{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:15:33Z","timestamp":1791670533146,"version":"4.3.4"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20790"],"award-info":[{"award-number":["U24A20790"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2022ZYD0088"],"award-info":[{"award-number":["2022ZYD0088"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2024NSFSC0054"],"award-info":[{"award-number":["2024NSFSC0054"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2021JDRC0041"],"award-info":[{"award-number":["2021JDRC0041"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["ZYYCXTD-D-202209"],"award-info":[{"award-number":["ZYYCXTD-D-202209"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["QJJJ2023009Q"],"award-info":[{"award-number":["QJJJ2023009Q"]}],"id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["BSZ2023041"],"award-info":[{"award-number":["BSZ2023041"]}],"id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jep.2025.120987","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T07:58:39Z","timestamp":1764575919000},"page":"120987","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Forsythiaside A ameliorates acetaminophen-induced liver injury by suppressing ferroptosis through activating USP11\/SIRT3-mediated mitophagy"],"prefix":"10.1016","volume":"358","author":[{"given":"Mengling","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9256-5716","authenticated-orcid":false,"given":"Yunxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"26","key":"10.1016\/j.jep.2025.120987_bib1","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1056\/NEJMra1208937","article-title":"Acute liver failure","volume":"369","author":"Bernal","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.jep.2025.120987_bib2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.cld.2018.01.007","article-title":"Acetaminophen (APAP or N-Acetyl-p-Aminophenol) and acute liver failure","volume":"22","author":"Bunchorntavakul","year":"2018","journal-title":"Clin. Liver Dis."},{"issue":"38","key":"10.1016\/j.jep.2025.120987_bib3","doi-asserted-by":"crossref","first-page":"42887","DOI":"10.1021\/acsami.2c10506","article-title":"Astaxanthin activated the Nrf2\/HO-1 pathway to enhance autophagy and inhibit ferroptosis, ameliorating acetaminophen-induced liver injury","volume":"14","author":"Cai","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"10.1016\/j.jep.2025.120987_bib4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41388-023-02847-8","article-title":"USP11 potentiates HGF\/AKT signaling and drives metastasis in hepatocellular carcinoma","volume":"43","author":"Chen","year":"2024","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.jep.2025.120987_bib5","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2337\/db22-0553","article-title":"Isorhapontigenin attenuates cardiac microvascular injury in diabetes via the inhibition of mitochondria-associated ferroptosis through PRDX2-MFN2-ACSL4 pathways","volume":"72","author":"Chen","year":"2023","journal-title":"Diabetes"},{"key":"10.1016\/j.jep.2025.120987_bib6","series-title":"Pharmacopeia of the People's Republic of China","author":"Commission","year":"2020"},{"issue":"2","key":"10.1016\/j.jep.2025.120987_bib7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1365-2125.2011.04067.x","article-title":"Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity","volume":"73","author":"Craig","year":"2012","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2025.120987_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155458","article-title":"Xanthohumol ameliorates drug-induced hepatic ferroptosis via activating Nrf2\/xCT\/GPX4 signaling pathway","volume":"126","author":"Deng","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.120987_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103737","article-title":"Discovery of a novel chalcone-derived covalent Keap1 binder for mitigating cisplatin-induced mitochondrial dysfunction and nephrotoxicity","volume":"85","author":"Deng","year":"2025","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.jep.2025.120987_bib10","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.jep.2025.120987_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22091466","article-title":"Forsythiae fructus: a review on its phytochemistry, quality control, pharmacology and pharmacokinetics","volume":"22","author":"Dong","year":"2017","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jep.2025.120987_bib12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41413-024-00390-0","article-title":"Isovitexin targets SIRT3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis","volume":"13","author":"Fan","year":"2025","journal-title":"Bone Res."},{"key":"10.1016\/j.jep.2025.120987_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113185","article-title":"Forsythiaside A alleviated carbon tetrachloride-induced liver fibrosis by modulating gut microbiota composition to increase short-chain fatty acids and restoring bile acids metabolism disorder","volume":"151","author":"Fu","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.120987_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105690","article-title":"A review of pharmacological and pharmacokinetic properties of forsythiaside A","volume":"169","author":"Gong","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"11","key":"10.1016\/j.jep.2025.120987_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202202228","article-title":"CD44-Targeting drug delivery system of exosomes loading forsythiaside A combats liver fibrosis via regulating NLRP3-Mediated pyroptosis","volume":"12","author":"Gong","year":"2023","journal-title":"Adv. Healthcare Mater."},{"issue":"1","key":"10.1016\/j.jep.2025.120987_bib16","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2404138","article-title":"Intestinal deguelin drives resistance to acetaminophen-induced hepatotoxicity in female mice","volume":"16","author":"Gong","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jep.2025.120987_bib17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.freeradbiomed.2024.05.042","article-title":"Forsythiaside-A improved bile-duct-ligation-induced liver fibrosis in mice: the involvement of alleviating mitochondrial damage and ferroptosis in hepatocytes via activating Nrf2","volume":"222","author":"Guo","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2025.120987_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103657","article-title":"Ferroptosis in acute liver failure: unraveling the hepcidin-ferroportin axis and therapeutic interventions","volume":"84","author":"He","year":"2025","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.jep.2025.120987_bib19","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/hep.21106","article-title":"Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study","volume":"43","author":"Holubek","year":"2006","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jep.2025.120987_bib20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11064-014-1461-5","article-title":"Forsythiaside protects against hydrogen peroxide-induced oxidative stress and apoptosis in PC12 cell","volume":"40","author":"Huang","year":"2015","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.jep.2025.120987_bib21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/03602532.2011.602688","article-title":"Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity","volume":"44","author":"Jaeschke","year":"2012","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.jep.2025.120987_bib22","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev-pathmechdis-051122-094016","article-title":"Acetaminophen hepatotoxicity: Paradigm for understanding mechanisms of drug-induced liver injury","volume":"19","author":"Jaeschke","year":"2024","journal-title":"Annu. Rev. Pathol."},{"issue":"8","key":"10.1016\/j.jep.2025.120987_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/nu13082901","article-title":"Forsythia fruit prevents fulminant hepatitis in mice and ameliorates inflammation in murine macrophages","volume":"13","author":"Jeong","year":"2021","journal-title":"Nutrients"},{"issue":"8","key":"10.1016\/j.jep.2025.120987_bib24","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1080\/15548627.2019.1582743","article-title":"SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions","volume":"15","author":"Kim","year":"2019","journal-title":"Autophagy"},{"issue":"7","key":"10.1016\/j.jep.2025.120987_bib25","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41419-023-05978-8","article-title":"Autophagy mediates an amplification loop during ferroptosis","volume":"14","author":"Lee","year":"2023","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.jep.2025.120987_bib26","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1039\/D2FO02716J","article-title":"Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation","volume":"14","author":"Li","year":"2023","journal-title":"Food Funct."},{"issue":"21","key":"10.1016\/j.jep.2025.120987_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/cells11213368","article-title":"Ancient Herbal Formula Mahuang Lianqiao Chixiaodou Decoction Protects Acute and Acute-on-Chronic Liver Failure via Inhibiting von Willebrand Factor Signaling","volume":"11","author":"Lin","year":"2022","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.jep.2025.120987_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.564","article-title":"SIRT3 protects hepatocytes from oxidative injury by enhancing ROS scavenging and mitochondrial integrity","volume":"8","author":"Liu","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2025.120987_bib29","article-title":"Ferroptosis as an emerging therapeutic target in liver diseases","volume":"14","author":"Lu","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2025.120987_bib30","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jhep.2016.04.025","article-title":"Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice","volume":"65","author":"Ni","year":"2016","journal-title":"J. Hepatol."},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2025.120987_bib31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0168-8278(97)82332-X","article-title":"Paracetamol-induced acute liver failure: prevention and management","volume":"26","author":"O'Grady","year":"1997","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.jep.2025.120987_bib32","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.intimp.2015.03.009","article-title":"Protective effect of forsythiaside A on lipopolysaccharide\/d-galactosamine-induced liver injury","volume":"26","author":"Pan","year":"2015","journal-title":"Int. Immunopharmacol."},{"issue":"10","key":"10.1016\/j.jep.2025.120987_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107768","article-title":"USP11 deubiquitinates E-cadherin and maintains the luminal fate of mammary tumor cells to suppress breast cancer","volume":"300","author":"Qian","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2025.120987_bib34","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3389\/fphar.2020.00156","article-title":"Li-Dan-He-Ji improves infantile cholestasis hepatopathy through inhibiting calcium-sensing receptor-mediated hepatocyte apoptosis","volume":"11","author":"Qin","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"28","key":"10.1016\/j.jep.2025.120987_bib35","doi-asserted-by":"crossref","first-page":"17940","DOI":"10.1074\/jbc.273.28.17940","article-title":"Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry","volume":"273","author":"Qiu","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2025.120987_bib36","doi-asserted-by":"crossref","first-page":"96","DOI":"10.47278\/journal.abr\/2024.041","article-title":"Impact of Fusobacterium nucleatum infection on ferroptosis suppression, oxidative stress, and prognostic outcomes in esophageal squamous cell carcinoma","volume":"18","author":"Shafiq","year":"2024","journal-title":"Agrobiol. Records"},{"issue":"1","key":"10.1016\/j.jep.2025.120987_bib37","doi-asserted-by":"crossref","first-page":"7598","DOI":"10.1038\/s41467-023-43308-w","article-title":"Targeting ferroptosis by poly(acrylic) acid coated Mn(3)O(4) nanoparticles alleviates acute liver injury","volume":"14","author":"Shan","year":"2023","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.jep.2025.120987_bib38","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jep.2025.120987_bib39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.34133\/bmr.0167","article-title":"Natural polyphenol-mediated inhibition of ferroptosis alleviates oxidative damage and inflammation in acute liver injury","volume":"29","author":"Su","year":"2025","journal-title":"Biomater. Res."},{"key":"10.1016\/j.jep.2025.120987_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106361","article-title":"Progress in the treatment of drug-induced liver injury with natural products","volume":"183","author":"Sun","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.jep.2025.120987_bib41","first-page":"198","article-title":"Acute liver failure","volume":"28","author":"Vasques","year":"2022","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.jep.2025.120987_bib42","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.freeradbiomed.2025.08.020","article-title":"Kaempferol induces mitophagy and disrupts iron metabolism via SFXN2 leading to apoptosis in multiple myeloma cells","volume":"240","author":"Wang","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2025.120987_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103259","article-title":"Protein modification and degradation in ferroptosis","volume":"75","author":"Wang","year":"2024","journal-title":"Redox Biol."},{"issue":"11","key":"10.1016\/j.jep.2025.120987_bib44","article-title":"Multienzyme active manganese oxide alleviates acute liver injury by mimicking redox regulatory system and inhibiting ferroptosis","volume":"13","author":"Wu","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.jep.2025.120987_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156053","article-title":"Shaoyao-gancao decoction, a famous Chinese medicine formula, protects against APAP-induced liver injury by promoting autophagy\/mitophagy","volume":"135","author":"Wu","year":"2024","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.jep.2025.120987_bib46","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41419-020-2334-2","article-title":"Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure","volume":"11","author":"Yamada","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2025.120987_bib47","series-title":"Different sensitivity of acetaminophen-induced acute liver injury in mice of different genders","author":"Yan","year":"2017"},{"key":"10.1016\/j.jep.2025.120987_bib48","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.redox.2018.04.019","article-title":"Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions","volume":"17","author":"Yan","year":"2018","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.jep.2025.120987_bib49","doi-asserted-by":"crossref","first-page":"428","DOI":"10.14218\/JCTH.2023.00446","article-title":"Subnormal serum liver enzyme levels: a review of pathophysiology and clinical significance","volume":"12","author":"Youssef","year":"2024","journal-title":"J. Clin. Transl. Hepatol."},{"issue":"5","key":"10.1016\/j.jep.2025.120987_bib50","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.chom.2023.04.002","article-title":"Liberation of daidzein by gut microbial \u03b2-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice","volume":"31","author":"Zeng","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jep.2025.120987_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103557","article-title":"Quercetin alleviates LPS\/iE-DAP-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux","volume":"81","author":"Zhang","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2025.120987_bib52","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.semcancer.2019.03.002","article-title":"Ferroptosis is a type of autophagy-dependent cell death","volume":"66","author":"Zhou","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.jep.2025.120987_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102707","article-title":"The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing Sirt3","volume":"62","author":"Zhu","year":"2023","journal-title":"Redox Biol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125016794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125016794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:49:13Z","timestamp":1777571353000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125016794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":53,"alternative-id":["S0378874125016794"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120987","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Forsythiaside A ameliorates acetaminophen-induced liver injury by suppressing ferroptosis through activating USP11\/SIRT3-mediated mitophagy","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120987","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120987"}}