{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T15:07:21Z","timestamp":1793200041280,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260007"],"award-info":[{"award-number":["82260007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011789","name":"Jilin Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["YDZJ202501ZYTS227"],"award-info":[{"award-number":["YDZJ202501ZYTS227"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011789","name":"Jilin Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["20240602100RC"],"award-info":[{"award-number":["20240602100RC"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"The Education Department of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20240698KJ"],"award-info":[{"award-number":["JJKH20240698KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"The Education Department of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20210576KJ"],"award-info":[{"award-number":["JJKH20210576KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020230","name":"Jilin Province Health Commission","doi-asserted-by":"publisher","award":["2024A062"],"award-info":[{"award-number":["2024A062"]}],"id":[{"id":"10.13039\/501100020230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020230","name":"Jilin Province Health Commission","doi-asserted-by":"publisher","award":["2024A063"],"award-info":[{"award-number":["2024A063"]}],"id":[{"id":"10.13039\/501100020230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jep.2025.120936","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T17:33:07Z","timestamp":1763659987000},"page":"120936","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Multi-omics elucidation of HDRSD alleviating allergic rhinitis via IL-1\u03b2\/TRPV1 pathway regulation"],"prefix":"10.1016","volume":"357","author":[{"given":"Yunong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruobai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yedong","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghai","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmei","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"18","key":"10.1016\/j.jep.2025.120936_bib1","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202401321R","article-title":"The emerging role of ethanolamine phosphate phospholyase in regulating hepatic phosphatidylethanolamine and plasma lipoprotein metabolism in mice","volume":"38","author":"A Elmihi","year":"2024","journal-title":"FASEB J. : Off. Publ. Feder. Amer. Soc. Exp. Biol."},{"issue":"10","key":"10.1016\/j.jep.2025.120936_bib2","doi-asserted-by":"crossref","first-page":"5243","DOI":"10.3390\/ijerph18105243","article-title":"Scutellaria baicalensis and their natural FlavoneCompounds as potential medicinal drugs for the treatment of nicotine-induced non-small-cell lung cancer and asthma","volume":"18","author":"Alsharairi","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health"},{"issue":"3","key":"10.1016\/j.jep.2025.120936_bib3","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.anai.2017.01.018","article-title":"Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis after allergen challenge chamber exposure","volume":"118","author":"Badorrek","year":"2017","journal-title":"Ann. Allergy Asthma Immunol. : Off. Publ. Amer. Coll. Allergy Asthma & Immunol."},{"issue":"1","key":"10.1016\/j.jep.2025.120936_bib4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41572-020-00227-0","article-title":"Allergic rhinitis","volume":"6","author":"Bousquet","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"4","key":"10.1016\/j.jep.2025.120936_bib5","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.jaci.2017.03.050","article-title":"Allergic rhinitis and its impact on asthma (ARIA) guidelines-2016 revision","volume":"140","author":"Bro\u017cek","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1 Pt 1","key":"10.1016\/j.jep.2025.120936_bib6","first-page":"65","article-title":"A comparison of cytokine release from epithelial cells cultured from nasal biopsy specimens of atopic patients with and without rhinitis and nonatopic subjects without rhinitis","volume":"99","author":"Calder\u00f3n","year":"1997","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2025.120936_bib7","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jaci.2014.10.012","article-title":"Respiratory allergy caused by house dust mites: what do we really know?","volume":"136","author":"Calder\u00f3n","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.jep.2025.120936_bib10","doi-asserted-by":"crossref","DOI":"10.1098\/rsos.181081","article-title":"Metabolomics analysis of baicalin on ovalbumin-sensitized allergic rhinitis rats","volume":"6","author":"Chen","year":"2019","journal-title":"R. Soc. Open Sci."},{"issue":"5","key":"10.1016\/j.jep.2025.120936_bib12","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1177\/19458924221098847","article-title":"Astragalus polysaccharide relieves inflammatory responses in Guinea pigs with allergic rhinitis via ameliorating NF-kB-Mediated Treg\/Th17 imbalance","volume":"36","author":"He","year":"2022","journal-title":"Amer. J. Rhinol. & allerg."},{"issue":"4","key":"10.1016\/j.jep.2025.120936_bib14","doi-asserted-by":"crossref","first-page":"894","DOI":"10.3390\/molecules25040894","article-title":"Coixol suppresses NF-\u03baB, MAPK pathways and NLRP3 inflammasome activation in lipopolysaccharide-induced RAW 264.7 cells","volume":"25","author":"Hu","year":"2020","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.jep.2025.120936_bib16","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.3390\/ijms24031954","article-title":"Therapeutic potential of bioactive components from Scutellaria baicalensis georgi in inflammatory bowel disease and colorectal cancer: a review","volume":"24","author":"Jang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"14","key":"10.1016\/j.jep.2025.120936_bib17","doi-asserted-by":"crossref","first-page":"8134","DOI":"10.1073\/pnas.100129497","article-title":"Acid potentiation of the capsaicin receptor determined by a key extracellular site","volume":"97","author":"Jordt","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"6","key":"10.1016\/j.jep.2025.120936_bib18","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1046\/j.1523-1747.1998.00409.x","article-title":"Epidermal cytokines IL-1beta, TNF-alpha, and IL-12 in patients with atopic dermatitis: response to application of house dust mite antigens","volume":"111","author":"Junghans","year":"1998","journal-title":"J. Invest. Dermatol."},{"issue":"12","key":"10.1016\/j.jep.2025.120936_bib19","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.3390\/ijms21124341","article-title":"Paclitaxel induces upregulation of transient receptor potential vanilloid 1 expression in the rat spinal cord","volume":"21","author":"Kamata","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.jep.2025.120936_bib20","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1067\/mai.2002.121948","article-title":"The IL-1beta genotype carries asthma susceptibility only in men","volume":"109","author":"Karjalainen","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2025.120936_bib22","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cmet.2017.06.016","article-title":"Metabolic regulation of T cell longevity and function in tumor immunotherapy","volume":"26","author":"Kishton","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.jep.2025.120936_bib23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.molimm.2022.04.017","article-title":"Allergic inflammation in lungs and nasal epithelium of rat model is regulated by tissue-specific miRNA expression","volume":"147","author":"Langwi\u0144ski","year":"2022","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2025.120936_bib24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000440622","article-title":"Steroid treatment reduces allergic airway inflammation and does not alter the increased numbers of dendritic cells and calcitonin gene-related peptide-expressing neurons in airway sensory ganglia","volume":"23","author":"Le","year":"2016","journal-title":"Neuroimmunomodulation"},{"issue":"10","key":"10.1016\/j.jep.2025.120936_bib25","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1089\/jmf.2019.4595","article-title":"Fermented Platycodon grandiflorum extracts relieve airway inflammation and cough reflex sensitivity in vivo","volume":"23","author":"Lee","year":"2020","journal-title":"J. Med. Food"},{"issue":"4","key":"10.1016\/j.jep.2025.120936_bib26","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1002\/alr.22669","volume":"11","author":"Li","year":"2021","journal-title":"Int. forum allerg. & rhinol."},{"issue":"1","key":"10.1016\/j.jep.2025.120936_bib27","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1186\/s12951-024-02753-5","article-title":"Neutrophil membrane-derived nanoparticles protect traumatic brain injury via inhibiting calcium overload and scavenging ROS","volume":"22","author":"Li","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"7801","key":"10.1016\/j.jep.2025.120936_bib28","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41586-020-2121-3","article-title":"Metabolites released from apoptotic cells act as tissue messengers","volume":"580","author":"Medina","year":"2020","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jep.2025.120936_bib29","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jtcme.2015.06.001","article-title":"Effect of Shin'iseihaito on murine allergic reaction induced by nasal sensitization","volume":"6","author":"Minami","year":"2015","journal-title":"J. Tradit. Comp. Med."},{"issue":"17","key":"10.1016\/j.jep.2025.120936_bib31","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1016\/j.molcel.2024.08.001","article-title":"Consecutive palmitoylation and phosphorylation orchestrates NLRP3 membrane trafficking and inflammasome activation","volume":"84","author":"Nie","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jep.2025.120936_bib32","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2147\/JAA.S444923","article-title":"New insights into mechanisms traditional Chinese medicine for allergic rhinitis by regulating inflammatory and oxidative stress pathways","volume":"17","author":"Qin","year":"2024","journal-title":"J. Asthma Allergy"},{"issue":"1","key":"10.1016\/j.jep.2025.120936_bib33","doi-asserted-by":"crossref","first-page":"148","DOI":"10.18632\/oncotarget.6653","article-title":"The role of TRPV1 in the CD4+ T cell-mediated inflammatory response of allergic rhinitis","volume":"7","author":"Samivel","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jep.2025.120936_bib34","article-title":"Armeniacae semen amarum: a review on its botany, phytochemistry, pharmacology, clinical application, toxicology and pharmacokinetics","volume":"15","author":"Tang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120936_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/1265449","article-title":"IL-1\u03b2 and allergy: focusing on its role in allergic rhinitis","volume":"2023","author":"Wang","year":"2023","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jep.2025.120936_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156062","article-title":"Network pharmacology provides new insights into the mechanism of traditional Chinese medicine and natural products used to treat pulmonary hypertension","volume":"135","author":"Wang","year":"2024","journal-title":"Phytomedicine : Int. J. Phytother. Phytopharmacol."},{"key":"10.1016\/j.jep.2025.120936_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.133360","article-title":"Mediation of the JNC\/ILC2 pathway in DBP-exacerbated allergic asthma: a molecular toxicological study on neuroimmune positive feedback mechanism","volume":"465","author":"Xie","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jep.2025.120936_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156895","article-title":"Narirutin downregulates USP15 to inhibit the NLRP3 ubiquitination in HDM-induced allergic rhinitis","volume":"144","author":"Yang","year":"2025","journal-title":"Phytomedicine : Int. J. Phytother. Phytopharmacol."},{"key":"10.1016\/j.jep.2025.120936_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156658","article-title":"Traditional Chinese medicine in chronic rhinosinusitis: mechanisms and postoperative recovery","volume":"141","author":"Zhang","year":"2025","journal-title":"Phytomedicine : Int. J. Phytother. Phytopharmacol."},{"issue":"197","key":"10.1016\/j.jep.2025.120936_bib40","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.24976\/Discov.Med.202537197.97","article-title":"Amygdalin alleviates airway inflammation and remodeling in asthma mice: involvement of TGF-\u03b21\/Smads signaling pathway","volume":"37","author":"Zhao","year":"2025","journal-title":"Discov. Med."},{"key":"10.1016\/j.jep.2025.120936_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156299","article-title":"Kechuan decoction mitigates apoptosis of airway epithelial cells by improving lipid metabolism disorders and mitochondria dysfunction in HDM-induced asthma","volume":"136","author":"Zhao","year":"2025","journal-title":"Phytomedicine : Int. J. Phytother. Phytopharmacol."},{"key":"10.1016\/j.jep.2025.120936_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116153","article-title":"Ephedrae herba: a comprehensive review of its traditional uses, phytochemistry, pharmacology, and toxicology","volume":"307","author":"Zheng","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"6708","key":"10.1016\/j.jep.2025.120936_bib43","doi-asserted-by":"crossref","first-page":"eadk1679","DOI":"10.1126\/science.adk1679","article-title":"A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut","volume":"385","author":"Zhu","year":"2024","journal-title":"Science (New York, N.Y.)"},{"issue":"6708","key":"10.1016\/j.jep.2025.120936_bib44","doi-asserted-by":"crossref","first-page":"eadk1679","DOI":"10.1126\/science.adk1679","article-title":"A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut","volume":"385","author":"Zhu","year":"2024","journal-title":"Science (New York, N.Y.)"},{"issue":"6","key":"10.1016\/j.jep.2025.120936_bib45","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41422-025-01096-6","article-title":"Signal-induced NLRP3 phase separation initiates inflammasome activation","volume":"35","author":"Zou","year":"2025","journal-title":"Cell Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125016289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125016289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:37:05Z","timestamp":1778542625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125016289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":38,"alternative-id":["S0378874125016289"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120936","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-omics elucidation of HDRSD alleviating allergic rhinitis via IL-1\u03b2\/TRPV1 pathway regulation","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120936","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120936"}}