{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T02:58:45Z","timestamp":1773975525473,"version":"3.50.1"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination for the improvement of Higher Education Personnel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006181","name":"Foundation for Research Support of Bahia State","doi-asserted-by":"publisher","award":["PIE0001\/2024"],"award-info":[{"award-number":["PIE0001\/2024"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2014\/50316-7"],"award-info":[{"award-number":["2014\/50316-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jep.2025.121133","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T23:46:14Z","timestamp":1767051974000},"page":"121133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Decoding the extracts of Lippia alnifolia Schauer (Verbenaceae): Chemical composition and its impacts on nociception and inflammation"],"prefix":"10.1016","volume":"359","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3328-3823","authenticated-orcid":false,"given":"Iza Miranda Melo","family":"Paulo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hor\u00e1cio Freitas","family":"Bomfim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Nascimento","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilo","family":"Guerrero Perilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia Fumiko","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massuo Jorge","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilene Lopes","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang\u00e9lica Maria","family":"Lucchese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jep.2025.121133_bib1","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1590\/S0102-695X2008000300023","article-title":"Survey of medicinal plants used in the region Northeast of Brazil","volume":"18","author":"Agra","year":"2008","journal-title":"Rev. Bras. Farmacogn."},{"issue":"4","key":"10.1016\/j.jep.2025.121133_bib2","first-page":"329","article-title":"Anti-inflammatory and antinociceptive activities of Lippia nodiflora linn","volume":"59","author":"Ahmed","year":"2004","journal-title":"Pharmazie"},{"key":"10.1016\/j.jep.2025.121133_bib3","series-title":"Psicofarmacologia: Fundamentos Pr\u00e1ticos","first-page":"179","article-title":"Avalia\u00e7\u00e3o de drogas analg\u00e9sicas de a\u00e7\u00e3o central","author":"Almeida","year":"2006"},{"issue":"4","key":"10.1016\/j.jep.2025.121133_bib4","first-page":"528","article-title":"The effect of ethanolic extract of Lippia citriodora on rats with chronic constriction injury of neuropathic pain","volume":"19","author":"Amin","year":"2018","journal-title":"Cell J"},{"issue":"6","key":"10.1016\/j.jep.2025.121133_bib5","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1590\/S0102-695X2010005000039","article-title":"Anti-inflammatory activity of Adenanthera pavonina L., Fabaceae, in experimental animals","volume":"20","author":"Ara","year":"2010","journal-title":"Rev. Bras. Farmacogn."},{"issue":"1","key":"10.1016\/j.jep.2025.121133_bib6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40816-019-0133-z","article-title":"In vivo and in silico evaluation of analgesic activity of Lippia alba","volume":"5","author":"Aziz","year":"2019","journal-title":"Clin. Phytosci."},{"issue":"17","key":"10.1016\/j.jep.2025.121133_bib7","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.3390\/molecules26175156","article-title":"Mexican oregano (Lippia graveolens Kunth) as source of bioactive compounds: a review","volume":"26","author":"Bautista-Hern\u00e1ndez","year":"2021","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.jep.2025.121133_bib8","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41577-019-0147-2","article-title":"Pain and immunity: implications for host defence","volume":"19","author":"Baral","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2025.121133_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119905","article-title":"Anti-inflammatory effect of free and microencapsulated extract of Lippia graveolens Kunth in a carrageenan-induced paw edema model and an ovalbumin-induced asthma model in mice","volume":"348","author":"Bernal-Mill\u00e1n","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.121133_bib10","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jpba.2007.11.007","article-title":"HPLC\u2013DAD\u2013ESI\u2013MS analysis of the constituents of aqueous preparations of verbena and lemon verbena and evaluation of the antioxidant activity","volume":"46","author":"Bilia","year":"2008","journal-title":"J. Pharmaceut. Biomed."},{"issue":"8","key":"10.1016\/j.jep.2025.121133_bib11","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1002\/ptr.3550","article-title":"Sida cordifolia leaf extract reduces the orofacial nociceptive response in mice","volume":"25","author":"Bonjardim","year":"2011","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2025.121133_bib12","doi-asserted-by":"crossref","first-page":"224","DOI":"10.4103\/0971-6580.121674","article-title":"A new method for determining acute toxicity in animal models","volume":"20","author":"Chinedu","year":"2013","journal-title":"Toxicol. Int."},{"issue":"3","key":"10.1016\/j.jep.2025.121133_bib13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.jep.2007.04.007","article-title":"Anti-inflammatory activity of flavonoids from Eupatorium arnottianum","volume":"112","author":"Clavin","year":"2007","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.121133_bib14","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.pain.2009.12.002","article-title":"The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation","volume":"148","author":"Costa","year":"2010","journal-title":"Pain"},{"issue":"9","key":"10.1016\/j.jep.2025.121133_bib15","first-page":"1","article-title":"Antinociceptive activity of Zanthoxylum piperitum DC. Essential Oil. Evid.-based complement","author":"Donald","year":"2016","journal-title":"Altern. Med."},{"issue":"2\u20133","key":"10.1016\/j.jep.2025.121133_bib16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0304-3959(00)00362-6","article-title":"Glutamate-induced excitation and sensitization of nociceptors in rat glabrous skin","volume":"89","author":"Du","year":"2001","journal-title":"Pain"},{"issue":"7","key":"10.1016\/j.jep.2025.121133_bib17","first-page":"715","article-title":"Distribution of iridoid glucosides in plants from the genus Lippia (Verbenaceae): an investigation of Lippia alba (Mill.) NE brown","volume":"2","author":"Filho","year":"2007","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.jep.2025.121133_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118459","article-title":"Lippia alba essential oil: a powerful and valuable antinociceptive and anti-inflammatory medicinal plant from Brazil","volume":"333","author":"Froz","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.121133_bib19","doi-asserted-by":"crossref","first-page":"348","DOI":"10.4103\/0976-500X.103699","article-title":"Acetic acid induced painful endogenous infliction in writhing test on mice","volume":"3","author":"Gawade","year":"2012","journal-title":"J. Pharmacol. Pharmacother."},{"issue":"2","key":"10.1016\/j.jep.2025.121133_bib20","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jep.2011.03.032","article-title":"Characterisation of the anti-inflammatory and antinociceptive activities and the mechanism of the action of Lippia gracilis essential oil","volume":"135","author":"Guilhon","year":"2011","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.121133_bib21","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/s11418-011-0601-3","article-title":"Phytochemical characterization and antinociceptive effect of Lippia gracilis Schauer","volume":"66","author":"Guimaraes","year":"2012","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.jep.2025.121133_bib22","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3390\/cosmetics8040114","article-title":"Essential oils and their individual components in cosmetic products","volume":"8","author":"Guzm\u00e1n","year":"2021","journal-title":"Cosmetics"},{"issue":"2","key":"10.1016\/j.jep.2025.121133_bib23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jep.2007.11.044","article-title":"Ethnopharmacology of Lippia alba","volume":"116","author":"Hennebelle","year":"2008","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.121133_bib24","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0304-3959(87)90088-1","article-title":"The formalin test in mice: dissociation between inflammatory and non-inflammatory pain","volume":"30","author":"Hunskaar","year":"1987","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.jep.2025.121133_bib25","first-page":"24","article-title":"Essential oils in food preservation: mode of action, synergies, and interactions with food matrix components","volume":"3","author":"Hyldgaard","year":"2012","journal-title":"Front. Microbiol."},{"issue":"4","key":"10.1016\/j.jep.2025.121133_bib26","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.2042-7158.2011.01264.x","article-title":"Antihyperalgesic activity of verbascoside in two models of neuropathic pain","volume":"63","author":"Isacchi","year":"2011","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.121133_bib27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2202-11-33","article-title":"Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits wnt secretion: potential implications for opioid dependence","volume":"11","author":"Jin","year":"2010","journal-title":"BMC Neurosci."},{"issue":"1","key":"10.1016\/j.jep.2025.121133_bib28","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jep.2008.10.009","article-title":"Anti-inflammatory activities of Sieboldogenin from Smilax China Linn.: experimental and computational studies","volume":"121","author":"Khan","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.121133_bib29","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1046\/j.1460-9568.1998.00030.x","article-title":"Modulation of bradykinin-induced mechanical hyperalgesia in the rat by activity in abdominal vagal afferents","volume":"10","author":"Khasar","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.jep.2025.121133_bib30","first-page":"412","article-title":"Acetic acid for analgesic screening","volume":"18","author":"Koster","year":"1959","journal-title":"Fed. Proc."},{"key":"10.1016\/j.jep.2025.121133_bib31","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0031-6997(24)01514-X","article-title":"Animal models of nociception","volume":"53","author":"Le Bars","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jep.2025.121133_bib32","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.chroma.2017.09.004","article-title":"Counter-current chromatography with off-line detection by ultra high performance liquid chromatography\/high resolution mass spectrometry in the study of the phenolic profile of Lippia origanoides","volume":"1520","author":"Leit\u00e3o","year":"2017","journal-title":"J. Chromatogr., A"},{"issue":"5","key":"10.1016\/j.jep.2025.121133_bib33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jfca.2006.09.005","article-title":"Identification and quantification of flavonoids of Mexican oregano (Lippia graveolens) by LC-DAD-ESI\/MS analysis","volume":"20","author":"Lin","year":"2007","journal-title":"J. Food Compos. Anal."},{"issue":"2","key":"10.1016\/j.jep.2025.121133_bib34","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/10286020290027353","article-title":"A cytotoxic diterpenoid and antifungal phenolic compounds from Frullania muscicola Steph","volume":"4","author":"Lou","year":"2002","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.jep.2025.121133_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115099","article-title":"Lippia origanoides essential oil induces tocolytic effect in virgin rat uterus and inhibits writhing in a dysmenorrhea mouse model","volume":"290","author":"Mac\u00eado","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2025.121133_bib36","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1080\/0972060X.2025.2490807","article-title":"Lippia insignis essential oil induces tocolytic effect in virgin rat uterus and reduces writhing in a mouse model of dysmenorrhea","volume":"28","author":"Mac\u00eado","year":"2025","journal-title":"J. Essent. Oil Bear. Plants"},{"issue":"9","key":"10.1016\/j.jep.2025.121133_bib37","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1016\/S0031-9422(00)83891-1","article-title":"Phenolic and acetylenic metabolites from Artemisia assoana","volume":"26","author":"Mart\u00ednez","year":"1987","journal-title":"Phytochem"},{"issue":"17","key":"10.1016\/j.jep.2025.121133_bib38","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1080\/14786419.2018.1457665","article-title":"Spasmolytic and antidiarrheal activities of Lippia thymoides (Verbenaceae) essential oil","volume":"33","author":"Menezes","year":"2018","journal-title":"Nat. Prod. Res."},{"issue":"3","key":"10.1016\/j.jep.2025.121133_bib39","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.pharmthera.2011.01.005","article-title":"Glutamate pharmacology and metabolism in peripheral primary afferents: physiological and pathophysiological mechanisms","volume":"130","author":"Miller","year":"2011","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.jep.2025.121133_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep00380","article-title":"TRPA1 contributes to the acute inflammatory response and mediates carrageenan-induced paw edema in the mouse","volume":"2","author":"Moilanen","year":"2012","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.jep.2025.121133_bib41","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1021\/jf9906679","article-title":"Antimutagens in Gaiyou (Artemisia argyi Levl. et Vant.)","volume":"48","author":"Nakasugi","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2025.121133_bib42","article-title":"Test No. 423: acute oral toxicity - acute toxic class method","volume":"vol. 4","year":"2001"},{"issue":"2","key":"10.1016\/j.jep.2025.121133_bib43","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bjp.2014.03.001","article-title":"Ethnopharmacological studies of Lippia origanoides","volume":"24","author":"Oliveira","year":"2014","journal-title":"Rev. Bras. Farmacogn."},{"key":"10.1016\/j.jep.2025.121133_bib44","article-title":"Antinociceptive and anti-inflammatory effects of the essential oil of Lippia hermannioides, an endemic species of Brazil","volume":"75","author":"Oliveira","year":"2024","journal-title":"Rodriguesia"},{"issue":"1","key":"10.1016\/j.jep.2025.121133_bib45","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.sajb.2009.07.002","article-title":"Phenylethanoid glycosides from Lippia javanica","volume":"76","author":"Olivier","year":"2010","journal-title":"S. Afr. J. Bot."},{"issue":"1","key":"10.1016\/j.jep.2025.121133_bib46","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11418-007-0197-9","article-title":"DPPH radical-scavenging effect on some constituents from the aerial parts of Lippia triphylla","volume":"62","author":"Ono","year":"2008","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.jep.2025.121133_bib47","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1186\/1744-8069-3-40","article-title":"A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition","volume":"3","author":"Petrus","year":"2007","journal-title":"Mol. Pain"},{"issue":"3","key":"10.1016\/j.jep.2025.121133_bib48","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0378-8741(99)00169-5","article-title":"Studies on anti-complementary activity of extracts and isolated flavones from Ligustrum vulgare and Phillyrea latifolia leaves (Oleaceae)","volume":"70","author":"Pieroni","year":"2000","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.121133_bib49","article-title":"Antimicrobial activity of Lippia species from the Brazilian semiarid region traditionally used as antiseptic and anti-infective agents. Evid.-based complement","volume":"2013","author":"Pinto","year":"2013","journal-title":"Altern. Med."},{"key":"10.1016\/j.jep.2025.121133_bib50","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.chroma.2015.03.081","article-title":"Preparation and evaluation of surface-bonded tricationic ionic liquid silica as stationary phases for high-performance liquid chromatography","volume":"1396","author":"Qiao","year":"2015","journal-title":"J. Chromatogr., A"},{"key":"10.1016\/j.jep.2025.121133_bib51","first-page":"305","article-title":"Antinociceptive activity of citronellal in formalin-, capsaicin- and glutamate-induced orofacial nociception in rodents and its action on nerve excitability","volume":"24","author":"Quintans-J\u00fanior","year":"2010","journal-title":"J. Orofac. Pain"},{"issue":"12","key":"10.1016\/j.jep.2025.121133_bib52","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.phymed.2013.05.007","article-title":"Phenylpropanoids and their metabolites are the major compounds responsible for blood-cell protection against oxidative stress after administration of Lippia citriodora in rats","volume":"20","author":"Quirantes-Pin\u00e9","year":"2013","journal-title":"Phytomed"},{"key":"10.1016\/j.jep.2025.121133_bib53","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.foodres.2015.02.023","article-title":"Aboriginal bush foods: a major phloroglucinol from crimson bottlebrush flowers (Callistemon citrinus, Myrtaceae) displays strong antinociceptive and anti-inflammatory activity","volume":"77","author":"Radulovi\u0107","year":"2015","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jep.2025.121133_bib54","first-page":"409","article-title":"A method for measurement of analgesic activity on inflamed tissue","volume":"111","author":"Randall","year":"1957","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"issue":"1","key":"10.1016\/j.jep.2025.121133_bib55","first-page":"11","article-title":"Analgesic effectiveness of ketorolac compared to meperidine in the rat formalin test","volume":"44","author":"Randolph","year":"1997","journal-title":"Anesth. Prog."},{"issue":"3","key":"10.1016\/j.jep.2025.121133_bib56","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0305-1978(86)90106-7","article-title":"Iridoid glucosides as taxonomic markers in the genera Lantana, Lippia, Aloysia and Phyla","volume":"14","author":"Rimpler","year":"1986","journal-title":"Biochem. Systemat. Ecol."},{"key":"10.1016\/j.jep.2025.121133_bib57","unstructured":"Salimena, F. R. G.; Cardoso, P. H. Lippia in Flora e Funga do Brasil. Jardim Bot\u00e2nico do Rio de Janeiro. Dispon\u00edvel em: http:\/\/floradobrasil.jbrj.gov.br\/jabot\/floradobrasil\/FB21429 (accessed 1 July 2025)."},{"issue":"3","key":"10.1016\/j.jep.2025.121133_bib58","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0028-3908(02)00117-X","article-title":"Evidence for the involvement of glutamatergic receptors in the antinociception caused in mice by the sesquiterpene drimanial","volume":"43","author":"Scheidt","year":"2002","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.jep.2025.121133_bib59","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.foodchem.2008.06.064","article-title":"Major flavonoids with antioxidant activity from Teucrium polium L","volume":"112","author":"Sharififar","year":"2009","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2025.121133_bib60","first-page":"533","article-title":"Investiga\u00e7\u00e3o do efeito analg\u00e9sico central e antiinflamat\u00f3rio de Conocliniopsis prasiifolia (DC) RM King & H. Robinson em Roedores","volume":"24","author":"Silva","year":"2005","journal-title":"Acta Farm. Bonaerense"},{"key":"10.1016\/j.jep.2025.121133_bib61","first-page":"18","article-title":"Modelos experimentais para avalia\u00e7\u00e3o da atividade antinociceptiva de produtos naturais: uma revis\u00e3o","volume":"94","author":"Silva","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.jep.2025.121133_bib62","first-page":"982","article-title":"Composi\u00e7\u00e3o qu\u00edmica e atividade antinociceptiva em modelo animal do \u00f3leo essencial de Myrcia rostrata DC. (Myrtaceae)","volume":"41","author":"Silva","year":"2018","journal-title":"Quim. Nova"},{"key":"10.1016\/j.jep.2025.121133_bib63","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1515\/znc-2010-9-1004","article-title":"Antinociceptive activity of atranorin in mice orofacial nociception tests","volume":"65c","author":"Siqueira","year":"2010","journal-title":"Z. Naturforsch."},{"issue":"1","key":"10.1016\/j.jep.2025.121133_bib64","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.bjp.2018.11.006","article-title":"Central nervous system and analgesic profiles of Lippia genus","volume":"29","author":"Siqueira-Lima","year":"2019","journal-title":"Rev Bras Farmacogn"},{"issue":"12","key":"10.1016\/j.jep.2025.121133_bib65","first-page":"2017","article-title":"HPLC\/DAD\/ESI-MS analysis of non-volatile constituents of three Brazilian chemotypes of Lippia alba (Mill.) NE Brown","volume":"3","author":"Tim\u00f3teo","year":"2008","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.jep.2025.121133_bib66","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.foodchem.2014.11.129","article-title":"A validated HPLC method for the analysis of herbal teas from three chemotypes of Brazilian Lippia alba","volume":"175","author":"Tim\u00f3teo","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2025.121133_bib67","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0304-3959(92)90003-T","article-title":"The formalin test: an evaluation of the method","volume":"51","author":"Tj\u00f8lsen","year":"1992","journal-title":"Pain"},{"issue":"8","key":"10.1016\/j.jep.2025.121133_bib68","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/S0031-9422(00)84701-9","article-title":"Twelve 6-oxygenated flavone sulphates from Lippia nodiflora and L. canescens","volume":"26","author":"Tom\u00e1s-Barber\u00e1n","year":"1987","journal-title":"Phytochem"},{"issue":"9","key":"10.1016\/j.jep.2025.121133_bib69","article-title":"Antimicrobial activity of methanol extracts from different species of the genus Lippia","volume":"10","author":"Trindade","year":"2021","journal-title":"Res. Soc. Dev."},{"issue":"11","key":"10.1016\/j.jep.2025.121133_bib70","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.1021\/jf990444i","article-title":"Analysis of vervain flavonoids by HPLC\/diode array detector method. Its application to quality control","volume":"47","author":"Valent\u00e3o","year":"1999","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.jep.2025.121133_bib71","doi-asserted-by":"crossref","first-page":"281","DOI":"10.11646\/phytotaxa.478.2.10","article-title":"Taxonomic and nomenclatural notes on Lantana and Lippia (Verbenaceae)","volume":"478","author":"Val\u00e9rio","year":"2021","journal-title":"Phytotaxa"},{"issue":"2","key":"10.1016\/j.jep.2025.121133_bib72","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s11062-016-9575-9","article-title":"Analgesic effects of the aqueous lemon verbena extract in rats","volume":"48","author":"Veisi","year":"2016","journal-title":"Neurophysiology"},{"key":"10.1016\/j.jep.2025.121133_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112162","article-title":"Lippia alnifolia essential oil induces relaxation on Guinea-pig trachea by multiple pathways","volume":"246","author":"Vilela","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.121133_bib74","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3181\/00379727-111-27849","article-title":"Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs","volume":"111","author":"Winter","year":"1962","journal-title":"Proc. Soc. Exp. Biol. Med."},{"issue":"3","key":"10.1016\/j.jep.2025.121133_bib75","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0022-3565(25)09094-9","article-title":"The evaluation of the analgesic action of pethidine hydrochloride (Demerol)","volume":"80","author":"Woolfe","year":"1944","journal-title":"J. Pharmacol. Exp. Therapeut."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125018264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125018264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T02:01:45Z","timestamp":1773972105000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125018264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":75,"alternative-id":["S0378874125018264"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.121133","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decoding the extracts of Lippia alnifolia Schauer (Verbenaceae): Chemical composition and its impacts on nociception and inflammation","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.121133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121133"}}