","author":"Sun","year":"2025","journal-title":"Chin. Trad. Herb. Drugs"},{"key":"10.1016\/j.jep.2025.120879_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2021.102884","article-title":"Role of interleukin-6 in bone destruction and bone repair in rheumatoid arthritis","volume":"20","author":"Takeuchi","year":"2021","journal-title":"Autoimmun. Rev."},{"issue":"4","key":"10.1016\/j.jep.2025.120879_bib73","doi-asserted-by":"crossref","first-page":"289","DOI":"10.21010\/ajtcam.v14i4.32","article-title":"In vivo effect of guiding-herb radix platycodonis and radix cyathulae on paeoniflorin pharmacokinetics of xuefu zhuyu tang in rats","volume":"14","author":"Tang","year":"2017","journal-title":"Afr J Tradit Complement Altern Med"},{"issue":"9","key":"10.1016\/j.jep.2025.120879_bib74","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.3390\/molecules27092773","article-title":"Plant polysaccharides modulate immune function via the gut microbiome and May have potential in COVID-19 therapy. LID - 10.3390\/molecules27092773 [doi] LID - 2773","volume":"27","author":"Tang","year":"2022","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.jep.2025.120879_bib75","first-page":"99","article-title":"Cyasterone inhibits IL-1\u03b2-mediated apoptosis and inflammation via the NF-\u03baB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo","volume":"21","author":"Teng","year":"2023","journal-title":"Chin. J. Nat. Med."},{"issue":"8","key":"10.1016\/j.jep.2025.120879_bib76","first-page":"953","article-title":"Authentification of Radix Cyathule and its adulterants based on SCAR markers","volume":"35","author":"Tian","year":"2010","journal-title":"Chin J Chin Mater Med"},{"issue":"4","key":"10.1016\/j.jep.2025.120879_bib77","first-page":"580","article-title":"HPLC fingerprint of crude Cyathula officinalis and its processed products stir-fried with wine and salt and variation of their index components","volume":"47","author":"Tong","year":"2016","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"10.1016\/j.jep.2025.120879_bib78","unstructured":"Wang, A., 1998 edition. Ben Cao Bei Yao. China Traditional Chinese Medicine Press, Beijing.https:\/\/www.junshilei.cn\/n\/dsrqw\/book\/base\/15363699\/711df74e986e44a99c46ca844e523644\/a5192ec0c7a07c64bb1baa07ef2a6db1.shtml?dm=-339430255&dxid=000019568780&tp=dsrquanwen&uf=1&userid=7556&bt=qw&pagetype=6&sKey=%E6%9C%AC%E8%8D%89%E5%A4%87%E8%A6%81&sch=%E3%80%8A%E6%9C%AC%E8%8D%89%E5%A4%87%E8%A6%81%E3%80%8B%26%EF%BC%88%E6%B1%AA%E6%98%82%EF%BC%9B1683&searchtype=qw&sourceurl=43d26d1f384904422c3b78c07dc074f3ee866465eb801e9ae02205beb091265309be6624587199f26b0b22de804c317a999fec4ef642780dba391b1bb10c62fa0b501da7657a8879a131e3667a62fbe81c5060276e1cbab30f76f6399eea9fbbabd00a1b4f1e54d3e84465250bfb9aafea1b45a41f9c7cfbc95fc12f53b96a2b&template=dsrquanwen&zjid=000019568780_115."},{"issue":"19","key":"10.1016\/j.jep.2025.120879_bib79","first-page":"83","article-title":"Effects of ethanol extract of Cyathula officinalis Kuan on blood pressure and expression of angiotensin converting enzyme in spontaneously hypertensive rats","volume":"31","author":"Wang","year":"2012","journal-title":"IMJTCM"},{"issue":"29","key":"10.1016\/j.jep.2025.120879_bib80","first-page":"5063","article-title":"Estrogen effect of Cyathnla capitata Moq. in ovariectomized rats in vivo and its impact on lipid metabolism","volume":"30","author":"Wang","year":"2015","journal-title":"Matern Child Health Care China"},{"issue":"8","key":"10.1016\/j.jep.2025.120879_bib81","first-page":"918","article-title":"The protective effect of cyathula officinalis kuan on bone in ovariectomized rats","volume":"21","author":"Wang","year":"2015","journal-title":"Chin. J. Osteoporos."},{"issue":"6","key":"10.1016\/j.jep.2025.120879_bib82","doi-asserted-by":"crossref","first-page":"5814","DOI":"10.3390\/ijms24065814","article-title":"Hormone-Related and drug-induced osteoporosis: a cellular and molecular overview","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.jep.2025.120879_bib83","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1080\/00498254.2023.2270741","article-title":"Simultaneous determination of four phytoecdysteroids by LC-MS\/MS: application to a comparative pharmacokinetic study in normal and adjuvant arthritis rats after oral administration of C. officinalis Kuan phytoecdysteroids extract","volume":"53","author":"Wang","year":"2023","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jep.2025.120879_bib84","article-title":"Anti-hypertension effect of Wuwei Jiangya decoction via ACE2\/Ang1-7\/MAS signaling pathway in SHR based on network degree-distribution analysis","volume":"319","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2025.120879_bib85","first-page":"252","article-title":"Chemical constituents from Cyathulae Radix and their relaxant effects on uterine smooth muscle","volume":"37","author":"Wen","year":"2025","journal-title":"Nat. Prod. Res. Dev."},{"issue":"2","key":"10.1016\/j.jep.2025.120879_bib86","first-page":"68","article-title":"Protection of polysaccharids from Cyathula officinalis Kuan on PC12 cells injury induced by H2O2","volume":"33","author":"Wu","year":"2019","journal-title":"Chem. Eng."},{"issue":"9","key":"10.1016\/j.jep.2025.120879_bib87","first-page":"1726","article-title":"Study on the mechanism of achyranthes Radix in treating hypertension","volume":"35","author":"Wu","year":"2023","journal-title":"Clin. J. Tradit. Chin. Med."},{"issue":"2","key":"10.1016\/j.jep.2025.120879_bib88","article-title":"The anti-aging effect of a nutritional supplement based on Lycopene and grape extract","volume":"2","author":"Xie","year":"2025","journal-title":"Food & Med Homol"},{"key":"10.1016\/j.jep.2025.120879_bib89","series-title":"Experimental Study on the Effect of Ethanol Extract of Cyathula officinalis Kuan on Blood Pressure, LVH and SOD in SHR","author":"Xu","year":"2008"},{"issue":"7","key":"10.1016\/j.jep.2025.120879_bib90","first-page":"24","article-title":"The efficacy of the combination of valsartan and amlodipine besylate tablets in conjunction with Tongluo granules in treating primary hypertension","volume":"11","author":"Xu","year":"2023","journal-title":"Electron J Cardiovasc Dis Integr Tradit Chin West Med"},{"issue":"16","key":"10.1016\/j.jep.2025.120879_bib91","first-page":"5639","article-title":"Differential analysis of different origins and parts of Cyathula officinalis and its adulterants based on UPLC fingerprint coupled with chemical pattern recognition","volume":"55","author":"Xu","year":"2024","journal-title":"CHIN HERB MED"},{"key":"10.1016\/j.jep.2025.120879_bib92","series-title":"Experimental Study on the Effect of Ethanol Extract of Cyathula officinalis Kuan on Blood Pressure and ET in SHR","author":"Xuan","year":"2008"},{"key":"10.1016\/j.jep.2025.120879_bib93","unstructured":"Yang, S.Y., 2006 edition. Ren Zhai Zhi Zhi Fang. Second Military Medical University Press, Shanghai.https:\/\/www.zhengzhifl.cn\/n\/dsrqw\/book\/base\/14500165\/8a30d9ef0dc14dcdae10cd6f41ff1dc9\/448b59f6412cc397382483c936862ba5.shtml?dm=-1805745327&dxid=000030399453&tp=dsrquanwen&uf=1&userid=7556&bt=qw&pagetype=6&sKey=%E4%BB%81%E6%96%8B%E7%9B%B4%E6%8C%87%E6%96%B9&sch=%E3%80%8A%E4%BB%81%E6%96%8B%E7%9B%B4%E6%8C%87%E6%96%B9%E3%80%8B&searchtype=qw&sourceurl=43d26d1f384904422c3b78c07dc074f3ee866465eb801e9ae02205beb091265309be6624587199f26b0b22de804c317a999fec4ef642780dba391b1bb10c62faf8a78df6ae6d906edfe59b1c2cf506b6c275b85717acd3487a31aa5fe56157329b2d10ecc4367968e4924a0a3d6fdf117ba8dd15790a18db1b2cb1724a8a565e&template=dsrquanwen&zjid=000030399453_274."},{"key":"10.1016\/j.jep.2025.120879_bib94","series-title":"The 8th Member Congress and National Academic Conference of the Chinese Society of Biochemistry and Molecular Biology. Shanghai, China","first-page":"2","article-title":"Effect of Cyathula Radix polysaccharide on serum IgG content in CY-treated mice","author":"Yang","year":"2001"},{"issue":"42","key":"10.1016\/j.jep.2025.120879_bib95","article-title":"Discussion on the molecular mechanism of Duhuo Jisheng decoction in treating osteoarthritis based on network pharmacology and molecular docking","volume":"101","author":"Yang","year":"2022","journal-title":"Med"},{"key":"10.1016\/j.jep.2025.120879_bib96","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.phytochem.2022.113101","article-title":"Undescribed ecdysteroids and phenolic glycosides from the roots of Cyathula officinalis Kuan and their anti-inflammatory activity in LPS-induced RAW 264.7 macrophages in vitro","volume":"196","author":"Yang","year":"2022","journal-title":"Phytochem"},{"key":"10.1016\/j.jep.2025.120879_bib97","unstructured":"You, Y., 1983 editor. Yi Xue Du Shu Ji. Science and Technology Press, Nnanjing."},{"issue":"7","key":"10.1016\/j.jep.2025.120879_bib98","first-page":"1250","article-title":"The origin and application of drug Meridian theory","volume":"38","author":"Zeng","year":"2023","journal-title":"Guangming J Chin Med"},{"key":"10.1016\/j.jep.2025.120879_bib99","unstructured":"Zhang, B.C., 2015 edition. Ben Cao Bian Du. Shanghai Health Publishing House, Shanghai.https:\/\/www.junshilei.cn\/n\/dsrqw\/book\/base\/15363699\/9ecec51b4c2c4724a60120efb993e69b\/10b6b3b224dc1b1104c1333cc29107db.shtml?dm=-339430255&dxid=000019568780&tp=dsrquanwen&uf=1&userid=7556&bt=qw&pagetype=6&sKey=%E6%9C%AC%E8%8D%89%E4%BE%BF%E8%AF%BB&sch=%E3%80%8A%E6%9C%AC%E8%8D%89%E4%BE%BF%E8%AF%BB%E3%80%8B%26%EF%BC%88%E5%B7%B4%E5%A0%82%E8%AF%95%EF%BC%9B%E6%B8%85%E4%BB%A3%EF%BC%89&searchtype=qw&sourceurl=43d26d1f384904422c3b78c07dc074f3ee866465eb801e9ae02205beb091265309be6624587199f26b0b22de804c317a999fec4ef642780dba391b1bb10c62fa0b501da7657a8879a131e3667a62fbe81c5060276e1cbab30f76f6399eea9fbbabd00a1b4f1e54d3e84465250bfb9aafea1b45a41f9c7cfbc95fc12f53b96a2b&template=dsrquanwen&zjid=000019568780_828."},{"issue":"3","key":"10.1016\/j.jep.2025.120879_bib100","first-page":"458","article-title":"Study on the free radical scavenging effect of Cyathula Radix extract","volume":"36","author":"Zhang","year":"2013","journal-title":"J. Chin. Med. Mater."},{"issue":"16","key":"10.1016\/j.jep.2025.120879_bib101","first-page":"56","article-title":"Ameliorative effects of xue-fu-zhu-yu decoction, tian-ma-gou-teng-yin and Wen-Dan decoction on myocardial fibrosis in a hypertensive rat mode","volume":"6","author":"Zhang","year":"2016","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.jep.2025.120879_bib102","series-title":"Optimization of Processing Technology of wine-processed","author":"Zhang","year":"2024"},{"issue":"6","key":"10.1016\/j.jep.2025.120879_bib103","first-page":"5395","article-title":"Radix Cyathula officinalis Kuan inhibits arterial remodeling in spontaneously hypertensive rats","volume":"14","author":"Zhao","year":"2017","journal-title":"Exp. Ther. Med."},{"issue":"3","key":"10.1016\/j.jep.2025.120879_bib104","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.3892\/etm.2017.4053","article-title":"Whole extracts of Radix Achyranthis Bidentatae and Radix Cyathulae promote angiogenesis in human umbilical vein endothelial cells in vitro and in zebrafish in vivo","volume":"13","author":"Zhou","year":"2017","journal-title":"Exp. Ther. Med."},{"issue":"10","key":"10.1016\/j.jep.2025.120879_bib105","first-page":"2746","article-title":"Development history and frontier research progress of pharmacokinetics of traditional Chinese medicine","volume":"41","author":"Zhu","year":"2024","journal-title":"J. Guangzhou Univ. Chin. Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125015715?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125015715?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:48:30Z","timestamp":1777571310000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125015715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":104,"alternative-id":["S0378874125015715"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120879","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyathulae radix: A comprehensive review of botany, ethnopharmacology, phytochemistry, pharmacological effects, pharmacokinetics, safety and toxicity, processing methods, analysis methods, and quality control","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120879","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120879"}}