{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:19:19Z","timestamp":1786371559331,"version":"build-2736575974"},"reference-count":106,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007540","name":"Jiangsu Agricultural Science and Technology Innovation Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007540","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jep.2026.121298","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:24:12Z","timestamp":1769819052000},"page":"121298","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["A comprehensive review of the classical prescription Wuwei Xiaodu Decoction: meridian tropism and traditional efficacy, phytochemistry, quality control, pharmacology and clinical applications"],"prefix":"10.1016","volume":"362","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunming","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib1","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.biopha.2018.10.044","article-title":"Cardio-protective and antioxidant properties of caffeic acid and chlorogenic acid: mechanistic role of angiotensin converting enzyme, cholinesterase and arginase activities in cyclosporine induced hypertensive rats","volume":"109","author":"Agunloye","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.jep.2026.121298_bib2","first-page":"1","article-title":"Multifaceted effect of caffeic acid against Streptococcus mutans infection: microbicidal and immunomodulatory agent in macrophages","volume":"203","author":"Arterio","year":"2021","journal-title":"Arch. Microbiol."},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib3","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-022-08727-x","article-title":"Application of chloroplast genome in the identification of traditional Chinese medicine Viola philippica","volume":"23","author":"Cao","year":"2022","journal-title":"BMC Genom."},{"issue":"6","key":"10.1016\/j.jep.2026.121298_bib4","first-page":"974","article-title":"Exploration of a multidimensional integration method for clinical precision localization of proprietary Chinese medicines based on comprehensive clinical evaluation","volume":"31","author":"Cao","year":"2025","journal-title":"Chin. J. Basic Med. Tradit. Chin. Med."},{"issue":"9","key":"10.1016\/j.jep.2026.121298_bib5","first-page":"1814","article-title":"Research and development strategies in classical herbal formulae","volume":"42","author":"Chen","year":"2017","journal-title":"China J. Chin. Mater. Med."},{"issue":"10","key":"10.1016\/j.jep.2026.121298_bib6","first-page":"676","article-title":"Experimental study of wu wei xiao du ying in the treatment of acne","volume":"44","author":"Chen","year":"2013","journal-title":"Xin Yi Yao."},{"issue":"3","key":"10.1016\/j.jep.2026.121298_bib7","article-title":"Effects of different extraction temperatures on the structural characteristics and antioxidant activity of polysaccharides from dandelion leaves","volume":"283","author":"Chen","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"9","key":"10.1016\/j.jep.2026.121298_bib8","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s10337-024-04348-6","article-title":"Identification and Semi-quantification of 36 compounds from violae herba (zihuadiding) via UHPLC-Q-Orbitrap-MS\/MS as well as proposal of Anti-counterfeiting quality-marker for pharmacopeia","volume":"87","author":"Chen","year":"2024","journal-title":"Chromatographia."},{"issue":"11","key":"10.1016\/j.jep.2026.121298_bib9","first-page":"37","article-title":"Clinical study of modified wuwei xiaodu decoction in the prevention and treatment of radiation pneumonia in patients with non-small cell lung cancer after chemotherapy","volume":"51","author":"Chen","year":"2017","journal-title":"Shanghai J. Tradit. Chin. Med."},{"issue":"Z2","key":"10.1016\/j.jep.2026.121298_bib10","first-page":"2825","article-title":"The possible mechanism of treating nasopharyngeal carcinoma with Flos chrysanthemi indici based on network pharmacology","volume":"40","author":"Cheng","year":"2021","journal-title":"Genom. Appl. Biol."},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib11","first-page":"87","article-title":"The effect of five-flavored antiseptie drink on stoma-related complications in patients with urinary stoma for bladder cancer","volume":"25","author":"Cheng","year":"2024","journal-title":"Pract. Clin. Med."},{"issue":"2","key":"10.1016\/j.jep.2026.121298_bib12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.9734\/jocamr\/2021\/v13i230220","article-title":"Evaluation of vitamin contents, antioxidant and antimicrobial activities of different leaf extracts of Taraxacum officinale (dandelion)","volume":"13","author":"Daniel","year":"2021","journal-title":"J. Complement. Altern. Med. Res."},{"issue":"9","key":"10.1016\/j.jep.2026.121298_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12091678","article-title":"The antioxidant and prebiotic activities of mixtures honey\/biomimetic NaDES and polyphenols show differences between honeysuckle and raspberry extracts","volume":"12","author":"Dimitriu","year":"2023","journal-title":"Antioxidants."},{"issue":"11","key":"10.1016\/j.jep.2026.121298_bib14","first-page":"3531","article-title":"Analysis on chemical constituent in wuwei xiaodu decoction by UHPLC-Q-Exactive orbitrap MS","volume":"44","author":"Dong","year":"2022","journal-title":"Chin. Tradit. Pat. Med."},{"issue":"5","key":"10.1016\/j.jep.2026.121298_bib15","first-page":"336","article-title":"A study on the inhibitory effect of Radix semiaquilegiae extract on human hepatoma HEPG-2 and SMMC-7721 cells. Afr. J. Trad. Compl. Alt","volume":"10","author":"Duan","year":"2013","journal-title":"M\u00e9d. Sur"},{"issue":"10","key":"10.1016\/j.jep.2026.121298_bib16","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1080\/03601234.2020.1797426","article-title":"Analysis of heavy metal content in edible honeysuckle (Lonicera japonica thunb.) from China and health risk assessment","volume":"55","author":"Fan","year":"2020","journal-title":"J. Environ. Sci. Health. B"},{"issue":"2","key":"10.1016\/j.jep.2026.121298_bib17","first-page":"370","article-title":"Clinical study on wuwei xiaodu decoction combined with budesonide in the treatment of dry pharyngitis after radiotherapy of nasopharyngeal carcinoma by nasal inhalation","volume":"13","author":"Feng","year":"2018","journal-title":"WJTCM."},{"issue":"2","key":"10.1016\/j.jep.2026.121298_bib18","first-page":"370","article-title":"Clinical study on wuwei xiaodu decoction combined with budesonide in the treatment of dry pharyngitis after radiotherapy of nasopharyngeal carcinoma by nasal inhalation","volume":"13","author":"Feng","year":"2018","journal-title":"World J. Trad. Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3892\/mmr.2024.13244","article-title":"Protective effect of luteolin against oxidative stress-mediated cell injury via enhancing antioxidant systems","volume":"30","author":"Fernando","year":"2024","journal-title":"Mol. Med. Rep."},{"issue":"10","key":"10.1016\/j.jep.2026.121298_bib20","first-page":"1422","article-title":"Clinical efficacy of wuwei xiaodu decoction and dahuang mudan decoction combined with Western medicine in the treatment of acute pelvic inflammatory disease","volume":"23","author":"Gao","year":"2017","journal-title":"Chin. J. Basic Med. Trad. Chin. Med."},{"key":"10.1016\/j.jep.2026.121298_bib21","series-title":"A Research on the Regulation of Primary Macrophage Function by Wuweixiaodu Decoction and Luteolin","author":"Geng","year":"2023"},{"issue":"5","key":"10.1016\/j.jep.2026.121298_bib22","first-page":"1173","article-title":"Exploration of key issues in the research and development of ancient classic prescriptions in the context of integrative medicine","volume":"31","author":"Guo","year":"2025","journal-title":"Chin. J. Basic Med. Tradit. Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib23","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.2147\/IDR.S253363","article-title":"The antibacterial activity and mechanism of action of luteolin against Trueperella pyogenes","volume":"13","author":"Guo","year":"2020","journal-title":"Infect. Drug Resist."},{"issue":"7","key":"10.1016\/j.jep.2026.121298_bib24","first-page":"21","article-title":"An analysis of the experience of treating chronic atrophic gastritis based on \"Liver and Stomach Treatment\"","volume":"4","author":"Hao","year":"2023","journal-title":"Acad. J. Med. & Hlth. Sci."},{"issue":"22","key":"10.1016\/j.jep.2026.121298_bib25","article-title":"An effective workflow for differentiating the same genus herbs of Chrysanthemum morifolium flower and Chrysanthemum indicum flower","volume":"12","author":"He","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2026.121298_bib26","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3390\/molecules29020421","article-title":"Trollius chinensis bunge: a comprehensive review of research on botany, materia medica, ethnopharmacological use, phytochemistry, pharmacology, and quality control","volume":"29","author":"He","year":"2024","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.jep.2026.121298_bib27","first-page":"856","article-title":"Mechanism of wuwei xiaodu decoction in treating acne: based on network pharmacology and molecular docking Hebei","volume":"45","author":"Hu","year":"2023","journal-title":"J. Tradit. Chin. Med."},{"issue":"3","key":"10.1016\/j.jep.2026.121298_bib28","first-page":"185","article-title":"Protective effects of wuwei xiaodu decoction against chronic osteomyelitis through Foxp3+CD25+CD4+ regulatory T cell (treg) cells via the IL-2\/STAT5 signaling pathway","volume":"20","author":"Huang","year":"2022","journal-title":"Chin. J. Nat. Med."},{"issue":"12","key":"10.1016\/j.jep.2026.121298_bib29","first-page":"3053","article-title":"Clinical research of reducing toxicity and increasing efficiency of shashen maidong decoction combined with wuwei xiaodu decoction on \u2162 Stage Non - small nell Lung Cancer lndercoing Cuemotherapy","volume":"37","author":"Huang","year":"2019","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"issue":"4","key":"10.1016\/j.jep.2026.121298_bib30","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.3892\/ol.2017.5771","article-title":"Polyphenolic compounds from Korean Lonicera japonica thunb. Induces apoptosis via AKT and caspase Cascade activation in A549 cells","volume":"13","author":"Il","year":"2017","journal-title":"Oncol. Lett."},{"issue":"5","key":"10.1016\/j.jep.2026.121298_bib31","article-title":"The screening research of anti-inflammatory bioactive markers from different flowering phases of flos Lonicerae japonicae","volume":"9","author":"Jiang","year":"2017","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.jep.2026.121298_bib32","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.3892\/etm.2016.3860","article-title":"Protective effect of taraxasterol against rheumatoid arthritis by the modulation of inflammatory responses in mice","volume":"12","author":"Jiang","year":"2016","journal-title":"Exp. Ther. Med."},{"issue":"4","key":"10.1016\/j.jep.2026.121298_bib33","first-page":"416","article-title":"Antioxidant and anti-inflammatory activities of Chrysanthemum indicum linne extracts at different ethanol ratios","volume":"53","author":"Kang","year":"2021","journal-title":"Korean J. Food Sci. Technol."},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib34","first-page":"91","article-title":"Effects ofWuwei xiaodu decoction and DangguiShaoyaoPowder on pain and hemorheology in patients with lower limb fracture. West","volume":"34","year":"2021","journal-title":"J. Tradit. Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib35","article-title":"Isolation and identification of compounds from bioactive extracts of Taraxacum officinale weber ex F. H. Wigg. (Dandelion) as a potential source of antibacterial agents. J. Evid.-Based complement","volume":"2018","author":"Katy","year":"2018","journal-title":"Altern. Med."},{"issue":"4","key":"10.1016\/j.jep.2026.121298_bib36","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/ptr.5276","article-title":"Characterisation of antimicrobial extracts from dandelion root (Taraxacum officinale) using LC-SPE-NMR","volume":"29","author":"Kenny","year":"2015","journal-title":"Phytother Res."},{"issue":"15","key":"10.1016\/j.jep.2026.121298_bib37","doi-asserted-by":"crossref","first-page":"5638","DOI":"10.3390\/molecules28155638","article-title":"Iodine biofortification of dandelion plants (Taraxacum officinale F.H. wiggers coll.) with the use of inorganic and organic iodine compounds","volume":"28","author":"Ledwo\u017cyw-Smole\u0144","year":"2023","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.jep.2026.121298_bib38","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s13765-016-0220-5","article-title":"Anti-inflammatory effects of luteolin and luteoloside from Taraxacum coreanum in RAW264.7 macrophage cells","volume":"59","author":"Lee","year":"2016","journal-title":"Appl. Biol. Chem."},{"issue":"11","key":"10.1016\/j.jep.2026.121298_bib39","first-page":"1256","article-title":"Determination of 15 chemical constituents in dandelion leaves from different areas of production based on UPLC-MS\/MS","volume":"21","author":"Lei","year":"2024","journal-title":"Chin. J. Pharmacovigil."},{"issue":"3","key":"10.1016\/j.jep.2026.121298_bib40","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4236\/cm.2017.83006","article-title":"Inter-organ relationships among gut, lung and skin beyond the pathogenesis of allergies: relevance to the Zang-Fu theory in Chinese medicine","volume":"8","author":"Leung","year":"2017","journal-title":"Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib41","first-page":"1","article-title":"Research progress on chemical composition, pharmacological action and clinical application of wuwei xiaodu decoction and predictive analysis of quality marker (Q-Marker)","author":"Li","year":"2025","journal-title":"Chin. Arch. Tradit. Chin. Med. 07"},{"issue":"11","key":"10.1016\/j.jep.2026.121298_bib42","first-page":"1937","article-title":"Influences of wuwei xiaodu decoction retention enema on levels of serum IL-8,CRP and D-D and immunological indices of elderly patients with excessive accumulation of Phlegm-dampness type acute pelvic inflammatory disease","volume":"27","author":"Liang","year":"2018","journal-title":"Tradit. Chin. Med. Emerg."},{"issue":"16","key":"10.1016\/j.jep.2026.121298_bib43","first-page":"16","article-title":"Observation on treating non-puerperal mastitis in acute stage with Wuwei Xiaodu decoction and an analysis of the related factors of recurrence","volume":"12","author":"Liang","year":"2020","journal-title":"J. Chin. Clin. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib44","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.micpath.2016.08.004","article-title":"Antimicrobial and enhancement of the antibiotic activity by phenolic compounds: gallic acid, caffeic acid and pyrogallol","volume":"99","author":"Lima","year":"2016","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.jep.2026.121298_bib45","article-title":"Chinese classical decoction wuwei xiaodu decoction alleviates gout arthritis by suppressing NLRP3-Mediated inflammation","volume":"15","author":"Lin","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"11","key":"10.1016\/j.jep.2026.121298_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.70031","article-title":"Ferulic acid protects human lens epithelial cells against UVA-induced oxidative damage by downregulating the DNA demethylation of the Keap1 promoter","volume":"38","author":"Ling","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib47","doi-asserted-by":"crossref","DOI":"10.1186\/s13020-022-00679-4","article-title":"Chemometrics integrated with in silico pharmacology to reveal antioxidative and anti-inflammatory markers of dandelion for its quality control","volume":"17","author":"Liu","year":"2022","journal-title":"Chin. Med."},{"issue":"19","key":"10.1016\/j.jep.2026.121298_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29194609","article-title":"Differences in the determination of volatile organic compounds between Chrysanthemum morifolium ramat. and Chrysanthemum indicum L. (Wild chrysanthemum) by HS-GC-IMS","volume":"29","author":"Liu","year":"2024","journal-title":"Molecules"},{"issue":"12","key":"10.1016\/j.jep.2026.121298_bib49","first-page":"3263","article-title":"Quality control mode between Lonicera macranthoides and L. japonica based on multi-elemental difference through inductively coupled plasma mass spectrometry. China J. Chin","volume":"49","author":"Liu","year":"2024","journal-title":"Mater. Med."},{"issue":"11","key":"10.1016\/j.jep.2026.121298_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104132","article-title":"In vitro and in vivo evaluation of antibacterial activity and mechanism of luteolin from Humulus scandens against Escherichia coli from chicken","volume":"103","author":"Liu","year":"2024","journal-title":"Poult. Sci."},{"issue":"13","key":"10.1016\/j.jep.2026.121298_bib51","first-page":"1006","article-title":"WuWeiXiaoDuYin network pharmacology breast cancer traditional Chinese medicine formulas","volume":"24","author":"Liu","year":"2024","journal-title":"Xian Dai Yang Sheng"},{"issue":"8","key":"10.1016\/j.jep.2026.121298_bib52","first-page":"132","article-title":"Progress in the study of chemical composition and pharmacological effects of Taraxacum officinale and analysis of quality markers prediction","volume":"42","author":"Liu","year":"2024","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"issue":"9","key":"10.1016\/j.jep.2026.121298_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27092632","article-title":"Material basis elucidation and quantification of dandelion through spectrum\u2013effect relationship study between UHPLC fingerprint and antioxidant activity via multivariate statistical analysis","volume":"27","author":"Liu","year":"2022","journal-title":"Molecules"},{"issue":"48","key":"10.1016\/j.jep.2026.121298_bib54","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000032135","article-title":"Efficacy and safety of Chinese herbal medicine wuwei xiaodu decoction for wound infection: a protocol for systematic review and meta-analysis","volume":"101","author":"Luo","year":"2022","journal-title":"Med. (Baltimore)"},{"issue":"26","key":"10.1016\/j.jep.2026.121298_bib55","first-page":"120","article-title":"Analyzing the medication pattern of professor yanping Bai in the treatment of rosacea based on data mining","volume":"19","author":"Luo","year":"2022","journal-title":"Chin. Med. Herald."},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib56","doi-asserted-by":"crossref","DOI":"10.1186\/s13020-021-00471-w","article-title":"A comprehensive review of the botany, ethnopharmacology, biochemistry, pharmacology, pharmacokinetics and toxicity of filifolium sibiricum (L.)Kitam","volume":"16","author":"Lv","year":"2021","journal-title":"Chin. Med."},{"issue":"16","key":"10.1016\/j.jep.2026.121298_bib57","first-page":"153","article-title":"Effect of Shashen maidong decoction combined with five-ingredient toxindispersing beverage on elderly patients with middle and advanced lung cancer of yin deficiency toxin heat syndrome","volume":"6","author":"Ma","year":"2021","journal-title":"Clin. Res. Pract."},{"issue":"5","key":"10.1016\/j.jep.2026.121298_bib58","first-page":"518","article-title":"Discussion on the application of the meridian and collateral identification theory of \u201cMedical Zong Jin Jian\u201d in the diagnosis and treatment of traditional Chinese medicine surgery. Beijing J. Trad","volume":"43","author":"Ma","year":"2024","journal-title":"Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib59","article-title":"Luteolin exhibits antimicrobial actions against Salmonella Typhimurium and escherichia coli: impairment of cell adhesion, membrane integrity, and energy metabolism","volume":"166","author":"Mahamud","year":"2024","journal-title":"Food Control"},{"issue":"3","key":"10.1016\/j.jep.2026.121298_bib60","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1142\/S0192415X19500289","article-title":"Luteolin: a natural flavonoid enhances the survival of HUVECs against oxidative stress by modulating AMPK\/PKC pathway","volume":"47","author":"Ou","year":"2019","journal-title":"Am. J. Chin. Med."},{"issue":"4","key":"10.1016\/j.jep.2026.121298_bib61","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jff.2019.02.034","article-title":"Dandelion polysaccharides exert anticancer effect on Hepatocellular carcinoma by inhibiting PI3K\/AKT\/mTOR pathway and enhancing immune response","volume":"55","author":"Ren","year":"2019","journal-title":"J. Funct.Foods"},{"issue":"11","key":"10.1016\/j.jep.2026.121298_bib62","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.4014\/jmb.1807.07042","article-title":"Synergistic antimicrobial effect of Lonicera japonica and Magnolia obovata extracts and potential as a plant-derived natural preservative","volume":"28","author":"Seul","year":"2018","journal-title":"J. Microbiol. Biotechnol."},{"issue":"9","key":"10.1016\/j.jep.2026.121298_bib63","first-page":"507","article-title":"Hydroalcoholic extract of Taraxacum officinale induces apoptosis and autophagy in 4T1 breast cancer cells","volume":"14","author":"Sharareh","year":"2023","journal-title":"Vet. Res. Forum"},{"issue":"4","key":"10.1016\/j.jep.2026.121298_bib64","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1007\/s43450-023-00397-4","article-title":"A novel caffeoylquinic acid from Lonicera japonica exerts cytotoxic activity by blocking the YAP-CTGF signaling pathway in hepatocellular carcinoma","volume":"33","author":"Shen","year":"2023","journal-title":"Rev. Bras. Farmacogn."},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib65","first-page":"1","article-title":"Spectrum-effect relationships between chemical fingerprints and antibacterial effects of Lonicerae japonicae flos and lonicerae flos base on UPLC and microcalorimetry","volume":"7","author":"Shi","year":"2016","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.jep.2026.121298_bib66","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1080\/01480545.2016.1252919","article-title":"Immunomodulatory and cellular anti-oxidant activities of caffeic, ferulic, and p-coumaric phenolic acids: a structure-activity relationship study","volume":"40","author":"Soumaya","year":"2017","journal-title":"Drug Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib67","first-page":"30","article-title":"Study on the preparation process and characteristic map of Wuwei Xiaodu DecoctionBased on determination of multi index component content","volume":"20","author":"Sun","year":"2024","journal-title":"APT"},{"key":"10.1016\/j.jep.2026.121298_bib68","article-title":"Topical application of Chrysanthemum indicum L. attenuates the development of atopic dermatitis-like skin lesions by suppressing serum IgE levels, interferon-\u03b3 (IFN-\u03b3), and IL-4 in Nc\/Nga mice","author":"Sunmin","year":"2012","journal-title":"eCAM"},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib69","first-page":"5","article-title":"Effect of wuwei xiaodu decoction on proliferation inhibition and promoting apoptosis of A431","volume":"33","author":"Tan","year":"2018","journal-title":"Acta Chin. Med."},{"issue":"2","key":"10.1016\/j.jep.2026.121298_bib70","article-title":"Topical Chinese herbal compound in the treatment of oral candidiasis: a systematic review and meta-analysis of randomized controlled trials","volume":"9","author":"Ting","year":"2023","journal-title":"Heliyon"},{"issue":"4","key":"10.1016\/j.jep.2026.121298_bib71","first-page":"127","article-title":"Study on the mechanism of action of wuweixiaodu decoction in the treatment of mastitis based on network pharmacology","volume":"17","author":"Wang","year":"2021","journal-title":"Asia. Pac. Trad. Med."},{"issue":"2","key":"10.1016\/j.jep.2026.121298_bib72","doi-asserted-by":"crossref","first-page":"8","DOI":"10.26689\/bas.v3i2.10308","article-title":"Exploration of the value of extract of wuwei xiaodu decoction on rabbit model of spinal infection","volume":"3","author":"Wang","year":"2025","journal-title":"Bone Arthrosc. Sci."},{"key":"10.1016\/j.jep.2026.121298_bib73","article-title":"Dandelion extract inhibits triple-negative breast cancer cell proliferation by interfering with glycerophospholipids and unsaturated fatty acids metabolism","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.jep.2026.121298_bib74","doi-asserted-by":"crossref","DOI":"10.3390\/molecules30091922","article-title":"A comprehensive review of the phytochemistry and therapeutic efficacy of Viola yedoensis makino","volume":"30","author":"Wang","year":"2025","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121298_bib75","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jep.2016.04.031","article-title":"Anti-inflammatory and anti-arthritic effects of taraxasterol on adjuvant-induced arthritis in rats","volume":"187","author":"Wang","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2026.121298_bib76","first-page":"114","article-title":"Effect of modified wuwei Xiaodu Decoction combined with facial rolling needle inTreating post-acne chromatosis of stasis-heat binding syndrome","volume":"33","author":"Wang","year":"2024","journal-title":"Chin. J. Aesthet. Med."},{"issue":"5","key":"10.1016\/j.jep.2026.121298_bib77","article-title":"Analysis of bioactive substances and antioxidant activity in leaves and flower buds of Flos Lonicerae","volume":"237","author":"Wang","year":"2019","journal-title":"IOP Conf. Ser. Earth Environ. Sci."},{"issue":"5","key":"10.1016\/j.jep.2026.121298_bib78","first-page":"1129","article-title":"Serum metabolomics of the purgative and detoxifying effects of Honeysuckle flower","volume":"39","author":"Wang","year":"2016","journal-title":"Chin. Med. Mat."},{"issue":"5","key":"10.1016\/j.jep.2026.121298_bib79","first-page":"331","article-title":"Clinical observation on the treatment of acute gouty arthritis (damp heat accumulation syndrome) with modified wuwei disinfection drink","volume":"33","author":"Wang","year":"2024","journal-title":"Clin. Med. Pract."},{"issue":"2","key":"10.1016\/j.jep.2026.121298_bib80","first-page":"38","article-title":"Effects of Wuwei xiaodu decoction on uterine energy metabolism and serum inflammatory factors in rats with acute pelvic inflammatory disease","volume":"15","author":"Wu","year":"2024","journal-title":"Med. Plants"},{"issue":"5","key":"10.1016\/j.jep.2026.121298_bib81","article-title":"The screening research of anti-inflammatory bioactive markers from different flowering phases of Flos Lonicerae Japonicae","volume":"9","author":"Wu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2026.121298_bib82","article-title":"The application of citrus folium in breast cancer and the mechanism of its main component nobiletin: a systematic review","volume":"2021","author":"Wu","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"29","key":"10.1016\/j.jep.2026.121298_bib83","first-page":"148","article-title":"Clinical effect of wuwei Xiaodu decoction Drink combined with fire needle in the treatment of pustular acne vulgaris","volume":"17","author":"Wu","year":"2024","journal-title":"J Clin Ration Drug Use"},{"issue":"29","key":"10.1016\/j.jep.2026.121298_bib84","first-page":"148","article-title":"Clinical efficacy of Wuwei Xiaodu decoction combined with fire needle therapy for pustular acne","volume":"17","author":"Wu","year":"2024","journal-title":"Chin. J. Clin. Rational Drug Use"},{"issue":"24","key":"10.1016\/j.jep.2026.121298_bib85","first-page":"7616","article-title":"Establishment of HPLC fingerprints and chemical pattern recognition of wild chrysanthemums from different origins","volume":"52","author":"Xie","year":"2021","journal-title":"Chin. Herb. Med."},{"issue":"4","key":"10.1016\/j.jep.2026.121298_bib86","first-page":"805","article-title":"Taraxasterol inhibits inflammation in osteoarthritis rat model by regulating miRNAs and NF-\u03baB signaling pathway","volume":"69","author":"Xie","year":"2022","journal-title":"Acta Biochim. Pol."},{"issue":"3","key":"10.1016\/j.jep.2026.121298_bib87","doi-asserted-by":"crossref","first-page":"395","DOI":"10.26855\/ijcemr.2021.07.026","article-title":"Discussing professor yin kejing's drug use law for mammary hyperplasia based on data mining technology","volume":"5","author":"Xu","year":"2021","journal-title":"Int. J. Clin. Exp. Med. Res."},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib88","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1515\/abm-2020-0004","article-title":"Variation in contents of active components and antibacterial activity in different parts of Lonicera japonica thunb","volume":"14","author":"Yan","year":"2020","journal-title":"Asian Biomed."},{"issue":"5","key":"10.1016\/j.jep.2026.121298_bib89","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.molstruc.2016.03.039","article-title":"Rapid identification of Lonicerae japonicae flos and lonicerae Flos by Fourier transform infrared (FT-IR) spectroscopy and two-dimensional correlation analysis","volume":"1124","author":"Yan","year":"2016","journal-title":"J. Mol. Struct."},{"issue":"10","key":"10.1016\/j.jep.2026.121298_bib90","first-page":"811","article-title":"Connotation and modern scientific evidence for\u201cheart controlling mental activities","volume":"39","author":"Yang","year":"2016","journal-title":"J. Beijing Univ. Trad. Chin. Med."},{"issue":"4","key":"10.1016\/j.jep.2026.121298_bib91","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.apsb.2017.04.012","article-title":"Approaches to establish Q-markers for the quality standards of traditional Chinese medicines","volume":"7","author":"Yang","year":"2017","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib92","article-title":"The antioxidant polysaccharide from Semiaquilegia adoxoides (DC.) makino adjusts the immune response of mice infected by bacteria","volume":"2020","author":"Yang","year":"2020","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib93","first-page":"123","article-title":"Study on the medication rules of traditional Chinese medicine for acne treated from lung based on data mining","volume":"6","author":"Yao","year":"2024","journal-title":"MEDS Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib94","first-page":"182","article-title":"Application progress of Wuwei xiaodu decoction in surgery","volume":"24","author":"Yuan","year":"2022","journal-title":"J. Liaoning Univ. Trad. Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib95","article-title":"Evaluating bioactivity retention in metabolism: a comparative study of chlorogenic acid and its metabolite dihydrocaffeic acid on antioxidant, anti-inflammatory, and anti-obesogenic activities in vitro","volume":"22","author":"Zaldivar","year":"2024","journal-title":"CYTA. J. Food."},{"key":"10.1016\/j.jep.2026.121298_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.105095","article-title":"Viola stocksii: a rich source of antioxidant and anti-inflammatory flavonoid glycosides with converged therapeutic potential against SARS-CoV-2 MPro, spike trimer, and surface glycoproteins","volume":"62","author":"Zamir","year":"2024","journal-title":"Food Biosci."},{"key":"10.1016\/j.jep.2026.121298_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154228","article-title":"Viola yedoensis makino formula alleviates DNCB-Induced atopic dermatitis by activating JAK2\/STAT3 signaling pathway and promoting M2 macrophages polarization","volume":"103","author":"Zeng","year":"2022","journal-title":"Phytomed"},{"issue":"10","key":"10.1016\/j.jep.2026.121298_bib98","first-page":"1641","article-title":"Clinical observation of modified Wuwei xiaodu decoction combined with Huanglian jiedu decoction in treating acute pelvic inflammatory Disease(Syndrome of damp-heat and blood stasis)","volume":"34","author":"Zhang","year":"2025","journal-title":"Tradit. Chin. Med. Emerg."},{"key":"10.1016\/j.jep.2026.121298_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154202","article-title":"Holism of Chinese herbal medicine prescriptions for inflammatory bowel disease: a review based on clinical evidence and experimental research","volume":"102","author":"Zhang","year":"2022","journal-title":"Phytomedicine"},{"issue":"10","key":"10.1016\/j.jep.2026.121298_bib100","first-page":"15","article-title":"Anti-inflammatory mechanism of wuwei xiaodu decoction on IgA nephropathy rats based on NF-\u03baB inflammatory signaling pathway","volume":"27","author":"Zhang","year":"2021","journal-title":"CJETMF"},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib101","first-page":"1","article-title":"Jia-Wei-Si-Miao-yong-an decoction modulates intestinal flora and metabolites in acute coronary syndrome model","volume":"9","author":"Zhao","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"issue":"3","key":"10.1016\/j.jep.2026.121298_bib102","first-page":"84","article-title":"Network pharmacology to investigate the mechanism of ginseng and atractylodis macrocephalae to prevent diarrhea","volume":"2","author":"Zhao","year":"2023","journal-title":"Front. Med. Sci. Res."},{"issue":"1","key":"10.1016\/j.jep.2026.121298_bib103","first-page":"16","article-title":"Quality analysis of semiaquilegiae radix of different origins based on characteristic fingerprint and content determination of two components","volume":"33","author":"Zhi-qiang","year":"2020","journal-title":"Shandong Sci."},{"issue":"19","key":"10.1016\/j.jep.2026.121298_bib104","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.3390\/nu15194120","article-title":"Dandelion polysaccharides ameliorate high-fat-diet-induced atherosclerosis in mice through antioxidant and anti-inflammatory capabilities","volume":"15","author":"Zhou","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2026.121298_bib105","article-title":"Two new quinolinone glycoalkaloids from Chrysanthemum indicum L. and their antimicrobial activity","volume":"1\u20138","author":"Zhu","year":"2023","journal-title":"Nat. Prod. Res."},{"issue":"6","key":"10.1016\/j.jep.2026.121298_bib106","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/j.fshw.2023.03.031","article-title":"Effective anti-inflammatory phenolic compounds from dandelion: identification and mechanistic insights using UHPLC-ESI-MS\/MS, fluorescence quenching and anisotropy, molecular docking and dynamics simulation","volume":"12","author":"Zou","year":"2023","journal-title":"Food Sci. Hum. Wellness"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126001492?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126001492?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:39:08Z","timestamp":1775306348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126001492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":106,"alternative-id":["S0378874126001492"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121298","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comprehensive review of the classical prescription Wuwei Xiaodu Decoction: meridian tropism and traditional efficacy, phytochemistry, quality control, pharmacology and clinical applications","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121298","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121298"}}