{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:17:49Z","timestamp":1792793869613,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012556","name":"Foundation for Innovative Research Groups of Hubei Province of China","doi-asserted-by":"publisher","award":["2024BCA002"],"award-info":[{"award-number":["2024BCA002"]}],"id":[{"id":"10.13039\/501100012556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074081"],"award-info":[{"award-number":["82074081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374104"],"award-info":[{"award-number":["82374104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005290","name":"South-Central University for Nationalities","doi-asserted-by":"publisher","award":["XTZ24028"],"award-info":[{"award-number":["XTZ24028"]}],"id":[{"id":"10.13039\/501100005290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005290","name":"South-Central University for Nationalities","doi-asserted-by":"publisher","award":["PTZ25025"],"award-info":[{"award-number":["PTZ25025"]}],"id":[{"id":"10.13039\/501100005290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019981","name":"South-Central University for Nationalities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019981","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jep.2025.121013","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T16:50:01Z","timestamp":1765299001000},"page":"121013","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Potentilla freyniana bornm. and its active component tangeretin ameliorate gouty arthritis by inhibiting the MAPK\/NF-\u03bab\/NLRP3 signaling pathway"],"prefix":"10.1016","volume":"358","author":[{"given":"Kaiqun","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhui","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilu","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangkai","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4318-3033","authenticated-orcid":false,"given":"Lvyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.121013_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113412","article-title":"Recent phytochemical and pharmacological advances in the genus potentilla L. sensu lato - an update covering the period from 2009 to 2020","volume":"266","author":"Augustynowicz","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.121013_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116147","article-title":"Potential anti-gout properties of wuwei Shexiang pills based on network pharmacology and pharmacological verification","volume":"305","author":"Bai","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"15","key":"10.1016\/j.jep.2025.121013_bib3","doi-asserted-by":"crossref","first-page":"7667","DOI":"10.1080\/07391102.2023.2241102","article-title":"An in silico molecular docking, ADMET and molecular dynamics simulations studies of azolyl-2H-chroman-4-ones as potential inhibitors against pathogenic fungi and bacteria","volume":"42","author":"Chandrika","year":"2024","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"1\u20132","key":"10.1016\/j.jep.2025.121013_bib4","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jep.2004.09.020","article-title":"Antioxidant activities of extracts from five anti-viral medicinal plants","volume":"96","author":"Chen","year":"2005","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2025.121013_bib5","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s10753-021-01439-6","article-title":"The signaling pathways regulating NLRP3 inflammasome activation","volume":"44","author":"Chen","year":"2021","journal-title":"Inflammation"},{"issue":"21","key":"10.1016\/j.jep.2025.121013_bib6","first-page":"9230","article-title":"MiR-146a alleviates inflammation of acute gouty arthritis rats through TLR4\/MyD88 signal transduction pathway","volume":"23","author":"Chen","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"7","key":"10.1016\/j.jep.2025.121013_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24076328","article-title":"The potential benefits of Quercetin for brain health: a review of anti-inflammatory and neuroprotective mechanisms","volume":"24","author":"Chiang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.121013_bib8","series-title":"Pharmacopoeia of the People's Republic of China, Volume I","first-page":"233","year":"2020"},{"issue":"10287","key":"10.1016\/j.jep.2025.121013_bib9","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/S0140-6736(21)00569-9","volume":"397","author":"Dalbeth","year":"2021","journal-title":"Gout. Lancet"},{"issue":"9","key":"10.1016\/j.jep.2025.121013_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ph16091229","article-title":"Anticancer potential of flavonoids: an overview with an emphasis on tangeretin","volume":"16","author":"de Luna","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jep.2025.121013_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2020.100924","article-title":"An overview of the non-canonical inflammasome","volume":"76","author":"Downs","year":"2020","journal-title":"Mol. Aspect. Med."},{"issue":"3","key":"10.1016\/j.jep.2025.121013_bib12","doi-asserted-by":"crossref","first-page":"Itc33","DOI":"10.7326\/ANNALS-24-03951","article-title":"Gout","volume":"178","author":"FitzGerald","year":"2025","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.jep.2025.121013_bib13","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 inflammasome assembly and activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.jep.2025.121013_bib14","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1080\/1062936X.2024.2382973","article-title":"Essential oil components interacting with insect odorant-binding proteins: a molecular modelling approach","volume":"35","author":"Fuentes-Lopez","year":"2024","journal-title":"SAR QSAR Environ. Res."},{"issue":"1","key":"10.1016\/j.jep.2025.121013_bib15","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1186\/s12974-020-02014-w","article-title":"Pinocembrin ameliorates intermittent hypoxia-induced neuroinflammation through BNIP3-dependent mitophagy in a murine model of sleep apnea","volume":"17","author":"Gong","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2025.121013_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1617180","article-title":"Hybrid Cannabis sativa L. inflorescences exert an anti-inflammatory effect through the modulation of MAPK\/NF-\u03baB\/NLRP3 inflammasome and JAK1\/STAT6 pathway in HaCaT cells","volume":"16","author":"Han","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.121013_bib17","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1016\/S2665-9913(20)30221-6","article-title":"Cardiovascular risk in inflammatory arthritis: rheumatoid arthritis and gout","volume":"3","author":"Hansildaar","year":"2021","journal-title":"The Lancet Rheumatology"},{"issue":"12","key":"10.1016\/j.jep.2025.121013_bib18","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and regulation of NLRP3 inflammasome activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jep.2025.121013_bib19","volume":"vol. 155","year":"1972"},{"key":"10.1016\/j.jep.2025.121013_bib20","first-page":"1039","article-title":"Research progress on chemical constituents and pharmacological activities of Potentilla freyniana bornm","volume":"40","author":"Huang","year":"2020","journal-title":"J. Hunan Univ. Chin. Med"},{"issue":"12","key":"10.1016\/j.jep.2025.121013_bib21","first-page":"2674","article-title":"Chemical constituents from Potentilla fregniana","volume":"37","author":"Huiling","year":"2015","journal-title":"prepared prescription (Chinese medicine)"},{"key":"10.1016\/j.jep.2025.121013_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1529756","article-title":"Epigenetic regulation of transcription factors involved in NLRP3 inflammasome and NF-kB signaling pathways","volume":"16","author":"Kaszycki","year":"2025","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.jep.2025.121013_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbspin.2020.105092","article-title":"The role of interleukin-1 family members in hyperuricemia and gout","volume":"88","author":"Kl\u00fcck","year":"2021","journal-title":"Jt. Bone Spine"},{"issue":"1","key":"10.1016\/j.jep.2025.121013_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10753-016-0447-7","article-title":"Indirubin inhibits LPS-Induced inflammation via TLR4 abrogation mediated by the NF-kB and MAPK signaling pathways","volume":"40","author":"Lai","year":"2017","journal-title":"Inflammation"},{"issue":"8","key":"10.1016\/j.jep.2025.121013_bib25","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/s41584-024-01137-1","article-title":"The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies","volume":"20","author":"Leask","year":"2024","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2025.121013_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157145","article-title":"Cis-resveratrol blocks crystal-induced NLRP3 inflammasome activation via the TRPV4-Ca2+-phagocytosis-ROS axis","volume":"146","author":"Lei","year":"2025","journal-title":"Phytomedicine : international journal of phytotherapy and phytopharmacology"},{"issue":"5","key":"10.1016\/j.jep.2025.121013_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12051755","article-title":"Establishment and validation of predictive model of tophus in gout patients","volume":"12","author":"Lei","year":"2023","journal-title":"J. Clin. Med."},{"issue":"3","key":"10.1016\/j.jep.2025.121013_bib28","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3390\/nu8030167","article-title":"Quercetin, inflammation and immunity","volume":"8","author":"Li","year":"2016","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jep.2025.121013_bib29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00011-023-01819-8","article-title":"Tangeretin attenuates acute lung injury in septic mice by inhibiting ROS-Mediated NLRP3 inflammasome activation via regulating PLK1\/AMPK\/DRP1 signaling axis","volume":"73","author":"Liu","year":"2024","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.jep.2025.121013_bib30","article-title":"Role of NLRP3 in the pathogenesis and treatment of gout arthritis","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.121013_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106205","article-title":"Phloretin ameliorates diabetes-induced endothelial injury through AMPK-dependent anti-EndMT pathway","volume":"179","author":"Mao","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.jep.2025.121013_bib32","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.7150\/thno.40650","article-title":"A mouse model of MSU-induced acute inflammation in vivo suggests imiquimod-dependent targeting of Il-1\u03b2 as relevant therapy for gout patients","volume":"10","author":"Mariotte","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.jep.2025.121013_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.911968","article-title":"Excess uric acid induces gouty nephropathy through crystal formation: a review of recent insights","volume":"13","author":"Mei","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2025.121013_bib34","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4651090","article-title":"Molecularly distinct NLRP3 inducers mediate diverse ratios of Interleukin-1\u03b2 and Interleukin-18 from human monocytes","volume":"2020","author":"Midtb\u00f6","year":"2020","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jep.2025.121013_bib35","doi-asserted-by":"crossref","first-page":"892","DOI":"10.3389\/fphar.2018.00892","article-title":"Pharmacological properties, molecular mechanisms, and pharmaceutical development of asiatic acid: a pentacyclic triterpenoid of therapeutic promise","volume":"9","author":"Nagoor Meeran","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.121013_bib36","volume":"vol. 335","year":"2006"},{"issue":"9","key":"10.1016\/j.jep.2025.121013_bib37","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.7150\/thno.54004","article-title":"Exosome-inflammasome crosstalk and their roles in inflammatory responses","volume":"11","author":"Noonin","year":"2021","journal-title":"Theranostics"},{"issue":"9","key":"10.1016\/j.jep.2025.121013_bib38","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.1002\/ptr.8294","article-title":"Tangeretin alleviates inflammation and oxidative response induced by spinal cord injury by activating the Sesn2\/Keap1\/Nrf2 pathway","volume":"38","author":"Peng","year":"2024","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2025.121013_bib39","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.jconrel.2023.09.011","article-title":"Gout therapeutics and drug delivery","volume":"362","author":"Peng","year":"2023","journal-title":"J. Contr. Release : official journal of the Controlled Release Society"},{"key":"10.1016\/j.jep.2025.121013_bib40","series-title":"Gout and NLRP3 Inflammasome Biology","author":"Poulsen","year":"2025"},{"key":"10.1016\/j.jep.2025.121013_bib41","volume":"vol.102","year":"1971"},{"issue":"18","key":"10.1016\/j.jep.2025.121013_bib42","doi-asserted-by":"crossref","first-page":"5882","DOI":"10.1021\/acs.jpcb.5b00689","article-title":"The general AMBER force field (GAFF) can accurately predict thermodynamic and transport properties of many ionic liquids","volume":"119","author":"Sprenger","year":"2015","journal-title":"J. Phys. Chem. B"},{"issue":"2","key":"10.1016\/j.jep.2025.121013_bib43","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jphs.2022.12.006","article-title":"Caffeic acid protects against atherosclerotic lesions and cognitive decline in ApoE(-\/-) mice","volume":"151","author":"Sun","year":"2023","journal-title":"J. Pharmacol. Sci."},{"issue":"16","key":"10.1016\/j.jep.2025.121013_bib44","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s40265-023-01944-y","article-title":"Emerging urate-lowering drugs and pharmacologic treatment strategies for gout: a narrative review","volume":"83","author":"Terkeltaub","year":"2023","journal-title":"Drugs"},{"key":"10.1016\/j.jep.2025.121013_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119977","article-title":"Acute toxicity study of ethanol extract of Potentilla freyniana bornm rhizome in rats","volume":"349","author":"Tian","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.121013_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118254","article-title":"Piper longum L. ameliorates gout through the MAPK\/PI3K-AKT pathway","volume":"330","author":"Wu","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.121013_bib47","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1038\/s41598-025-86090-z","article-title":"A comprehensive analysis of trends in the burden of gout in China and globally from 1990 to 2021","volume":"15","author":"Xie","year":"2025","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.jep.2025.121013_bib48","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.tibs.2022.10.002","article-title":"The NLRP3 inflammasome: activation and regulation","volume":"48","author":"Xu","year":"2023","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jep.2025.121013_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111932","article-title":"Signaling pathways in uric acid homeostasis and gout: from pathogenesis to therapeutic interventions","volume":"132","author":"Yang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.121013_bib50","article-title":"The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors","volume":"13","author":"Zhan","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.121013_bib51","article-title":"NLRP3 inflammasome: checkpoint connecting innate and adaptive immunity in autoimmune diseases","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"issue":"20","key":"10.1016\/j.jep.2025.121013_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/nu15204349","article-title":"Eriodictyol alleviated LPS\/D-GalN-Induced acute liver injury by inhibiting oxidative stress and cell apoptosis via PI3K\/AKT signaling pathway","volume":"15","author":"Zheng","year":"2023","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.jep.2025.121013_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/nu13020554","article-title":"Caffeic acid modulates processes associated with intestinal inflammation","volume":"13","author":"Zieli\u0144ska","year":"2021","journal-title":"Nutrients"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125017052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125017052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:48:57Z","timestamp":1777571337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125017052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":53,"alternative-id":["S0378874125017052"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.121013","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potentilla freyniana bornm. and its active component tangeretin ameliorate gouty arthritis by inhibiting the MAPK\/NF-\u03bab\/NLRP3 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.121013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121013"}}