{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T05:57:27Z","timestamp":1793685447498,"version":"4.5.1"},"reference-count":152,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004733","name":"University of Macau","doi-asserted-by":"publisher","award":["MYRG-GRG2024-00268-ICMS-UMDF"],"award-info":[{"award-number":["MYRG-GRG2024-00268-ICMS-UMDF"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004733","name":"University of Macau","doi-asserted-by":"publisher","award":["MYRG-CRG2023-00007-ICMS-IAS"],"award-info":[{"award-number":["MYRG-CRG2023-00007-ICMS-IAS"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006469","name":"Fund for the Development of Science and Technology","doi-asserted-by":"publisher","award":["0049\/2024\/AGJ"],"award-info":[{"award-number":["0049\/2024\/AGJ"]}],"id":[{"id":"10.13039\/501100006469","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jep.2026.121224","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:10:44Z","timestamp":1768435844000},"page":"121224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Citri Grandis Exocarpium with medicine and food homology: A review regarding its potential anti-obesity effects and future applications"],"prefix":"10.1016","volume":"361","author":[{"given":"Peng-fei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-yun","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-long","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-ming","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-lin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-shu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5244-8577","authenticated-orcid":false,"given":"Yuan-jia","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.121224_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tibtech.2003.10.012","article-title":"High content screening applied to large-scale cell biology","volume":"22","author":"Abraham","year":"2004","journal-title":"Trends Biotechnol."},{"issue":"1","key":"10.1016\/j.jep.2026.121224_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/advances\/nmz086","article-title":"Perspective: guiding principles for the implementation of personalized nutrition approaches that benefit health and function","volume":"11","author":"Adams","year":"2020","journal-title":"Adv. Nutr."},{"issue":"5","key":"10.1016\/j.jep.2026.121224_bib3","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nm.3159","article-title":"PPAR\u03b3 signaling and metabolism: the good, the bad and the future","volume":"19","author":"Ahmadian","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.jep.2026.121224_bib4","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3945\/an.113.005603","article-title":"Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action","volume":"5","author":"Alam","year":"2014","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.jep.2026.121224_bib5","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3390\/nu5030637","article-title":"Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats","volume":"5","author":"Alam","year":"2013","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.jep.2026.121224_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/nu13041133","article-title":"Twelve-week mediterranean diet intervention increases citrus bioflavonoid levels and reduces inflammation in people with type 2 diabetes mellitus","volume":"13","author":"Al-Aubaidy","year":"2021","journal-title":"Nutrients"},{"issue":"10\u201311","key":"10.1016\/j.jep.2026.121224_bib7","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s00011-022-01599-7","article-title":"The effect of immunomodulatory properties of naringenin on the inhibition of inflammation and oxidative stress in autoimmune disease models: a systematic review and meta-analysis of preclinical evidence","volume":"71","author":"Alimohammadi","year":"2022","journal-title":"Inflamm. Res."},{"issue":"4","key":"10.1016\/j.jep.2026.121224_bib8","doi-asserted-by":"crossref","first-page":"461","DOI":"10.5114\/ceji.2020.103418","article-title":"Obesity and chronic inflammation crosslinking","volume":"45","author":"Artemniak-Wojtowicz","year":"2020","journal-title":"Cejoi"},{"issue":"11","key":"10.1016\/j.jep.2026.121224_bib9","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.3390\/pharmaceutics15112635","article-title":"Anti-obesity drug delivery systems: recent progress and challenges","volume":"15","author":"Ashour","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jep.2026.121224_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1036655","article-title":"Naringenin, a citrus flavanone, enhances browning and brown adipogenesis: role of peroxisome proliferator-activated receptor gamma","volume":"9","author":"Bae","year":"2022","journal-title":"Front. Nutr."},{"issue":"6","key":"10.1016\/j.jep.2026.121224_bib11","first-page":"593","article-title":"Metabolic surgery for adult obesity: common questions and answers","volume":"105","author":"Banerjee","year":"2022","journal-title":"Am. Fam. Physician"},{"issue":"7905","key":"10.1016\/j.jep.2026.121224_bib12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s41586-022-04536-0","article-title":"Obesity alters pathology and treatment response in inflammatory disease","volume":"604","author":"Bapat","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jep.2026.121224_bib13","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1194\/jlr.M087387","article-title":"Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in obese Ldlr\u2212\/\u2212 mice","volume":"59","author":"Burke","year":"2018","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jep.2026.121224_bib14","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1039\/C9NP00011A","article-title":"Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2","volume":"36","author":"Caesar","year":"2019","journal-title":"Nat. Prod. Rep."},{"issue":"4","key":"10.1016\/j.jep.2026.121224_bib15","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.fshw.2022.10.043","article-title":"Naringenin inhibits lipid accumulation by activating the AMPK pathway in vivo and vitro","volume":"12","author":"Cai","year":"2023","journal-title":"Food Sci. Hum. Wellness"},{"issue":"3","key":"10.1016\/j.jep.2026.121224_bib16","first-page":"347","article-title":"Essential role of medicine and food homology in health and wellness","volume":"15","author":"Chen","year":"2023","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.jep.2026.121224_bib17","doi-asserted-by":"crossref","first-page":"7838","DOI":"10.1038\/s41467-022-35470-4","article-title":"Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects","volume":"13","author":"Chen","year":"2022","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.jep.2026.121224_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/osp4.763","article-title":"Effects of traditional Chinese medicines on weight management among adults with overweight or obesity: a systematic review and network meta-analysis","volume":"10","author":"Chen","year":"2024","journal-title":"Obes. Sci. Pract."},{"key":"10.1016\/j.jep.2026.121224_bib19","doi-asserted-by":"crossref","first-page":"791","DOI":"10.3390\/foods14050791","article-title":"Polysaccharides from Exocarpium citri grandis: graded ethanol precipitation, structural characterization, inhibition of \u03b1-Glucosidase activity, anti-oxidation, and anti-glycation potentials","volume":"14","author":"Chen","year":"2025","journal-title":"Foods"},{"key":"10.1016\/j.jep.2026.121224_bib20","article-title":"The pharmacological effects and potential applications of limonene from Citrus plants: a review","volume":"19","author":"Chen","year":"2024","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.jep.2026.121224_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2024.102553","article-title":"Adipose tissue targeted sequential delivery system regulating glycolipid metabolism for systemic obesity and its comorbidities","volume":"59","author":"Chen","year":"2024","journal-title":"Nano Today"},{"key":"10.1016\/j.jep.2026.121224_bib22","first-page":"305","article-title":"Pulsed electric field extraction of flavonoids from Exocarpium Citri grandis and its antioxidant activity detection","volume":"47","author":"Chen","year":"2021","journal-title":"J. Hunan Agric. Univ."},{"issue":"2","key":"10.1016\/j.jep.2026.121224_bib23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00394-010-0117-8","article-title":"Dietary naringenin increases hepatic peroxisome proliferators\u2013activated receptor \u03b1 protein expression and decreases plasma triglyceride and adiposity in rats","volume":"50","author":"Cho","year":"2011","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.jep.2026.121224_bib24","series-title":"Pharmacopoeia of the People's Republic of China, Part I","year":"2020"},{"issue":"1","key":"10.1016\/j.jep.2026.121224_bib25","first-page":"1","article-title":"White adipose tissue browning and obesity","volume":"31","author":"Cui","year":"2016","journal-title":"J. Biomed. Res."},{"key":"10.1016\/j.jep.2026.121224_bib26","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3389\/fmicb.2017.00563","article-title":"Gut microbiota modulation and its relationship with obesity using prebiotic fibers and probiotics: a review","volume":"8","author":"Dahiya","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jep.2026.121224_bib27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/biom9030099","article-title":"Antidiabetic properties of naringenin: a citrus fruit polyphenol","volume":"9","author":"Den Hartogh","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.jep.2026.121224_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116559","article-title":"Exocarpium Citri Grandis alleviates the aggravation of NAFLD by mitigating lipid accumulation and iron metabolism disorders","volume":"313","author":"Deng","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121224_bib29","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/s41366-023-01325-1","article-title":"Obesity-related complications, healthcare resource use and weight loss strategies in six European countries: the RESOURCE survey","volume":"47","author":"Evans","year":"2023","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.jep.2026.121224_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.696603","article-title":"The anti-obesity effect of traditional Chinese medicine on lipid metabolism","volume":"12","author":"Fan","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2026.121224_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2023.117996","article-title":"Combined analysis of GC-MS, RNA-seq and ATAC-seq elucidates the essential oils variation and terpenes biosynthesis in Citrus grandis \u2018Tomentosa","volume":"209","author":"Fan","year":"2024","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.jep.2026.121224_bib33","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/s42255-019-0095-y","article-title":"Leptin and the endocrine control of energy balance","volume":"1","author":"Friedman","year":"2019","journal-title":"Nat. Metab."},{"key":"10.1016\/j.jep.2026.121224_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.141631","article-title":"Microbes: drivers of Chenpi manufacturing, biotransformation, and physiological effects","volume":"464","author":"Fu","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2026.121224_bib35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/jmf.2006.9.49","article-title":"The effects of grapefruit on weight and insulin resistance: relationship to the metabolic syndrome","volume":"9","author":"Fujioka","year":"2006","journal-title":"J. Med. Food"},{"key":"10.1016\/j.jep.2026.121224_bib36","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/foods10010128","article-title":"Functionality of food components and emerging technologies","volume":"10","author":"Galanakis","year":"2021","journal-title":"Foods"},{"issue":"9","key":"10.1016\/j.jep.2026.121224_bib37","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.31982","article-title":"Weight loss outcomes associated with semaglutide treatment for patients with overweight or obesity","volume":"5","author":"Ghusn","year":"2022","journal-title":"JAMA Netw. Open"},{"issue":"2","key":"10.1016\/j.jep.2026.121224_bib38","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/antiox8020035","article-title":"Potential role of flavonoids in treating chronic inflammatory diseases with a special focus on the anti-inflammatory activity of apigenin","volume":"8","author":"Ginwala","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2026.121224_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012399","article-title":"Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPAR\u03b1, PPAR\u03b3 and LXR\u03b1","volume":"5","author":"Goldwasser","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jep.2026.121224_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.34","article-title":"Obesity","volume":"3","author":"Gonz\u00e1lez-Muniesa","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.jep.2026.121224_bib41","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1080\/21623945.2019.1583037","article-title":"Harnessing adipogenesis to prevent obesity","volume":"8","author":"Haider","year":"2019","journal-title":"Adipocyte"},{"key":"10.1016\/j.jep.2026.121224_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2023.103484","article-title":"Beneficial effects of nobiletin on regulation of lipid metabolism","volume":"57","author":"Hao","year":"2024","journal-title":"Food Biosci."},{"issue":"2","key":"10.1016\/j.jep.2026.121224_bib43","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1017\/S0954422410000168","article-title":"High-fat diet-induced obesity in animal models","volume":"23","author":"Hariri","year":"2010","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.jep.2026.121224_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.1073350","article-title":"Tremella fuciformis polysaccharide reduces obesity in high-fat diet-fed mice by modulation of gut microbiota","volume":"13","author":"He","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jep.2026.121224_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1393575","article-title":"The anti-obesity effects of polyphenols: a comprehensive review of molecular mechanisms and signal pathways in regulating adipocytes","volume":"11","author":"He","year":"2024","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jep.2026.121224_bib46","doi-asserted-by":"crossref","first-page":"13","DOI":"10.53388\/HPM2019D0803","article-title":"A brief discussion on the concept of location San Jiao","volume":"1","author":"Hou","year":"2019","journal-title":"History and Philosophy of Medicine"},{"key":"10.1016\/j.jep.2026.121224_bib47","series-title":"Study on the underlying molecular mechanism by which citrus grandis \u2018Tomentosa\u2019 exerts anti-non-small cell lung cancer effects by regulating Skp2\/p27 axis","first-page":"79","author":"Huang","year":"2023"},{"key":"10.1016\/j.jep.2026.121224_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2023.105428","article-title":"Systems pharmacology-based dissection of potential mechanisms of Exocarpium Citri Grandis for the treatment of chronic bronchitis","volume":"17","author":"Huang","year":"2024","journal-title":"Arab. J. Chem."},{"issue":"17","key":"10.1016\/j.jep.2026.121224_bib49","first-page":"57","article-title":"Correlation among Citri Grandis exocarpium decoction slices, standard decoction and dispensing granules","volume":"32","author":"Huang","year":"2023","journal-title":"China Pharm."},{"key":"10.1016\/j.jep.2026.121224_bib50","doi-asserted-by":"crossref","first-page":"81","DOI":"10.15302\/J-SSCAE-2022.06.008","article-title":"Strategic thinking on the development of food-medicine industry","volume":"24","author":"Huang","year":"2022","journal-title":"Chin. J. Eng. Sci."},{"issue":"2","key":"10.1016\/j.jep.2026.121224_bib51","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3390\/medicina61020358","article-title":"The role of artificial intelligence in obesity risk prediction and management: approaches, insights, and recommendations","volume":"61","author":"Huang","year":"2025","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.jep.2026.121224_bib52","article-title":"Transcriptomic and targeted metabolome analyses revealed the regulatory mechanisms of the synthesis of bioactive compounds in Citrus grandis \u2018tomentosa","volume":"12","author":"Huang","year":"2024","journal-title":"PeerJ"},{"issue":"23","key":"10.1016\/j.jep.2026.121224_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/nu15234978","article-title":"Diet change improves obesity and lipid deposition in high-fat diet-induced mice","volume":"15","author":"Ji","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2026.121224_bib54","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1111\/jam.15740","article-title":"The intestinal microbiome associated with lipid metabolism and obesity in humans and animals","volume":"133","author":"Jian","year":"2022","journal-title":"J. Appl. Microbiol."},{"issue":"3","key":"10.1016\/j.jep.2026.121224_bib56","first-page":"2160","article-title":"Isoimperatorin enhances 3T3-L1 preadipocyte differentiation by regulating PPAR\u03b3 and C\/EBP\u03b1 through the Akt signaling pathway","volume":"18","author":"Jiang","year":"2019","journal-title":"Exp. Ther. Med."},{"issue":"13","key":"10.1016\/j.jep.2026.121224_bib57","first-page":"17","article-title":"Activity and mechanism of Citri grandis Exocarpium-Cordyceps militaris compound on reliving cough based on network pharmacology","volume":"43","author":"Jiao","year":"2022","journal-title":"Sci. Technol. Food Ind."},{"key":"10.1016\/j.jep.2026.121224_bib58","article-title":"Biotics vs food systems: challenges and perspectives","author":"Junior","year":"2025","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jep.2026.121224_bib59","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13020-023-00766-0","article-title":"Citrus alkaline extracts improve LPS-induced pulmonary fibrosis via epithelial mesenchymal transition signals","volume":"18","author":"Junjie","year":"2023","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2026.121224_bib60","first-page":"83","article-title":"Obesity and inflammation. European. Cytokine","volume":"29","author":"Karczewski","year":"2018","journal-title":"Network"},{"key":"10.1016\/j.jep.2026.121224_bib61","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00394-018-1663-8","article-title":"Differential effects of dietary flavonoids on adipogenesis","volume":"58","author":"Khalilpourfarshbafi","year":"2019","journal-title":"Eur. J. Nutr."},{"issue":"1","key":"10.1016\/j.jep.2026.121224_bib62","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4093\/dmj.2016.40.1.12","article-title":"Brown fat and browning for the treatment of obesity and related metabolic disorders","volume":"40","author":"Kim","year":"2016","journal-title":"Diabetes Metab. J"},{"issue":"3","key":"10.1016\/j.jep.2026.121224_bib63","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3390\/medicines6030094","article-title":"Functional foods and bioactive compounds: a review of its possible role on weight management and obesity's metabolic consequences","volume":"6","author":"Konstantinidi","year":"2019","journal-title":"Medicines"},{"key":"10.1016\/j.jep.2026.121224_bib64","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6852276","article-title":"Biogenic phytochemicals modulating obesity: from molecular mechanism to preventive and therapeutic approaches","volume":"2022","author":"Kumar","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.jep.2026.121224_bib65","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s12272-023-01432-7","article-title":"Naringin promotes fat browning mediated by UCP1 activation via the AMPK signaling pathway in 3T3-L1 adipocytes","volume":"46","author":"Lee","year":"2023","journal-title":"Arch Pharm. Res. (Seoul)"},{"issue":"11","key":"10.1016\/j.jep.2026.121224_bib66","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.3390\/nu12113501","article-title":"Metabolic syndrome: past, present and future","volume":"12","author":"Lemieux","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2026.121224_bib67","series-title":"Nutraceutical and Functional Food Regulations in the United States and Around the World","first-page":"203","author":"Lewis","year":"2019"},{"key":"10.1016\/j.jep.2026.121224_bib68","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.2147\/DMSO.S274534","article-title":"The mechanism of traditional Chinese medicine for the treatment of obesity","volume":"13","author":"Li","year":"2020","journal-title":"DMSO"},{"key":"10.1016\/j.jep.2026.121224_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2022.127538","article-title":"Microbial cell factories for the production of flavonoids\u2013barriers and opportunities","volume":"360","author":"Li","year":"2022","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jep.2026.121224_bib70","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jpba.2013.11.030","article-title":"Systematic chemical profiling of Citrus grandis \u2018Tomentosa\u2019 by ultra-fast liquid chromatography\/diode-array detector\/quadrupole time-of-flight tandem mass spectrometry","volume":"90","author":"Li","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2026.121224_bib71","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.fct.2014.01.023","article-title":"Six months chronic toxicological evaluation of naringin in sprague-dawley rats","volume":"66","author":"Li","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2026.121224_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fct.2013.07.019","article-title":"Acute and 13 weeks subchronic toxicological evaluation of naringin in sprague-dawley rats","volume":"60","author":"Li","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.jep.2026.121224_bib73","first-page":"1","article-title":"The pre-clinical studies of Naringin, an innovative drug, derived from citri grandis exocarpium","volume":"54","author":"Li","year":"2015","journal-title":"Acta Sci. Nat. Univ. Sunyatseni"},{"key":"10.1016\/j.jep.2026.121224_bib74","series-title":"\u201cCompendium of Materia Medica\u201d Correction","author":"Li","year":"1982"},{"key":"10.1016\/j.jep.2026.121224_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.crfs.2024.100683","article-title":"Naringin ameliorates obesity via stimulating adipose thermogenesis and browning, and modulating gut microbiota in diet-induced obese mice","volume":"8","author":"Li","year":"2024","journal-title":"Curr. Res. Food Sci."},{"key":"10.1016\/j.jep.2026.121224_bib76","first-page":"18","article-title":"Research progress on extraction, detection and pharmacological action of the effective components of Citri Grandis Exocarpium","volume":"50","author":"Liang","year":"2022","journal-title":"Guangzhou Chem. Ind."},{"key":"10.1016\/j.jep.2026.121224_bib77","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/10826070601084886","article-title":"Preparative isolation and purification of two closely related glycosidic flavonoids from Exocarpium Citri Grandis by high-speed countercurrent chromatography","volume":"30","author":"Liang","year":"2007","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"10.1016\/j.jep.2026.121224_bib78","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3390\/nu15020267","article-title":"D-Limonene promotes anti-obesity in 3T3-L1 adipocytes and high-calorie diet-induced Obese rats by activating the AMPK signaling pathway","volume":"15","author":"Liao","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2026.121224_bib79","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.706978","article-title":"Obesity: epidemiology, pathophysiology, and therapeutics","volume":"12","author":"Lin","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2026.121224_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101237","article-title":"Challenges in tackling energy expenditure as obesity therapy: from preclinical models to clinical application","volume":"51","author":"L\u00f6ffler","year":"2021","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.jep.2026.121224_bib81","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.lfs.2016.04.010","article-title":"Monoterpene limonene induces brown fat-like phenotype in 3T3-L1 white adipocytes","volume":"153","author":"Lone","year":"2016","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.jep.2026.121224_bib82","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.3390\/molecules28031450","article-title":"Could naringenin participate as a regulator of obesity and satiety?","volume":"28","author":"L\u00f3pez-Almada","year":"2023","journal-title":"Molecules"},{"issue":"13","key":"10.1016\/j.jep.2026.121224_bib83","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.3748\/wjg.v10.i13.1854","article-title":"Theory of traditional Chinese medicine and therapeutic method of diseases","volume":"10","author":"Lu","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2026.121224_bib84","first-page":"79","article-title":"Effect of Citri Grandis Exocarpium polysaccharide on antioxidant capacity of spleen in mice with immunological injury induced by cyclophosphamide","volume":"32","author":"Lv","year":"2018","journal-title":"Chem. Eng."},{"key":"10.1016\/j.jep.2026.121224_bib85","article-title":"Research progress of Lycium barbarum L. as functional food: phytochemical composition and health benefits","volume":"47","author":"Ma","year":"2022","journal-title":"Curr. Opin. Food Sci."},{"issue":"1","key":"10.1016\/j.jep.2026.121224_bib86","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12986-022-00694-0","article-title":"Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases","volume":"19","author":"Machado","year":"2022","journal-title":"Nutr. Metab."},{"issue":"5","key":"10.1016\/j.jep.2026.121224_bib87","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.3390\/nu12051488","article-title":"Effect of Hesperidin on cardiovascular disease risk factors: the role of intestinal microbiota on Hesperidin bioavailability","volume":"12","author":"Mas-Capdevila","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2026.121224_bib88","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5530\/bems.4.1.3","article-title":"Methanolic extract of peel of Citrus maxima fruits exhibit analgesic, CNS depressant and anti-inflammatory activities in swiss albino mice","volume":"4","author":"Md Ibrahim","year":"2018","journal-title":"BEMS Reports"},{"issue":"4","key":"10.1016\/j.jep.2026.121224_bib89","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.foodchem.2004.11.042","article-title":"Evaluation of the antioxidant activity of extracts from buntan (Citrus grandis Osbeck) fruit tissues","volume":"94","author":"Mokbel","year":"2006","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2026.121224_bib90","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.biopha.2017.02.108","article-title":"Medicinal plants and phytochemicals with anti-obesogenic potentials: a review","volume":"89","author":"Mopuri","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2026.121224_bib91","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nature21697","article-title":"MC4R-dependent suppression of appetite by bone-derived lipocalin 2","volume":"543","author":"Mosialou","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jep.2026.121224_bib92","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.3390\/polym15102373","article-title":"Polysaccharides\u2014Naturally occurring immune modulators","volume":"15","author":"Murphy","year":"2023","journal-title":"Polymers"},{"key":"10.1016\/j.jep.2026.121224_bib93","doi-asserted-by":"crossref","DOI":"10.1111\/ijcp.14852","article-title":"Does naringenin supplementation improve lipid profile, severity of hepatic steatosis and probability of liver fibrosis in overweight\/obese patients with NAFLD? A randomised, double\u2010blind, placebo\u2010controlled, clinical trial","volume":"75","author":"Namkhah","year":"2021","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.jep.2026.121224_bib94","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.3390\/pr12122701","article-title":"Polysaccharide-based fat replacers in the functional food products","volume":"12","author":"Nikoli\u0107","year":"2024","journal-title":"Processes"},{"issue":"24","key":"10.1016\/j.jep.2026.121224_bib95","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.3390\/molecules25245959","article-title":"Toxicological screening of four bioactive citroflavonoids: in vitro, in vivo, and in silico approaches","volume":"25","author":"Ortiz-Andrade","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121224_bib96","first-page":"340","article-title":"Inhibitory effects of naringenin on estrogen deficiency-induced obesity via regulation of mitochondrial dynamics and AMPK activation associated with white adipose tissue browning","author":"Pan","year":"2024","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.jep.2026.121224_bib97","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","article-title":"Molecular mechanism of PPAR\u03b1 action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease","volume":"62","author":"Pawlak","year":"2015","journal-title":"J.Hepato."},{"issue":"5","key":"10.1016\/j.jep.2026.121224_bib98","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1590\/S1516-31802011000500001","article-title":"Obesity: the greatest epidemic of the 21st century?","volume":"129","author":"P\u00eago-Fernandes","year":"2011","journal-title":"Sao Paulo Med. J."},{"issue":"10382","key":"10.1016\/j.jep.2026.121224_bib99","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/S0140-6736(22)02403-5","article-title":"Contemporary medical, device, and surgical therapies for obesity in adults","volume":"401","author":"Perdomo","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2026.121224_bib100","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s42255-019-0036-9","article-title":"AMPK activation protects against diet-induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue","volume":"1","author":"Pollard","year":"2019","journal-title":"Nat. Metab."},{"key":"10.1016\/j.jep.2026.121224_bib101","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000000973","article-title":"Obesity and cardiovascular disease: a scientific statement from the American heart Association","volume":"143","author":"Powell-Wiley","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2026.121224_bib102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/9752826","article-title":"Preventive effect of naringin on metabolic syndrome and its mechanism of action: a systematic review","volume":"2019","author":"Raja Kumar","year":"2019","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.jep.2026.121224_bib103","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3390\/pharmaceutics15030863","article-title":"Naringin: nanotechnological strategies for potential pharmaceutical applications","volume":"15","author":"Ravetti","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jep.2026.121224_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.135671","article-title":"CgLS mediates limonene synthesis of main essential oil component in secretory cavity cells of Citrus grandis \u2018Tomentosa\u2019 fruits","volume":"280","author":"Rong","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.121224_bib105","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1001\/jama.2021.3224","article-title":"Effect of continued weekly subcutaneous semaglutide vs placebo on eeight loss maintenance in adults with overweight or obesity: the STEP 4 randomized clinical trial","volume":"325","author":"Rubino","year":"2021","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.jep.2026.121224_bib106","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/med.21740","article-title":"Flavonoids as antiobesity agents: a review","volume":"41","author":"Rufino","year":"2021","journal-title":"Med. Res. Rev."},{"issue":"5","key":"10.1016\/j.jep.2026.121224_bib107","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1021\/acs.molpharmaceut.7b00797","article-title":"Grapefruit flavonoid naringenin regulates the expression of LXR\u03b1 in THP-1 macrophages by modulating AMP-activated protein kinase","volume":"15","author":"Saenz","year":"2018","journal-title":"Mol. Pharm."},{"issue":"7","key":"10.1016\/j.jep.2026.121224_bib108","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3390\/life14070856","article-title":"The interplay between obesity and inflammation","volume":"14","author":"Savulescu-Fiedler","year":"2024","journal-title":"Life"},{"key":"10.1016\/j.jep.2026.121224_bib109","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1056\/NEJMoa1600869","article-title":"Bariatric surgery versus intensive medical therapy for diabetes \u2014 5-year outcomes","volume":"376","author":"Schauer","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.jep.2026.121224_bib110","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/obr.12541","article-title":"Weight\u2010loss interventions and gut microbiota changes in overweight and obese patients: a systematic review","volume":"18","author":"Seganfredo","year":"2017","journal-title":"Obes. Rev."},{"key":"10.1016\/j.jep.2026.121224_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2021.110231","article-title":"Insights into the chemical composition and bioactivities of citrus peel essential oils","volume":"143","author":"Singh","year":"2021","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jep.2026.121224_bib112","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-clinpsy-100219-060201","article-title":"Prevention and management of childhood obesity and its psychological and health comorbidities","volume":"16","author":"Smith","year":"2020","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"10.1016\/j.jep.2026.121224_bib113","article-title":"Safety of semaglutide","volume":"12","author":"Smits","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2026.121224_bib114","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1111\/1750-3841.14623","article-title":"Inclusion complex of Exocarpium Citri Grandis essential oil with \u03b2\u2010cyclodextrin: characterization, stability, and antioxidant activity","volume":"84","author":"Su","year":"2019","journal-title":"J. Food Sci."},{"key":"10.1016\/j.jep.2026.121224_bib115","doi-asserted-by":"crossref","DOI":"10.1111\/1750-3841.17654","article-title":"Dynamic changes of drying behavior, physicochemical quality, and volatile oil of Exocarpium citri grandis under different drying temperatures","volume":"90","author":"Sun","year":"2025","journal-title":"J. Food Sci."},{"key":"10.1016\/j.jep.2026.121224_bib116","doi-asserted-by":"crossref","DOI":"10.26599\/FMH.2024.9420014","article-title":"Transformation from traditional medicine-food homology to modern food-medicine homology","volume":"1","author":"Sun-Waterhouse","year":"2024","journal-title":"Food & Medicine Homology"},{"key":"10.1016\/j.jep.2026.121224_bib117","doi-asserted-by":"crossref","first-page":"208","DOI":"10.5534\/wjmh.200010","article-title":"Anti-obesity drugs: long-term efficacy and safety: an updated review","volume":"39","author":"Tak","year":"2021","journal-title":"World J. Mens. Health"},{"issue":"1","key":"10.1016\/j.jep.2026.121224_bib118","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health effects of overweight and obesity in 195 countries over 25 years","volume":"377","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2026.121224_bib119","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.3390\/nu5093367","article-title":"Flavonoid bioavailability and attempts for bioavailability enhancement","volume":"5","author":"Thilakarathna","year":"2013","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.jep.2026.121224_bib120","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1111\/1541-4337.12561","article-title":"Valorization of pomelo (Citrus grandis Osbeck) peel: a review of current utilization, phytochemistry, bioactivities, and mechanisms of action","volume":"19","author":"Tocmo","year":"2020","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.jep.2026.121224_bib121","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1017\/S0007114512005260","article-title":"Coumarin attenuates hepatic steatosis by down-regulating lipogenic gene expression in mice fed a high-fat diet","volume":"109","author":"Um","year":"2013","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.jep.2026.121224_bib122","unstructured":"Unschuld, P. U. Huang Di Nei Jing Su Wen. 475 BC-221 BC."},{"key":"10.1016\/j.jep.2026.121224_bib123","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00394-011-0182-7","article-title":"Dietary d-limonene alleviates insulin resistance and oxidative stress\u2013induced liver injury in high-fat diet and L-NAME-treated rats","volume":"51","author":"Victor Antony Santiago","year":"2012","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.jep.2026.121224_bib124","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmpp.2022.101815","article-title":"Intensification of supercritical fluid in the extraction of flavonoids: a comprehensive review","volume":"118","author":"Vinitha","year":"2022","journal-title":"Physiol. Mol. Plant Pathol."},{"key":"10.1016\/j.jep.2026.121224_bib125","series-title":"Obesity and Overweight Fact Sheet","year":"2020"},{"key":"10.1016\/j.jep.2026.121224_bib126","first-page":"1076","article-title":"Research progress of citri grandis exocarpium. Mod. Traditional. Chin. Med. Mater. Med. World","volume":"19","author":"Wang","year":"2017","journal-title":"Sci. Technol."},{"key":"10.1016\/j.jep.2026.121224_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.105391","article-title":"Limonene alleviates hepatic lipid accumulation by regulating fatty acids metabolism: insights from the transcriptome","volume":"62","author":"Wang","year":"2024","journal-title":"Food Biosci."},{"issue":"11","key":"10.1016\/j.jep.2026.121224_bib128","first-page":"747","article-title":"Textual research on the homology of Huajuhong both as medicine and as food","volume":"41","author":"Wang","year":"2022","journal-title":"J. Pharma Res."},{"issue":"1","key":"10.1016\/j.jep.2026.121224_bib129","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41392-022-01149-x","article-title":"Signaling pathways in obesity: mechanisms and therapeutic interventions","volume":"7","author":"Wen","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"11","key":"10.1016\/j.jep.2026.121224_bib130","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1056\/NEJMoa2032183","article-title":"Once-weekly semaglutide in adults with overweight or obesity","volume":"384","author":"Wilding","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2026.121224_bib131","first-page":"113","article-title":"Multi-omics approaches for precision obesity management: potentials and limitations of omics in precision prevention, treatment and risk reduction of obesity","volume":"135","author":"Woldemariam","year":"2023","journal-title":"Wien. Klin. Wochenschr."},{"key":"10.1016\/j.jep.2026.121224_bib132","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.2147\/DMSO.S275898","article-title":"Obesity, insulin resistance, and type 2 diabetes: associations and therapeutic implications","volume":"13","author":"Wondmkun","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.jep.2026.121224_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.116089","article-title":"Selection and evaluation of quality markers for the regulation of PXR-CYP3A4\/FXR-LXR\u03b1 by Exocarpium Citri Grandis for the treatment of hyperlipidaemia with dispelling blood stasis and removing phlegm","volume":"170","author":"Wu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2026.121224_bib134","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3748\/wjg.v4.i1.2","article-title":"Current concept of spleen-stomach theory and spleen deficiency syndrome in TCM","volume":"4","author":"Wu","year":"1998","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2026.121224_bib135","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1039\/C9FO03015H","article-title":"Vinegar extract ameliorates alcohol-induced liver damage associated with the modulation of gut microbiota in mice","volume":"11","author":"Xia","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2026.121224_bib136","doi-asserted-by":"crossref","DOI":"10.59717\/j.xinn-med.2024.100090","article-title":"Navigating obesity: a comprehensive review of epidemiology, pathophysiology, complications and management strategies","volume":"2","author":"Xiao","year":"2024","journal-title":"Time"},{"issue":"1","key":"10.1016\/j.jep.2026.121224_bib137","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/10286020.2011.632369","article-title":"Toxicokinetics of naringin and its metabolite naringenin after 180-day repeated oral administration in beagle dogs assayed by a rapid resolution liquid chromatography\/tandem mass spectrometric method","volume":"14","author":"Yang","year":"2012","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.jep.2026.121224_bib138","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.3390\/healthcare10091616","article-title":"The related metabolic diseases and treatments of obesity","volume":"10","author":"Yang","year":"2022","journal-title":"Healthcare"},{"key":"10.1016\/j.jep.2026.121224_bib139","article-title":"PBPK modeling on organs-on-chips: an overview of recent advancements","volume":"10","author":"Yang","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.jep.2026.121224_bib140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2022.108967","article-title":"Beneficial effects of citrus flavanones naringin and naringenin and their food sources on lipid metabolism: an update on bioavailability, pharmacokinetics, and mechanisms","volume":"104","author":"Yang","year":"2022","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.jep.2026.121224_bib141","first-page":"95","article-title":"Study on antioxidant capacity and anti-fatigue effect of Exocarpium Citri Grandis polysaccharides","volume":"32","author":"Yao","year":"2019","journal-title":"Cereals Oils"},{"issue":"7","key":"10.1016\/j.jep.2026.121224_bib142","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13811","article-title":"\u2018Obesities\u2019: position statement on a complex disease entity with multifaceted drivers","volume":"52","author":"Y\u00e1rnoz\u2010Esquiroz","year":"2022","journal-title":"Eur. J. Clin. Invest."},{"issue":"11","key":"10.1016\/j.jep.2026.121224_bib143","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1136\/gutjnl-2020-323106","article-title":"Effect of green-Mediterranean diet on intrahepatic fat: the DIRECT PLUS randomised controlled trial","volume":"70","author":"Yaskolka Meir","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.jep.2026.121224_bib144","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12934-023-02172-5","article-title":"Metabolic engineering strategies for naringenin production enhancement in Streptomyces albidoflavus J1074","volume":"22","author":"Ye","year":"2023","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.jep.2026.121224_bib145","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3390\/membranes12100943","article-title":"The flavonoid molecule procyanidin reduces phase separation in model membranes","volume":"12","author":"Yoda","year":"2022","journal-title":"Membranes"},{"issue":"1","key":"10.1016\/j.jep.2026.121224_bib146","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-98612-6","article-title":"The combined effect of green tea and alpha-glucosyl hesperidin in preventing obesity: a randomized placebo-controlled clinical trial","volume":"11","author":"Yoshitomi","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2026.121224_bib147","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2023.105578","article-title":"Naringenin prevents NAFLD in the diet-induced C57BL\/6J obesity model by regulating the intestinal barrier function and microbiota","volume":"105","author":"Yu","year":"2023","journal-title":"J. Funct.Foods"},{"key":"10.1016\/j.jep.2026.121224_bib148","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1007\/s12161-014-0071-9","article-title":"Chromatographic fingerprint analysis of Exocarpium Citri Grandis by high-performance liquid chromatography coupled with diode-array detector","volume":"8","author":"Yu","year":"2015","journal-title":"Food Anal. Methods"},{"key":"10.1016\/j.jep.2026.121224_bib149","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1556\/1326.2016.28.1.10","article-title":"Simultaneous determination of four major constituents in Citri Grandis Exocarpium by HPLC-DAD","volume":"28","author":"Yu","year":"2016","journal-title":"Acta Chromatogr."},{"key":"10.1016\/j.jep.2026.121224_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119975","article-title":"Flavonoid-statin interactions causing myopathy and the possible significance of OATP transport, CYP450 metabolism and mevalonate synthesis","volume":"291","author":"Zechner","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2026.121224_bib151","doi-asserted-by":"crossref","first-page":"9918","DOI":"10.1039\/D2FO01610A","article-title":"Naringenin activates beige adipocyte browning in high fat diet-fed C57BL\/6 mice by shaping the gut microbiota","volume":"13","author":"Zhang","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2026.121224_bib152","first-page":"2265","article-title":"Exocarpium Citri Grandis formula granules alleviate fatty liver disease in Zebrafish by maintaining iron homeostasis and suppressing lipid peroxidation and ferroptosis","volume":"44","author":"Zhang","year":"2024","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"10.1016\/j.jep.2026.121224_bib153","series-title":"Gleanings from the Materia Medica","author":"Zhao","year":"1998"},{"key":"10.1016\/j.jep.2026.121224_bib154","first-page":"1297","article-title":"Overview and progress on the study of the pharmacokinetics of naringin","volume":"18","author":"Zhu","year":"2013","journal-title":"Chin. J. Clin. Pharmacol. Therapeut."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126000759?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126000759?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:14:02Z","timestamp":1778692442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126000759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":152,"alternative-id":["S0378874126000759"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121224","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Citri Grandis Exocarpium with medicine and food homology: A review regarding its potential anti-obesity effects and future applications","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121224","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121224"}}