{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:11:13Z","timestamp":1792267873569,"version":"4.4.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020230","name":"Health Commission of Jilin Province","doi-asserted-by":"publisher","award":["2024A082"],"award-info":[{"award-number":["2024A082"]}],"id":[{"id":"10.13039\/501100020230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["YDZJ202301ZYTS138"],"award-info":[{"award-number":["YDZJ202301ZYTS138"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["YDZJ202401147ZYTS"],"award-info":[{"award-number":["YDZJ202401147ZYTS"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jep.2025.120990","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T23:33:38Z","timestamp":1765668818000},"page":"120990","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Research on the mechanism of Zuogui Wan in ameliorating oligoasthenozoospermia in rats via modulating cuproptosis-related pathways"],"prefix":"10.1016","volume":"359","author":[{"given":"Yarong","family":"Zha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhitao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120990_bib1","first-page":"277","article-title":"Coenzyme Q10 improves sperm motility and antioxidant status in infertile men with idiopathic oligoasthenospermia","volume":"49","author":"Alahmar","year":"2022","journal-title":"CERM"},{"issue":"Database issue","key":"10.1016\/j.jep.2025.120990_bib2","doi-asserted-by":"crossref","first-page":"D789","DOI":"10.1093\/nar\/gku1205","article-title":"OMIM.org: Online mendelian inheritance in man (OMIM\u00ae), an online catalog of human genes and genetic disorders","volume":"43","author":"Amberger","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2025.120990_bib3","first-page":"1287","article-title":"The impact of exogenous testosterone supplementation on spermatogenesis in a rat model of oligoasthenospermia","volume":"13","author":"An","year":"2020","journal-title":"IJCEP"},{"issue":"2","key":"10.1016\/j.jep.2025.120990_bib4","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1073\/pnas.1612322114","article-title":"Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes","volume":"114","author":"Andreu-Fern\u00e1ndez","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"3","key":"10.1016\/j.jep.2025.120990_bib5","first-page":"319","article-title":"Galectin-1 reduces the severity of dextran sulfate sodium (DSS)-Induced ulcerative colitis by suppressing inflammatory and oxidative stress response","volume":"20","author":"Arda-Pirincci","year":"2020","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"10.1016\/j.jep.2025.120990_bib6","article-title":"Effects of branched-chain amino acid supplementation And\/or aerobic exercise on mouse sperm quality and testosterone production","volume":"51","author":"Bahadorani","year":"2018","journal-title":"Andrologia"},{"key":"10.1016\/j.jep.2025.120990_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2021.101097","article-title":"A review of the functional effects of pine nut oil, pinolenic acid and its derivative eicosatrienoic acid and their potential health benefits","volume":"82","author":"Baker","year":"2021","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.jep.2025.120990_bib8","article-title":"Enhancing the fertility potential: a case report on the management of oligoasthenozoospermia using a microfluidic device","volume":"16","author":"Bedwal","year":"2024","journal-title":"Cureus"},{"issue":"2","key":"10.1016\/j.jep.2025.120990_bib9","doi-asserted-by":"crossref","DOI":"10.59565\/YKWF8666","article-title":"You Gui Wan (restore the right [Kidney] pill)","volume":"17","author":"Beebe","year":"2022","journal-title":"American Journal of Traditional Chinese Veterinary Medicine"},{"key":"10.1016\/j.jep.2025.120990_bib10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1745-7262.2006.00123.x","article-title":"Male idiopathic oligoasthenoteratozoospermia","volume":"8","author":"Cavallini","year":"2006","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.jep.2025.120990_bib11","first-page":"964","article-title":"Lycium barbarum polysaccharides exert an antioxidative effect on rat chondrocytes by activating the nuclear factor (erythroid-derived 2)-like 2 signaling pathway","volume":"16","author":"Chen","year":"2018","journal-title":"AMS"},{"key":"10.1016\/j.jep.2025.120990_bib12","article-title":"Copper homeostasis and cuproptosis in health and disease","volume":"7","author":"Chen","year":"2022","journal-title":"STTT"},{"issue":"8","key":"10.1016\/j.jep.2025.120990_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e18655","article-title":"FDX1 inhibits thyroid cancer malignant progression by inducing cuprotosis","volume":"9","author":"Chen","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2025.120990_bib14","first-page":"51","article-title":"Zuoguiwan for treating congenital essence deficiency in offspring","author":"Chen","year":"2024","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2025.120990_bib15","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.taap.2019.04.014","article-title":"Untargeted LC-MS-based metabonomics revealed that aristolochic acid I induces testicular toxicity by inhibiting amino acids metabolism, glucose metabolism, \u03b2-oxidation of fatty acids and the TCA cycle in Male mice","volume":"373","author":"Cui","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2025.120990_bib16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/01485010390219656","article-title":"Asthenozoospermia: analysis of a large population","volume":"49","author":"Curi","year":"2003","journal-title":"Arch. Androl."},{"key":"10.1016\/j.jep.2025.120990_bib17","article-title":"Hua-Tan-Sheng-Jing decoction treats obesity with oligoasthenozoospermia by Up-Regulating the PI3K-AKT and down-regulating the JNK MAPK signaling pathways: at the crossroad of obesity and oligoasthenozoospermia","volume":"13","author":"Dong","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120990_bib18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/2090598X.2019.1599624","article-title":"Oxidative stress and sperm function: a systematic review on evaluation and management","volume":"17","author":"Dutta","year":"2019","journal-title":"Arab J. Urol"},{"key":"10.1016\/j.jep.2025.120990_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221810043","article-title":"Oxidative stress, testicular inflammatory pathways, and Male reproduction","volume":"22","author":"Dutta","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.120990_bib20","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/andr.12743","article-title":"Predictive value of oxidative stress testing in semen for sperm DNA fragmentation assessed by sperm chromatin dispersion test","volume":"8","author":"Elbardisi","year":"2020","journal-title":"Andrology"},{"key":"10.1016\/j.jep.2025.120990_bib21","first-page":"1","article-title":"Prolactin and Male fertility: the long and short feedback regulation","volume":"2009","author":"Gill-Sharma","year":"2009","journal-title":"Internet J. Endocrinol."},{"key":"10.1016\/j.jep.2025.120990_bib22","first-page":"557","article-title":"Effects of Cistanche deserticola extract on penis erectile response in castrated rats","volume":"29","author":"Gu","year":"2016","journal-title":"PJPS"},{"key":"10.1016\/j.jep.2025.120990_bib23","doi-asserted-by":"crossref","first-page":"52","DOI":"10.4103\/aja.aja_9_20","article-title":"Serum vitamin D content is associated with semen parameters and serum testosterone levels in men","volume":"23","author":"Hallak","year":"2021","journal-title":"Asian J. Androl."},{"issue":"6652","key":"10.1016\/j.jep.2025.120990_bib24","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1126\/science.adi6827","article-title":"Staving off cell death","volume":"380","author":"Hardie","year":"2023","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.jep.2025.120990_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21239053","article-title":"Molecular regulation of copper homeostasis in the Male gonad during the process of spermatogenesis","volume":"21","author":"Herman","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.120990_bib27","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/andr.12678","article-title":"Symptoms of sexual dysfunction among men from infertile couples: prevalence and association with testosterone deficiency","volume":"8","author":"Kruljac","year":"2019","journal-title":"Andrology"},{"key":"10.1016\/j.jep.2025.120990_bib28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1080\/13880209.2019.1693603","article-title":"Effects of zuogui wan on testis structure and expression of c-Kit and Oct4 in rats with impaired spermatogenesis","volume":"58","author":"Li","year":"2019","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2025.120990_bib29","first-page":"7092","article-title":"Analysis of the factors influencing Male infertility of reproductive age in jinan","volume":"27","author":"Li","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.jep.2025.120990_bib31","first-page":"4074","article-title":"Pan-cancer profiles of the cuproptosis gene set","volume":"12","author":"Liu","year":"2022","journal-title":"Am. J. Cancer Res."},{"issue":"2","key":"10.1016\/j.jep.2025.120990_bib32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41419-024-06489-w","article-title":"Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers","volume":"15","author":"Liu","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2025.120990_bib33","first-page":"1","article-title":"An analysis of treating osteoporosis with Zuogui Wan in possible molecular mechanisms and biological processes","author":"Lu","year":"2023","journal-title":"Clin. J. Chin. Med."},{"key":"10.1016\/j.jep.2025.120990_bib34","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cbpa.2010.01.003","article-title":"Human copper homeostasis: a network of interconnected pathways","volume":"14","author":"Lutsenko","year":"2010","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.jep.2025.120990_bib35","first-page":"1580","article-title":"Charting the travels of copper in eukaryotes from yeast to mammals","volume":"1823","author":"Nevitt","year":"2012","journal-title":"Bba-mol Cell Res"},{"key":"10.1016\/j.jep.2025.120990_bib36","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1080\/17435390.2022.2133647","article-title":"Treatment of copper nanoparticles (CuNPs) for two spermatogenic cycles impairs testicular activity via down-regulating steroid receptors and inhibition of germ cell proliferation in a mice model","volume":"16","author":"Nicy","year":"2022","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.jep.2025.120990_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.603262","article-title":"The role of mitochondrial impairment and oxidative stress in the pathogenesis of lithium-induced reproductive toxicity in Male mice","volume":"8","author":"Ommati","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.jep.2025.120990_bib38","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/humupd\/dmr018","article-title":"Absolute asthenozoospermia and ICSI: what are the options?","volume":"17","author":"Ortega","year":"2011","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jep.2025.120990_bib39","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70039","article-title":"Cuproptosis: mechanisms, biological significance, and advances in disease treatment\u2014A systematic review","volume":"30","author":"Pan","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"4","key":"10.1016\/j.jep.2025.120990_bib40","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0168-9525(97)01103-7","article-title":"GeneCards: integrating information about genes, proteins and diseases","volume":"13","author":"Rebhan","year":"1997","journal-title":"Trends Genet. : TIG"},{"key":"10.1016\/j.jep.2025.120990_bib41","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Cheminf."},{"key":"10.1016\/j.jep.2025.120990_bib42","first-page":"737","article-title":"Oxidative stress and Male infertility: from research bench to clinical practice","volume":"23","author":"Saleh","year":"2002","journal-title":"Andrology"},{"key":"10.1016\/j.jep.2025.120990_bib43","doi-asserted-by":"crossref","first-page":"478","DOI":"10.4103\/aja.aja_110_18","article-title":"Heavy cigarette smoking and alcohol consumption are associated with impaired sperm parameters in primary infertile men","volume":"21","author":"Salonia","year":"2019","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.jep.2025.120990_bib44","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cancergen.2024.12.006","article-title":"Omics approaches: role in acute myeloid leukemia biomarker discovery and therapy","volume":"292\u2013293","author":"Shafiei","year":"2025","journal-title":"Cancer Genet."},{"key":"10.1016\/j.jep.2025.120990_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.00694","article-title":"Lifestyle, oxidative stress, and antioxidants: back and forth in the pathophysiology of chronic diseases","volume":"11","author":"Sharifi-Rad","year":"2020","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.jep.2025.120990_bib46","article-title":"Biomimetics through bioconjugation of 16-methylheptadecanoic acid to damaged hair for hair barrier recovery","volume":"14","author":"Song","year":"2024","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.jep.2025.120990_bib48","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.3390\/ijms24021171","article-title":"The beneficial effects of pine nuts and its major fatty acid, pinolenic acid, on inflammation and metabolic perturbations in inflammatory disorders","volume":"24","author":"Takala","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.jep.2025.120990_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294236","article-title":"SRplot: a free online platform for data visualization and graphing","volume":"18","author":"Tang","year":"2023","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jep.2025.120990_bib50","doi-asserted-by":"crossref","first-page":"516","DOI":"10.7150\/ijbs.84399","article-title":"p32 regulates glycometabolism and TCA cycle to inhibit ccRCC progression via copper-induced DLAT lipoylation oligomerization","volume":"20","author":"Tian","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jep.2025.120990_bib51","article-title":"Infertility affects quality of life for men too","volume":"386","author":"Titley","year":"2024","journal-title":"BMJ"},{"key":"10.1016\/j.jep.2025.120990_bib52","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.jep.2025.120990_bib53","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cancergen.2025.08.010","article-title":"Comprehensive analysis of oncogenic determinants across tumor types via multi-omics integration","volume":"298\u2013299","author":"Ubaid","year":"2025","journal-title":"Cancer Genet."},{"key":"10.1016\/j.jep.2025.120990_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104295","article-title":"Two resveratrol analogs, pinosylvin and 4,4'-dihydroxystilbene, improve oligoasthenospermia in a mouse model by attenuating oxidative stress via the Nrf2-ARE pathway","volume":"104","author":"Wang","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.jep.2025.120990_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113790","article-title":"To study the mechanism of Cuscuta chinensis lam. and Lycium barbarum L. in the treatment of asthenospermia based on network pharmacology","volume":"270","author":"Wang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120990_bib56","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40001-022-00968-6","article-title":"Efficacy and safety of nonpharmacological strategies for the treatment of oligoasthenospermia: a systematic review and bayesian network meta-analysis","volume":"28","author":"Wang","year":"2023","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.jep.2025.120990_bib57","article-title":"Mechanisms of oxidative stress-induced sperm dysfunction","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Endocrinol."},{"issue":"11","key":"10.1016\/j.jep.2025.120990_bib58","first-page":"553","article-title":"Quercetin protects goat sperm motility by inhibiting neutrophil extracellular traps and maintaining plasma membrane and acrosome integrity","volume":"11","author":"Wei","year":"2024","journal-title":"Vet. Sci."},{"key":"10.1016\/j.jep.2025.120990_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.981764","article-title":"Multi-omics pan-cancer study of cuproptosis core gene FDX1 and its role in kidney renal clear cell carcinoma","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.jep.2025.120990_bib60","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1080\/15548627.2023.2200554","article-title":"Copper metabolism in cell death and autophagy","volume":"19","author":"Xue","year":"2023","journal-title":"Autophagy"},{"issue":"5","key":"10.1016\/j.jep.2025.120990_bib61","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.ccell.2025.02.015","article-title":"Hypoxia inducible factor-1\u03b1 drives cancer resistance to cuproptosis","volume":"43","author":"Yang","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jep.2025.120990_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1074271","article-title":"Identification of immune infiltration and cuproptosis-related subgroups in crohn's disease","volume":"13","author":"Yuan","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.120990_bib63","doi-asserted-by":"crossref","first-page":"295","DOI":"10.4103\/aja202383","article-title":"Cuproptosis mediates copper-induced testicular spermatogenic cell death","volume":"26","author":"Zhang","year":"2024","journal-title":"Asian J. Androl."},{"issue":"14","key":"10.1016\/j.jep.2025.120990_bib64","doi-asserted-by":"crossref","first-page":"20726","DOI":"10.1021\/acsami.4c22546","article-title":"Engineering dual-responsive nanoplatform achieves copper metabolism disruption and glutathione consumption to provoke cuproptosis\/ferroptosis\/apoptosis for cancer therapy","volume":"17","author":"Zhang","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jep.2025.120990_bib66","first-page":"137","article-title":"Discussion on regulative effects of ZGWls and yougui pills on immune system from the theory of vital gate water and fire","volume":"20","author":"Zou","year":"2023","journal-title":"CACMS"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125016824?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125016824?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:48:19Z","timestamp":1777571299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125016824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":62,"alternative-id":["S0378874125016824"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120990","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Research on the mechanism of Zuogui Wan in ameliorating oligoasthenozoospermia in rats via modulating cuproptosis-related pathways","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120990","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"120990"}}