{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T03:48:14Z","timestamp":1776138494695,"version":"3.50.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2020-JYB-XJSJJ-039"],"award-info":[{"award-number":["2020-JYB-XJSJJ-039"]}],"id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004846","name":"Beijing University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004846","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374407"],"award-info":[{"award-number":["82374407"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673758"],"award-info":[{"award-number":["81673758"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jep.2025.120972","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T07:54:54Z","timestamp":1764230094000},"page":"120972","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Shenlian-Fumai formula attenuates ventricular arrhythmias via modulating sodium channel function in heart failure mice"],"prefix":"10.1016","volume":"357","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1143-0391","authenticated-orcid":false,"given":"Xinyan","family":"Qu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianshi","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bairu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruli","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaixin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4940-3092","authenticated-orcid":false,"given":"Qun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120972_bib1","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1161\/01.RES.0000194329.41863.89","article-title":"Ca2+\/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure","volume":"97","author":"Ai","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2025.120972_bib2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s10840-019-00623-x","article-title":"Heart failure as a substrate and trigger for ventricular tachycardia","volume":"56","author":"Alvarez","year":"2019","journal-title":"J. Intervent. Card Electrophysiol."},{"key":"10.1016\/j.jep.2025.120972_bib3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.hrthm.2009.08.005","article-title":"Cardiac ion channels in health and disease","volume":"7","author":"Amin","year":"2010","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jep.2025.120972_bib4","doi-asserted-by":"crossref","first-page":"19856","DOI":"10.1074\/jbc.M111.322537","article-title":"Ca2+\/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites","volume":"287","author":"Ashpole","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2025.120972_bib5","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1039\/C9NP00011A","article-title":"Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2","volume":"36","author":"Caesar","year":"2019","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.jep.2025.120972_bib6","first-page":"1103","article-title":"Effects of 8-oxoberberine on sodium current in rat ventricular and human atrial myocytes","volume":"13","author":"Chi","year":"1997","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.jep.2025.120972_bib7","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jep.2013.07.008","article-title":"Inhibitory effect of Coptis chinensis on inflammation in LPS-induced endotoxemia","volume":"149","author":"Choi","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120972_bib8","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1016\/j.bbadis.2013.04.002","article-title":"Electrophysiological changes in heart failure and their implications for arrhythmogenesis","volume":"1832","author":"Coronel","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jep.2025.120972_bib9","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/14656566.2019.1703950","article-title":"Current pharmacotherapeutic strategies for cardiac arrhythmias in heart failure","volume":"21","author":"Correa","year":"2020","journal-title":"Expet Opin. Pharmacother."},{"key":"10.1016\/j.jep.2025.120972_bib10","first-page":"2518","article-title":"Clinical efficacy of Yiqi Fumai Formula in treating ventricular premature contractions of qi-deficiency and blood-stasis with phlegm-stasis obstruction type [\u76ca\u6c14\u590d\u8109\u65b9\u6cbb\u7597\u6c14\u865a\u8840\u7600\u3001\u75f0\u7600\u4e92\u963b\u578b\u5ba4\u6027\u671f\u524d\u6536\u7f29\u7684\u4e34\u5e8a\u7597\u6548]","volume":"22","author":"Cui","year":"2024","journal-title":"Zhongxi Yi Jiehe Xinnaoxueguanbing Zazhi (Chinese Journal of Integrative Medicine on Cardio-\/Cerebrovascular Disease)"},{"key":"10.1016\/j.jep.2025.120972_bib11","doi-asserted-by":"crossref","first-page":"33404","DOI":"10.1074\/jbc.M110.114058","article-title":"The sodium channel beta3-subunit induces multiphasic gating in NaV1.3 and affects fast inactivation via distinct intracellular regions","volume":"285","author":"Cusdin","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2025.120972_bib12","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.tips.2010.12.001","article-title":"Cardiac electrical remodeling in health and disease","volume":"32","author":"Cutler","year":"2011","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jep.2025.120972_bib13","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1161\/01.CIR.0000016701.85760.97","article-title":"Intracellular Na(+) concentration is elevated in heart failure but Na\/K pump function is unchanged","volume":"105","author":"Despa","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2025.120972_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1162036","article-title":"A review of the botany, ethnopharmacology, phytochemistry, analysis method and quality control, processing methods, pharmacological effects, pharmacokinetics and toxicity of codonopsis radix","volume":"14","author":"Dong","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120972_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112141","article-title":"Soporific effect of modified Suanzaoren Decoction on mice models of insomnia by regulating Orexin-A and HPA axis homeostasis","volume":"143","author":"Dong","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.120972_bib16","first-page":"1504","article-title":"Effects of Shenlian-Fumai Granules on ventricular arrhythmia and late sodium current in heart failure mice [\u53c2\u8fde\u590d\u8109\u9897\u7c92\u5bf9\u5fc3\u529b\u8870\u7aed\u5c0f\u9f20\u5fc3\u5f8b\u5931\u5e38\u53ca\u5fc3\u808c\u7ec6\u80de\u665a\u94a0\u7535\u6d41\u7684\u5f71\u54cd]","volume":"60","author":"Gao","year":"2019","journal-title":"Zhongyi Zazhi (Journal of Traditional Chinese Medicine)"},{"key":"10.1016\/j.jep.2025.120972_bib17","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1161\/CIRCULATIONAHA.114.015218","article-title":"Voltage-Gated sodium channel phosphorylation at Ser571 regulates late Current, arrhythmia, and cardiac function in vivo","volume":"132","author":"Glynn","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2025.120972_bib18","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0896-6273(00)00116-1","article-title":"Nomenclature of voltage-gated sodium channels","volume":"28","author":"Goldin","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.jep.2025.120972_bib19","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.2174\/092986710793205336","article-title":"Disposition pathways and pharmacokinetics of herbal medicines in humans","volume":"17","author":"He","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jep.2025.120972_bib20","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1161\/CIRCULATIONAHA.121.057237","article-title":"Empagliflozin reverses late Na(+) Current enhancement and cardiomyocyte proarrhythmia in a translational murine model of heart failure with preserved ejection fraction","volume":"145","author":"Hegyi","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2025.120972_bib21","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1161\/01.RES.84.6.713","article-title":"Identification and expression of delta-isoforms of the multifunctional Ca2+\/calmodulin-dependent protein kinase in failing and nonfailing human myocardium","volume":"84","author":"Hoch","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2025.120972_bib22","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.cell.2019.11.041","article-title":"Structure of the Cardiac sodium channel","volume":"180","author":"Jiang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jep.2025.120972_bib23","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/ejhf.1594","article-title":"Survival of patients with chronic heart failure in the community: a systematic review and meta-analysis","volume":"21","author":"Jones","year":"2019","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.jep.2025.120972_bib24","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0008-6363(98)00296-X","article-title":"Activity of cAMP-dependent protein kinase and Ca2+\/calmodulin-dependent protein kinase in failing and nonfailing human hearts","volume":"42","author":"Kirchhefer","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jep.2025.120972_bib25","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1113\/jphysiol.2010.187708","article-title":"Activation of reverse Na+-Ca2+ exchange by the Na+ current augments the cardiac Ca2+ transient: evidence from NCX knockout mice","volume":"588","author":"Larbig","year":"2010","journal-title":"J. Physiol."},{"key":"10.1016\/j.jep.2025.120972_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119921","article-title":"Ferulic acid: a review of its pharmacology, pharmacokinetics and derivatives","volume":"284","author":"Li","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2025.120972_bib27","article-title":"Therapeutic effects of traditional Chinese medicine on cardiovascular diseases: the central role of calcium signaling","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120972_bib28","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/aps.2017.193","article-title":"Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics","volume":"39","author":"Li","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2025.120972_bib29","first-page":"744","article-title":"[The effect of tanshinone II A on the transmembrance action potential of myocardial cells in LQT2 rabbit models]","volume":"44","author":"Liang","year":"2013","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.jep.2025.120972_bib30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2165\/00129785-200303030-00003","article-title":"Mutations in cardiac sodium channels: clinical implications","volume":"3","author":"Liu","year":"2003","journal-title":"Am. J. PharmacoGenomics"},{"key":"10.1016\/j.jep.2025.120972_bib31","first-page":"287","article-title":"Effects of Codonopsis pilosula on electrophysiological remodeling in pressure overload-induced heart failure mice","volume":"16","author":"Liu","year":"2018","journal-title":"Zhongxi Yi Jiehe Xinnaoxueguanbing Zazhi (Chinese Journal of Integrative Medicine on Cardio-\/Cerebrovascular Disease)"},{"key":"10.1016\/j.jep.2025.120972_bib32","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1111\/pace.13206","article-title":"Wenxin Keli diminishes Ca(2+) overload induced by hypoxia\/reoxygenation in cardiomyocytes through inhibiting I(NaL) and I(CaL)","volume":"40","author":"Luo","year":"2017","journal-title":"Pacing Clin. Electrophysiol."},{"key":"10.1016\/j.jep.2025.120972_bib33","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1161\/01.CIR.0000121421.61896.24","article-title":"Distinct subcellular localization of different sodium channel alpha and beta subunits in single ventricular myocytes from mouse heart","volume":"109","author":"Maier","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2025.120972_bib34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.tcm.2015.05.006","article-title":"Late sodium current: a mechanism for angina, heart failure, and arrhythmia","volume":"26","author":"Makielski","year":"2016","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.jep.2025.120972_bib35","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.cardiores.2005.08.015","article-title":"A multi-modal composition of the late Na+ current in human ventricular cardiomyocytes","volume":"69","author":"Maltsev","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jep.2025.120972_bib36","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/ejhf.2212","article-title":"Sudden cardiac death in heart failure: more than meets the eye","volume":"23","author":"Mulder","year":"2021","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.jep.2025.120972_bib37","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pharmthera.2016.10.006","article-title":"CaMKII as a target for arrhythmia suppression","volume":"176","author":"Mustroph","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jep.2025.120972_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2021.151748","article-title":"Protein 4.1 family and ion channel proteins interact to regulate the process of heart failure in rats","volume":"123","author":"Ning","year":"2021","journal-title":"Acta Histochem."},{"key":"10.1016\/j.jep.2025.120972_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21041330","article-title":"Advances in chemistry and bioactivity of magnoflorine and magnoflorine-containing extracts","volume":"21","author":"Okon","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.120972_bib40","doi-asserted-by":"crossref","first-page":"H1227","DOI":"10.1152\/ajpheart.00185.2017","article-title":"Ca(2+)\/calmodulin-dependent kinase II-dependent regulation of atrial myocyte late Na(+) current, Ca(2+) cycling, and excitability: a mathematical modeling study","volume":"313","author":"Onal","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jep.2025.120972_bib41","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.31083\/j.rcm2204143","article-title":"Amiodarone in ventricular arrhythmias: still a valuable resource?","volume":"22","author":"Pannone","year":"2021","journal-title":"Rev. Cardiovasc. Med."},{"key":"10.1016\/j.jep.2025.120972_bib42","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1113\/jphysiol.2013.262261","article-title":"CrossTalk proposal: the late sodium current is an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction)","volume":"592","author":"Pourrier","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.jep.2025.120972_bib43","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/aps.2009.180","article-title":"CPU86017, a berberine derivative, attenuates cardiac failure through normalizing calcium leakage and downregulated phospholamban and exerting antioxidant activity","volume":"31","author":"Qi","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2025.120972_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115257","article-title":"Pharmacological activities and pharmacokinetics of liquiritin: a review","volume":"293","author":"Qin","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120972_bib45","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1161\/CIRCHEARTFAILURE.109.865279","article-title":"Calcium\/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure","volume":"2","author":"Sag","year":"2009","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jep.2025.120972_bib46","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/164_2017_43","article-title":"Cardiac arrhythmias related to sodium channel dysfunction","volume":"246","author":"Savio-Galimberti","year":"2018","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.jep.2025.120972_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113685","article-title":"Medicinal plants from the 14(th) edition of the Russian Pharmacopoeia, recent updates","volume":"268","author":"Shikov","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120972_bib48","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s00246-012-0303-y","article-title":"Cardiac sodium channel Nav1.5 mutations and cardiac arrhythmia","volume":"33","author":"Song","year":"2012","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.jep.2025.120972_bib49","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1113\/EP089088","article-title":"SCN5A-C683R exhibits combined gain-of-function and loss-of-function properties related to adrenaline-triggered ventricular arrhythmia","volume":"106","author":"Steinberg","year":"2021","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.jep.2025.120972_bib50","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neulet.2018.12.008","article-title":"Fenamates inhibit human sodium channel Nav1.7 and Nav1.8","volume":"696","author":"Sun","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jep.2025.120972_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118178","article-title":"Exploring the effective components of honey-processed licorice (Glycyrrhiza uralensis Fisch.) in attenuating Doxorubicin-induced myocardial cytotoxicity by combining network pharmacology and in vitro experiments","volume":"329","author":"Sun","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120972_bib52","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.yjmcc.2013.03.021","article-title":"Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease","volume":"61","author":"Toischer","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.jep.2025.120972_bib53","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1172\/JCI26620","article-title":"Ca2+\/calmodulin-dependent protein kinase II regulates cardiac Na+ channels","volume":"116","author":"Wagner","year":"2006","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jep.2025.120972_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/plants10122751","article-title":"Glycyrrhiza glabra (Licorice): a comprehensive review on its phytochemistry, biological activities, clinical evidence and toxicology","volume":"10","author":"Wahab","year":"2021","journal-title":"Plants"},{"key":"10.1016\/j.jep.2025.120972_bib55","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/13880209.2019.1577466","article-title":"Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology","volume":"57","author":"Wang","year":"2019","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2025.120972_bib56","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/ptr.3097","article-title":"Berberine elicits anti-arrhythmic effects via IK1\/Kir2.1 in the rat type 2 diabetic myocardial infarction model","volume":"25","author":"Wang","year":"2011","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2025.120972_bib57","doi-asserted-by":"crossref","first-page":"616","DOI":"10.3389\/fphar.2019.00616","article-title":"Neuregulin-1beta partially improves cardiac function in volume-overload heart failure through regulation of abnormal calcium handling","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120972_bib58","article-title":"Ligusticum chuanxiong: a chemical, pharmacological and clinical review","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120972_bib59","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1113\/expphysiol.2014.083972","article-title":"Protein kinase C and Ca(2+) -calmodulin-dependent protein kinase II mediate the enlarged reverse INCX induced by ouabain-increased late sodium current in rabbit ventricular myocytes","volume":"100","author":"Wu","year":"2015","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.jep.2025.120972_bib60","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13020-024-00944-8","article-title":"Natural L-type calcium channels antagonists from Chinese medicine","volume":"19","author":"Xu","year":"2024","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2025.120972_bib61","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1253\/circj.70.1407","article-title":"Arrhythmogenic effects of arsenic trioxide in patients with acute promyelocytic leukemia and an electrophysiological study in isolated Guinea pig papillary muscles","volume":"70","author":"Yamazaki","year":"2006","journal-title":"Circ. J."},{"key":"10.1016\/j.jep.2025.120972_bib62","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00424-017-2079-7","article-title":"Late sodium current associated cardiac electrophysiological and mechanical dysfunction","volume":"470","author":"Yu","year":"2018","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.jep.2025.120972_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154483","article-title":"Therapeutic potential of Polygala saponins in neurological diseases","volume":"108","author":"Zhang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120972_bib64","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1161\/01.RES.0000069686.31472.C5","article-title":"The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure","volume":"92","author":"Zhang","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2025.120972_bib65","first-page":"1450","article-title":"Effect of berberine on acetylcholine-induced atrial fibrillation in rabbit","volume":"7","author":"Zhou","year":"2015","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.jep.2025.120972_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e22153","article-title":"A review of the research progress on Pinellia ternata (Thunb.) Breit.: botany, traditional uses, phytochemistry, pharmacology, toxicity and quality control","volume":"9","author":"Zou","year":"2023","journal-title":"Heliyon"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125016642?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125016642?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:52:04Z","timestamp":1776135124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125016642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":66,"alternative-id":["S0378874125016642"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120972","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shenlian-Fumai formula attenuates ventricular arrhythmias via modulating sodium channel function in heart failure mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120972","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"120972"}}