{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:51:56Z","timestamp":1790596316714,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jep.2025.120952","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T16:41:05Z","timestamp":1764088865000},"page":"120952","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A machine learning-based assessment strategy for Artemisia argyi Folium: Exploring the dose-effect relationship between anti-inflammatory activity and chemical composition"],"prefix":"10.1016","volume":"357","author":[{"given":"Wennan","family":"Nie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubo","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengkai","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7961-7975","authenticated-orcid":false,"given":"Wenlong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120952_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsps.2023.101802","article-title":"Network pharmacology based virtual screening of flavonoids from dodonea angustifolia and the molecular mechanism against inflammation","volume":"31","author":"Alamri","year":"2023","journal-title":"Saudi Pharm. J."},{"key":"10.1016\/j.jep.2025.120952_bib2","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202200991","article-title":"Chemical composition analysis and discrimination of essential oils of AAF argyi folium from different germplasm resources based on electronic nose and GC\/MS combined with chemometrics","volume":"20","author":"Guo","year":"2023","journal-title":"Chem. Biodiversity"},{"key":"10.1016\/j.jep.2025.120952_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105077","article-title":"Exploration of the mechanism of traditional chinese medicine by AI approach using unsupervised machine learning for cellular functional similarity of compounds in heterogeneous networks, XiaoErFuPi granules as an example","volume":"160","author":"Guo","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2025.120952_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155574","article-title":"Artificial aging conditions for AAF argyi leaves based on quality-inflammation-quality marker transformation","volume":"129","author":"Guo","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120952_bib5","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s41587-025-02681-1","article-title":"Biopharma dives into tumor-seeking radioactive drugs","volume":"43","author":"Harrison","year":"2025","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jep.2025.120952_bib6","doi-asserted-by":"crossref","first-page":"4603","DOI":"10.3390\/molecules24244603","article-title":"Study of the variation of phenolic acid and flavonoid content from fresh AAFe argyi folium to moxa wool","volume":"24","author":"Li","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.120952_bib7","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.3390\/ijms24054844","article-title":"Study on anti-constipation effects of hemerocallis citrina baroni through a novel strategy of network pharmacology screening","volume":"24","author":"Liang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.120952_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154481","article-title":"Computer especially AI-assisted drug virtual screening and design in traditional chinese medicine","volume":"107","author":"Lin","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120952_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2023.109868","article-title":"AAF argyi essential oil as a green extraction solvent for in-syringe kapok fiber-supported liquid-phase microextraction and determination of triazole fungicide residues","volume":"197","author":"Liu","year":"2024","journal-title":"Microchem. J."},{"key":"10.1016\/j.jep.2025.120952_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116170","article-title":"Interdisciplinary strategies for deciphering the mechanisms of chinese medicines","volume":"306","author":"Luan","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120952_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13020-023-00741-9","article-title":"Machine learning in TCM with natural products and molecules: current status and future perspectives","volume":"18","author":"Ma","year":"2023","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2025.120952_bib12","article-title":"The influence of fermentation and drying methods on the functional activities and sensory quality of AAF argyi H.l\u00e9v. & vaniot herbal tea","volume":"30","author":"Ng","year":"2022","journal-title":"J. Appl. Res. Med. Aromat. Plants"},{"key":"10.1016\/j.jep.2025.120952_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2025.466138","article-title":"A multi-omics approach combining GC-MS, LC-MS, and FT-NIR with chemometrics and machine learning for metabolites systematic profiling and geographical origin tracing of AAF argyi folium","volume":"1757","author":"Nie","year":"2025","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jep.2025.120952_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118458","article-title":"AAF argyi essential oil alleviates asthma by regulating 5-LOX-CysLTs and IDO-1-KYN pathways: insights from metabolomics","volume":"333","author":"Rong","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120952_bib15","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/j.fshw.2023.03.022","article-title":"Network pharmacology-based screening of the active ingredients and mechanisms of cymbaria daurica against diabetes mellitus","volume":"12","author":"Shi","year":"2023","journal-title":"Food Sci. Hum. Wellness"},{"key":"10.1016\/j.jep.2025.120952_bib16","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.ijbiomac.2016.10.101","article-title":"Microwave-assisted synthesis, structure and anti-tumor activity of selenized AAF sphaerocephala polysaccharide","volume":"95","author":"Wang","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2025.120952_bib17","article-title":"Antibacterial activity of a polysaccharide isolated from AAF argyi leaf against staphylococcus aureus and mechanism investigation","volume":"253","author":"Wang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2025.120952_bib18","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s11101-023-09910-y","article-title":"AAF argyi H. L\u00e9v. & vaniot: a comprehensive review on traditional uses, phytochemistry, and pharmacological activities","volume":"23","author":"Wei","year":"2024","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.jep.2025.120952_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2021.113951","article-title":"Polyphenols from AAF argyi leaves: environmentally friendly extraction under high hydrostatic pressure and biological activities","volume":"171","author":"Wu","year":"2021","journal-title":"Ind. Crops Prod."},{"key":"10.1016\/j.jep.2025.120952_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2024.106932","article-title":"Polysaccharides from AAF argyi leaves: environmentally friendly ultrasound-assisted extraction and antifatigue activities","volume":"107","author":"Yu","year":"2024","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.jep.2025.120952_bib21","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/pca.3359","article-title":"Metabolomic analysis reveals the changing trend and differential markers of volatile and nonvolatile components of AAFe argyi with different aging years","volume":"35","author":"Zhang","year":"2024","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.jep.2025.120952_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.202200624","article-title":"Quantitative fingerprint and antioxidative properties of AAF argyi leaves combined with chemometrics","volume":"46","author":"Zhang","year":"2023","journal-title":"J. Separ. Sci."},{"key":"10.1016\/j.jep.2025.120952_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.115968","article-title":"Quality difference analysis of raw and vinegar-processed products of qingpi based on color and component correlation","volume":"241","author":"Zhang","year":"2024","journal-title":"J. Pharm. Biomed. Anal."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125016447?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125016447?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:48:00Z","timestamp":1777571280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125016447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":23,"alternative-id":["S0378874125016447"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120952","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A machine learning-based assessment strategy for Artemisia argyi Folium: Exploring the dose-effect relationship between anti-inflammatory activity and chemical composition","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120952","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120952"}}