{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:57:28Z","timestamp":1793228248094,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LMS25H280001"],"award-info":[{"award-number":["LMS25H280001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2024KY917"],"award-info":[{"award-number":["2024KY917"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008867","name":"Department of Education of Zhejiang Province","doi-asserted-by":"publisher","award":["KYYB2023002"],"award-info":[{"award-number":["KYYB2023002"]}],"id":[{"id":"10.13039\/501100008867","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jep.2025.120965","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T16:02:29Z","timestamp":1764086549000},"page":"120965","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Linderane from Lindera aggregata attenuates ulcerative colitis by suppressing IL-6\/STAT3-mediated Th17 differentiation and apoptosis resistance"],"prefix":"10.1016","volume":"357","author":[{"given":"Huimin","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weida","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pansheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0007-9372","authenticated-orcid":false,"given":"Mincong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120965_bib1","doi-asserted-by":"crossref","DOI":"10.1007\/s12013-025-01816-0","article-title":"The significance of STAT3 in colonic diseases: a comprehensive study of pathological roles and therapeutic implications","author":"Ahmed","year":"2025","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.jep.2025.120965_bib2","first-page":"15","article-title":"Dextran sulfate sodium (DSS)-Induced colitis in mice","volume":"104","author":"Chassaing","year":"2014","journal-title":"Curr. Protoc. Im."},{"issue":"21","key":"10.1016\/j.jep.2025.120965_bib3","first-page":"5719","article-title":"Chemical constituents of Lindera aggregata and their bioactivities: a review","volume":"48","author":"Chen","year":"2023","journal-title":"Zhongguo Zhongyao Zazhi"},{"issue":"1","key":"10.1016\/j.jep.2025.120965_bib4","doi-asserted-by":"crossref","first-page":"6081","DOI":"10.1038\/s41598-023-33388-5","article-title":"Identification of diagnostic biomarks and immune cell infiltration in ulcerative colitis","volume":"13","author":"Chen","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2025.120965_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2024.07.008","article-title":"Therapeutic inhibition of the JAK-STAT pathway in the treatment of inflammatory bowel disease","volume":"79","author":"Chen","year":"2024","journal-title":"Cytokine Growth Factor Rev."},{"issue":"4","key":"10.1016\/j.jep.2025.120965_bib6","doi-asserted-by":"crossref","first-page":"989","DOI":"10.3892\/ijmm.2013.1287","article-title":"Aberrant expression of circulating Th17, Th1 and Tc1 cells in patients with active and inactive ulcerative colitis","volume":"31","author":"Dong","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jep.2025.120965_bib7","article-title":"Exploring novel herbal compounds and formulations for inflammatory bowel disease (IBD) management","volume":"39","author":"Dubey","year":"2023","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"issue":"23","key":"10.1016\/j.jep.2025.120965_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10235660","article-title":"Efficacy, safety and future perspectives of JAK inhibitors in the IBD treatment","volume":"10","author":"Dudek","year":"2021","journal-title":"J. Clin. Med."},{"issue":"4","key":"10.1016\/j.jep.2025.120965_bib9","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1093\/ibd\/izae293","article-title":"Inflammation-induced Th17 cells synergize with the inflammation-trained microbiota to mediate host resiliency against intestinal injury","volume":"31","author":"Golob","year":"2025","journal-title":"Inflamm. Bowel Dis."},{"issue":"12","key":"10.1016\/j.jep.2025.120965_bib10","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1038\/s44319-025-00464-y","article-title":"Genetic disruption of the circadian gene Bmal1 in the intestinal epithelium reduces colonic inflammation","volume":"26","author":"Hua","year":"2025","journal-title":"EMBO Rep."},{"issue":"11","key":"10.1016\/j.jep.2025.120965_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/cells11111851","article-title":"Ulcerative colitis in response to fecal microbiota transplantation via modulation of gut microbiota and Th17\/Treg cell balance","volume":"11","author":"Huang","year":"2022","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.jep.2025.120965_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctmp.2024.200152","article-title":"Appraising the quality of clinical practice guidelines in Chinese patent medicine","volume":"5","author":"Jin","year":"2024","journal-title":"Clinical Traditional Medicine and Pharmacology"},{"issue":"8","key":"10.1016\/j.jep.2025.120965_bib13","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1136\/gutjnl-2024-334010","article-title":"GPR171 restrains intestinal inflammation by suppressing FABP5-mediated Th17 cell differentiation and lipid metabolism","volume":"74","author":"Kou","year":"2025","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.jep.2025.120965_bib14","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/ecco-jcc\/jjac142","article-title":"Epidemiology, treatment strategy, natural disease course and surgical outcomes of patients with ulcerative colitis in Western Hungary - a population-based study between 2007 and 2018: data from the Veszprem county cohort","volume":"17","author":"Kurti","year":"2023","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.jep.2025.120965_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.615506","article-title":"Root extract of Lindera aggregata (Sims) kosterm. Modulates the Th17\/Treg balance to attenuate DSS-induced colitis in mice by IL-6\/STAT3 signaling pathway","volume":"12","author":"Lai","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"10401","key":"10.1016\/j.jep.2025.120965_bib16","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.jep.2025.120965_bib17","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1080\/08820139.2025.2556790","article-title":"Molecular mechanism of butyrate modulating Treg\/Th17 balance in UC through cAMP-PKA\/mTOR axis","volume":"54","author":"Li","year":"2025","journal-title":"Immunol. Investig."},{"key":"10.1016\/j.jep.2025.120965_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2023.07.001","article-title":"Recent advances in the treatment of IBD: targets, mechanisms and related therapies","volume":"71\u201372","author":"Liu","year":"2023","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.jep.2025.120965_bib19","article-title":"A review on the chemical constituents and pharmacological efficacies of Lindera aggregata (sims) kosterm","volume":"9","author":"Lv","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jep.2025.120965_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.117939","article-title":"Modulation of occludin, NF-kappaB, p-STAT3, and Th17 response by DJ-X-025 decreases inflammation and ameliorates experimental colitis","volume":"185","author":"Mandal","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.120965_bib21","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2147\/CEG.S368040","article-title":"Downregulated mucosal autophagy, alpha Kinase-1 and IL-17 signaling pathways in active and quiescent ulcerative colitis","volume":"15","author":"Moraes Holst","year":"2022","journal-title":"Clin. Exp. Gastroenterol."},{"issue":"3","key":"10.1016\/j.jep.2025.120965_bib22","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41575-018-0084-8","article-title":"IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting","volume":"16","author":"Moschen","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.jep.2025.120965_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccmp.2024.100129","article-title":"A comprehensive review on preclinical safety and toxicity of medicinal plants","volume":"4","author":"Mugale","year":"2024","journal-title":"Clinical Complementary Medicine and Pharmacology"},{"issue":"6","key":"10.1016\/j.jep.2025.120965_bib24","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1053\/j.gastro.2020.01.001","article-title":"Safety of Janus kinase inhibitors in patients with inflammatory bowel diseases or other immune-mediated diseases: a systematic review and meta-analysis","volume":"158","author":"Olivera","year":"2020","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.jep.2025.120965_bib25","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s12325-022-02364-2","article-title":"Burden of fatigue among patients with ulcerative colitis and Crohn's Disease: results from a Global Survey of patients and gastroenterologists","volume":"40","author":"Regueiro","year":"2023","journal-title":"Adv. Ther."},{"issue":"6","key":"10.1016\/j.jep.2025.120965_bib26","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41575-020-0273-0","article-title":"JAK-STAT pathway targeting for the treatment of inflammatory bowel disease","volume":"17","author":"Salas","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"7","key":"10.1016\/j.jep.2025.120965_bib27","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cgh.2024.08.011","article-title":"Epidemiology of elderly onset IBD: a nationwide population-based cohort Study","volume":"23","author":"Singh","year":"2025","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"Pt A","key":"10.1016\/j.jep.2025.120965_bib28","article-title":"Traditional uses, phytochemistry, pharmacology, processing methods and quality control of Lindera aggregata (Sims) Kosterm: a critical review","volume":"318","author":"Tao","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120965_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155868","article-title":"Linderae Radix extract attenuates ulcerative colitis by inhibiting the JAK\/STAT signaling pathway","volume":"132","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120965_bib30","doi-asserted-by":"crossref","first-page":"goaf021","DOI":"10.1093\/gastro\/goaf021","article-title":"Gasdermin E-mediated intestinal epithelial pyroptosis promotes chemically induced colitis in mice","volume":"13","author":"Wu","year":"2025","journal-title":"Gastroenterol Rep (Oxf)"},{"key":"10.1016\/j.jep.2025.120965_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2023.107778","article-title":"Biomarkers prediction and immune landscape in ulcerative colitis: findings based on bioinformatics and machine learning","volume":"168","author":"Yang","year":"2024","journal-title":"Comput. Biol. Med."},{"issue":"5","key":"10.1016\/j.jep.2025.120965_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.112508","article-title":"Gut microbiota-driven pathogenic Th17 cells mediated autoimmune epididymo-orchitis in a mouse model of colitis","volume":"28","author":"Zeng","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.jep.2025.120965_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114717","article-title":"Specific MSI2 deletion maintains intestinal barrier integrity by down-regulating ILC3s-derived IL-17 a in mice with colitis","volume":"156","author":"Zhang","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"7","key":"10.1016\/j.jep.2025.120965_bib34","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1142\/S0192415X22500756","article-title":"Chinese medicine in the treatment of ulcerative colitis: the mechanisms of signaling pathway regulations","volume":"50","author":"Zheng","year":"2022","journal-title":"Am. J. Chin. Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125016575?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125016575?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:49:39Z","timestamp":1777571379000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125016575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":34,"alternative-id":["S0378874125016575"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120965","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Linderane from Lindera aggregata attenuates ulcerative colitis by suppressing IL-6\/STAT3-mediated Th17 differentiation and apoptosis resistance","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120965","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120965"}}