{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:09:00Z","timestamp":1787656140045,"version":"build-2736575974"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011338","name":"Hunan Normal University Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research Ministry of Education of China","doi-asserted-by":"publisher","award":["2017YFC1701000"],"award-info":[{"award-number":["2017YFC1701000"]}],"id":[{"id":"10.13039\/501100011338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jep.2025.120946","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:28:57Z","timestamp":1764030537000},"page":"120946","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Allium macrostemon Bge. delays chronic renal failure by modulating IL-17 signaling pathway and affecting tryptophan\/glycerophospholipid metabolism"],"prefix":"10.1016","volume":"358","author":[{"given":"Yuan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Xin","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou-Xuan","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai-Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo-Wei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Fang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He-Zhen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jep.2025.120946_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/biom11081144","article-title":"Mitochondrial redox signaling and oxidative stress in kidney diseases","volume":"11","author":"Aranda-Rivera","year":"2021","journal-title":"Biomolecules"},{"issue":"11","key":"10.1016\/j.jep.2025.120946_bib2","article-title":"Effects of Allicin on pathophysiological mechanisms during the progression of nephropathy associated to diabetes","volume":"9","author":"Arellano-Buendia","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jep.2025.120946_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108402","article-title":"The role of IL-17 and anti-IL-17 agents in the immunopathogenesis and management of autoimmune and inflammatory diseases","volume":"102","author":"Berry","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120946_bib4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s12640-009-9051-z","article-title":"Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons","volume":"16","author":"Braidy","year":"2009","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.jep.2025.120946_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111098","article-title":"Lindera aggregata intervents adenine-induced chronic kidney disease by mediating metabolism and TGF-beta\/Smad signaling pathway","volume":"134","author":"Cai","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.jep.2025.120946_bib6","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/s12276-022-00738-8","article-title":"Indoxyl sulfate- and P-cresol-induced monocyte adhesion and migration is mediated by integrin-linked kinase-dependent podosome formation","volume":"54","author":"Campillo","year":"2022","journal-title":"Exp. Mol. Med."},{"issue":"16","key":"10.1016\/j.jep.2025.120946_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/nu15163568","article-title":"Supplemented very low protein diet (sVLPD) in patients with advanced chronic renal failure: clinical and economic benefits","volume":"15","author":"Cecchi","year":"2023","journal-title":"Nutrients"},{"issue":"22","key":"10.1016\/j.jep.2025.120946_bib8","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1042\/CS20241713","article-title":"CXCL5 inhibition ameliorates acute kidney injury and prevents the progression from acute kidney injury to chronic kidney disease","volume":"138","author":"Chang","year":"2024","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.jep.2025.120946_bib9","article-title":"A Chinese patent medicine's long-term efficacy on non-dialysis patients with CKD stages 3-5: a retrospective cohort study","volume":"15","author":"Chen","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120946_bib10","article-title":"Cross-talk of renal cells through WNT signal transduction in the development of fibrotic kidneys","volume":"12","author":"Chen","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.jep.2025.120946_bib11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41413-021-00154-0","article-title":"Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease","volume":"9","author":"Courbon","year":"2021","journal-title":"Bone Res."},{"key":"10.1016\/j.jep.2025.120946_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1213473","article-title":"Role and mechanisms of SGLT-2 inhibitors in the treatment of diabetic kidney disease","volume":"14","author":"Dai","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.120946_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2024.105748","article-title":"The diverse role of corticotropin-releasing factor (CRF) and its CRF1 and CRF2 receptors under pathophysiological conditions: insights into stress\/anxiety, depression, and brain injury processes","volume":"163","author":"Domin","year":"2024","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"12","key":"10.1016\/j.jep.2025.120946_bib14","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1038\/s41401-021-00620-9","article-title":"Natural products: potential treatments for cisplatin-induced nephrotoxicity","volume":"42","author":"Fang","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"issue":"2S","key":"10.1016\/j.jep.2025.120946_bib15","doi-asserted-by":"crossref","first-page":"S819","DOI":"10.1016\/j.ajog.2020.08.108","article-title":"Proteinuria during pregnancy: definition, pathophysiology, methodology, and clinical significance","volume":"226","author":"Fishel Bartal","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jep.2025.120946_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154535","article-title":"Adverse reactions of Niaoduqing granules: a systematic review and meta-analysis","volume":"109","author":"Fu","year":"2023","journal-title":"Phytomedicine"},{"issue":"20","key":"10.1016\/j.jep.2025.120946_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/nu14204297","article-title":"Evolving concepts on inflammatory biomarkers and malnutrition in chronic kidney disease","volume":"14","author":"Graterol Torres","year":"2022","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jep.2025.120946_bib18","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2215\/CJN.0000000000000017","article-title":"Global, Regional, and National Burden of CKD due to Glomerulonephritis from 1990 to 2019: a Systematic Analysis from the Global Burden of Disease Study 2019","volume":"18","author":"Hu","year":"2023","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.jep.2025.120946_bib19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41392-023-01379-7","article-title":"Kidney fibrosis: from mechanisms to therapeutic medicines","volume":"8","author":"Huang","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"1","key":"10.1016\/j.jep.2025.120946_bib20","doi-asserted-by":"crossref","first-page":"E24","DOI":"10.1152\/ajpendo.00179.2022","article-title":"Obesity and chronic kidney disease","volume":"324","author":"Jiang","year":"2023","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"12","key":"10.1016\/j.jep.2025.120946_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/cells12121581","article-title":"The role of inflammation in CKD","volume":"12","author":"Kadatane","year":"2023","journal-title":"Cells"},{"issue":"2S","key":"10.1016\/j.jep.2025.120946_bib22","doi-asserted-by":"crossref","first-page":"S1182","DOI":"10.1016\/j.ajog.2020.11.029","article-title":"Chronic hypertension and superimposed preeclampsia: screening and diagnosis","volume":"226","author":"Kametas","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"20","key":"10.1016\/j.jep.2025.120946_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/foods12203777","article-title":"Effects of Allium macrostemon Bunge Extract on adipose tissue inflammation and hepatic endoplasmic reticulum stress in high-fat diet-fed and bisphenol A-Treated C57BL\/6N mice","volume":"12","author":"Kim","year":"2023","journal-title":"Foods"},{"issue":"30","key":"10.1016\/j.jep.2025.120946_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202310731","article-title":"Ultrasmall Polyphenol-NAD(+) nanoparticle-mediated renal delivery for mitochondrial repair and anti-inflammatory treatment of AKI-to-CKD progression","volume":"36","author":"Kong","year":"2024","journal-title":"Adv. Mater."},{"issue":"4","key":"10.1016\/j.jep.2025.120946_bib25","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/1744666X.2022.2045952","article-title":"Interleukin 6 in diabetes, chronic kidney disease, and cardiovascular disease: mechanisms and therapeutic perspectives","volume":"18","author":"Kreiner","year":"2022","journal-title":"Expet Rev. Clin. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2025.120946_bib26","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s42003-024-06021-y","article-title":"Common mouse models of chronic kidney disease are not associated with cachexia","volume":"7","author":"Lair","year":"2024","journal-title":"Commun. Biol."},{"issue":"1","key":"10.1016\/j.jep.2025.120946_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9010272","article-title":"Could IL-17A be a novel therapeutic target in diabetic nephropathy?","volume":"9","author":"Lavoz","year":"2020","journal-title":"J. Clin. Med."},{"issue":"9","key":"10.1016\/j.jep.2025.120946_bib28","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.3724\/abbs.2024049","article-title":"Aminophylline suppresses chronic renal failure progression by activating SIRT1\/AMPK\/mTOR-dependent autophagy","volume":"56","author":"Liao","year":"2024","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"issue":"2","key":"10.1016\/j.jep.2025.120946_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/toxins13020142","article-title":"Uremic toxins in the progression of chronic kidney disease and cardiovascular disease: mechanisms and therapeutic targets","volume":"13","author":"Lim","year":"2021","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.jep.2025.120946_bib30","article-title":"Allium macrostemon Saponin Inhibits activation of platelet via the CD40 signaling pathway","volume":"11","author":"Ling","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.120946_bib31","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s00018-020-03645-1","article-title":"Gut microbiota-derived tryptophan metabolism mediates renal fibrosis by aryl hydrocarbon receptor signaling activation","volume":"78","author":"Liu","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jep.2025.120946_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156548","article-title":"TaoHeChengQi Decotion alleviate chronic renal failure via regulation of PHD2\/UCP1 and RIPK3\/AKT\/TGF-beta pathway","volume":"141","author":"Liu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120946_bib33","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3389\/fphys.2020.00757","article-title":"Programming of renal development and chronic disease in adult life","volume":"11","author":"Lumbers","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jep.2025.120946_bib34","article-title":"Effect of fushengong decoction on PTEN\/PI3K\/AKT\/NF-kappaB pathway in rats with chronic renal failure via dual-dimension network pharmacology strategy","volume":"13","author":"Luo","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120946_bib35","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1038\/s41598-019-38811-4","article-title":"Interleukin 17A promotes diabetic kidney injury","volume":"9","author":"Ma","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2025.120946_bib71","first-page":"480","article-title":"KEGG for linking genomes to life and the environment","volume":"36","author":"Minoru","year":"2008","journal-title":"Nucl. Acids Res."},{"issue":"1","key":"10.1016\/j.jep.2025.120946_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166825","article-title":"2,8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 expression and impaired renal mitochondrial function","volume":"1870","author":"Moellmann","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"5","key":"10.1016\/j.jep.2025.120946_bib37","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.cmet.2021.04.004","article-title":"KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease","volume":"33","author":"Mori","year":"2021","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.jep.2025.120946_bib38","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.154773","article-title":"The tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase 1 regulates polycystic kidney disease progression","volume":"8","author":"Nguyen","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.jep.2025.120946_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108678","article-title":"Allium tuberosum alleviates diabetic nephropathy by supressing hyperglycemia-induced oxidative stress and in fl ammation in high fat diet\/streptozotocin treated rats","volume":"112","author":"Ni","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.120946_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.996675","article-title":"Characterization of volatile organic compounds with anti-atherosclerosis effects in Allium macrostemon Bge. and Allium chinense G. Don by head space solid phase microextraction coupled with gas chromatography tandem mass spectrometry","volume":"10","author":"Qin","year":"2023","journal-title":"Front. Nutr."},{"issue":"Pt 1","key":"10.1016\/j.jep.2025.120946_bib41","article-title":"Structural and in vivo-in vitro myocardial injury protection features of two novel polysaccharides from Allium macrostemon Bunge and Allium chinense G. Don","volume":"264","author":"Qin","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.jep.2025.120946_bib42","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13020-024-00957-3","article-title":"Deciphering the benefits and intensity levels of primary metabolites from Allium macrostemon Bunge and Allium chinense G. Don","volume":"19","author":"Qin","year":"2024","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2025.120946_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2024.1289663","article-title":"Sodium-glucose cotransporter 2 inhibitor dapagliflozin prevents ejection fraction reduction, reduces myocardial and renal NF-kappaB expression and systemic pro-inflammatory biomarkers in models of short-term doxorubicin cardiotoxicity","volume":"11","author":"Quagliariello","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"issue":"7","key":"10.1016\/j.jep.2025.120946_bib44","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.1016\/j.clnu.2021.03.005","article-title":"From the distinctive smell to therapeutic effects: garlic for cardiovascular, hepatic, gut, diabetes and chronic kidney disease","volume":"40","author":"Ribeiro","year":"2021","journal-title":"Clin. Nutr."},{"issue":"5","key":"10.1016\/j.jep.2025.120946_bib45","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41581-023-00694-0","article-title":"Regulated cell death pathways in kidney disease","volume":"19","author":"Sanz","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jep.2025.120946_bib46","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.molimm.2018.09.005","article-title":"Mechanisms and functions of IL-17 signaling in renal autoimmune diseases","volume":"104","author":"Schmidt","year":"2018","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jep.2025.120946_bib47","first-page":"52","article-title":"Vascular wall microenvironment: endothelial cells original exosomes mediated melatonin-suppressed vascular calcification and vascular ageing in a m6A methylation dependent manner","volume":"42","author":"Shan","year":"2024","journal-title":"Bioact. Mater."},{"issue":"3","key":"10.1016\/j.jep.2025.120946_bib48","doi-asserted-by":"crossref","DOI":"10.1002\/fsn3.70010","article-title":"Allium Macrostemon bge. Attenuates the cognitive decline of aging mice by enhancing BDNF\/TrkB pathway","volume":"13","author":"Sheng","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.jep.2025.120946_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1180751","article-title":"The efficacy and safety of Niaoduqing granules in the treatment of diabetic kidney disease: a systematic review and meta-analysis","volume":"14","author":"Song","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120946_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153777","article-title":"Protective effects of huang-lian-jie-du Decoction on diabetic nephropathy through regulating AGEs\/RAGE\/Akt\/Nrf2 pathway and metabolic profiling in db\/db mice","volume":"95","author":"Tang","year":"2022","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.jep.2025.120946_bib51","doi-asserted-by":"crossref","DOI":"10.1111\/1750-3841.70028","article-title":"Ultrasound-enzyme-assisted extraction of flavonoids, polysaccharides, and triterpenes from Gualou and Xiebai: optimization, bioactivity, in vitro digestive stability, and impact on lipid digestion","volume":"90","author":"Tong","year":"2025","journal-title":"J. Food Sci."},{"issue":"11","key":"10.1016\/j.jep.2025.120946_bib52","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1681\/ASN.2020091310","article-title":"Indoleamine 2,3-dioxygenase-1, a novel therapeutic target for post-vascular injury thrombosis in CKD","volume":"32","author":"Walker","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.jep.2025.120946_bib53","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40168-022-01443-4","article-title":"Perturbed gut microbiome and fecal and serum metabolomes are associated with chronic kidney disease severity","volume":"11","author":"Wang","year":"2023","journal-title":"Microbiome"},{"key":"10.1016\/j.jep.2025.120946_bib54","article-title":"The effect and mechanism of Fushen Granule on gut microbiome in the prevention and treatment of chronic renal failure","volume":"13","author":"Wang","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"3","key":"10.1016\/j.jep.2025.120946_bib55","first-page":"226","article-title":"Five new spirosterol saponins from Allii Macrostemonis Bulbus","volume":"21","author":"Wang","year":"2023","journal-title":"Chin. J. Nat. Med."},{"issue":"12","key":"10.1016\/j.jep.2025.120946_bib56","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1136\/gutjnl-2019-319766","article-title":"Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents","volume":"69","author":"Wang","year":"2020","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.jep.2025.120946_bib57","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s13577-024-01072-z","article-title":"Crosstalk among proximal tubular cells, macrophages, and fibroblasts in acute kidney injury: single-cell profiling from the perspective of ferroptosis","volume":"37","author":"Wang","year":"2024","journal-title":"Hum. Cell"},{"issue":"11","key":"10.1016\/j.jep.2025.120946_bib58","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/s41419-024-07260-x","article-title":"Lipocalin-2 promotes CKD vascular calcification by aggravating VSMCs ferroptosis through NCOA4\/FTH1-mediated ferritinophagy","volume":"15","author":"Wang","year":"2024","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.jep.2025.120946_bib59","doi-asserted-by":"crossref","DOI":"10.1289\/EHP7612","article-title":"The kidney-related effects of polystyrene microplastics on human kidney proximal tubular epithelial cells HK-2 and Male C57BL\/6 mice","volume":"129","author":"Wang","year":"2021","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.jep.2025.120946_bib60","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41401-022-00947-x","article-title":"Integrative phosphatidylcholine metabolism through phospholipase A(2) in rats with chronic kidney disease","volume":"44","author":"Wang","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2025.120946_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154276","article-title":"Diosgenin protects against podocyte injury in early phase of diabetic nephropathy through regulating SIRT6","volume":"104","author":"Wang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120946_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115942","article-title":"Shenqi granule upregulates CD2AP and alpha-actinin4 and activates autophagy through regulation of mTOR\/ULK1 pathway in MPC5 cells","volume":"303","author":"Wei","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.jep.2025.120946_bib63","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1093\/ndt\/gfae013","article-title":"Gut flora metagenomic analysis coupled with metabolic and deep immune profiling in chronic kidney disease","volume":"39","author":"Wu","year":"2024","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.jep.2025.120946_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105965","article-title":"Traf6 inhibitor boosts antitumor immunity by impeding regulatory T cell migration in Hepa1-6 tumor model","volume":"77","author":"Wu","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"33","key":"10.1016\/j.jep.2025.120946_bib65","article-title":"Uremic toxin receptor AhR facilitates renal senescence and fibrosis via suppressing mitochondrial biogenesis","volume":"11","author":"Xie","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"5","key":"10.1016\/j.jep.2025.120946_bib66","doi-asserted-by":"crossref","first-page":"684","DOI":"10.4168\/aair.2021.13.5.684","article-title":"Arachidonic acid 15-Lipoxygenase: effects of its expression, metabolites, and genetic and epigenetic variations on airway inflammation","volume":"13","author":"Xu","year":"2021","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jep.2025.120946_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114495","article-title":"Allium macrostemon Bunge. exerts analgesic activity by inhibiting NaV1.7 channel","volume":"281","author":"Yang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120946_bib68","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.biopha.2017.08.115","article-title":"Erhuang Formula ameliorates renal damage in adenine-induced chronic renal failure rats via inhibiting inflammatory and fibrotic responses","volume":"95","author":"Zhang","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"11","key":"10.1016\/j.jep.2025.120946_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12112622","article-title":"Epigenetics of hypertensive nephropathy","volume":"12","author":"Zhang","year":"2024","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.jep.2025.120946_bib70","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2025.2502875","article-title":"Shen Shuai II Recipe alleviates renal fibrosis in chronic kidney disease by improving of hypoxia and inhibition of TLR4\/MyD88\/NF-kappaB\/NLRP3 pathway","volume":"47","author":"Zhou","year":"2025","journal-title":"Ren. Fail."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125016381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125016381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:51:44Z","timestamp":1777571504000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125016381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":71,"alternative-id":["S0378874125016381"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120946","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Allium macrostemon Bge. delays chronic renal failure by modulating IL-17 signaling pathway and affecting tryptophan\/glycerophospholipid metabolism","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120946","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120946"}}