{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:46:31Z","timestamp":1784198791984,"version":"3.55.0"},"reference-count":160,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007161","name":"Instituto Polit\u00e9cnico Nacional Secretar\u00eda de Investigaci\u00f3n y Posgrado","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007161","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004881","name":"Instituto Mexicano del Seguro Social","doi-asserted-by":"publisher","award":["R-2023-785-014 ( GM M-S"],"award-info":[{"award-number":["R-2023-785-014 ( GM M-S"]}],"id":[{"id":"10.13039\/501100004881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009834","name":"Universidad Aut\u00f3noma de Yucat\u00e1n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003069","name":"Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"publisher","award":["2024-A232 (A D-B"],"award-info":[{"award-number":["2024-A232 (A D-B"]}],"id":[{"id":"10.13039\/501100003069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003069","name":"Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"publisher","award":["B230577"],"award-info":[{"award-number":["B230577"]}],"id":[{"id":"10.13039\/501100003069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jep.2026.121265","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:30:15Z","timestamp":1770222615000},"page":"121265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["In-vitro and in-silico anti-staphylococcal effects of the Mayan medicinal plant Krugiodendron ferreum (Vahl) Urb. (X-chintok): Disarming its resistance mechanisms and virulence factors"],"prefix":"10.1016","volume":"362","author":[{"given":"\u00c1ngel","family":"Dzul-Beh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haziel Eleazar","family":"Dzib-Baak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Jos\u00e9","family":"Palacios-Can","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrna","family":"D\u00e9ciga-Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avel Adolfo","family":"Gonz\u00e1lez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s Humberto","family":"Uc-Cach\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3961-6449","authenticated-orcid":false,"given":"Gloria Mar\u00eda","family":"Molina-Salinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.121265_bib1","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.3390\/plants12173077","article-title":"Back to nature: medicinal plants as promising sources for antibacterial drugs in the post-antibiotic era","volume":"12","author":"Abdallah","year":"2023","journal-title":"Plants"},{"key":"10.1016\/j.jep.2026.121265_bib2","doi-asserted-by":"crossref","first-page":"7641","DOI":"10.2147\/IDR.S428103","article-title":"Methicillin resistant Staphylococcus aureus: molecular mechanisms underlying drug resistance development and novel strategies to combat","volume":"16","author":"Abebe","year":"2023","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.jep.2026.121265_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.prmcm.2023.100297","article-title":"An updated review of Ziziphus jujube: major focus on its phytochemicals and pharmacological properties","volume":"8","author":"Agrawal","year":"2023","journal-title":"Pharmacol. Res. Mod. Chin. Med."},{"key":"10.1016\/j.jep.2026.121265_bib4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s43088-021-00170-3","article-title":"Stigmasterol and \u03b2-sitosterol: antimicrobial compounds in the leaves of Icacina trichantha identified by GC\u2013MS","volume":"10","author":"Alawode","year":"2021","journal-title":"Beni Suef Univ. J. Basic. Appl. Sci."},{"key":"10.1016\/j.jep.2026.121265_bib6","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3390\/metabo9110258","article-title":"A comprehensive review on medicinal plants as antimicrobial therapeutics: potential avenues of biocompatible drug discovery","volume":"9","author":"Anand","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/j.jep.2026.121265_bib7","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3390\/antibiotics13080746","article-title":"Plant-derived antimicrobials and their crucial role in combating antimicrobial resistance","volume":"13","author":"Angelini","year":"2024","journal-title":"Antibiotics"},{"key":"10.1016\/j.jep.2026.121265_bib8","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3390\/biom14060697","article-title":"Exploring therapeutic potential of catalase: strategies in disease prevention and management","volume":"14","author":"Anwar","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.jep.2026.121265_bib9","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s12010-019-02985-4","article-title":"Major Phytoconstituents of Prunus cerasoides responsible for antimicrobial and antibiofilm potential against some reference strains of pathogenic bacteria and clinical isolates of MRSA","volume":"188","author":"Arora","year":"2019","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.jep.2026.121265_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/bs.mim.2023.05.002","article-title":"Monospecies and polymicrobial biofilms in static and flow environments","volume":"53","author":"Arzmi","year":"2023","journal-title":"Methods Microbiol."},{"key":"10.1016\/j.jep.2026.121265_bib11","article-title":"Phytochemical, antioxidant, and antimicrobial properties of Bellardia trixago methanol and ethanol extracts: insights from ADMET and molecular docking approaches","author":"Aytar","year":"2025","journal-title":"J. Food Sci. Technol."},{"key":"10.1016\/j.jep.2026.121265_bib12","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.3390\/antiox11101912","article-title":"Health benefits and pharmacological properties of stigmasterol","volume":"11","author":"Bakrim","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2026.121265_bib13","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.ejmech.2009.12.052","article-title":"Synthesis and characterization of novel fatty acid analogs of cholesterol: in vitro antimicrobial activity","volume":"45","author":"Banday","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jep.2026.121265_bib14","doi-asserted-by":"crossref","first-page":"8165","DOI":"10.1073\/pnas.0914229107","article-title":"Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores","volume":"107","author":"Banerjee","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jep.2026.121265_bib15","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3390\/toxics13050390","article-title":"What do we know about Staphylococcus aureus and oxidative stress? Resistance, virulence, new targets, and therapeutic alternatives","volume":"13","author":"Bastos","year":"2025","journal-title":"Toxics"},{"key":"10.1016\/j.jep.2026.121265_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2021.e06310","article-title":"Antibacterial activity of medicinal plants against ESKAPE: an update","volume":"7","author":"Bhatia","year":"2021","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2026.121265_bib18","series-title":"Discovery Studio Visualizer, 25.1.0.24284","year":"2021"},{"key":"10.1016\/j.jep.2026.121265_bib19","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41589-022-00994-9","article-title":"Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus","volume":"18","author":"Brawley","year":"2022","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jep.2026.121265_bib20","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41589-022-00994-9","article-title":"Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus","volume":"18","author":"Brawley","year":"2022","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jep.2026.121265_bib21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12941-015-0086-0","article-title":"Antibacterial activity of native California medicinal plant extracts isolated from Rhamnus californica and Umbellularia californica","volume":"14","author":"Carranza","year":"2015","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"10.1016\/j.jep.2026.121265_bib22","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02132-20","article-title":"Analysis of multidrug resistance in Staphylococcus aureus with a machine learning-generated antibiogram","volume":"65","author":"Cazer","year":"2021","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jep.2026.121265_bib23","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.04876-22","article-title":"Efflux pump inhibitory potential of indole derivatives against NorA overexpressing Staphylococcus aureus","volume":"11","author":"Chandal","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.jep.2026.121265_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.586548","article-title":"A systematic review of plants with antibacterial activities: a taxonomic and phylogenetic perspective","volume":"11","author":"Chassagne","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2026.121265_bib25","first-page":"1029","article-title":"A review on molecular docking: novel tool for drug discovery","volume":"4","author":"Chaudhary","year":"2016","journal-title":"JSM Chem"},{"key":"10.1016\/j.jep.2026.121265_bib26","first-page":"71","article-title":"M\u00e9dicos y medicinas en el mundo peninsular maya colonial y decimon\u00f3nico","volume":"6","author":"Ch\u00e1vez-Guzm\u00e1n","year":"2011","journal-title":"Pen\u00ednsula"},{"key":"10.1016\/j.jep.2026.121265_bib27","doi-asserted-by":"crossref","DOI":"10.1590\/fst.69522","article-title":"Study on the antioxidant activity of \u03b2-sitosterol and stigmasterol from Sacha Inchi oil and Prinsepia oil added to walnut oil","volume":"42","author":"Cheng","year":"2022","journal-title":"Food Sci. Technol."},{"key":"10.1016\/j.jep.2026.121265_bib28","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/21505594.2021.1878688","article-title":"Pathogenicity and virulence of Staphylococcus aureus","volume":"12","author":"Cheung","year":"2021","journal-title":"Virulence"},{"key":"10.1016\/j.jep.2026.121265_bib29","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jep.2006.04.003","article-title":"Anti-infective potential of natural products","volume":"106","author":"Cos","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121265_bib30","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.physbeh.2008.02.013","article-title":"Modulation of tonic immobility by homocysteic acid","volume":"94","author":"Coutinho","year":"2008","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.jep.2026.121265_bib31","doi-asserted-by":"crossref","DOI":"10.1093\/jambio\/lxad315","article-title":"Evaluation of selected natural sesquiterpenes as sensitizing agents of \u03b2-lactam-resistant bacterial strains","volume":"135","author":"Cruz-Mart\u00ednez","year":"2024","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.jep.2026.121265_bib32","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s11095-020-02849-1","article-title":"Bioprospecting for antibacterial drugs","volume":"37","author":"Cushnie","year":"2020","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jep.2026.121265_bib33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.micpath.2009.04.012","article-title":"Staphylococcal catalase protects intracellularly survived bacteria by destroying H2O2 produced by the murine peritoneal macrophages","volume":"47","author":"Das","year":"2009","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.jep.2026.121265_bib34","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.3390\/antibiotics10121502","article-title":"Efflux pump mediated antimicrobial resistance by staphylococci in health-related environments: challenges and the quest for inhibition","volume":"10","author":"Dashtbani-Roozbehani","year":"2021","journal-title":"Antibiotics"},{"key":"10.1016\/j.jep.2026.121265_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115738","article-title":"Antimicrobial potential of the Mayan medicine plant Matayba oppositifolia (A. Rich.) Britton against antibiotic-resistant priority pathogens","volume":"300","author":"de Jes\u00fas Dzul-Beh","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121265_bib36","doi-asserted-by":"crossref","first-page":"262","DOI":"10.18683\/germs.2022.1328","article-title":"Review Anti-virulence therapeutic strategies against bacterial infections: recent advances","volume":"12","author":"Dehbanipour","year":"2022","journal-title":"Germs"},{"key":"10.1016\/j.jep.2026.121265_bib37","doi-asserted-by":"crossref","first-page":"7692","DOI":"10.1038\/s41598-019-44242-y","article-title":"American Civil War plant medicines inhibit biofilm formation","volume":"9","author":"Dettweiler","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2026.121265_bib38","doi-asserted-by":"crossref","first-page":"10757","DOI":"10.1021\/acsomega.3c00312","article-title":"Antibiotic adjuvants: a versatile approach to combat antibiotic resistance","author":"Dhanda","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.jep.2026.121265_bib39","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1007\/s10096-025-05148-y","article-title":"The virulence toolkit of Staphylococcus aureus: a comprehensive review of toxin diversity, molecular mechanisms, and clinical implications","volume":"44","author":"Di Bella","year":"2025","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.jep.2026.121265_bib40","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrd.2017.23","article-title":"Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance","volume":"16","author":"Dickey","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jep.2026.121265_bib41","first-page":"80","article-title":"Hemolysins of Staphylococcus aureus\u2014an update on their biology, role in pathogenesis and as targets for anti-virulence therapy","volume":"9","author":"Divyakolu","year":"2019","journal-title":"Adv. Infect. Dis."},{"key":"10.1016\/j.jep.2026.121265_bib42","article-title":"Enhancing activity and overcoming ciprofloxacin resistance via multifunctional nanostructured lipid carriers","volume":"108","author":"Dlamini","year":"2025","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jep.2026.121265_bib43","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.bjp.2019.06.001","article-title":"In vitro growth inhibition and bactericidal activity of spathulenol against drug-resistant clinical isolates of Mycobacterium tuberculosis","volume":"29","author":"Dzul-Beh","year":"2020","journal-title":"Rev. Bras. Farmacogn."},{"key":"10.1016\/j.jep.2026.121265_bib44","first-page":"84","article-title":"Exploring Mangifera indica leaf and bark extracts as potential antibiotic adjuvants","volume":"6","author":"Ekamgue","year":"2023","journal-title":"IMCP"},{"key":"10.1016\/j.jep.2026.121265_bib45","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3390\/antibiotics10050511","article-title":"Catalase protects biofilm of Staphylococcus aureus against daptomycin activity","volume":"10","author":"El Haj","year":"2021","journal-title":"Antibiotics"},{"key":"10.1016\/j.jep.2026.121265_bib46","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00988-17","article-title":"Role of fatty acid kinase in cellular lipid homeostasis and SaeRS-dependent virulence factor expression in Staphylococcus aureus","volume":"8","author":"Ericson","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.jep.2026.121265_bib47","first-page":"90","article-title":"Kalanchoe crenata extract potentiates antibiotics against multidrug-resistant Gram-negative bacteria","volume":"7","author":"Fokou","year":"2024","journal-title":"IMCP"},{"key":"10.1016\/j.jep.2026.121265_bib48","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/femsre\/fux007","article-title":"Antibiotic resistance in Staphylococcus aureus: current status and future prospects","volume":"41","author":"Foster","year":"2017","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.jep.2026.121265_bib166","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3390\/ijms26020607","article-title":"Potential Use of Selected Natural Compounds with Anti-Biofilm Activity","volume":"26","author":"Fydrych","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jep.2026.121265_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136674","article-title":"A label-free strategy for direct detection of Staphylococcus aureus in complex matrices based on RCA and aptamer","volume":"422","author":"Gan","year":"2025","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.jep.2026.121265_bib50","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/ptr.2001","article-title":"Screening of some medicinal plants from Cameroon for \u03b2-lactamase inhibitory activity","volume":"21","author":"Gangou\u00e9-Pi\u00e9boji","year":"2007","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2026.121265_bib51","article-title":"Medicina maya tradicional: confrontaci\u00f3n con el sistema conceptual chino, first ed","author":"Garc\u00eda","year":"1996","journal-title":"Educaci\u00f3n, Cultura y Ecolog\u00eda"},{"key":"10.1016\/j.jep.2026.121265_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2012.00033","article-title":"Staphylococcal response to oxidative stress","volume":"2","author":"Gaupp","year":"2012","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jep.2026.121265_bib53","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/cbdd.12478","article-title":"Antibiotic adjuvants: diverse strategies for controlling drug-resistant pathogens","volume":"85","author":"Gill","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.jep.2026.121265_bib54","series-title":"WHO Global Antimicrobial Resistance and Use Surveillance System (GLASS)","year":"2025"},{"key":"10.1016\/j.jep.2026.121265_bib55","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.3390\/molecules28031068","article-title":"Current landscape of methods to evaluate antimicrobial activity of natural extracts","volume":"28","author":"Gonz\u00e1lez-Pastor","year":"2023","journal-title":"Mol"},{"key":"10.1016\/j.jep.2026.121265_bib56","doi-asserted-by":"crossref","DOI":"10.15517\/lank.v3i3.22991","article-title":"Una segunda especie de Krugiodendron (Rhamnaceae) en el Neotr\u00f3pico","volume":"3","author":"Gonz\u00e1lez-Ram\u00edrez","year":"2016","journal-title":"Lankesteriana"},{"key":"10.1016\/j.jep.2026.121265_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115518","article-title":"Antibacterial and antibiotic-potentiation activities of the hydro-ethanolic extract and protoberberine alkaloids from the stem bark of Enantia chlorantha against multidrug-resistant bacteria expressing active efflux pumps","volume":"296","author":"Guefack","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121265_bib58","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1758-2946-4-17","article-title":"Avogadro: an advanced semantic chemical editor, visualization, and analysis platform","volume":"4","author":"Hanwell","year":"2012","journal-title":"J. Cheminf."},{"key":"10.1016\/j.jep.2026.121265_bib59","doi-asserted-by":"crossref","DOI":"10.1063\/5.0275885","article-title":"Pre-loaded H2O2 breaks the low-pH dependency of plasma-activated water for bacteria inactivation via catalase suppression and oxidative attack","volume":"127","author":"He","year":"2025","journal-title":"Appl. Phys. Lett."},{"key":"10.1016\/j.jep.2026.121265_bib60","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1021\/acs.jnatprod.8b00959","article-title":"Natural products from the yucatecan flora: structural diversity and biological activity","volume":"82","author":"Hern\u00e1ndez-Bolio","year":"2019","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2026.121265_bib61","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1556\/1886.2024.00035","article-title":"Methods for screening and evaluation of antimicrobial activity: a review of protocols, advantages, and limitations","volume":"14","author":"Hossain","year":"2024","journal-title":"Eur. J. Microbiol. Immunol"},{"key":"10.1016\/j.jep.2026.121265_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2024.112389","article-title":"Kaempferol: paving the path for advanced treatments in aging-related diseases","volume":"188","author":"Hussain","year":"2024","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.jep.2026.121265_bib63","first-page":"72","article-title":"Gas chromatography-mass spectrometry (GC-MS): a comprehensive review of synergistic combinations and their applications in the past two decades","volume":"5","author":"International","year":"2023","journal-title":"J. Anal. Sci. Appl. Biotech."},{"issue":"Suppl. 4","key":"10.1016\/j.jep.2026.121265_bib64","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/j.ijid.2010.05.003","article-title":"Methicillin-resistant Staphylococcus aureus: the superbug","volume":"14","author":"Ippolito","year":"2010","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.jep.2026.121265_bib65","doi-asserted-by":"crossref","first-page":"6727","DOI":"10.3390\/ma15196727","article-title":"Quantitative analyses of biofilm using crystal violet staining and optical reflection","volume":"15","author":"Kamimura","year":"2022","journal-title":"Materials"},{"key":"10.1016\/j.jep.2026.121265_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1491363","article-title":"Natural compounds in the fight against Staphylococcus aureus biofilms: a review of antibiofilm strategies","volume":"15","author":"Kashi","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2026.121265_bib67","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s12374-020-09245-7","article-title":"Plant secondary metabolite synthesis and regulation under biotic and abiotic constraints","volume":"63","author":"Khare","year":"2020","journal-title":"J. Plant Biol."},{"key":"10.1016\/j.jep.2026.121265_bib68","doi-asserted-by":"crossref","first-page":"22977","DOI":"10.1021\/acsomega.2c03094","article-title":"Screening of Rhamnus Purpurea (Edgew.) leaves for antimicrobial, antioxidant, and cytotoxic potential","volume":"7","author":"Khuda","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.jep.2026.121265_bib70","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1248\/bpb.27.1321","article-title":"Antimicrobial activity of saturated fatty acids and fatty amines against methicillin-resistant Staphylococcus aureus","volume":"27","author":"Kitahara","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2026.121265_bib71","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.foodchem.2012.08.026","article-title":"Anthraquinone profile, antioxidant and antimicrobial activity of bark extracts of Rhamnus spp","volume":"136","author":"Kosalec","year":"2013","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2026.121265_bib72","first-page":"248","article-title":"Antimicrobial and resistance modulatory activity of Alpinia katsumadai seed phenolic extract, essential oil and post-distillation extract","volume":"52","author":"Kov\u0103c","year":"2014","journal-title":"Food Technol. Biotechnol."},{"key":"10.1016\/j.jep.2026.121265_bib73","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1293633","article-title":"Antibiotic adjuvants: synergistic tool to combat multidrug-resistant pathogens","volume":"13","author":"Kumar","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jep.2026.121265_bib74","doi-asserted-by":"crossref","first-page":"9034","DOI":"10.1038\/s41598-021-88260-1","article-title":"Cytotoxic, analgesic and anti-inflammatory activity of colchicine and its C-10 sulfur containing derivatives","volume":"11","author":"Kurek","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2026.121265_bib75","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ijmm.2017.10.011","article-title":"First description of a catalase-negative Staphylococcus aureus from a healthy carrier, with a novel nonsense mutation in the katA gene","volume":"307","author":"Laub","year":"2017","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.jep.2026.121265_bib76","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.3389\/fmicb.2015.01174","article-title":"Quorum-sensing regulation in staphylococci-an overview","volume":"6","author":"Le","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jep.2026.121265_bib77","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01330-22","article-title":"Inhibition of Staphylococcus aureus biofilm formation and virulence factor production by petroselinic acid and other unsaturated C18 fatty acids","volume":"10","author":"Lee","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.jep.2026.121265_bib78","doi-asserted-by":"crossref","first-page":"7958","DOI":"10.3390\/molecules16097958","article-title":"Allicin reduces the production of \u03b1-toxin by Staphylococcus aureus","volume":"16","author":"Leng","year":"2011","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121265_bib79","doi-asserted-by":"crossref","DOI":"10.1093\/femsle\/fnaf020","article-title":"Biofilm destruction activity of \u03b1-tocopherol against Staphylococcus aureus, Proteus mirabilis, and Pseudomonas aeruginosa","volume":"372","author":"Leong","year":"2025","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.jep.2026.121265_bib80","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.semarthrit.2015.06.013","article-title":"Colchicine-Update on mechanisms of action and therapeutic uses","volume":"45","author":"Leung","year":"2015","journal-title":"Semin. Arthritis Rheum."},{"issue":"15","key":"10.1016\/j.jep.2026.121265_bib81","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.1038\/s41467-024-48759-3","article-title":"Proton-coupled transport mechanism of the efflux pump NorA","volume":"15","author":"Li","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2026.121265_bib82","doi-asserted-by":"crossref","first-page":"10942","DOI":"10.1039\/D3NJ01045G","article-title":"A fluorometric graphene oxide-based assay for determination of agrB gene transcription in methicillin-resistant Staphylococcus aureus by coupling exonuclease III-assisted target recycling and hybridization chain reaction","volume":"47","author":"Liu","year":"2023","journal-title":"New J. Chem."},{"key":"10.1016\/j.jep.2026.121265_bib83","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s44259-024-00046-3","article-title":"Mechanisms of antimicrobial resistance in biofilms","volume":"2","author":"Liu","year":"2024","journal-title":"NPJ Antimicrob Resist"},{"key":"10.1016\/j.jep.2026.121265_bib84","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01658-19","article-title":"MazEF toxin\u2013antitoxin system drives Staphylococcus aureus biofilm formation","volume":"10","author":"Ma","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.jep.2026.121265_bib86","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fcimb.2019.00074","article-title":"Recent advances in anti-virulence therapeutic strategies with a focus on dismantling bacterial membrane microdomains, toxin neutralization, quorum-sensing interference and biofilm inhibition","volume":"9","author":"Mart\u00ednez","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jep.2026.121265_bib87","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.tvjl.2005.09.004","article-title":"In vitro anthelmintic, antibacterial and cytotoxic effects of extracts from plants used in South African ethnoveterinary medicine","volume":"173","author":"McGaw","year":"2007","journal-title":"Vet. J."},{"key":"10.1016\/j.jep.2026.121265_bib88","series-title":"Bachelor's Degree Thesis in Biology. Universidad Aut\u00f3noma De M\u00e9xico, Facultad De Ciencias","article-title":"Plantas medicinales del estado de Yucat\u00e1n","author":"Mendieta","year":"1982"},{"key":"10.1016\/j.jep.2026.121265_bib89","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3390\/ph18010081","article-title":"Antibiotic resistance of Staphylococcus aureus strains: searching for new antimicrobial agents","volume":"18","author":"Michalik","year":"2025","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jep.2026.121265_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104231","article-title":"Preparation and optimization of ciprofloxacin encapsulated niosomes: a new approach for enhanced antibacterial activity, biofilm inhibition and reduced antibiotic resistance in ciprofloxacin-resistant methicillin-resistance Staphylococcus aureus","volume":"103","author":"Mirzaie","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.jep.2026.121265_bib91","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.566325","article-title":"Natural anti-biofilm agents","volume":"11","author":"Mishra","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jep.2026.121265_bib92","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.jep.2026.121265_bib93","doi-asserted-by":"crossref","first-page":"712","DOI":"10.3390\/toxins14100712","article-title":"Toxicity of compounds yielded by staphylococci on Vero cells","volume":"14","author":"Modimola","year":"2022","journal-title":"Toxins"},{"key":"10.1016\/j.jep.2026.121265_bib94","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.3390\/plants13243498","article-title":"Mayan medicinal plants Bignonia potosina and Thouinia paucidentata demonstrate anti-infective properties against the priority antibiotic-resistant bacteria Acinetobacter baumannii and Pseudomonas aeruginosa","volume":"13","author":"Molina-Salinas","year":"2024","journal-title":"Plants"},{"key":"10.1016\/j.jep.2026.121265_bib95","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s12906-016-1279-6","article-title":"Evaluation of the in vitro antibacterial activity of the solvent fractions of the leaves of Rhamnus prinoides l\u2019h\u00e9rit (Rhamnaceae)","volume":"16","author":"Molla","year":"2016","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2026.121265_bib96","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0233854","article-title":"S. aureus alpha-toxin monomer binding and heptamer formation in host cell membranes-Do they determine sensitivity of airway epithelial cells toward the toxin?","volume":"15","author":"M\u00f6ller","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2026.121265_bib97","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4103\/abr.abr_143_18","article-title":"Identification of hemolysine genes and their association with antimicrobial resistance pattern among clinical isolates of Staphylococcus aureus in West of Iran","volume":"7","author":"Motamedi","year":"2018","journal-title":"Adv. Biomed. Res."},{"key":"10.1016\/j.jep.2026.121265_bib98","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","author":"Murray","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2026.121265_bib99","first-page":"233","article-title":"Global burden of bacterial antimicrobial resistance in 2021: a systematic analysis","volume":"403","author":"Naghavi","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2026.121265_bib100","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13104-020-4938-0","article-title":"Identification of hemolysin encoding genes and their association with antimicrobial resistance pattern among clinical isolates of coagulase-negative Staphylococci","volume":"13","author":"Nasaj","year":"2020","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.jep.2026.121265_bib101","first-page":"899","article-title":"Phytochemicals, traditional uses and pharmacological activity of Rhamnus prinoides: a review","volume":"8","author":"Nigussie","year":"2021","journal-title":"Int. J. Second. Metab"},{"key":"10.1016\/j.jep.2026.121265_bib102","doi-asserted-by":"crossref","first-page":"899","DOI":"10.18596\/jotcsa.929188","article-title":"Traditional medicinal uses, phytochemicals, and pharmacological activities of genus Rhamnus: a review","volume":"8","author":"Nigussie","year":"2021","journal-title":"JOTCSA"},{"key":"10.1016\/j.jep.2026.121265_bib103","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1186\/s12906-017-2005-8","article-title":"In vitro cytotoxic activity of medicinal plants from Nigerian ethnomedicine","volume":"17","author":"Ogbole","year":"2017","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2026.121265_bib104","doi-asserted-by":"crossref","first-page":"930","DOI":"10.2166\/wh.2019.177","article-title":"Multi-drug resistance traits of methicillin-resistant Staphylococcus aureus and other Staphylococcal species from clinical and environmental sources","volume":"17","author":"Oladipo","year":"2019","journal-title":"J. Water Health"},{"key":"10.1016\/j.jep.2026.121265_bib105","first-page":"2437","article-title":"Microtiter dish biofilm formation assay","volume":"47","author":"O'Toole","year":"2011","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jep.2026.121265_bib106","doi-asserted-by":"crossref","DOI":"10.1002\/hsr2.1480","article-title":"Superbugs or multidrug resistant microbes: a new threat to the society","volume":"6","author":"Painuli","year":"2023","journal-title":"Health Sci. Rep."},{"key":"10.1016\/j.jep.2026.121265_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114125","article-title":"The development of a targeted and more potent, anti-inflammatory derivative of colchicine: implications for gout","volume":"180","author":"Par\u00e9","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2026.121265_bib108","article-title":"Current treatment strategies against multidrug-resistant bacteria: a review","volume":"388","author":"Parmanik","year":"2022","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.jep.2026.121265_bib109","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/antibiotics12010012","article-title":"A review of biofilm formation of Staphylococcus aureus and its regulation mechanism","volume":"12","author":"Peng","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.jep.2026.121265_bib110","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera - a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jep.2026.121265_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2025.121378","article-title":"Efflux pump inhibitors from plant compounds: a new strategy to modulate bacterial growth and morphology","volume":"233","author":"Pietrowska","year":"2025","journal-title":"Ind. Crops Prod."},{"key":"10.1016\/j.jep.2026.121265_bib112","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s11101-015-9436-y","article-title":"Plant derived inhibitors of bacterial efflux pumps: an update","volume":"14","author":"Prasch","year":"2015","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.jep.2026.121265_bib113","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3390\/pathogens14020185","article-title":"Staphylococcus aureus in inflammation and pain: update on pathologic mechanisms","volume":"14","author":"Rasquel-Oliveira","year":"2025","journal-title":"Pathogens"},{"key":"10.1016\/j.jep.2026.121265_bib114","doi-asserted-by":"crossref","DOI":"10.1051\/e3sconf\/202340002007","article-title":"In Silico antibacterial activity of selected active compounds of cherry leaf (Muntingia calabura) to Staphylococcus aureus","volume":"400","author":"Rifda","year":"2023","journal-title":"E3S Web of Conferences"},{"key":"10.1016\/j.jep.2026.121265_bib115","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jep.2005.04.025","article-title":"Medicinal plants and antimicrobial activity","volume":"100","author":"R\u00edos","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121265_bib116","first-page":"7","article-title":"Chemical derivatization of phytoconstituents to enhance therapeutic potential","volume":"5","author":"Sabale","year":"2025","journal-title":"BVMJ"},{"key":"10.1016\/j.jep.2026.121265_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2023.127345","article-title":"Anti-virulence compounds against Staphylococcus aureus associated with bovine mastitis: a new therapeutic option?","volume":"271","author":"Sabino","year":"2023","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.jep.2026.121265_bib118","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12982-024-00196-9","article-title":"Exploring plant and microbial antimicrobials for sustainable public health and environmental preservation","volume":"21","author":"Saini","year":"2024","journal-title":"Discov. public health"},{"key":"10.1016\/j.jep.2026.121265_bib119","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1007\/s11101-022-09835-y","article-title":"Phytochemical diversity and pharmacological effects of triterpenes from genus Ziziphus: a comprehensive review","volume":"22","author":"Sakna","year":"2023","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.jep.2026.121265_bib120","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.3390\/antibiotics12071168","article-title":"Resveratrol as an inhibitor of the NorA efflux pump and resistance modulator in Staphylococcus aureus","volume":"12","author":"Santos","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.jep.2026.121265_bib122","first-page":"9","article-title":"Analysis of IR, NMR and antimicrobial activity of \u03b2-Sitosterol isolated from Momordica charantia","volume":"1","author":"Sen","year":"2012","journal-title":"Sci. Secure J. Biotech."},{"key":"10.1016\/j.jep.2026.121265_bib123","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0314958","article-title":"Methanol extracts as adjuvants to enhance antibiotic efficacy against priority bacteria","volume":"20","author":"Seukep","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2026.121265_bib124","article-title":"Phenolic-rich fractions from Caesalpinia pulcherrima and efflux protein inhibition","volume":"358","author":"Seukep","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121265_bib125","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4103\/ijmr.IJMR_2079_17","article-title":"Efflux pump inhibitors for bacterial pathogens: from bench to bedside","volume":"149","author":"Sharma","year":"2019","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.jep.2026.121265_bib126","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.3390\/microorganisms11061614","article-title":"Microbial biofilm: a review on formation, infection, antibiotic resistance, control measures, and innovative treatment","volume":"11","author":"Sharma","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.jep.2026.121265_bib127","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.3390\/foods13111754","article-title":"Phytosterols: physiological functions and potential application","volume":"13","author":"Shen","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.jep.2026.121265_bib128","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1039\/c1md00044f","article-title":"Computational ligand-based rational design: role of conformational sampling and force fields in model development","volume":"2","author":"Shim","year":"2011","journal-title":"Medchemcomm"},{"key":"10.1016\/j.jep.2026.121265_bib129","article-title":"Effect of palladium (II) complexes on NorA efflux pump inhibition and resensitization of fluoroquinolone-resistant Staphylococcus aureus: in vitro and in silico approach","volume":"13","author":"Shobana","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jep.2026.121265_bib130","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1080\/13880209.2022.2127791","article-title":"In vitro and in silico \u03b2-lactamase inhibitory properties and phytochemical profile of Ocimum basilicum cultivated in central delta of Egypt","volume":"60","author":"Shoeib","year":"2022","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2026.121265_bib131","doi-asserted-by":"crossref","first-page":"9162","DOI":"10.1021\/acs.chemrev.6b00184","article-title":"Plant natural products targeting bacterial virulence factors","volume":"116","author":"Silva","year":"2016","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jep.2026.121265_bib132","doi-asserted-by":"crossref","first-page":"368","DOI":"10.15698\/mic2024.11.839","article-title":"Efflux pumps: gatekeepers of antibiotic resistance in Staphylococcus aureus biofilms","volume":"11","author":"Sinha","year":"2024","journal-title":"Microb. Cell"},{"key":"10.1016\/j.jep.2026.121265_bib133","doi-asserted-by":"crossref","first-page":"789","DOI":"10.2174\/1385272821666170620110041","article-title":"A Review of natural products with anti-biofilm activity","volume":"22","author":"Song","year":"2017","journal-title":"Curr. Org. Chem."},{"key":"10.1016\/j.jep.2026.121265_bib135","article-title":"Biofilms: formation, research models, potential targets, and methods for prevention and treatment","volume":"29","author":"Su","year":"2022","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.jep.2026.121265_bib136","doi-asserted-by":"crossref","first-page":"9185","DOI":"10.2147\/DDDT.S551862","article-title":"Promising future of novel beta-lactam antibiotics against bacterial resistance","volume":"19","author":"Tayeb","year":"2025","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.jep.2026.121265_bib137","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.700198","article-title":"Development of an antibiotic resistance breaker to resensitize drug-resistant Staphylococcus aureus: in silico and in vitro approach","volume":"11","author":"Thamilselvan","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jep.2026.121265_bib138","first-page":"743","article-title":"Investigation OF BIOCHEMICAL properties, antimicrobial, antioxidant and antiproliferative activity OF the rhamnus cathartica L. extracts collected from Kazakhstan","volume":"49","author":"Tileshnova","year":"2025","journal-title":"2025. J. Fac. Pharm. Ankara."},{"key":"10.1016\/j.jep.2026.121265_bib139","first-page":"315","article-title":"Action of cholecalciferol and alpha-tocopherol on Staphylococcus aureus efflux pumps","volume":"15","author":"Tintino","year":"2016","journal-title":"EXCLI J"},{"key":"10.1016\/j.jep.2026.121265_bib140","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.micpath.2017.01.019","article-title":"Cholesterol and ergosterol affect the activity of Staphylococcus aureus antibiotic efflux pumps","volume":"104","author":"Tintino","year":"2017","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.jep.2026.121265_bib141","article-title":"Anti-staphylococcal activity and resistance modulation effects of Harungana madagascariensis","volume":"20","author":"Tiwa","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2026.121265_bib142","doi-asserted-by":"crossref","first-page":"8702","DOI":"10.1038\/s41467-024-52714-7","article-title":"Enhanced Staphylococcus aureus protection by uncoupling of the \u03b1-toxin-ADAM10 interaction during murine neonatal vaccination","volume":"15","author":"Tomaszewski","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2026.121265_bib143","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3390\/antibiotics14050470","article-title":"Staphylococcus aureus: a review of the pathogenesis and virulence mechanisms","volume":"14","author":"Touaitia","year":"2025","journal-title":"Antibiotics"},{"key":"10.1016\/j.jep.2026.121265_bib144","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jep.2026.121265_bib145","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.tim.2022.02.005","article-title":"Population genetics, biofilm recalcitrance, and antibiotic resistance evolution","volume":"30","author":"Trubenov\u00e1","year":"2022","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.jep.2026.121265_bib146","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114369","article-title":"Antibacterial and antibiofilm activities of Mayan medicinal plants against Methicillin-susceptible and -resistant strains of Staphylococcus aureus","volume":"279","author":"Uc-Cach\u00f3n","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121265_bib147","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.3390\/plants13091172","article-title":"Potential anti-infectious activity of essential oil chemotypes of Lippia origanoides Kunth on antibiotic-resistant Staphylococcus aureus strains","volume":"13","author":"Uc-Cach\u00f3n","year":"2024","journal-title":"Plants"},{"key":"10.1016\/j.jep.2026.121265_bib148","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e31420","article-title":"Investigating the anti-growth, anti-resistance, and anti-virulence activities of Schoepfia schreberi J.F.Gmel. against the superbug Acinetobacter baumannii","volume":"10","author":"Uc-Cach\u00f3n","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2026.121265_bib149","doi-asserted-by":"crossref","first-page":"8122","DOI":"10.3390\/ijms25158122","article-title":"Stigmasterol: an enigmatic plant stress sterol with versatile functions","volume":"25","author":"Valitova","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2026.121265_bib150","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fcimb.2012.00012","article-title":"Staphylococcus aureus hemolysins, bi-component leukocidins, and cytolytic peptides: a redundant arsenal of membrane-damaging virulence factors?","volume":"2","author":"Vandenesch","year":"2012","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jep.2026.121265_bib151","author":"Villalobos\u2013Perera"},{"key":"10.1016\/j.jep.2026.121265_bib165","first-page":"559","article-title":"Checklist of the native vascular plants of Mexico","volume":"87","author":"Villase\u00f1or","year":"2016","journal-title":"Rev. Mex. Biodivers."},{"key":"10.1016\/j.jep.2026.121265_bib152","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1021\/ci100241y","article-title":"Analyzing the topology of active sites: on the prediction of pockets and subpockets","volume":"50","author":"Volkamer","year":"2010","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.jep.2026.121265_bib153","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155258","article-title":"Inhibition of inflammation by berberine: molecular mechanism and network pharmacology analysis","volume":"128","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.121265_bib154","series-title":"Antimicrobial Resistance and the United Nations Sustainable Development Cooperation Framework: Guidance for United Nations Country Teams","year":"2021"},{"key":"10.1016\/j.jep.2026.121265_bib155","series-title":"World Health Organization, Geneva.World Health Organization, 2025. Global Antibiotic Resistance Surveillance Report 2025: WHO Global Antimicrobial Resistance and Use Surveillance System (GLASS)","article-title":"WHO bacterial priority pathogens list, 2024: bacterial pathogens of public health importance to guide research, development and strategies to prevent and control antimicrobial resistance","year":"2024"},{"key":"10.1016\/j.jep.2026.121265_bib156","doi-asserted-by":"crossref","first-page":"13195","DOI":"10.1021\/acs.jafc.9b05595","article-title":"Natural products that target virulence factors in antibiotic-resistant Staphylococcus aureus","volume":"67","author":"Wu","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2026.121265_bib157","article-title":"Staphylococcus aureus biofilm: formulation, regulatory, and emerging natural products-derived therapeutics","volume":"7","author":"Wu","year":"2024","journal-title":"Biofilms"},{"key":"10.1016\/j.jep.2026.121265_bib158","article-title":"Physicochemical characterization and antitumor activity of a polysaccharide from Christia vespertilionis","volume":"290","author":"Xiao","year":"2025","journal-title":"J. Bio. Macromol."},{"key":"10.1016\/j.jep.2026.121265_bib159","doi-asserted-by":"crossref","first-page":"762","DOI":"10.3390\/molecules23040762","article-title":"Response of plant secondary metabolites to environmental factors","volume":"23","author":"Yang","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121265_bib160","doi-asserted-by":"crossref","first-page":"903","DOI":"10.2147\/IDR.S505311","article-title":"Effectiveness of omadacycline in a patient with Chlamydia psittaci and KPC-producing gram-negative bacteria infection","author":"Yang","year":"2025","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.jep.2026.121265_bib161","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.3390\/molecules26144352","article-title":"Bioguided isolation of active compounds from Rhamnus alaternus against methicillin-resistant Staphylococcus aureus (MRSA) and panton\u2013valentine leucocidin-positive strains","volume":"26","author":"Zeouk","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121265_bib162","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3390\/antibiotics13030260","article-title":"Role of \u03b2-Lactamase inhibitors as potentiators in antimicrobial chemotherapy targeting Gram-negative bacteria","volume":"13","author":"Zhang","year":"2024","journal-title":"Antibiotics"},{"key":"10.1016\/j.jep.2026.121265_bib163","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jfutfo.2022.03.014","article-title":"A comprehensive review on mechanism of natural products against Staphylococcus aureus","volume":"2","author":"Zhao","year":"2022","journal-title":"J. Future Foods"},{"key":"10.1016\/j.jep.2026.121265_bib164","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1137947","article-title":"Understanding bacterial biofilms: from definition to treatment strategies","volume":"13","author":"Zhao","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126001169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126001169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:34:07Z","timestamp":1778538847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126001169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":160,"alternative-id":["S0378874126001169"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121265","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In-vitro and in-silico anti-staphylococcal effects of the Mayan medicinal plant Krugiodendron ferreum (Vahl) Urb. (X-chintok): Disarming its resistance mechanisms and virulence factors","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121265","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121265"}}