{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:11:30Z","timestamp":1792181490629,"version":"4.4.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003824","name":"Hunan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ5313"],"award-info":[{"award-number":["2024JJ5313"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ80981"],"award-info":[{"award-number":["2025JJ80981"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ6358"],"award-info":[{"award-number":["2024JJ6358"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010909","name":"Excellent Young Scientists Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010909","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jep.2025.121097","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T16:18:57Z","timestamp":1766506737000},"page":"121097","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["HSYA attenuates Inflammation - Necroptosis to ameliorate secondary brain injury after intracerebral hemorrhage"],"prefix":"10.1016","volume":"359","author":[{"given":"Lei","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanchen","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihou","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.121097_bib1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s11910-023-01282-2","article-title":"Neuroinflammation in acute ischemic and hemorrhagic stroke","volume":"23","author":"Alsbrook","year":"2023","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.jep.2025.121097_bib2","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14397","article-title":"RIPK3 activation promotes DAXX-dependent neuronal necroptosis after intracerebral hemorrhage in mice","volume":"30","author":"Bai","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jep.2025.121097_bib3","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14397","article-title":"RIPK3 activation promotes DAXX-dependent neuronal necroptosis after intracerebral hemorrhage in mice","volume":"30","author":"Bai","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jep.2025.121097_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.01265","article-title":"Therapeutic potential of hydroxysafflor yellow A on cardio-cerebrovascular diseases","volume":"11","author":"Bai","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.121097_bib5","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","article-title":"Necroptosis, pyroptosis and apoptosis: an intricate game of cell death","volume":"18","author":"Bertheloot","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jep.2025.121097_bib6","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41419-019-1716-9","article-title":"Microglia-derived TNF-\u03b1 mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke","volume":"10","author":"Chen","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2025.121097_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2021.12.262","article-title":"Hydroxysafflor yellow A and anhydrosafflor yellow B alleviate ferroptosis and parthanatos in PC12 cells injured by OGD\/R","volume":"179","author":"Chen","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2025.121097_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2023.116494","article-title":"Hydroxysafflor yellow A protects against colitis in mice by suppressing pyroptosis via inhibiting HK1\/NLRP3\/GSDMD and modulating gut microbiota","volume":"467","author":"Chen","year":"2023","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2025.121097_bib9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s11064-025-04452-5","article-title":"Hydroxysafflor yellow A ameliorates ischemic stroke by inhibiting NLRP3, AIM2, and pyrin inflammasome-mediated pyroptosis","volume":"50","author":"Ding","year":"2025","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jep.2025.121097_bib10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12974-024-03101-y","article-title":"Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke","volume":"21","author":"Duan","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2025.121097_bib11","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12974-019-1613-2","article-title":"Quercetin prevents necroptosis of oligodendrocytes by inhibiting macrophages\/microglia polarization to M1 phenotype after spinal cord injury in rats","volume":"16","author":"Fan","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2025.121097_bib12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13024-016-0081-8","article-title":"Reactive astrocytes undergo M1 microglia\/macrohpages-induced necroptosis in spinal cord injury","volume":"11","author":"Fan","year":"2016","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.jep.2025.121097_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.929169","article-title":"Antioxidant and anti-inflammatory properties of hydroxyl safflower yellow a in diabetic nephropathy: a meta-analysis of randomized controlled trials","volume":"13","author":"Fu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.121097_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116298","article-title":"Annao pingchong decoction alleviate the neurological impairment by attenuating neuroinflammation and apoptosis in intracerebral hemorrhage rats","volume":"310","author":"Guo","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.121097_bib15","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1080\/13880209.2023.2229379","article-title":"Metabolomics reveals the effects of hydroxysafflor yellow A on neurogenesis and axon regeneration after experimental traumatic brain injury","volume":"61","author":"Hu","year":"2023","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2025.121097_bib16","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.it.2023.05.007","article-title":"Cell death checkpoints in the TNF pathway","volume":"44","author":"Huyghe","year":"2023","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jep.2025.121097_bib17","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1177\/0271678X20984565","article-title":"Potential therapeutic effects of Nrf2 activators on intracranial hemorrhage","volume":"41","author":"Imai","year":"2021","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.jep.2025.121097_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241914771","article-title":"Ursolic acid alleviates neuroinflammation after intracerebral hemorrhage by mediating microglial pyroptosis via the NF-\u03baB\/NLRP3\/GSDMD pathway","volume":"24","author":"Lei","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.121097_bib19","article-title":"Edaravone plays protective effects on LPS-induced microglia by switching M1\/M2 phenotypes and regulating NLRP3 inflammasome activation","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.121097_bib20","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.csbj.2021.01.033","article-title":"Integrated metabolomics and network pharmacology to reveal the mechanisms of hydroxysafflor yellow A against acute traumatic brain injury","volume":"19","author":"Li","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.jep.2025.121097_bib21","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2462039","article-title":"Protective effects of two safflower derived compounds, kaempferol and hydroxysafflor yellow A, on hyperglycaemic stress-induced podocyte apoptosis via modulating of macrophage M1\/M2 polarization","author":"Li","year":"2020","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.jep.2025.121097_bib22","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bbrc.2018.02.150","article-title":"RIP3 deficiency protects against traumatic brain injury (TBI) through suppressing oxidative stress, inflammation and apoptosis: dependent on AMPK pathway","volume":"499","author":"Liu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2025.121097_bib23","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.3389\/fimmu.2019.01360","article-title":"Melatonin suppresses microglial necroptosis by regulating deubiquitinating enzyme A20 after intracerebral hemorrhage","volume":"10","author":"Lu","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.121097_bib24","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1177\/0271678X20973609","article-title":"Cell-specific activation of RIPK1 and MLKL after intracerebral hemorrhage in mice","volume":"41","author":"Lule","year":"2021","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.jep.2025.121097_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120329","article-title":"Protecting the brain from stroke: huoxue rongluo formula (HXRLF) targets ferroptosis for neuroprotection","volume":"353","author":"Ma","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.121097_bib26","series-title":"Chinese Pharmacopoeia","year":"2020"},{"key":"10.1016\/j.jep.2025.121097_bib27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/17474930241307876","article-title":"World stroke organization (WSO): global intracerebral hemorrhage factsheet 2025","volume":"20","author":"Parry-Jones","year":"2025","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.jep.2025.121097_bib28","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12974-017-0870-1","article-title":"HSYA alleviates secondary neuronal death through attenuating oxidative stress, inflammatory response, and neural apoptosis in SD rat spinal cord compression injury","volume":"14","author":"Pei","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2025.121097_bib29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41572-023-00424-7","article-title":"Intracerebral haemorrhage","volume":"9","author":"Puy","year":"2023","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.jep.2025.121097_bib30","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/s41419-024-07293-2","article-title":"A20 negatively regulates necroptosis-induced microglia\/macrophages polarization and mediates cerebral ischemic tolerance via inhibiting the ubiquitination of RIP3","volume":"15","author":"Qiu","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2025.121097_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2025.1637053","article-title":"Pharmacological actions and applications of safflower flavonoids","volume":"12","author":"Ren","year":"2025","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jep.2025.121097_bib32","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1007\/s11064-021-03484-x","article-title":"Hydroxysafflor yellow A inhibits A\u03b21-42-Induced neuroinflammation by modulating the phenotypic transformation of microglia via TREM2\/TLR4\/NF-\u03baB pathway in BV-2 cells","volume":"47","author":"Ren","year":"2022","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jep.2025.121097_bib33","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/s12276-021-00634-7","article-title":"Necroptosis molecular mechanisms: recent findings regarding novel necroptosis regulators","volume":"53","author":"Seo","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jep.2025.121097_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.58","article-title":"Role for RIP1 in mediating necroptosis in experimental intracerebral hemorrhage model both in vivo and in vitro","volume":"8","author":"Shen","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2025.121097_bib35","series-title":"Bencao Tujing","author":"Su","year":"1994"},{"key":"10.1016\/j.jep.2025.121097_bib36","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cell.2011.11.031","article-title":"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase","volume":"148","author":"Sun","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jep.2025.121097_bib37","series-title":"The Rat Brain in Stereotaxic Coordinates","year":"2006"},{"key":"10.1016\/j.jep.2025.121097_bib38","doi-asserted-by":"crossref","first-page":"29","DOI":"10.5853\/jos.2019.02236","article-title":"Neuroinflammation after intracerebral hemorrhage and potential therapeutic targets","volume":"22","author":"Tschoe","year":"2020","journal-title":"J Stroke"},{"key":"10.1016\/j.jep.2025.121097_bib39","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.pneurobio.2010.08.001","article-title":"Preclinical and clinical research on inflammation after intracerebral hemorrhage","volume":"92","author":"Wang","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jep.2025.121097_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1509877","article-title":"The critical role of MLKL in hemorrhagic stroke and the therapeutic potential of its associated protein network","volume":"12","author":"Wang","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jep.2025.121097_bib41","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.3390\/cells11233726","article-title":"Hydroxysafflor yellow A exerts neuroprotective effects via HIF-1\u03b1\/BNIP3 pathway to activate neuronal autophagy after OGD\/R","volume":"11","author":"Wei","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jep.2025.121097_bib42","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12964-023-01387-8","article-title":"Free heme induces neuroinflammation and cognitive impairment by microglial activation via the TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"22","author":"Wei","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.jep.2025.121097_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113462","article-title":"Comprehensive review of two groups of flavonoids in Carthamus tinctorius L","volume":"153","author":"Xian","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.121097_bib44","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S1474-4422(20)30364-1","article-title":"Neuroinflammation in intracerebral haemorrhage: immunotherapies with potential for translation","volume":"19","author":"Xue","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jep.2025.121097_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153694","article-title":"Hydroxysafflor yellow A, a natural compound from Carthamus tinctorius L with good effect of alleviating atherosclerosis","volume":"91","author":"Xue","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.121097_bib46","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3892\/mmr.2021.12183","article-title":"Perampanel, an AMPAR antagonist, alleviates experimental intracerebral hemorrhage-induced brain injury via necroptosis and neuroinflammation","volume":"24","author":"Yang","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2025.121097_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1063035","article-title":"Protective potential of hydroxysafflor yellow A in cerebral ischemia and reperfusion injury: an overview of evidence from experimental studies","volume":"13","author":"Yu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.121097_bib48","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.immuni.2025.02.024","article-title":"Single-cell transcriptomic and functional studies identify glial state changes and a role for inflammatory RIPK1 signaling in ALS pathogenesis","volume":"58","author":"Zelic","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.jep.2025.121097_bib49","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12974-021-02141-y","article-title":"Inhibition of MLKL-dependent necroptosis via downregulating interleukin-1R1 contributes to neuroprotection of hypoxic preconditioning in transient global cerebral ischemic rats","volume":"18","author":"Zhan","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2025.121097_bib50","series-title":"BO WU ZHI","author":"Zhang","year":"1990"},{"key":"10.1016\/j.jep.2025.121097_bib51","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3390\/biology11010027","article-title":"Gap junctions and hemichannels composed of connexins and pannexins mediate the secondary brain injury following intracerebral hemorrhage","volume":"11","author":"Zhang","year":"2021","journal-title":"Biology"},{"key":"10.1016\/j.jep.2025.121097_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2025.110576","article-title":"Hydroxysafflor yellow A attenuates the blood-brain barrier dysfunction and neuroinflammation through anti-inflammatory microglial polarization after intracerebral hemorrhage","volume":"278","author":"Zheng","year":"2025","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jep.2025.121097_bib53","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s12013-015-0584-x","article-title":"Early combined therapy with pharmacologically induced hypothermia and edaravone exerts neuroprotective effects in a rat model of intracerebral hemorrhage","volume":"73","author":"Zhu","year":"2015","journal-title":"Cell Biochem. Biophys."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125017908?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125017908?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:48:59Z","timestamp":1777571339000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125017908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":53,"alternative-id":["S0378874125017908"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.121097","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HSYA attenuates Inflammation - Necroptosis to ameliorate secondary brain injury after intracerebral hemorrhage","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.121097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121097"}}