{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:22:52Z","timestamp":1778048572162,"version":"3.51.4"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018806","name":"Department of Science and Technology of Hubei Province","doi-asserted-by":"publisher","award":["2023AFD141"],"award-info":[{"award-number":["2023AFD141"]}],"id":[{"id":"10.13039\/501100018806","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018806","name":"Department of Science and Technology of Hubei Province","doi-asserted-by":"publisher","award":["ZY2025L031"],"award-info":[{"award-number":["ZY2025L031"]}],"id":[{"id":"10.13039\/501100018806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jep.2025.121011","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:02:25Z","timestamp":1765353745000},"page":"121011","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Yishen Qianggu Mixture formulation suppresses osteometabolic inflammation by modulating the IL-17\/NF-\u03baB\/MAPK signaling axis"],"prefix":"10.1016","volume":"358","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2342-2424","authenticated-orcid":false,"given":"Jun","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gao-gao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Die","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-jie","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao-zhu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-jia","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-qing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9469-5533","authenticated-orcid":false,"given":"Mi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.121011_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241914583","article-title":"Osteoporosis: molecular pathology, diagnostics, and therapeutics","volume":"24","author":"Adejuyigbe","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.121011_bib2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/med.20067","article-title":"Combining docking and molecular dynamic simulations in drug design","volume":"26","author":"Alonso","year":"2006","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jep.2025.121011_bib3","article-title":"Chinese proprietary medicine Xianling Gubao capsule for osteoporosis: a systematic review and meta-analysis of randomized clinical trials","volume":"13","author":"Br","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2025.121011_bib4","first-page":"88","article-title":"Clinical study on Yishen Qianggu Mixture in treatment of senile osteoporosis with kidney yang deficiency","author":"Cao","year":"2021","journal-title":"J. Hubei Univ. Chin. Med."},{"key":"10.1016\/j.jep.2025.121011_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1370900","article-title":"Traditional Chinese medicine in osteoporosis: from pathogenesis to potential activity","volume":"15","author":"Cao","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.121011_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2024.102886","article-title":"Introducing dysfunctional Protein-Protein Interactome (dfPPI) - a platform for systems-level protein-protein interaction (PPI) dysfunction investigation in disease","volume":"88","author":"Chakrabarty","year":"2024","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.jep.2025.121011_bib7","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nbt.2377","article-title":"A cross-platform toolkit for mass spectrometry and proteomics","volume":"30","author":"Chambers","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jep.2025.121011_bib8","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/sj.bjp.0706945","article-title":"Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation","volume":"149","author":"Chen","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.121011_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112893","article-title":"Cardamonin attenuates iron overload-induced osteoblast oxidative stress through the HIF-1\u03b1\/ROS pathway","volume":"142","author":"Chen","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.121011_bib10","article-title":"Pyroptosis mediates osteoporosis via the inflammation immune microenvironment","volume":"15","author":"Chen","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.121011_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117059","article-title":"Isoliquiritigenin, a potential therapeutic agent for treatment of inflammation-associated diseases","volume":"318","author":"Chen","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.121011_bib12","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1001\/jama.2018.7498","article-title":"Screening for osteoporosis to prevent fractures: US preventive services task force recommendation statement","volume":"319","author":"Curry","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.jep.2025.121011_bib13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s40824-023-00413-7","article-title":"Emerging nano-scale delivery systems for the treatment of osteoporosis","volume":"27","author":"Dayanandan","year":"2023","journal-title":"Biomater. Res."},{"key":"10.1016\/j.jep.2025.121011_bib14","article-title":"Kidney tonifying traditional Chinese medicine: potential implications for the prevention and treatment of osteoporosis","volume":"13","author":"Duan","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.121011_bib15","article-title":"The effect of inflammation on bone","volume":"11","author":"Epsley","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jep.2025.121011_bib16","doi-asserted-by":"crossref","first-page":"D1197","DOI":"10.1093\/nar\/gkaa1063","article-title":"HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine","volume":"49","author":"Fang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2025.121011_bib17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s11914-024-00868-0","article-title":"Quercetin in osteoporosis treatment: a comprehensive review of its mechanisms and therapeutic potential","volume":"22","author":"Feng","year":"2024","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.jep.2025.121011_bib18","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.3390\/molecules22112029","article-title":"Dynamic docking: a paradigm shift in computational drug discovery","volume":"22","author":"Gioia","year":"2017","journal-title":"Molecules : J. Synth. Chem. Nat. Product Chem."},{"key":"10.1016\/j.jep.2025.121011_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2022.106182","article-title":"Inhibition of estrogen sulfation by xian-ling-gu-bao capsule","volume":"225","author":"He","year":"2023","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jep.2025.121011_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1408581","article-title":"Role of gut microbiota and metabolomics in the lipid-lowering efficacy of statins among Chinese patients with coronary heart disease and hypercholesterolemia","volume":"14","author":"Hu","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jep.2025.121011_bib21","first-page":"676","article-title":"Clinical observation on Yishen qianggu mixture in the treatment of low back pain after lumbar endoscopic surgery","author":"Huang","year":"2024","journal-title":"J. Li shizhen Tradition. Chin. Med."},{"key":"10.1016\/j.jep.2025.121011_bib22","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.3390\/molecules25173908","article-title":"Isoliquiritigenin derivatives inhibit RANKL-induced osteoclastogenesis by regulating p38 and NF-\u03baB activation in RAW 264.7 cells","volume":"25","author":"Jeong","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.121011_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001058","article-title":"Akt1 in osteoblasts and osteoclasts controls bone remodeling","volume":"2","author":"Kawamura","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2025.121011_bib24","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.3390\/cells9092073","article-title":"Osteoblast-osteoclast communication and bone homeostasis","volume":"9","author":"Kim","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jep.2025.121011_bib25","doi-asserted-by":"crossref","first-page":"D1110","DOI":"10.1093\/nar\/gkad926","article-title":"BATMAN-TCM 2.0: an enhanced integrative database for known and predicted interactions between traditional Chinese medicine ingredients and target proteins","volume":"52","author":"Kong","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2025.121011_bib26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s41232-023-00279-1","article-title":"Bone regeneration in inflammation with aging and cell-based immunomodulatory therapy","volume":"43","author":"Kushioka","year":"2023","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.jep.2025.121011_bib27","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1038\/s41590-019-0514-y","article-title":"IL-17 receptor-based signaling and implications for disease","volume":"20","author":"Li","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jep.2025.121011_bib28","article-title":"Anti-inflammatory and antioxidant traditional Chinese medicine in treatment and prevention of osteoporosis","volume":"14","author":"Li","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.121011_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155137","article-title":"Jiangu granules ameliorate postmenopausal osteoporosis via rectifying bone homeostasis imbalance: a network pharmacology analysis based on multi-omics validation","volume":"122","author":"Li","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.121011_bib30","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s11658-022-00371-3","article-title":"Osteoporosis pathogenesis and treatment: existing and emerging avenues","volume":"27","author":"Liang","year":"2022","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.jep.2025.121011_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119549","article-title":"Aqueous extract of rehmanniae radix praeparata improves bone health in ovariectomized rats by modulating the miR-29a-3p\/NFIA\/Wnt signaling pathway axis","volume":"344","author":"Luo","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.121011_bib32","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/gb-2008-9-s1-s4","article-title":"GeneMANIA: a real-time multiple association network integration algorithm for predicting gene function","volume":"9","author":"Mostafavi","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.jep.2025.121011_bib33","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1186\/s12964-025-02324-7","article-title":"Non-coding RNA modulation in osteoclasts and its implications for osteoblast lineage cell behavior in a co-culture system","volume":"23","author":"Moura","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.jep.2025.121011_bib34","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1302\/2046-3758.139.BJR-2024-0122.R1","article-title":"The interactions of macrophages, lymphocytes, and mesenchymal stem cells during bone regeneration","volume":"13","author":"Murayama","year":"2024","journal-title":"Bone Joint Res."},{"key":"10.1016\/j.jep.2025.121011_bib35","doi-asserted-by":"crossref","first-page":"hcad069","DOI":"10.1093\/qjmed\/hcad069.698","article-title":"Relation between postmenopausal osteoporosis and IL-17 serum level","volume":"116","author":"Nassar","year":"2023","journal-title":"QJM: Int. J. Med."},{"key":"10.1016\/j.jep.2025.121011_bib36","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1002\/jbmr.4899","article-title":"Effects of Moderate- to high-impact exercise training on bone structure across the lifespan: a systematic review and meta-analysis of randomized controlled trials","volume":"38","author":"Ng","year":"2023","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jep.2025.121011_bib37","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41419-024-06475-2","article-title":"IL-17 promotes osteoclast-induced bone loss by regulating glutamine-dependent energy metabolism","volume":"15","author":"Peng","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2025.121011_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.779638","article-title":"Flavonoids: classification, function, and molecular mechanisms involved in bone remodelling","volume":"12","author":"Ramesh","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2025.121011_bib39","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.3390\/pharmaceutics15071944","article-title":"Lipid-based delivery systems for flavonoids and Flavonolignans: liposomes, nanoemulsions, and solid lipid nanoparticles","volume":"15","author":"Ranjbar","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jep.2025.121011_bib40","first-page":"925","article-title":"Study on quality standards of yishen qianggu mixture","author":"Rao","year":"2023","journal-title":"Chin. J. Pharmacoepidemiol."},{"key":"10.1016\/j.jep.2025.121011_bib41","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Cheminf."},{"key":"10.1016\/j.jep.2025.121011_bib42","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1186\/s13018-021-02821-8","article-title":"Global prevalence of osteoporosis among the world older adults: a comprehensive systematic review and meta-analysis","volume":"16","author":"Salari","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.jep.2025.121011_bib43","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1186\/s13018-021-02772-0","article-title":"The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis","volume":"16","author":"Salari","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.jep.2025.121011_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242417482","article-title":"Local effects of steroid hormones within the bone microenvironment","volume":"24","author":"Sandor","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.121011_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jbmr.1998","article-title":"Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American society for bone and mineral research","volume":"29","author":"Shane","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jep.2025.121011_bib46","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3390\/pharmaceutics16080975","article-title":"Long-circulating and brain-targeted liposomes loaded with isoliquiritigenin: formation, characterization, pharmacokinetics, and distribution","volume":"16","author":"Song","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jep.2025.121011_bib47","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/ptr.8032","article-title":"Isoliquiritin treatment of osteoporosis by promoting osteogenic differentiation and autophagy of bone marrow mesenchymal stem cells","volume":"38","author":"Su","year":"2024","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2025.121011_bib48","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ecl.2024.08.008","article-title":"Postmenopausal osteoporosis: a review of latest guidelines","volume":"53","author":"Subarajan","year":"2024","journal-title":"Endocrinol Metab. Clin. N. Am."},{"key":"10.1016\/j.jep.2025.121011_bib49","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.7150\/thno.33376","article-title":"Licorice isoliquiritigenin-encapsulated mesoporous silica nanoparticles for osteoclast inhibition and bone loss prevention","volume":"9","author":"Sun","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.jep.2025.121011_bib50","doi-asserted-by":"crossref","DOI":"10.1093\/qjmed\/hcaf120","article-title":"Incorporating multi-omics technologies with traditional Chinese medicine","author":"Ting","year":"2025","journal-title":"QJM hcaf120"},{"key":"10.1016\/j.jep.2025.121011_bib51","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1007\/s11914-023-00824-4","article-title":"Inflammatory processes affecting bone health and repair","volume":"21","author":"Torres","year":"2023","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.jep.2025.121011_bib52","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.21106","article-title":"Prevalence of osteoporosis and fracture in China: the China osteoporosis prevalence study","volume":"4","author":"Wang","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.jep.2025.121011_bib53","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12944-021-01615-5","article-title":"Lipid metabolism within the bone micro-environment is closely associated with bone metabolism in physiological and pathophysiological stages","volume":"21","author":"Wang","year":"2022","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.jep.2025.121011_bib54","article-title":"Salvia miltiorrhiza in osteoporosis: a review of its phytochemistry, traditional clinical uses and preclinical studies (2014-2024)","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.121011_bib55","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.eprac.2021.02.001","article-title":"American association of clinical endocrinologists\/american college of endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal Osteoporosis-2020 update","volume":"27","author":"Watts","year":"2021","journal-title":"Endocr. Pract."},{"key":"10.1016\/j.jep.2025.121011_bib56","doi-asserted-by":"crossref","first-page":"D622","DOI":"10.1093\/nar\/gkab1062","article-title":"Hmdb 5.0: the human metabolome database for 2022","volume":"50","author":"Wishart","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2025.121011_bib57","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.jep.2025.121011_bib58","article-title":"The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review","volume":"14","author":"Xu","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.121011_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.664871","article-title":"The macrophage-osteoclast axis in osteoimmunity and osteo-related diseases","volume":"12","author":"Yao","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.121011_bib60","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3390\/cimb47080627","article-title":"An integrated network pharmacology, molecular docking, molecular dynamics simulation, and experimental validation study to investigate the potential mechanism of isoliquiritigenin in the treatment of ischemic stroke","volume":"47","author":"Yuan","year":"2025","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.jep.2025.121011_bib61","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1142\/S0192415X1550086X","article-title":"Clinical strategy for optimal traditional chinese medicine (TCM) herbal dose selection in disease therapeutics: expert consensus on classic TCM herbal formula dose conversion","volume":"43","author":"Zha","year":"2015","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2025.121011_bib62","article-title":"Osteoporosis guidelines on TCM drug therapies: a systematic quality evaluation and content analysis","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2025.121011_bib63","article-title":"Research trends and hotspots on osteoporosis: a decade-long bibliometric and visualization analysis from 2014 to 2023","volume":"11","author":"Zhang","year":"2024","journal-title":"Front. Med."},{"key":"10.1016\/j.jep.2025.121011_bib64","article-title":"Yougui pills prevent ovariectomy-induced bone loss by suppressing Th17 response and IL-17\/NF-\u03baB pathway","volume":"57","author":"Zhang","year":"2025","journal-title":"Ann. Med."},{"key":"10.1016\/j.jep.2025.121011_bib65","first-page":"58","article-title":"Exploring the mechanism of yishen qianggu mixture in the treatment of osteoporosis of kidney yang deficiency based on network pharmacology","author":"Zhao","year":"2024","journal-title":"Bachu Med. J."},{"key":"10.1016\/j.jep.2025.121011_bib66","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.3390\/biomedicines13061443","article-title":"Beyond bone loss: a biology perspective on osteoporosis pathogenesis, multi-omics approaches, and interconnected mechanisms","volume":"13","author":"Zhao","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.jep.2025.121011_bib67","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2437247","article-title":"Gut microbiota and microbial metabolites for osteoporosis","volume":"17","author":"Zheng","year":"2025","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jep.2025.121011_bib68","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s12603-023-1971-4","article-title":"Sex specific global burden of osteoporosis in 204 countries and territories, from 1990 to 2030: an age-period-cohort modeling study","volume":"27","author":"Zhu","year":"2023","journal-title":"J. Nutr. Health Aging"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125017039?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125017039?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:51:10Z","timestamp":1777571470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125017039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":68,"alternative-id":["S0378874125017039"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.121011","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Yishen Qianggu Mixture formulation suppresses osteometabolic inflammation by modulating the IL-17\/NF-\u03baB\/MAPK signaling axis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.121011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"121011"}}