{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T09:07:14Z","timestamp":1776157634169,"version":"3.50.1"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020912","name":"King Faisal University","doi-asserted-by":"publisher","award":["KFU254793"],"award-info":[{"award-number":["KFU254793"]}],"id":[{"id":"10.13039\/501100020912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023674","name":"Deanship of Scientific Research, King Khalid University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019224","name":"King Faisal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jep.2026.121199","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:10:28Z","timestamp":1768435828000},"page":"121199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Exploring the effects of Citrus aurantifolia fruits peel essential oil, cultivated in Al-Hasa, in Methotrexate induced kidney and hepatic toxicities: Network Pharmacology, Molecular Docking, and in vivo Experiments"],"prefix":"10.1016","volume":"361","author":[{"given":"Maged E.","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4309-7095","authenticated-orcid":false,"given":"Nancy Safwat","family":"Younis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.121199_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111298","article-title":"The enteroprotective effect of nifuroxazide against methotrexate-induced intestinal injury involves co-activation of PPAR-\u03b3, SIRT1, Nrf2, and suppression of NF-\u03baB and JAK1\/STAT3 signals","volume":"127","author":"Abd-alhameed","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2026.121199_bib2","series-title":"Identification of Essential Oils by Gas Chromatography\/Mass Spectroscopy","author":"Adams","year":"2007"},{"key":"10.1016\/j.jep.2026.121199_bib3","first-page":"26","article-title":"Histomorphological effects of citrus aurantifolia (LIME) leaf extract on acetaminophen-induced hepatotoxicity in Wistar rats","volume":"6","author":"Adanma","year":"2019","journal-title":"IJIRAS"},{"issue":"2","key":"10.1016\/j.jep.2026.121199_bib4","first-page":"108","article-title":"Chemical composition and in-vitro antioxidant and antimicrobial activity of the essential oil of citrus aurantifolia L. leaves grown in Eastern Oman","volume":"13","author":"Al-Aamri","year":"2018","journal-title":"J. Taibah Unive. Med. Sci."},{"issue":"8","key":"10.1016\/j.jep.2026.121199_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/nu14081620","article-title":"Geraniol ameliorates doxorubicin-mediated kidney injury through alteration of antioxidant status, inflammation, and apoptosis: potential roles of NF-\u03baB and Nrf2\/Ho-1","volume":"14","author":"AlAsmari","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2026.121199_bib6","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.toxrep.2024.01.007","article-title":"Geraniol prevents CCl(4)-induced hepatotoxicity via suppression of hepatic oxidative stress, pro-inflammation and apoptosis in rats","volume":"12","author":"Algefare","year":"2024","journal-title":"Toxicol. Rep."},{"issue":"11","key":"10.1016\/j.jep.2026.121199_bib7","doi-asserted-by":"crossref","first-page":"8165","DOI":"10.1007\/s00210-024-03164-x","article-title":"Molecular mechanisms underlying methotrexate-induced intestinal injury and protective strategies","volume":"397","author":"Ali","year":"2024","journal-title":"N. Schmied. Arch. Pharmacol."},{"key":"10.1016\/j.jep.2026.121199_bib8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cbi.2017.05.002","article-title":"Protective effect of chlorogenic acid against methotrexate induced oxidative stress, inflammation and apoptosis in rat liver: an experimental approach","volume":"272","author":"Ali","year":"2017","journal-title":"Chem. Biol. Interact."},{"issue":"11","key":"10.1016\/j.jep.2026.121199_bib9","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1007\/s00210-020-01915-0","article-title":"Hepatoprotective effect of limonene against chronic immobilization induced liver damage in rats","volume":"393","author":"Amini","year":"2020","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"issue":"4","key":"10.1016\/j.jep.2026.121199_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153643","article-title":"Anti-inflammatory properties and chemical characterization of the essential oils of four citrus species","volume":"11","author":"Amorim","year":"2016","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.jep.2026.121199_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22514","article-title":"JAK1\/STAT3 regulatory effect of \u03b2\u2010caryophyllene on MG\u201063 osteosarcoma cells via ROS\u2010induced apoptotic mitochondrial pathway by DNA fragmentation","volume":"34","author":"Annamalai","year":"2020","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"1","key":"10.1016\/j.jep.2026.121199_bib12","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jep.2004.10.019","article-title":"Pharmacological properties of citrus and their ancient and medieval uses in the Mediterranean region","volume":"97","author":"Arias","year":"2005","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.jep.2026.121199_bib13","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1002\/ptr.3227","article-title":"Essential oil from citrus aurantifolia prevents ketotifen\u2010induced weight\u2010gain in mice","volume":"24","author":"Asnaashari","year":"2010","journal-title":"Phytother Res."},{"issue":"6","key":"10.1016\/j.jep.2026.121199_bib14","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1080\/0972060X.2014.884767","article-title":"Essential oil composition of Myrtus communis L. under different storage conditions","volume":"18","author":"Bahmanzadegan","year":"2015","journal-title":"J. Essent. Oil Bear. Plants"},{"key":"10.1016\/j.jep.2026.121199_bib15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.sajb.2024.03.027","article-title":"Citrus aurantifolia (Christm.) swingle extract ameliorates oxidative stress, dyslipidemia, and inflammation in galactose-induced aging in female rats","volume":"168","author":"Bankole","year":"2024","journal-title":"South Afr. J. Bot."},{"key":"10.1016\/j.jep.2026.121199_bib16","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.3390\/ijms13044673","article-title":"Comparative study of essential oils extracted from Algerian Myrtus communis L. leaves using microwaves and hydrodistillation","volume":"13","author":"Berka-Zougali","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2026.121199_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.etap.2017.12.005","article-title":"Acetyl-l-carnitine attenuates arsenic-induced liver injury by abrogation of mitochondrial dysfunction, inflammation, and apoptosis in rats","volume":"58","author":"Bodaghi-Namileh","year":"2018","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.121199_bib18","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/10942912.2022.2158864","article-title":"Toxicity and therapeutic applications of citrus essential oils (CEOs): a review","volume":"26","author":"Brah","year":"2023","journal-title":"Int. J. Food Prop."},{"key":"10.1016\/j.jep.2026.121199_bib19","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ejphar.2018.07.031","article-title":"Hepatoprotective effect of rhein against methotrexate-induced liver toxicity","volume":"834","author":"Bu","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"W1","key":"10.1016\/j.jep.2026.121199_bib20","doi-asserted-by":"crossref","first-page":"W324","DOI":"10.1093\/nar\/gkae300","article-title":"SwissDock 2024: major enhancements for small-molecule docking with Attracting Cavities and AutoDock Vina","volume":"52","author":"Bugnon","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.jep.2026.121199_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/med.21925","article-title":"KEAP1-NRF2 protein-protein interaction inhibitors: design, pharmacological properties and therapeutic potential","volume":"43","author":"Crisman","year":"2023","journal-title":"Med. Res. Rev."},{"issue":"8","key":"10.1016\/j.jep.2026.121199_bib23","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1021\/acs.jmedchem.6b00228","article-title":"Monoacidic inhibitors of the kelch-like ECH-associated protein 1: nuclear factor erythroid 2-Related factor 2 (KEAP1:NRF2) protein\u2013protein interaction with high cell potency identified by fragment-based discovery","volume":"59","author":"Davies","year":"2016","journal-title":"J. Med. Chem."},{"issue":"23","key":"10.1016\/j.jep.2026.121199_bib24","doi-asserted-by":"crossref","first-page":"20677","DOI":"10.1074\/jbc.M110.213736","article-title":"A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor","volume":"286","author":"Eathiraj","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.jep.2026.121199_bib25","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.jep.2026.121199_bib26","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s40199-019-00309-9","article-title":"Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction via up-regulating Nrf2 expression and inhibiting the I\u0138B\u03b1\/NF\u0138B in rats","volume":"27","author":"Ebrahimi","year":"2019","journal-title":"Daru"},{"key":"10.1016\/j.jep.2026.121199_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.119296","article-title":"Mangiferin mitigates methotrexate-induced liver injury and suppresses hepatic stellate cells activation in rats: imperative role of Nrf2\/NF-\u03baB\/NLRP3 signaling axis","volume":"340","author":"El-Sayed","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121199_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152840","article-title":"Hepatotoxic potentials of methotrexate: understanding the possible toxicological molecular mechanisms","volume":"458","author":"Ezhilarasan","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.jep.2026.121199_bib29","first-page":"45","article-title":"The ameliorating potential of citrus aurantifolia peel extract in the 2, 4, 6-trinitrobenzenesulfonic acid model of mice colitis","volume":"79","author":"Faradiani","year":"2024","journal-title":"Med. J. Malaysia"},{"issue":"1","key":"10.1016\/j.jep.2026.121199_bib30","article-title":"Vitamin B17 ameliorates methotrexate-induced reproductive toxicity, oxidative stress, and testicular injury in Male rats","volume":"2020","author":"Felemban","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"8","key":"10.1016\/j.jep.2026.121199_bib31","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.3390\/antiox12081491","article-title":"Advances in understanding the role of NRF2 in liver pathophysiology and its relationship with hepatic-specific Cyclooxygenase-2 expression","volume":"12","author":"Fuertes-Agudo","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2026.121199_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2019.00012","article-title":"Volatile compounds in citrus essential oils: a comprehensive review","volume":"10","author":"Gonz\u00e1lez-Mas","year":"2019","journal-title":"Front. Plant Sci."},{"issue":"13","key":"10.1016\/j.jep.2026.121199_bib33","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.3390\/molecules24132471","article-title":"Antibacterial activity of terpenes and terpenoids present in essential oils","volume":"24","author":"Guimar\u00e3es","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121199_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119754","article-title":"Berberine and\/or zinc protect against methotrexate-induced intestinal damage: role of GSK-3\u03b2\/NRF2 and JAK1\/STAT-3 signaling pathways","volume":"281","author":"Hassanein","year":"2021","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.jep.2026.121199_bib35","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s12272-023-01436-3","article-title":"Apocynin abrogates methotrexate-induced nephrotoxicity: role of TLR4\/NF-\u03baB-p65\/p38-MAPK, IL-6\/STAT-3, PPAR-\u03b3, and SIRT1\/FOXO3 signaling pathways","volume":"46","author":"Hassanein","year":"2023","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2026.121199_bib36","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.biopha.2018.08.050","article-title":"Mitochondrial dysfunction and oxidative stress are involved in the mechanism of methotrexate-induced renal injury and electrolytes imbalance","volume":"107","author":"Heidari","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.jep.2026.121199_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/0972060X.2019.1590246","article-title":"Essential oil from aerial parts of wild Algerian rosemary: screening of chemical composition, antimicrobial and antioxidant activities","volume":"22","author":"Hendel","year":"2019","journal-title":"J. Essent. Oil Bear. Plants"},{"key":"10.1016\/j.jep.2026.121199_bib38","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cotox.2016.10.002","article-title":"The multifaceted role of Nrf2 in mitochondrial function","volume":"1","author":"Holmstr\u00f6m","year":"2016","journal-title":"Curr Opin Toxicol"},{"issue":"8","key":"10.1016\/j.jep.2026.121199_bib39","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.freeradbiomed.2012.01.014","article-title":"\u03b2-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner","volume":"52","author":"Horv\u00e1th","year":"2012","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.jep.2026.121199_bib40","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1055\/a-0662-5607","article-title":"Antidiabetic potentials of citrus aurantifolia leaf essential oil","volume":"69","author":"Ibrahim","year":"2019","journal-title":"Drug Res."},{"issue":"10","key":"10.1016\/j.jep.2026.121199_bib41","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.3390\/foods12102036","article-title":"Bioactive components and their activities from different parts of citrus aurantifolia (Christm.) swingle for food development","volume":"12","author":"Indriyani","year":"2023","journal-title":"Foods"},{"issue":"2","key":"10.1016\/j.jep.2026.121199_bib42","article-title":"A comprehensive review on Citrus aurantifolia essential oil: its phytochemistry and pharmacological aspects","volume":"3","author":"Jain","year":"2020","journal-title":"Brazilian J. Natural Sci."},{"issue":"6","key":"10.1016\/j.jep.2026.121199_bib43","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1021\/jm5000529","article-title":"Discovery of potent Keap1\u2013Nrf2 protein\u2013protein interaction inhibitor based on molecular binding determinants analysis","volume":"57","author":"Jiang","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jep.2026.121199_bib44","doi-asserted-by":"crossref","first-page":"782","DOI":"10.3389\/fphar.2019.00782","article-title":"The essential oils and eucalyptol from Artemisia vulgaris L. prevent acetaminophen-induced liver injury by activating Nrf2-Keap1 and enhancing APAP clearance through non-toxic metabolic pathway","volume":"10","author":"Jiang","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.121199_bib45","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/08923973.2021.1999973","article-title":"Role of IL-6\/STAT3 pathway in mediating the protective effect of agomelatine against methotrexate-induced lung\/intestinal tissues damage in rats","volume":"44","author":"Kamel","year":"2022","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"2","key":"10.1016\/j.jep.2026.121199_bib46","doi-asserted-by":"crossref","DOI":"10.4081\/jbr.2020.8951","article-title":"Antibacterial and anti-inflammatory effects of lime (citrus aurantifolia) peel extract in Balb\/c mice infected by Salmonella typhi","volume":"93","author":"Kasim","year":"2020","journal-title":"J. Biol. Res. Bollettino della societ\u00e0 italiana di biologia sperimentale"},{"issue":"10","key":"10.1016\/j.jep.2026.121199_bib47","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/mc.22035","article-title":"\u03b2-caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase","volume":"53","author":"Kim","year":"2014","journal-title":"Mol. Carcinog."},{"issue":"4","key":"10.1016\/j.jep.2026.121199_bib48","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1007\/s11033-023-08286-8","article-title":"Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2\/HO-1 and Bax\/Bcl2\/Caspase-3 signaling pathways","volume":"50","author":"K\u0131z\u0131l","year":"2023","journal-title":"Mol. Biol. Rep."},{"issue":"18","key":"10.1016\/j.jep.2026.121199_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810466","article-title":"Atomic simulation of the binding of JAK1 and JAK2 with the selective inhibitor ruxolitinib","volume":"23","author":"Kondratyev","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jep.2026.121199_bib50","doi-asserted-by":"crossref","first-page":"363","DOI":"10.13005\/bpj\/1649","article-title":"The effects of citrus leaf extract on renal oxidative stress, renal function and histological changes in rats fed with heated palm oil","volume":"12","author":"Li","year":"2019","journal-title":"Biomed. Pharmacol. J."},{"key":"10.1016\/j.jep.2026.121199_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112178","article-title":"Modified citrus pectin prevents isoproterenol-induced cardiac hypertrophy associated with p38 signalling and TLR4\/JAK\/STAT3 pathway","volume":"143","author":"Li","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2026.121199_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/foods8090398","article-title":"Lime (citrus aurantifolia (Christm.) Swingle) essential oils: volatile compounds, antioxidant capacity, and hypolipidemic effect","author":"Lin","year":"2019","journal-title":"Foods"},{"issue":"9","key":"10.1016\/j.jep.2026.121199_bib53","doi-asserted-by":"crossref","first-page":"5331","DOI":"10.1039\/C6RA26281C","article-title":"An activity-calibrated chemical standardization approach for quality evaluation of Salvia miltiorrhiza Bge","volume":"7","author":"Liu","year":"2017","journal-title":"RSC Adv."},{"issue":"15","key":"10.1016\/j.jep.2026.121199_bib54","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1002\/jsfa.5708","article-title":"Evaluation of citrus aurantifolia peel and leaves extracts for their chemical composition, antioxidant and anti-cholinesterase activities","volume":"92","author":"Loizzo","year":"2012","journal-title":"J. Sci. Food Agric."},{"issue":"4","key":"10.1016\/j.jep.2026.121199_bib55","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1021\/jf010924l","article-title":"Volatile components of peel and leaf oils of lemon and lime species","volume":"50","author":"Lota","year":"2002","journal-title":"J. Agric. Food Chem."},{"issue":"10","key":"10.1016\/j.jep.2026.121199_bib56","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.1007\/s13197-019-03937-w","article-title":"Peel oils from three citrus species: volatile constituents, antioxidant activities and related contributions of individual components","volume":"56","author":"Lu","year":"2019","journal-title":"J. Food Sci. Technol."},{"key":"10.1016\/j.jep.2026.121199_bib57","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2018-224722","article-title":"Severe bone marrow suppression due to methotrexate toxicity following aceclofenac-induced acute kidney injury","volume":"2018","author":"Manappallil","year":"2018","journal-title":"BMJ Case Rep."},{"key":"10.1016\/j.jep.2026.121199_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.fochx.2022.100217","article-title":"Terpenes and terpenoids as main bioactive compounds of essential oils, their roles in human health and potential application as natural food preservatives","volume":"13","author":"Masyita","year":"2022","journal-title":"Food Chem. X"},{"issue":"11","key":"10.1016\/j.jep.2026.121199_bib59","doi-asserted-by":"crossref","DOI":"10.1002\/pro.4792","article-title":"UCSF ChimeraX: tools for structure building and analysis","volume":"32","author":"Meng","year":"2023","journal-title":"Protein Sci."},{"key":"10.1016\/j.jep.2026.121199_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117912","article-title":"Discovery of novel thiazolylhydrazone derivatives as potent anti-cancer agents inducing ferroptosis via direct NRF2 inhibition","volume":"297","author":"Meng","year":"2025","journal-title":"Eur. J. Med. Chem."},{"issue":"20","key":"10.1016\/j.jep.2026.121199_bib61","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/0973-7847.194043","article-title":"Anticancer activity of key lime, citrus aurantifolia","volume":"10","author":"Narang","year":"2016","journal-title":"Pharmacogn. Rev."},{"key":"10.1016\/j.jep.2026.121199_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.109957","article-title":"In silico and in vitro antileishmanial effects of gamma-terpinene: multifunctional modes of action","volume":"361","author":"Nooshadokht","year":"2022","journal-title":"Chem. Biol. Interact."},{"issue":"4","key":"10.1016\/j.jep.2026.121199_bib63","article-title":"Hepatoprotective effects of hydroethanol extracts of citrus aurantifolia fruits in CCl4-induced hepatotoxic rats","volume":"4","author":"Okoro","year":"2019","journal-title":"Sokoto Journal of Medical Laboratory Science"},{"key":"10.1016\/j.jep.2026.121199_bib64","series-title":"Assessment of Nephroprotective Potentials of Citrus Aurantifolia (Christm) Swingle Peels Extract in Gentamicin-Induced Kidney Toxicity in Mice","author":"Oyinloye","year":"2024"},{"key":"10.1016\/j.jep.2026.121199_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.prmcm.2024.100412","article-title":"Citrus aurantifolia (Chrism.) Swingle peel extract attenuate nephrotoxicity induced by doxorubicin","volume":"11","author":"Oyinloye","year":"2024","journal-title":"Pharmacological Research - Modern Chinese Medicine"},{"issue":"S","key":"10.1016\/j.jep.2026.121199_bib66","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4314\/njpr.v20iS.3s","article-title":"Assessment of nephroprotective potentials of citrus aurantifolia (Christm) swingle peels extract in gentamicin-induced kidney toxicity in mice","volume":"20","author":"Oyinloye","year":"2025","journal-title":"Niger. J. Pharmaceut. Res."},{"issue":"5","key":"10.1016\/j.jep.2026.121199_bib67","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1067\/msy.2001.117376","article-title":"The role of caspases in methotrexate-induced gastrointestinal toxicity","volume":"130","author":"Papaconstantinou","year":"2001","journal-title":"Surgery"},{"issue":"2","key":"10.1016\/j.jep.2026.121199_bib68","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/fsn3.3785","article-title":"The effects of different extraction methods on essential oils from orange and tangor: from the peel to the essential oil","volume":"12","author":"Park","year":"2024","journal-title":"Food Sci. Nutr."},{"issue":"3","key":"10.1016\/j.jep.2026.121199_bib69","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1080\/0972060X.2018.1492975","article-title":"Antifungal activity of essential oil of Commiphora molmol Oleo gum resin","volume":"21","author":"Perveen","year":"2018","journal-title":"J. Essent. Oil Bear. Plants"},{"key":"10.1016\/j.jep.2026.121199_bib70","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12061238","article-title":"Waste citrus limon leaves as source of essential oil rich in limonene and citral: Chemical characterization, antimicrobial and antioxidant properties, and effects on cancer cell viability","author":"Petretto","year":"2023","journal-title":"Antioxidants"},{"issue":"8","key":"10.1016\/j.jep.2026.121199_bib71","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1002\/mnfr.201501017","article-title":"Multiple regulations of Keap1\/Nrf2 system by dietary phytochemicals","volume":"60","author":"Qin","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"issue":"9","key":"10.1016\/j.jep.2026.121199_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e29721","article-title":"Ethnobotany and diversity of Citrus spp.(Rutaceae) as a source of \u201cKem-kem\u201d traditional medicine used among the Karo sub-ethnic in North Sumatra, Indonesia","volume":"10","author":"Rahayu","year":"2024","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.jep.2026.121199_bib73","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3727\/105221617X15084371374138","article-title":"Acetaminophen toxicity: novel insights into mechanisms and future perspectives","volume":"18","author":"Ramachandran","year":"2018","journal-title":"Gene Expr."},{"issue":"2","key":"10.1016\/j.jep.2026.121199_bib74","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0308-8146(99)00247-2","article-title":"Antioxidant activity of selected essential oil components in two lipid model systems","volume":"69","author":"Ruberto","year":"2000","journal-title":"Food Chem."},{"issue":"10","key":"10.1016\/j.jep.2026.121199_bib75","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1177\/09603271211009964","article-title":"Apigenin alleviates methotrexate-induced liver and kidney injury in mice","volume":"40","author":"Sahindokuyucu-Kocasari","year":"2021","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.jep.2026.121199_bib76","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.fct.2017.04.007","article-title":"Modulatory effect of curcumin against genotoxicity and oxidative stress induced by cisplatin and methotrexate in male mice","volume":"105","author":"Salem","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2026.121199_bib77","first-page":"1","article-title":"Vitamin C attenuates methotrexate-induced oxidative stress in kidney and liver of rats","author":"Savran","year":"2017","journal-title":"Phys. Int."},{"issue":"23","key":"10.1016\/j.jep.2026.121199_bib78","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232315116","article-title":"Methotrexate-Induced liver injury is associated with oxidative stress, impaired mitochondrial respiration, and endoplasmic reticulum stress in vitro","volume":"23","author":"Schmidt","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.jep.2026.121199_bib79","first-page":"579","article-title":"Protective effect of citrus sinensis and citrus aurantifolia against osteoporosis and their phytochemical constituents","volume":"5","author":"Shalaby","year":"2011","journal-title":"J. Med. Plants Res."},{"issue":"4","key":"10.1016\/j.jep.2026.121199_bib80","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1080\/01480545.2020.1862859","article-title":"Hepatoprotective effect of Ginkgo biloba extract against methotrexate-induced hepatotoxicity via targeting STAT3\/miRNA-21 axis","volume":"45","author":"Sherif","year":"2022","journal-title":"Drug Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.jep.2026.121199_bib81","doi-asserted-by":"crossref","DOI":"10.5530\/pj.2023.15.88","article-title":"Anti-Gastritis activity of cloves (Eugenia caryophyllata Thunberg) and lime (citrus aurantifolia) leaf extracts combination in absolute alcohol induced-gastric injury mice","volume":"15","author":"Studiawan","year":"2023","journal-title":"Pharmacogn. J."},{"issue":"1","key":"10.1016\/j.jep.2026.121199_bib82","doi-asserted-by":"crossref","first-page":"H40","DOI":"10.1111\/j.1750-3841.2011.02511.x","article-title":"Comparative study on the antioxidant capacity and cholinesterase inhibitory activity of citrus aurantifolia swingle, C. aurantium L., and C. bergamia Risso and Poit. peel essential oils","volume":"77","author":"Tundis","year":"2012","journal-title":"J. Food Sci."},{"issue":"9","key":"10.1016\/j.jep.2026.121199_bib83","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics16091165","article-title":"Biological evaluations and computer-aided approaches of Janus kinases 2 and 3 inhibitors for cancer treatment: a review","volume":"16","author":"V\u00e1zquez-Jim\u00e9nez","year":"2024","journal-title":"Pharmaceutics"},{"issue":"12","key":"10.1016\/j.jep.2026.121199_bib84","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.18240\/ijo.2022.12.02","article-title":"Anti-inflammatory effects of \u03b1-humulene and \u03b2-caryophyllene on pterygium fibroblasts","volume":"15","author":"Viveiros","year":"2022","journal-title":"Int. J. Ophthalmol."},{"issue":"6","key":"10.1016\/j.jep.2026.121199_bib85","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1634\/theoncologist.11-6-694","article-title":"Understanding and managing methotrexate nephrotoxicity","volume":"11","author":"Widemann","year":"2006","journal-title":"Oncologist"},{"issue":"47","key":"10.1016\/j.jep.2026.121199_bib86","doi-asserted-by":"crossref","first-page":"28446","DOI":"10.1074\/jbc.M115.678136","article-title":"Characterization of RA839, a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling \u2217","volume":"290","author":"Winkel","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2026.121199_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106210","article-title":"The role of JAK\/STAT signaling pathway and its inhibitors in diseases","volume":"80","author":"Xin","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"10","key":"10.1016\/j.jep.2026.121199_bib88","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24101929","article-title":"\u03b2-Caryophyllene as a potential protective agent against myocardial injury: the role of toll-like receptors","volume":"24","author":"Younis","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121199_bib89","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ebiom.2018.06.029","article-title":"Induction and amelioration of methotrexate-induced gastrointestinal toxicity are related to immune response and Gut Microbiota","volume":"33","author":"Zhou","year":"2018","journal-title":"EBioMedicine"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126000504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126000504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:15:21Z","timestamp":1776154521000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126000504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":88,"alternative-id":["S0378874126000504"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121199","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the effects of Citrus aurantifolia fruits peel essential oil, cultivated in Al-Hasa, in Methotrexate induced kidney and hepatic toxicities: Network Pharmacology, Molecular Docking, and in vivo Experiments","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121199","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121199"}}