{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:12:08Z","timestamp":1793394728938,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010814","name":"Anhui Provincial Department of Education","doi-asserted-by":"publisher","award":["gxgwfx2022020"],"award-info":[{"award-number":["gxgwfx2022020"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903765"],"award-info":[{"award-number":["81903765"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jep.2025.121063","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T07:49:05Z","timestamp":1766130545000},"page":"121063","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Metabolic profiling of Danzhi Jiangtang capsule in rat plasma, urine and feces by UPLC-Q-TOF\/MSE combined with a multiple-point screening mass defect filtering strategy"],"prefix":"10.1016","volume":"359","author":[{"given":"Junting","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jindong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuge","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2752-8035","authenticated-orcid":false,"given":"Huan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.121063_bib1","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/j.biopha.2018.09.179","article-title":"Catechin attenuates diabetic autonomic neuropathy in streptozotocin induced diabetic rats","volume":"108","author":"Addepalli","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.jep.2025.121063_bib2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/13813455.2018.1498901","article-title":"Betulinic acid improves insulin sensitivity, hyperglycemia, inflammation and oxidative stress in metabolic syndrome rats via PI3K\/Akt pathways","volume":"126","author":"Ajala-Lawal","year":"2020","journal-title":"Arch. Physiol. Biochem."},{"issue":"20","key":"10.1016\/j.jep.2025.121063_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.70164","article-title":"Therapeutic potential of cinnamic acid as an SGLT2 inhibitor in mitigating diabetic nephropathy in a rat model of type 2 diabetes","volume":"69","author":"Alotaibi","year":"2025","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.jep.2025.121063_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110985","article-title":"Gallic acid: pharmacological activities and molecular mechanisms involved in inflammation-related diseases","volume":"133","author":"Bai","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.jep.2025.121063_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22060951","article-title":"Anti-inflammatory activities and liver protection of alisol F and 25-Anhydroalisol F through the inhibition of MAPK, STAT3, and NF-\u03baB activation in vitro and in vivo","volume":"22","author":"Bi","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.121063_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115875","article-title":"A UPLC-QTOF\/MS-based hepatic tissue metabolomics approach deciphers the mechanism of Huachansu tablets-based intervention against hepatocellular carcinoma","volume":"239","author":"Chen","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.jep.2025.121063_bib7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12906-019-2802-3","article-title":"Alisol A-24-acetate promotes glucose uptake via activation of AMPK in C2C12 myotubes","volume":"20","author":"Chen","year":"2020","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.jep.2025.121063_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2025.116696","article-title":"Rapid and accurate metabolite identification of traditional Chinese medicine based on UPLC-Q-TOF-MS coupled with UNIFI analysis platform and quantitative structure-retention relationship: Danshen-Honghua herbal pair as an example","volume":"257","author":"Chen","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"4","key":"10.1016\/j.jep.2025.121063_bib9","first-page":"608","article-title":"Danzhi Jiangtang capsule alleviate hyperglycemia and periodontitis via Wnt\/\u03b2-catenin signaling in diabetic rat","volume":"41","author":"Dong","year":"2021","journal-title":"J. Tradit. Chin. Med."},{"issue":"21","key":"10.1016\/j.jep.2025.121063_bib10","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1002\/jssc.201900466","article-title":"A target-group-change couple with mass defect filtering strategy to identify the metabolites of \"Dogel ebs\" in rats plasma, urine and bile","volume":"42","author":"Dong","year":"2019","journal-title":"J. Separ. Sci."},{"key":"10.1016\/j.jep.2025.121063_bib11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.sajb.2021.01.028","article-title":"Secondary metabolites from Scutellaria brevibracteata subsp. subvelutina and their in vitro anti-inflammatory activities","volume":"139","author":"Erdo\u011fan","year":"2021","journal-title":"South Afr. J. Bot."},{"issue":"2","key":"10.1016\/j.jep.2025.121063_bib12","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2023.2291185","article-title":"The effects of Danzhi Jiangtang capsule on clinical indices and vascular endothelial function in patients with impaired glucose tolerance of Qi-Yin deficiency type","volume":"55","author":"Fang","year":"2023","journal-title":"Ann. Med."},{"issue":"12","key":"10.1016\/j.jep.2025.121063_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5748","article-title":"Metabolic profiling of Qi-Yu-San-Long decoction in rat feces by ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry combined with a post-targeted screening strategy","volume":"37","author":"Fu","year":"2023","journal-title":"Biomed. Chromatogr."},{"issue":"5","key":"10.1016\/j.jep.2025.121063_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/jms.5140","article-title":"Rapid identification of chemical compounds in Danzhi Jiangtang Capsule using ultra-performance liquid chromatography Quadrupole time-of-flight mass spectrometry combined with multiple data processing techniques","volume":"60","author":"Fu","year":"2025","journal-title":"J. Mass Spectrom."},{"issue":"6","key":"10.1016\/j.jep.2025.121063_bib15","doi-asserted-by":"crossref","first-page":"448","DOI":"10.2174\/1389200224666230705142901","article-title":"Pharmacokinetics, mass balance, tissue distribution, and metabolism of [(3)H]Catalpol in rats: the main bioactive component of Rehmannia glutinosa for the treatment of ischemic stroke","volume":"24","author":"Ge","year":"2023","journal-title":"Curr. Drug Metabol."},{"key":"10.1016\/j.jep.2025.121063_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115400","article-title":"A mass defect filtering combined background subtraction strategy for rapid screening and identification of metabolites in rat plasma after oral administration of Yindan Xinnaotong soft capsule","volume":"231","author":"Huang","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"9","key":"10.1016\/j.jep.2025.121063_bib17","first-page":"2887","article-title":"Comparative study on metabolites of oxypaeoniflorin in normal and depressed rats","volume":"55","author":"Jin","year":"2024","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"2","key":"10.1016\/j.jep.2025.121063_bib18","first-page":"312","article-title":"Danzhi Jiangtang capsule reduces renal injury in rats with diabetes induced by high fat diet and streptozotocin downregulating toll-like receptor 4-nuclear factor-\u03baB pathway and apoptosis","volume":"43","author":"Jing","year":"2023","journal-title":"J. Tradit. Chin. Med."},{"issue":"6","key":"10.1016\/j.jep.2025.121063_bib19","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.jpha.2019.11.005","article-title":"Comparative analysis of constitutes and metabolites for traditional Chinese medicine using IDA and SWATH data acquisition modes on LC-Q-TOF MS","volume":"10","author":"Kang","year":"2020","journal-title":"J. Pharm. Anal."},{"issue":"6","key":"10.1016\/j.jep.2025.121063_bib20","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jpha.2019.09.007","article-title":"Estimation of boswellic acids in herbal formulations containing Boswellia serrata extract and comprehensive characterization of secondary metabolites using UPLC-Q-Tof-MS(e)","volume":"9","author":"Katragunta","year":"2019","journal-title":"J. Pharm. Anal."},{"issue":"4","key":"10.1016\/j.jep.2025.121063_bib21","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1039\/D1FO03838A","article-title":"Cryptochlorogenic acid and its metabolites ameliorate myocardial hypertrophy through a HIF1\u03b1-related pathway","volume":"13","author":"Li","year":"2022","journal-title":"Food Funct."},{"issue":"7","key":"10.1016\/j.jep.2025.121063_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.100973","article-title":"Pharmacometabolomics and mass spectrometry imaging approach to reveal the neurochemical mechanisms of Polygala tenuifolia","volume":"14","author":"Li","year":"2024","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jep.2025.121063_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.114866","article-title":"An integrated strategy to delineate the chemical and dynamic metabolic profile of Huachansu tablets in rat plasma based on UPLC-ESI-QTOF\/MS(E)","volume":"218","author":"Li","year":"2022","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2025.121063_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119417","article-title":"Betulinic acid from Inonotus obliquus ameliorates T2DM by modulating short-chain fatty acids producing bacteria and amino acids metabolism in db\/db mice","volume":"342","author":"Lin","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.121063_bib25","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.biopha.2018.08.129","article-title":"Protective effects of Danzhi jiangtang capsule on vascular endothelial damages induced by high-fat diet and palmitic acid","volume":"107","author":"Lu","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"7","key":"10.1016\/j.jep.2025.121063_bib26","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/rcm.3951","article-title":"Generic dealkylation: a tool for increasing the hit-rate of metabolite rationalization, and automatic customization of mass defect filters","volume":"23","author":"Mortishire-Smith","year":"2009","journal-title":"Rapid Commun. Mass Spectrom."},{"issue":"1","key":"10.1016\/j.jep.2025.121063_bib27","first-page":"61","article-title":"Anti-inflammatory iridoids from the stems of Cistanche deserticola cultured in Tarim Desert","volume":"14","author":"Nan","year":"2016","journal-title":"Chin. J. Nat. Med."},{"issue":"3","key":"10.1016\/j.jep.2025.121063_bib28","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/mas.20128","article-title":"Analytical strategies for identifying drug metabolites","volume":"26","author":"Prakash","year":"2007","journal-title":"Mass Spectrom. Rev."},{"issue":"6","key":"10.1016\/j.jep.2025.121063_bib29","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1360\/SSV-2021-0369","article-title":"Research methods and progress of effective components intraditional Chinese medicines","volume":"52","author":"Qiao","year":"2022","journal-title":"Scientia Sinica Vitae"},{"key":"10.1016\/j.jep.2025.121063_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.115981","article-title":"Rapid identification of chemical constituents and dynamic metabolic profile of Shenqi-Tiaoshen formula in rat plasma based on UPLC-Q-TOF\/MS(E)","volume":"241","author":"Rong","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"12","key":"10.1016\/j.jep.2025.121063_bib31","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.jsps.2021.11.004","article-title":"In vivo and in vitro studies of Danzhi Jiangtang capsules against diabetic cardiomyopathy via TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"29","author":"Shi","year":"2021","journal-title":"Saudi Pharm. J."},{"issue":"3","key":"10.1016\/j.jep.2025.121063_bib32","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jpha.2021.09.013","article-title":"Characterization of multiple chemical components of GuiLingJi by UHPLC-MS and (1)H NMR analysis","volume":"12","author":"Shi","year":"2022","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jep.2025.121063_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109625","article-title":"Catalpol ameliorates endothelial dysfunction and inflammation in diabetic nephropathy via suppression of RAGE\/RhoA\/ROCK signaling pathway","volume":"348","author":"Shu","year":"2021","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2025.121063_bib34","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.fct.2018.02.016","article-title":"Diet with high content of advanced glycation end products induces systemic inflammation and weight gain in experimental mice: protective role of curcumin and gallic acid","volume":"114","author":"Sowndhar Rajan","year":"2018","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.jep.2025.121063_bib35","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jpha.2020.03.010","article-title":"Comprehensive metabolic profiling of Alismatis Rhizoma triterpenes in rats based on characteristic ions and a triterpene database","volume":"11","author":"Wang","year":"2021","journal-title":"J. Pharm. Anal."},{"issue":"1","key":"10.1016\/j.jep.2025.121063_bib36","first-page":"162","article-title":"Research progress on absorption and transport mechanism of tetracyclic triterpenes in traditional Chinese medicine","volume":"45","author":"Wang","year":"2022","journal-title":"Drug Eval. Res."},{"key":"10.1016\/j.jep.2025.121063_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2025.116441","article-title":"Integrating mass defect filtering and targeted molecular networking for foodomics research: a case study of Magnolia officinalis cortex","volume":"210","author":"Wang","year":"2025","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jep.2025.121063_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2022.463405","article-title":"2,4-dinitrophenylhydrazine capturing combined with mass defect filtering strategy to identify aliphatic aldehydes in biological samples","volume":"1679","author":"Wang","year":"2022","journal-title":"J. Chromatogr. A"},{"issue":"1","key":"10.1016\/j.jep.2025.121063_bib39","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/bmc.3241","article-title":"Simultaneous determination of neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid and geniposide in rat plasma by UPLC-MS\/MS and its application to a pharmacokinetic study after administration of Reduning injection","volume":"29","author":"Wang","year":"2015","journal-title":"Biomed. Chromatogr."},{"issue":"1","key":"10.1016\/j.jep.2025.121063_bib40","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s13659-024-00453-z","article-title":"Comparative metabolite analysis of Piper sarmentosum organs approached by LC-MS-based metabolic profiling","volume":"14","author":"Ware","year":"2024","journal-title":"Nat. Prod. Bioprospect."},{"issue":"1","key":"10.1016\/j.jep.2025.121063_bib41","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3109\/03602532.2014.1001029","article-title":"Applications of mass spectrometry in drug metabolism: 50 years of progress","volume":"47","author":"Wen","year":"2015","journal-title":"Drug Metab. Rev."},{"issue":"21","key":"10.1016\/j.jep.2025.121063_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/nu14214681","article-title":"The role of catechins in regulating diabetes: an update review","volume":"14","author":"Wen","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2025.121063_bib43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jchromb.2018.10.013","article-title":"Intervention effect of qi-yu-san-long Decoction on Lewis lung carcinoma in C57BL\/6 mice: insights from UPLC-QTOF\/MS-based metabolic profiling","volume":"1102\u20131103","author":"Wu","year":"2018","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jep.2025.121063_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2025.115950","article-title":"Chemical profiles of allspice (Pimenta dioica (L.) Merr.) water and ethanol extracts and their antivirus and radical scavenging activities","volume":"205","author":"Wu","year":"2025","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jep.2025.121063_bib45","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jpba.2015.07.026","article-title":"An untargeted metabolomics-driven approach based on LC-TOF\/MS and LC-MS\/MS for the screening of xenobiotics and metabolites of Zhi-Zi-Da-Huang decoction in rat plasma","volume":"115","author":"Wu","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"10","key":"10.1016\/j.jep.2025.121063_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/foods13101550","article-title":"Chemical composition of turmeric (Curcuma longa L.) ethanol extract and its antimicrobial activities and free radical scavenging capacities","volume":"13","author":"Wu","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.jep.2025.121063_bib47","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.chroma.2012.01.017","article-title":"Rapid identification of ophiopogonins and ophiopogonones in Ophiopogon japonicus extract with a practical technique of mass defect filtering based on high resolution mass spectrometry","volume":"1227","author":"Xie","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jep.2025.121063_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2019.121934","article-title":"Rapid identification of absorbed components and metabolites of gandou decoction in rat plasma and liver by UPLC-Q-TOF-MS(E)","volume":"1137","author":"Xu","year":"2020","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"issue":"3","key":"10.1016\/j.jep.2025.121063_bib49","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jpba.2010.05.004","article-title":"Rapid and global detection and characterization of aconitum alkaloids in Yin Chen Si Ni Tang, a traditional Chinese medical formula, by ultra performance liquid chromatography-high resolution mass spectrometry and automated data analysis","volume":"53","author":"Yan","year":"2010","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.jep.2025.121063_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.70069","article-title":"Identification and characterization of chemical compounds in compound shougong powder by UHPLC-Q-TOF\/MS(E) combined with multiple data processing techniques","volume":"48","author":"Yang","year":"2025","journal-title":"J. Separ. Sci."},{"issue":"15","key":"10.1016\/j.jep.2025.121063_bib51","first-page":"2097","article-title":"Absorption and transport characteristic of paeoniflorin and its derivativesin model of Caco-2 cell monolayers","volume":"44","author":"Yang","year":"2013","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"5","key":"10.1016\/j.jep.2025.121063_bib52","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/pca.2508","article-title":"Rapid identification of polymethoxylated flavonoids in traditional Chinese medicines with a practical strategy of stepwise mass defect filtering coupled to diagnostic product ions analysis based on a hybrid LTQ-Orbitrap mass spectrometer","volume":"25","author":"Zhang","year":"2014","journal-title":"Phytochem. Anal."},{"issue":"14","key":"10.1016\/j.jep.2025.121063_bib53","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1055\/s-0033-1350649","article-title":"Antioxidative and anti-inflammatory activities of paeoniflorin and oxypaeoniflora on AGEs-induced mesangial cell damage","volume":"79","author":"Zhang","year":"2013","journal-title":"Planta Med."},{"issue":"10","key":"10.1016\/j.jep.2025.121063_bib54","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.1039\/D3FO05400D","article-title":"(+)-Catechin ameliorates diabetic nephropathy injury by inhibiting endoplasmic reticulum stress-related NLRP3-mediated inflammation","volume":"15","author":"Zhang","year":"2024","journal-title":"Food Funct."},{"issue":"5","key":"10.1016\/j.jep.2025.121063_bib55","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jpha.2022.05.005","article-title":"The dynamic metabolic profile of Qi-Yu-San-Long decoction in rat urine using UPLC-QTOF-MS(E) coupled with a post-targeted screening strategy","volume":"12","author":"Zheng","year":"2022","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jep.2025.121063_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2022.463149","article-title":"A strategy integrating parent ions list-modified mass defect filtering-diagnostic product ions for rapid screening and systematic characterization of flavonoids in Scutellaria barbata using hybrid quadrupole-orbitrap high-resolution mass spectrometry","volume":"1674","author":"Zhou","year":"2022","journal-title":"J. Chromatogr. A"},{"issue":"12","key":"10.1016\/j.jep.2025.121063_bib57","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1002\/mnfr.201400533","article-title":"(+)-Catechin ameliorates diabetic nephropathy by trapping methylglyoxal in type 2 diabetic mice","volume":"58","author":"Zhu","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.jep.2025.121063_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2019.460823","article-title":"Separation optimization in HPLC analysis implemented in R programming language","volume":"1617","author":"Zisi","year":"2020","journal-title":"J. Chromatogr. A"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125017568?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125017568?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:50:17Z","timestamp":1777571417000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125017568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":58,"alternative-id":["S0378874125017568"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.121063","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic profiling of Danzhi Jiangtang capsule in rat plasma, urine and feces by UPLC-Q-TOF\/MSE combined with a multiple-point screening mass defect filtering strategy","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.121063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121063"}}