{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T02:51:21Z","timestamp":1779331881591,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018531","name":"Major Science and Technology Projects in Yunnan Province","doi-asserted-by":"publisher","award":["202302AA310013"],"award-info":[{"award-number":["202302AA310013"]}],"id":[{"id":"10.13039\/501100018531","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007839","name":"Yunnan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007839","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202407AD110002"],"award-info":[{"award-number":["202407AD110002"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2023YKZY004"],"award-info":[{"award-number":["2023YKZY004"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2024YKZY001"],"award-info":[{"award-number":["2024YKZY001"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202302AP370006"],"award-info":[{"award-number":["202302AP370006"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202305AC160007"],"award-info":[{"award-number":["202305AC160007"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2022YKZY001"],"award-info":[{"award-number":["2022YKZY001"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jep.2025.120969","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T07:54:46Z","timestamp":1764230086000},"page":"120969","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Renoprotective effects of Stemona sessilifolia via suppression of the c-Myc\/c-Fos\/MAPK pathway in hyperuricemic nephropathy"],"prefix":"10.1016","volume":"358","author":[{"given":"Xin-Yao","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bang-Yin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Lin","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Li","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Dong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120969_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejim.2020.07.006","article-title":"Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease","volume":"80","author":"Borghi","year":"2020","journal-title":"Eur. J. Intern. Med."},{"issue":"9760","key":"10.1016\/j.jep.2025.120969_bib2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0140-6736(10)60665-4","article-title":"Gout therapeutics: new drugs for an old disease","volume":"377","author":"Burns","year":"2011","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.jep.2025.120969_bib3","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1055\/s-2006-957064","article-title":"Alkaloids from Stemona mairei","volume":"73","author":"Cai","year":"2007","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2025.120969_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.146416","article-title":"Exploring the characteristics and mechanisms of novel salt taste-enhancing peptides from porcine bone collagen via virtual screening, sensory evaluation, and molecular dynamics simulations","volume":"495","author":"Chen","year":"2025","journal-title":"Food Chem."},{"issue":"2","key":"10.1016\/j.jep.2025.120969_bib5","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1021\/np50056a002","article-title":"A study of stemona alkaloids, III. Application of 2D-nmr spectroscopy in the structure determination of stemoninine","volume":"51","author":"Cheng","year":"1988","journal-title":"J. Nat. Prod."},{"issue":"10","key":"10.1016\/j.jep.2025.120969_bib6","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1055\/s-2003-45100","article-title":"Antitussive activity of stemona alkaloids from Stemona tuberosa","volume":"69","author":"Chung","year":"2003","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2025.120969_bib7","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ejim.2022.04.022","article-title":"Uric acid in metabolic syndrome: does uric acid have a definitive role?","volume":"103","author":"Copur","year":"2022","journal-title":"Eur. J. Intern. Med."},{"issue":"2","key":"10.1016\/j.jep.2025.120969_bib8","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.semarthrit.2012.03.013","article-title":"Challenges associated with the management of gouty arthritis in patients with chronic kidney disease: a systematic review","volume":"42","author":"Curiel","year":"2012","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.jep.2025.120969_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.739686","article-title":"Astaxanthin protects tilapia head kidney cells against polystyrene microplastics-induced inflammation through MAPK and NF-\u03baB signaling pathways","volume":"574","author":"Deng","year":"2023","journal-title":"Aquaculture"},{"key":"10.1016\/j.jep.2025.120969_bib10","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.intimp.2019.04.030","article-title":"Stemona alkaloids suppress the positive feedback loop between M2 polarization and fibroblast differentiation by inhibiting JAK2\/STAT3 pathway in fibroblasts and CXCR4\/PI3K\/AKT1 pathway in macrophages","volume":"72","author":"Ding","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120969_bib11","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s41392-024-01916-y","article-title":"Hyperuricemia and its related diseases: mechanisms and advances in therapy","volume":"9","author":"Du","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"8","key":"10.1016\/j.jep.2025.120969_bib12","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock vina 1.2.0: new docking methods, expanded force field, and python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"issue":"5","key":"10.1016\/j.jep.2025.120969_bib13","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41401-019-0324-7","article-title":"Ganoderic acid hinders renal fibrosis via suppressing the TGF-\u03b2\/Smad and MAPK signaling pathways","volume":"41","author":"Geng","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"issue":"36","key":"10.1016\/j.jep.2025.120969_bib14","doi-asserted-by":"crossref","first-page":"22485","DOI":"10.1021\/acs.jafc.5c09146","article-title":"Urolithin C ameliorates hyperuricemia by mitigating renal dysfunction through ROS-p38\/ERK MAPK axis suppression","volume":"73","author":"Han","year":"2025","journal-title":"J. Agric. Food Chem."},{"issue":"12","key":"10.1016\/j.jep.2025.120969_bib15","doi-asserted-by":"crossref","DOI":"10.15252\/msb.202211401","article-title":"Coordination of MAPK and p53 dynamics in the cellular responses to DNA damage and oxidative stress","volume":"18","author":"Hanson","year":"2022","journal-title":"Mol. Syst. Biol."},{"issue":"10","key":"10.1016\/j.jep.2025.120969_bib16","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1080\/14786419.2015.1045507","article-title":"Non-alkaloids extract from Stemona sessilifolia enhances the activity of chemotherapeutic agents through P-glycoprotein-mediated multidrug-resistant cancer cells","volume":"30","author":"Han","year":"2016","journal-title":"Nat. Prod. Res."},{"issue":"51","key":"10.1016\/j.jep.2025.120969_bib17","doi-asserted-by":"crossref","first-page":"5746","DOI":"10.1016\/j.tetlet.2016.10.096","article-title":"Stemona-amines F and G, new alkaloids from Stemona tuberosa","volume":"57","author":"Hitotsuyanagi","year":"2016","journal-title":"Tetrahedron Lett."},{"issue":"8","key":"10.1016\/j.jep.2025.120969_bib18","article-title":"The SGLT2 inhibitor dapagliflozin ameliorates renal fibrosis in hyperuricemic nephropathy","volume":"5","author":"Hu","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.jep.2025.120969_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2020.104572","article-title":"Stemtuberolines A-G, new alkaloids from Stemona tuberosa and their anti-TMV activity","volume":"143","author":"Hu","year":"2020","journal-title":"Fitoterapia"},{"issue":"2","key":"10.1016\/j.jep.2025.120969_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2024.114361","article-title":"lncRNA-NEF regulates hepatic stellate cells proliferation, cell cycle, apoptosis and ECM synthesis through the ERK1\/2\/c-Fos axis","volume":"444","author":"Jia","year":"2025","journal-title":"Exp. Cell Res."},{"issue":"4","key":"10.1016\/j.jep.2025.120969_bib21","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/bmc.1474","article-title":"Development and validation of a high-performance liquid chromatographic method for the determination of stemoninine in rat plasma after administration of Stemona tuberosa extracts","volume":"25","author":"Jiang","year":"2011","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jep.2025.120969_bib23","series-title":"Compendium of Materia Medica [Ben Cao Gang Mu]","author":"Li","year":"1593"},{"key":"10.1016\/j.jep.2025.120969_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115644","article-title":"Fufang zhenzhu tiaozhi capsule ameliorates hyperuricemic nephropathy by inhibition of PI3K\/AKT\/NF-\u03baB pathway","volume":"298","author":"Li","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120969_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176528","article-title":"Protecting against ferroptosis in hyperuricemic nephropathy: the potential of ferrostatin-1 and its inhibitory effect on URAT1","volume":"971","author":"Li","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.120969_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117678","article-title":"The Terminalia chebula retz extract treats hyperuricemic nephropathy by inhibiting TLR4\/MyD88\/NF-\u03baB axis","volume":"322","author":"Liu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120969_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113112","article-title":"The traditional uses, phytochemistry, and pharmacology of stemona species: a review","volume":"265","author":"Liu","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.120969_bib29","doi-asserted-by":"crossref","DOI":"10.1681\/ASN.0000000000000054","article-title":"Genetic and physiological effects of insulin-like growth Factor-1 (IGF-1) on human urate homeostasis","volume":"34","author":"Mandal","year":"2023","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jep.2025.120969_bib30","first-page":"128","volume":"vol. 8","year":"1999"},{"key":"10.1016\/j.jep.2025.120969_bib31","series-title":"Pharmacopoeia of the People's Republic of China Volume I","first-page":"132","year":"2025"},{"issue":"6","key":"10.1016\/j.jep.2025.120969_bib32","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1080\/14656566.2023.2197591","article-title":"Advances in pharmacotherapies for hyperuricemia","volume":"24","author":"Piani","year":"2023","journal-title":"Expet Opin. Pharmacother."},{"issue":"5","key":"10.1016\/j.jep.2025.120969_bib33","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.kint.2020.05.056","article-title":"Hyperuricemia as a trigger of immune response in hypertension and chronic kidney disease","volume":"98","author":"Ponticelli","year":"2020","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.jep.2025.120969_bib34","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/hlca.200790037","article-title":"Novel alkaloids from Stemona sessilifolia","volume":"90","author":"Qian","year":"2007","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.jep.2025.120969_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156440","article-title":"Linarin attenuates hyperuricemic nephropathy by modulating Nrf2\/Keap1 and TLR4\/NF-\u03baB signaling pathways: linarin attenuates hyperuricemic nephropathy","volume":"139","author":"Qian","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120969_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157121","article-title":"Integrated bioinformatics and multi-omics reveal astragalus extract's gut-kidney axis mechanism in hyperuricemic nephropathy via purine metabolism","volume":"146","author":"Qu","year":"2025","journal-title":"Phytomedicine"},{"issue":"9","key":"10.1016\/j.jep.2025.120969_bib38","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1007\/s00706-005-0348-1","article-title":"New Pyrrolo[1,2-a]azepine type alkaloids from stemona and stichoneuron (stemonaceae)","volume":"136","author":"Schinnerl","year":"2005","journal-title":"Monatshefte fuer Chemie\/Chemical Monthly"},{"key":"10.1016\/j.jep.2025.120969_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154812","article-title":"Renal herb formula protects against hyperuricemic nephropathy by inhibiting apoptosis and inflammation","volume":"116","author":"Tang","year":"2023","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.jep.2025.120969_bib40","first-page":"810","article-title":"Study on the determination method of total alkaloids in Radix stemonae","volume":"34","author":"Tian","year":"2021","journal-title":"Heilongjiang Center for Disease Control and Prevention"},{"key":"10.1016\/j.jep.2025.120969_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154387","article-title":"Diacerein alleviates ang II-induced cardiac inflammation and remodeling by inhibiting the MAPKs\/c-Myc pathway","volume":"106","author":"Wang","year":"2022","journal-title":"Phytomedicine"},{"issue":"6","key":"10.1016\/j.jep.2025.120969_bib42","doi-asserted-by":"crossref","first-page":"612","DOI":"10.5582\/bst.2017.01259","article-title":"Yin-yang regulating effects of cancer-associated genes, proteins, and cells: an ancient Chinese concept in vogue in modern cancer research","volume":"11","author":"Wei","year":"2017","journal-title":"BioScience Trends"},{"key":"10.1016\/j.jep.2025.120969_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119926","article-title":"Clerodendranthus spicatus-Cordyceps cicadae regulates mitophagy and protects renal tubular epithelial cells from hyperuricemic nephropathy","volume":"349","author":"Wu","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2025.120969_bib44","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/S0031-9422(00)89558-8","article-title":"Alkaloids from Stemona tuberosa","volume":"37","author":"Yang","year":"1994","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2025.120969_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.112185","article-title":"Core signaling pathways in renal ischemia-reperfusion injury: network regulation and therapeutic prospects","volume":"136","author":"Yan","year":"2025","journal-title":"Cell. Signal."},{"issue":"1","key":"10.1016\/j.jep.2025.120969_bib46","doi-asserted-by":"crossref","first-page":"6463","DOI":"10.1038\/s41467-024-50752-9","article-title":"Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2025.120969_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2024.105998","article-title":"New alkaloids from Stemona tuberosa and structural revision of tuberostemonols P and R","volume":"176","author":"Zhao","year":"2024","journal-title":"Fitoterapia"},{"issue":"5","key":"10.1016\/j.jep.2025.120969_bib48","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3390\/md19050238","article-title":"Fucoidan from laminaria japonica inhibits expression of GLUT9 and URAT1 via PI3K\/Akt, JNK and NF-\u03baB pathways in uric acid-exposed HK-2 cells","volume":"19","author":"Zhang","year":"2021","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.jep.2025.120969_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112949","article-title":"Indole alkaloids from leaves of Alstonia scholaris (L.) R. Br. Protect against emphysema in mice","volume":"259","author":"Zhao","year":"2020","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125016617?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125016617?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:53:34Z","timestamp":1777571614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125016617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":46,"alternative-id":["S0378874125016617"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120969","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Renoprotective effects of Stemona sessilifolia via suppression of the c-Myc\/c-Fos\/MAPK pathway in hyperuricemic nephropathy","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120969","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120969"}}