{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:00:29Z","timestamp":1787878829462,"version":"build-2784847793"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD2201100"],"award-info":[{"award-number":["2023YFD2201100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jep.2025.120886","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T11:07:07Z","timestamp":1763636827000},"page":"120886","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Integrated transcriptomics and network pharmacology approaches to elucidate the anti-fibrotic mechanism of Eucommia ulmoides leaves against liver fibrosis"],"prefix":"10.1016","volume":"357","author":[{"given":"Wei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuming","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangjun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiping","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangjun","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxia","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120886_bib56","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s10522-024-10153-3","article-title":"Aging, ROS, and cellular senescence: a trilogy in the progression of liver fibrosis","volume":"26","author":"Almalki","year":"2025","journal-title":"Biogerontology"},{"key":"10.1016\/j.jep.2025.120886_bib1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","author":"Asrani","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2025.120886_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110074","article-title":"Aucubin ameliorates liver fibrosis and hepatic stellate cells activation in diabetic mice via inhibiting ER stress-mediated IRE1\u03b1\/TXNIP\/NLRP3 inflammasome through NOX4\/ROS pathway","volume":"365","author":"Bao","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2025.120886_bib3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/cei.13316","article-title":"IL-17 and TNF-\u03b1 co-operation contributes to the proinflammatory response of hepatic stellate cells","volume":"198","author":"Beringer","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jep.2025.120886_bib4","first-page":"19","article-title":"Optimization of flash extraction process of active ingredients from eucommiae folium","volume":"20","author":"Chen","year":"2014","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2025.120886_bib5","series-title":"Pharmacopoeia of the People's Republic of China","year":"2020"},{"key":"10.1016\/j.jep.2025.120886_bib6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/hep.26351","article-title":"C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice","volume":"58","author":"Chu","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2025.120886_bib7","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.3748\/wjg.v20.i10.2515","article-title":"Hepatic inflammation and progressive liver fibrosis in chronic liver disease","volume":"20","author":"Czaja","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2025.120886_bib8","doi-asserted-by":"crossref","first-page":"6304","DOI":"10.3748\/wjg.v26.i41.6304","article-title":"Efficacy and safety of anti-hepatic fibrosis drugs","volume":"26","author":"Damiris","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2025.120886_bib9","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2025.120886_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156370","article-title":"Anti-colorectal cancer actions of Glycyrrhiza uralensis fisch. And its underlying mechanism via HPLC integration and network pharmacological approaches","volume":"138","author":"Duan","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120886_bib11","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jcmgh.2020.01.002","article-title":"FoxM1 induces CCl2 secretion from hepatocytes triggering hepatic inflammation, injury, fibrosis, and liver cancer","volume":"9","author":"Filliol","year":"2020","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2025.120886_bib12","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41575-023-00807-x","article-title":"Hepatic inflammatory responses in liver fibrosis","volume":"20","author":"Hammerich","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2025.120886_bib13","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.fct.2006.03.009","article-title":"Du-Zhong (Eucommia ulmoides oliv.) leaves inhibits CCl4-induced hepatic damage in rats","volume":"44","author":"Hung","year":"2006","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2025.120886_bib14","first-page":"135","article-title":"Research progress on hepatic macrophages and liver fibrosis","volume":"42","author":"Jiang","year":"2024","journal-title":"J. Pharm. Pract. Serv."},{"key":"10.1016\/j.jep.2025.120886_bib15","first-page":"1180","article-title":"Experimental observation of alcohol extractive of folium eucommiae on the rats with hyperlipidemia Fatty liver","volume":"24","author":"Jiang","year":"2009","journal-title":"West China Med. J."},{"key":"10.1016\/j.jep.2025.120886_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107376","article-title":"The increase of long noncoding RNA Fendrr in hepatocytes contributes to liver fibrosis by promoting IL-6 production","volume":"300","author":"Kang","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2025.120886_bib17","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s005350050339","article-title":"Does IL-6 regulate liver fibrosis\/cirrhosis directly and indirectly?","volume":"35","author":"Kayano","year":"2000","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.jep.2025.120886_bib18","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.3390\/cells8101249","article-title":"Mechanisms underlying hepatitis C virus-associated hepatic fibrosis","volume":"8","author":"Khatun","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jep.2025.120886_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.5142\/jgr.2013.37.45","article-title":"Red ginseng extract protects against carbon tetrachloride-induced liver fibrosis","volume":"37","author":"Ki","year":"2013","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.jep.2025.120886_bib20","first-page":"1","article-title":"Deletion of Akt1 promotes kidney fibrosis in a murine model of unilateral ureteral obstruction","author":"Kim","year":"2020","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jep.2025.120886_bib21","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1478-3231.2012.02774.x","article-title":"Beneficial effects of candesartan, an angiotensin\u2010blocking agent, on compensated alcoholic liver fibrosis \u2010 A randomized open\u2010label controlled study","volume":"32","author":"Kim","year":"2012","journal-title":"Liver Int."},{"key":"10.1016\/j.jep.2025.120886_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155477","article-title":"Paeoniflorin promotes PPAR\u03b3 expression to suppress HSCs activation by inhibiting EZH2-mediated histone H3K27 trimethylation","volume":"128","author":"Lan","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120886_bib23","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jtcme.2017.07.002","article-title":"Herbal remedies for liver fibrosis: a review on the mode of action of fifty herbs","volume":"8","author":"Latief","year":"2018","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.jep.2025.120886_bib24","first-page":"323","article-title":"Network pharmacology approaches for research of Traditional Chinese Medicines","volume":"21","author":"Li","year":"2023","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2025.120886_bib26","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.3390\/foods13071089","article-title":"Polysaccharides from Eucommia ulmoides oliv. Leaves alleviate acute Alcoholic liver injury by modulating the microbiota\u2013gut\u2013liver axis in mice","volume":"13","author":"Li","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.jep.2025.120886_bib27","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.3748\/wjg.v11.i37.5782","article-title":"Effect of Astragalus complanatus flavonoid on anti-liver fibrosis in rats","volume":"11","author":"Liu","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2025.120886_bib28","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/path.5131","article-title":"Geranylgeranyl diphosphate synthase (GGPPS) regulates non\u2010alcoholic fatty liver disease (NAFLD)\u2013fibrosis progression by determining hepatic glucose\/fatty acid preference under high\u2010fat diet conditions","volume":"246","author":"Liu","year":"2018","journal-title":"J. Pathol."},{"key":"10.1016\/j.jep.2025.120886_bib29","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/liv.14370","article-title":"Succinate\u2010GPR\u201091 receptor signalling is responsible for nonalcoholic steatohepatitis\u2010associated fibrosis: effects of DHA supplementation","volume":"40","author":"Liu","year":"2020","journal-title":"Liver Int."},{"key":"10.1016\/j.jep.2025.120886_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005457","article-title":"Transcriptomics technologies","volume":"13","author":"Lowe","year":"2017","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.jep.2025.120886_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155006","article-title":"Combining transcriptomic analysis and network pharmacology to explore the mechanism by which Shaofu Zhuyu decoction improves diabetes mellitus erectile dysfunction","volume":"119","author":"Mao","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120886_bib32","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1007\/s00436-020-06700-9","article-title":"Gene expression in human liver fibrosis associated with Echinococcus granulosus sensu lato","volume":"119","author":"Mirzavand","year":"2020","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.jep.2025.120886_bib33","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1007\/s10620-016-4254-7","article-title":"Targeting hepatic fibrosis in autoimmune hepatitis","volume":"61","author":"Montano-Loza","year":"2016","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.jep.2025.120886_bib34","first-page":"1","article-title":"Quantitative proteomic analysis reveals the deregulation of nicotinamide adenine dinucleotide metabolism and CD38 in inflammatory bowel disease","author":"Ning","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jep.2025.120886_bib35","doi-asserted-by":"crossref","first-page":"5802","DOI":"10.1039\/D1BM00100K","article-title":"VEGFR2-targeted ultrasound molecular imaging of angiogenesis to evaluate liver allograft fibrosis","volume":"9","author":"Qiu","year":"2021","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.jep.2025.120886_bib36","doi-asserted-by":"crossref","first-page":"8083","DOI":"10.1074\/jbc.M212927200","article-title":"The role of focal adhesion kinase-phosphatidylinositol 3-Kinase-Akt signaling in hepatic stellate cell proliferation and type I collagen expression","volume":"278","author":"Reif","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2025.120886_bib37","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.3390\/cells8111337","article-title":"Akt1 and Akt 2 isoforms play distinct roles in regulating the development of inflammation and fibrosis associated with alcoholic liver disease","volume":"8","author":"Reyes-Gordillo","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jep.2025.120886_bib38","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.stem.2023.10.008","article-title":"VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis","volume":"30","author":"Rizvi","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jep.2025.120886_bib39","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3390\/cells9040875","article-title":"Liver fibrosis: mechanistic concepts and therapeutic perspectives","volume":"9","author":"Roehlen","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jep.2025.120886_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1389329","article-title":"The role of PI3k\/AKT signaling pathway in attenuating liver fibrosis: a comprehensive review","volume":"11","author":"Shamsan","year":"2024","journal-title":"Front. Med."},{"key":"10.1016\/j.jep.2025.120886_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.874408","article-title":"New drugs for hepatic fibrosis","volume":"13","author":"Shan","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120886_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112689","article-title":"A network pharmacology approach to investigating the mechanism of Tanshinone IIA for the treatment of liver fibrosis","volume":"253","author":"Shi","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120886_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.730176","article-title":"Liver fibrosis: therapeutic targets and advances in drug therapy","volume":"9","author":"Tan","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jep.2025.120886_bib44","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/j.jpedsurg.2008.08.045","article-title":"Modulation of the inflammatory response and apoptosis using epidermal growth factor and hepatocyte growth factor in a liver injury model: a potential approach to the management and treatment of cholestatic liver disease","volume":"43","author":"Thatch","year":"2008","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.jep.2025.120886_bib45","doi-asserted-by":"crossref","first-page":"R1147","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jep.2025.120886_bib46","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/hep.27406","article-title":"The global burden of liver disease: the major impact of China","volume":"60","author":"Wang","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2025.120886_bib47","first-page":"153","article-title":"Effect of polysaccharides from eucommiae cortex on expressions of genes of I,III Collagen,MMP-1,TIMP-1 and TGF-\u03b21 from hepatic fibrosis in rat models","volume":"24","author":"Wang","year":"2018","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2025.120886_bib48","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.fshw.2019.03.013","article-title":"Chemical constituents, biological functions and pharmacological effects for comprehensive utilization of Eucommia ulmoides Oliver","volume":"8","author":"Xing","year":"2019","journal-title":"Food Sci. Hum. Wellness"},{"key":"10.1016\/j.jep.2025.120886_bib49","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1172\/JCI66369","article-title":"Hepatic stellate cells in liver development, regeneration, and cancer","volume":"123","author":"Yin","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jep.2025.120886_bib57","doi-asserted-by":"crossref","first-page":"527","DOI":"10.4062\/biomolther.2020.016","article-title":"Selonsertib inhibits liver fibrosis via downregulation of ASK1\/ MAPK pathway of hepatic stellate cells","volume":"28","author":"Yoon","year":"2020","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.jep.2025.120886_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1057829","article-title":"The role of p53 in liver fibrosis","volume":"13","author":"Yu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120886_bib51","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.ejmech.2012.12.062","article-title":"Recent advances in natural products from plants for treatment of liver diseases","volume":"63","author":"Zhang","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jep.2025.120886_bib52","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41392-023-01727-7","article-title":"Hepatic Zbtb18 (Zinc Finger and BTB Domain containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor)","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.jep.2025.120886_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115870","article-title":"Liver protein and metabolite biolabels reveal hepatoprotective effects and active compounds of Eucommiae folium: exploration of new application of herb based on multi-omics and bioinformatics","volume":"239","author":"Zhang","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2025.120886_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116870","article-title":"Danggui Shaoyao San: chemical characterization and inhibition of oxidative stress and inflammation to treat CCl4-induced hepatic fibrosis","volume":"318","author":"Zhao","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120886_bib55","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202200933RR","article-title":"Curcumol alleviates liver fibrosis through inducing autophagy and ferroptosis in hepatic stellate cells","volume":"36","author":"Zheng","year":"2022","journal-title":"FASEB J."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125015788?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125015788?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:55:15Z","timestamp":1776135315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125015788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":56,"alternative-id":["S0378874125015788"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120886","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated transcriptomics and network pharmacology approaches to elucidate the anti-fibrotic mechanism of Eucommia ulmoides leaves against liver fibrosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120886","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120886"}}