{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:06:58Z","timestamp":1791356818409,"version":"4.3.1"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jep.2025.121124","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:37:52Z","timestamp":1767339472000},"page":"121124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Gardenia jasminoides fruit extract alleviates MC903-induced atopic dermatitis and reduces IL-4\/IL-13-induced tight junction disruption and inflammation by regulating the phosphorylation of STAT6"],"prefix":"10.1016","volume":"360","author":[{"given":"Peng","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoying","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6469-218X","authenticated-orcid":false,"given":"Liping","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jep.2025.121124_bib1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jaci.2010.10.018","article-title":"Tight junction defects in patients with atopic dermatitis","volume":"127","author":"Anna","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jep.2025.121124_bib2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.hepres.2003.09.004","article-title":"A case of severe acute hepatitis of unknown etiology treated with the Chinese herbal medicine Inchinko-to","volume":"28","author":"Arai","year":"2004","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.jep.2025.121124_bib3","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1038\/s41598-020-58718-9","article-title":"Claudin-1 decrease impacts epidermal barrier function in atopic dermatitis lesions dose-dependently","volume":"10","author":"Bergmann","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2025.121124_bib4","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1365-2133.2011.10775.x","article-title":"Efficacy and safety of topical WBI-1001 in patients with mild to severe atopic dermatitis: results from a 12-week, multicentre, randomized, placebo-controlled double-blind trial","volume":"166","author":"Bissonnette","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jep.2025.121124_bib5","doi-asserted-by":"crossref","first-page":"4360","DOI":"10.3892\/mmr.2017.6542","article-title":"Gardenia jasminoides has therapeutic effects on L-NNA-induced hypertension in vivo","volume":"15","author":"Chen","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2025.121124_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112829","article-title":"Gardenia jasminoides Ellis: ethnopharmacology, phytochemistry, and pharmacological and industrial applications of an important traditional Chinese medicine","volume":"257","author":"Chen","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.121124_bib7","doi-asserted-by":"crossref","first-page":"6660","DOI":"10.1038\/sj.onc.1204629","article-title":"Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes: involvement of STAT6, ERK and p38 MAPK pathways","volume":"20","author":"David","year":"2001","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.jep.2025.121124_bib8","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/exd.13113","article-title":"Methyl-\u03b2-cyclodextrin concurs with interleukin (IL)-4, IL-13 and IL-25 to induce alterations reminiscent of atopic dermatitis in reconstructed human epidermis","volume":"27","author":"De Vuyst","year":"2018","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jep.2025.121124_bib9","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.foodchem.2011.03.090","article-title":"Antioxidant activity of Gardenia jasminoides ellis fruit extracts","volume":"128","author":"Debnath","year":"2011","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2025.121124_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jaci.2014.10.037","article-title":"Identification of novel immune and barrier genes in atopic dermatitis by means of laser capture microdissection","volume":"135","author":"Esaki","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jep.2025.121124_bib11","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.jaci.2016.07.013","article-title":"Early-onset pediatric atopic dermatitis is T(H)2 but also T(H)17 polarized in skin","volume":"138","author":"Esaki","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jep.2025.121124_bib12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijbiomac.2022.02.056","article-title":"Gardenia jasminoides Ellis polysaccharide ameliorates cholestatic liver injury by alleviating gut microbiota dysbiosis and inhibiting the TLR4\/NF-\u03baB signaling pathway","volume":"205","author":"Fang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.jep.2025.121124_bib13","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/jssc.201300601","article-title":"Preparative separation of crocins and geniposide simultaneously from gardenia fruits using macroporous resin and reversed-phase chromatography","volume":"37","author":"Feng","year":"2014","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jep.2025.121124_bib14","doi-asserted-by":"crossref","first-page":"5382","DOI":"10.3390\/ijms21155382","article-title":"Regulation of filaggrin, loricrin, and involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: pathogenic implications in atopic dermatitis","volume":"21","author":"Furue","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.jep.2025.121124_bib15","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.alit.2016.12.002","article-title":"Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies","volume":"66","author":"Furue","year":"2017","journal-title":"Allergol. Int."},{"issue":"4","key":"10.1016\/j.jep.2025.121124_bib16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/imm.13120","article-title":"The IL-13-OVOL1-FLG axis in atopic dermatitis","volume":"158","author":"Furue","year":"2019","journal-title":"Immunology"},{"key":"10.1016\/j.jep.2025.121124_bib17","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.jaci.2020.02.008","article-title":"Reconciling innate and acquired immunity in atopic dermatitis","volume":"145","author":"Honda","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jep.2025.121124_bib18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.phymed.2018.07.005","article-title":"Comparative anti-arthritic investigation of iridoid glycosides and crocetin derivatives from Gardenia jasminoides Ellis in Freund's complete adjuvant-induced arthritis in rats","volume":"53","author":"Hu","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.121124_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1068260","article-title":"JAK\u2013STAT signaling pathway in the pathogenesis of atopic dermatitis: an updated review","volume":"13","author":"Huang","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2025.121124_bib20","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/10408398.2023.2270530","article-title":"Gardenia (Gardenia jasminoides Ellis) fruit: a critical review of its functional nutrients, processing methods, health-promoting effects, comprehensive application and future tendencies","volume":"65","author":"Jin","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.jep.2025.121124_bib21","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jdermsci.2018.02.014","article-title":"Protective role of 6-formylindolo[3,2-b] carbazole (FICZ), an endogenous ligand for aryl hydrocarbon receptor, in chronic mite-induced dermatitis","volume":"90","author":"Kiyomatsu-Oda","year":"2018","journal-title":"J. Dermatol. Sci."},{"issue":"6","key":"10.1016\/j.jep.2025.121124_bib22","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.fct.2009.01.037","article-title":"Gardenia jasminoides Ellis ethanol extract and its constituents reduce the risks of gastritis and reverse gastric lesions in rats","volume":"47","author":"Lee","year":"2009","journal-title":"Food Chemt. Toxicol."},{"key":"10.1016\/j.jep.2025.121124_bib23","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2332\/allergolint.13-RAI-0564","article-title":"New insights into atopic dermatitis: role of skin barrier and immune dysregulation","volume":"62","author":"Leung","year":"2013","journal-title":"Allergol. Int."},{"key":"10.1016\/j.jep.2025.121124_bib24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3390\/antiox13030293","article-title":"Qin, S. Extract of Gardenia jasminoides Ellis attenuates high-fat diet-induced glycolipid metabolism disorder in rats by targeting gut microbiota and TLR4\/Myd88\/NF-\u03baB pathway","volume":"13","author":"Lv","year":"2024","journal-title":"Antioxidants"},{"issue":"8","key":"10.1016\/j.jep.2025.121124_bib25","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/jdv.12288","article-title":"The imbalance of Th17 cells and CD4(+) CD25(high) Foxp3(+) Treg cells in patients with atopic dermatitis","volume":"28","author":"Ma","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.jep.2025.121124_bib26","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cyto.2015.05.023","article-title":"Commentary: IL-4 and IL-13 receptors and signaling","volume":"75","author":"McCormick","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.jep.2025.121124_bib27","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1111\/all.13437","article-title":"The IL-13\/periostin\/IL-24 pathway causes epidermal barrier dysfunction in allergic skin inflammation","volume":"73","author":"Mitamura","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jep.2025.121124_bib28","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1002\/pro.3519","article-title":"The molecular details of cytokine signaling via the JAK\/STAT pathway","volume":"27","author":"Morris","year":"2018","journal-title":"Protein Sci."},{"issue":"7","key":"10.1016\/j.jep.2025.121124_bib29","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/all.12619","article-title":"Atopic dermatitis from adolescence to adulthood in the TOACS cohort: prevalence, persistence and comorbidities","volume":"70","author":"Mortz","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.jep.2025.121124_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2021.155664","article-title":"Novel pathogenesis of atopic dermatitis from the view of cytokines in mice and humans","volume":"148","author":"Nakajima","year":"2021","journal-title":"Cytokine"},{"issue":"8","key":"10.1016\/j.jep.2025.121124_bib31","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1038\/jid.2014.141","article-title":"A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis","volume":"134","author":"Nikhil","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jep.2025.121124_bib32","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.3748\/wjg.15.2927","article-title":"Severe acute cholestatic hepatitis of unknown etiology successfully treated with the Chinese herbal medicine Inchinko-to (TJ-135)","volume":"15","author":"Ohwada","year":"2009","journal-title":"World J. Gastroenterol."},{"issue":"4","key":"10.1016\/j.jep.2025.121124_bib33","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1039\/C7FO00091J","article-title":"Gastrointestinal absorption, antiproliferative and anti-inflammatory effect of the major carotenoids of Gardenia jasminoides Ellis on cancer cells","volume":"8","author":"Oliveira","year":"2017","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2025.121124_bib34","doi-asserted-by":"crossref","first-page":"112015","DOI":"10.1016\/j.jep.2019.112015","article-title":"Gardenia jasminoides extract without crocin improved atopic dermatitis-like skin lesions via suppression of Th2-related cytokines in Dfe-induced NC\/Nga mice","volume":"241","author":"Park","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.121124_bib35","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.3390\/antiox10091418","article-title":"Fruit of Gardenia jasminoides induces mitochondrial activation and non-shivering thermogenesis through regulation of PPAR\u03b3","volume":"10","author":"Park","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2025.121124_bib36","doi-asserted-by":"crossref","first-page":"112344","DOI":"10.1016\/j.biopha.2021.112344","article-title":"Gardenia jasminoides extract ameliorates DfE-induced atopic dermatitis in mice through restoration of barrier function and T-helper 2-mediated immune response","volume":"145","author":"Park","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.121124_bib37","doi-asserted-by":"crossref","DOI":"10.2340\/actadv.v103.13382","article-title":"Crisaborole inhibits itch and pain by preventing neutrophil infiltration in a mouse model of atopic dermatitis","volume":"103","author":"Pavlenko","year":"2023","journal-title":"Acta Derm. Venereol."},{"issue":"10","key":"10.1016\/j.jep.2025.121124_bib38","doi-asserted-by":"crossref","first-page":"986","DOI":"10.3390\/ph14100986","article-title":"Gardenia jasminoides attenuates allergic rhinitis-induced inflammation by inhibiting periostin production","volume":"14","author":"Pyun","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jep.2025.121124_bib39","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jep.2016.04.023","article-title":"Two standardized fractions of Gardenia jasminoides Ellis with rapid antidepressant effects are differentially associated with BDNF up-regulation in the hippocampus","volume":"187","author":"Ren","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.jep.2025.121124_bib40","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1038\/jid.2014.51","article-title":"IL-17A as an inducer for Th2 immune responses in Murine Atopic dermatitis models","volume":"134","author":"Saeko","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jep.2025.121124_bib41","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1016\/j.jid.2017.05.004","article-title":"Tapinarof is a natural AhR agonist that resolves skin inflammation in mice and humans","volume":"137","author":"Smith","year":"2017","journal-title":"J. Invest. Dermatol."},{"issue":"12","key":"10.1016\/j.jep.2025.121124_bib42","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra2023911","article-title":"Atopic dermatitis","volume":"384","author":"St\u00e4nder","year":"2021","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.jep.2025.121124_bib43","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.jaci.2022.03.010","article-title":"Neuroimmune communication regulating pruritus in atopic dermatitis","volume":"149","author":"Steinhoff","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jep.2025.121124_bib44","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3390\/ijms19041169","article-title":"Glyteer, soybean tar, impairs IL-4\/Stat6 signaling in murine bone marrow-derived dendritic cells: the basis of its therapeutic effect on atopic dermatitis","volume":"19","author":"Takemura","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.121124_bib45","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2017.1336194","article-title":"Time- and dose-dependent claudin contribution to biological functions: lessons from claudin-1 in skin","volume":"5","author":"Tokumasu","year":"2017","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.jep.2025.121124_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.322","article-title":"Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis","volume":"8","author":"Tsuji","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2025.121124_bib47","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3390\/jcm9030891","article-title":"Aryl hydrocarbon receptor activation downregulates IL-33 expression in keratinocytes via Ovo-like 1","volume":"9","author":"Tsuji","year":"2020","journal-title":"J. Clin. Med."},{"issue":"3","key":"10.1016\/j.jep.2025.121124_bib48","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jid.2023.07.027","article-title":"Benvitimod inhibits IL-4\u2013 and IL-13\u2013Induced tight junction impairment by activating AHR\/ARNT pathway and inhibiting STAT6 phosphorylation in human keratinocytes","volume":"144","author":"Wang","year":"2024","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jep.2025.121124_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-018-0001-z","article-title":"Atopic dermatitis","volume":"4","author":"Weidinger","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.jep.2025.121124_bib50","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.clindermatol.2011.08.023","article-title":"Abnormal epidermal barrier in the pathogenesis of atopic dermatitis","volume":"30","author":"Wolf","year":"2018","journal-title":"Clin. Dermatol."},{"issue":"12","key":"10.1016\/j.jep.2025.121124_bib51","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1111\/jdv.16892","article-title":"ETFAD\/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children","volume":"34","author":"Wollenberg","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"1","key":"10.1016\/j.jep.2025.121124_bib52","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jfda.2016.11.005","article-title":"Chemistry and bioactivity of Gardenia jasminoides","volume":"25","author":"Xiao","year":"2017","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.jep.2025.121124_bib53","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbi.2021.08.211","article-title":"Innate immune regulates cutaneous sensory IL-13 receptor alpha 2 to promote atopic dermatitis","volume":"98","author":"Xiao","year":"2021","journal-title":"Brain Behav. Immun."},{"issue":"12","key":"10.1016\/j.jep.2025.121124_bib54","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1016\/j.jid.2022.05.1087","article-title":"Inhibiting keratinocyte-derived signal transducer and activator of transcription 6 improved atopic dermatitis in mice","volume":"142","author":"Xue","year":"2022","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.jep.2025.121124_bib55","doi-asserted-by":"crossref","DOI":"10.1111\/jfpp.14785","article-title":"Antidiabetic effects of fermented milk contained with Gardenia jasminoides water extracts on streptozotocin-induced mice","volume":"45","author":"Ye","year":"2021","journal-title":"J. Food Process. Preserv."},{"key":"10.1016\/j.jep.2025.121124_bib56","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/j.jaci.2018.11.036","article-title":"A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor","volume":"143","author":"Yu","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jep.2025.121124_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120267","article-title":"Elephantopus scaber attenuates MC903-caused atopic dermatitis and decreases TNF-\u03b1\/IFN-\u03b3-induced chemokines by suppressing MKP-1-mediated AP-1 signaling in keratinocytes","volume":"352","author":"Zang","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.jep.2025.121124_bib58","doi-asserted-by":"crossref","first-page":"966","DOI":"10.3390\/pharmaceutics14050966","article-title":"Essential oils of Gardenia jasminoides J. Ellis and Gardenia jasminoides f. longicarpa Z.W. Xie & M. Okada flowers: Chemical characterization and assessment of anti-inflammatory effects in alveolar macrophage","volume":"14","author":"Zhang","year":"2022","journal-title":"Pharmaceutics"},{"issue":"8","key":"10.1016\/j.jep.2025.121124_bib59","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.3390\/foods12081668","article-title":"Effective therapeutic verification of Crocin I, geniposide, and gardenia (Gardenia jasminoides Ellis) on type 2 diabetes mellitus in vivo and in vitro","volume":"12","author":"Zhou","year":"2023","journal-title":"Foods"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125018173?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125018173?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T18:30:53Z","timestamp":1773945053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125018173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":59,"alternative-id":["S0378874125018173"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.121124","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gardenia jasminoides fruit extract alleviates MC903-induced atopic dermatitis and reduces IL-4\/IL-13-induced tight junction disruption and inflammation by regulating the phosphorylation of STAT6","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.121124","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121124"}}