{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:04:15Z","timestamp":1788548655053,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3504102"],"award-info":[{"award-number":["2023YFC3504102"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2020MH374"],"award-info":[{"award-number":["ZR2020MH374"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jep.2026.121325","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T07:56:48Z","timestamp":1770191808000},"page":"121325","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Study on the effect of wine processing on the anti-thrombotic activity of Salvia miltiorrhiza"],"prefix":"10.1016","volume":"362","author":[{"given":"Guoxin","family":"Pei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunguo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiliang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jep.2026.121325_bib1","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.3390\/biomedicines13122924","article-title":"Xanthium strumarium L. exhibits potent antiplatelet and antithrombotic effects by modulating MAPK and PI3K\/AKT signaling pathways and inhibiting ferric chloride-induced thrombosis","volume":"13","author":"Akram","year":"2025","journal-title":"Biomedicines."},{"key":"10.1016\/j.jep.2026.121325_bib2","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1017\/erm.2022.25","article-title":"Erythrocyte oxidative stress and thrombosis","volume":"24","author":"Bettiol","year":"2022","journal-title":"Expet Rev. Mol. Med."},{"issue":"3","key":"10.1016\/j.jep.2026.121325_bib3","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1055\/a-1801-2055","article-title":"Circulating thrombomodulin: release mechanisms, measurements, and levels in diseases and medical procedures","volume":"6","author":"Boron","year":"2022","journal-title":"TH open"},{"key":"10.1016\/j.jep.2026.121325_bib4","series-title":"Pharmacopoeia of the People's Republic of China","year":"2025"},{"issue":"8","key":"10.1016\/j.jep.2026.121325_bib5","first-page":"1707","article-title":"Comparison of chromatographic peak attribution of HPLC fingerprint of Salvia miltiorrhiza before and after wine processing","volume":"46","author":"Cui","year":"2019","journal-title":"Liaoning J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2026.121325_bib6","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s11655-012-1291-5","article-title":"Blood stasis syndrome and its treatment with activating blood circulation to remove blood stasis therapy","volume":"18","author":"Chen","year":"2012","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2026.121325_bib7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jep.2017.06.023","article-title":"Salvia miltiorrhiza bunge (Danshen) extract attenuates permanent cerebral ischemia through inhibiting platelet activation in rats","volume":"207","author":"Fei","year":"2017","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2026.121325_bib8","first-page":"382","article-title":"Clinical application and experimental research progress of blood-activating and stasis-resolving traditional Chinese medicine in treating thrombotic diseases","volume":"35","author":"Gu","year":"2019","journal-title":"J. Changchun Univ. Chin. Med."},{"issue":"3","key":"10.1016\/j.jep.2026.121325_bib9","doi-asserted-by":"crossref","first-page":"600","DOI":"10.5530\/ijper.56.3.108","article-title":"Dose conversion between animals and humans: a practical solution","volume":"56","author":"Jacob","year":"2022","journal-title":"Indian J. Pharm. Educ. Res."},{"issue":"4","key":"10.1016\/j.jep.2026.121325_bib10","first-page":"474","article-title":"Diagnostic value of TAT, PIC, TM, and t-PAIC molecular markers in early disseminated intravascular coagulation","volume":"50","author":"Jiang","year":"2020","journal-title":"J. Univ. Sci. Technol. Chin."},{"issue":"9","key":"10.1016\/j.jep.2026.121325_bib11","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.3390\/jcm13092468","article-title":"Mechanical support in high-risk pulmonary embolism: review article","volume":"13","author":"Kadri","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jep.2026.121325_bib12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/978-1-0716-1924-7_21","article-title":"Investigation of platelet aggregation in atherosclerosis","volume":"2419","author":"Lordan","year":"2022","journal-title":"Methods Mol. Biol."},{"issue":"10","key":"10.1016\/j.jep.2026.121325_bib13","doi-asserted-by":"crossref","first-page":"8919","DOI":"10.1021\/acsomega.1c07316","article-title":"Establishment of a modified and standardized ferric chloride-induced rat carotid artery thrombosis model","volume":"7","author":"Lin","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.jep.2026.121325_bib14","article-title":"Inhibitory effect of caffeic acid on ADP-induced thrombus formation and platelet activation involves mitogen-activated protein kinases","volume":"5","author":"Lu","year":"2015","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.jep.2026.121325_bib15","first-page":"2058","article-title":"Study on the historical evolution of the processing of Salvia miltiorrhiza","volume":"24","author":"Li","year":"2006","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"issue":"4","key":"10.1016\/j.jep.2026.121325_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.rpth.2024.102443","article-title":"Salvianolic acid B inhibits thrombosis and directly blocks the thrombin catalytic site","volume":"8","author":"Neves","year":"2024","journal-title":"Res. Pract. Thromb. Haemost."},{"issue":"21","key":"10.1016\/j.jep.2026.121325_bib17","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1002\/elps.201900235","article-title":"Analysis of thrombin-antithrombin complex formation using microchip electrophoresis and mass spectrometry","volume":"40","author":"Nielsen","year":"2019","journal-title":"Electrophoresis."},{"issue":"17","key":"10.1016\/j.jep.2026.121325_bib18","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1182\/blood-2017-10-784074","article-title":"The search for new antithrombotic mechanisms and therapies that may spare hemostasis","volume":"131","author":"Plow","year":"2018","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.jep.2026.121325_bib19","first-page":"674","article-title":"Differential study of tanshinone extracts from Salvia miltiorrhiza before and after wine processing through in vitro biomimetic digestion","volume":"44","author":"Sun","year":"2025","journal-title":"J. Pharm. Res."},{"issue":"5","key":"10.1016\/j.jep.2026.121325_bib20","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.3390\/ijms25052523","article-title":"Research into new molecular mechanisms in thrombotic diseases paves the way for innovative therapeutic approaches","volume":"25","author":"Sacchetti","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"21","key":"10.1016\/j.jep.2026.121325_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232112772","article-title":"Platelets and their role in hemostasis and thrombosis-from physiology to pathophysiology and therapeutic implications","volume":"23","author":"Scridon","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"22","key":"10.1016\/j.jep.2026.121325_bib22","doi-asserted-by":"crossref","first-page":"6807","DOI":"10.3390\/molecules26226807","article-title":"Screening of potential anti-thrombotic ingredients from Salvia miltiorrhiza in zebrafish and by molecular docking","volume":"26","author":"Tang","year":"2021","journal-title":"Molecules"},{"issue":"13","key":"10.1016\/j.jep.2026.121325_bib23","doi-asserted-by":"crossref","first-page":"5380","DOI":"10.1039\/D5FO00366K","article-title":"Avenanthramide C from underutilized oat glumes exhibits dual anti-oxidant and anti-thrombotic effects in oxidative damage and thrombosis models","volume":"16","author":"Wang","year":"2025","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2026.121325_bib24","article-title":"Quercetin targeted NF-\u03baB to regulate platelet activation and prevent arterial thrombosis","volume":"99","author":"Wang","year":"2025","journal-title":"Tissue Cell"},{"issue":"1","key":"10.1016\/j.jep.2026.121325_bib25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s40164-024-00555-x","article-title":"Genetic factors, risk prediction and AI application of thrombotic diseases","volume":"13","author":"Wang","year":"2024","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.jep.2026.121325_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116697","article-title":"Bioactive components and molecular mechanisms of salvia miltiorrhiza Bunge in promoting blood circulation to remove blood stasis","volume":"317","author":"Wei","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.121325_bib27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12872-019-01289-z","article-title":"Tanshinone IIA prevents platelet activation and down-regulates CD36 and MKK4\/JNK2 signaling pathway","volume":"20","author":"Wang","year":"2020","journal-title":"BMC Cardiovasc. Disord."},{"issue":"5","key":"10.1016\/j.jep.2026.121325_bib28","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/MOH.0000000000000075","article-title":"Zebrafish as a model system for the study of hemostasis and thrombosis","volume":"21","author":"Weyand","year":"2014","journal-title":"Curr. Opin. Hematol."},{"issue":"3","key":"10.1016\/j.jep.2026.121325_bib29","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1182\/blood-2007-05-090944","article-title":"Vascular smooth muscle-derived tissue factor is critical for arterial thrombosis after ferric chloride-induced injury","volume":"113","author":"Wang","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jep.2026.121325_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119321","article-title":"P2Y12 receptor-independent antiplatelet mechanism of cryptotanshinone: network pharmacology and experimental validation of multi-target signaling pathways","volume":"341","author":"Xiao","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121325_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154271","article-title":"Danshensu prevents thrombosis by inhibiting platelet activation via SIRT1\/ROS\/mtDNA pathways without increasing bleeding risk","volume":"104","author":"Xue","year":"2022","journal-title":"Phytomedicine."},{"key":"10.1016\/j.jep.2026.121325_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2024.106224","article-title":"Exploring the molecular mechanism of Toddalia asiatica (L.) lam on the treatment of thrombosis based on zebrafish models, network pharmacology and experimental verification","volume":"179","author":"Yang","year":"2024","journal-title":"Fitoterapia"},{"issue":"4","key":"10.1016\/j.jep.2026.121325_bib33","first-page":"469","article-title":"Changes of new coagulation markers in healthy pregnant women and establishment of reference intervals in changsha","volume":"47","author":"Yang","year":"2022","journal-title":"J. Cent. South Univ."},{"issue":"10","key":"10.1016\/j.jep.2026.121325_bib34","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.1111\/jcmm.15278","article-title":"Dihydromyricetin increases endothelial nitric oxide production and inhibits atherosclerosis through microRNA-21 in apolipoprotein E-deficient mice","volume":"24","author":"Yang","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.jep.2026.121325_bib35","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12872-015-0124-z","article-title":"Endothelial cell control of thrombosis","volume":"15","author":"Yau","year":"2015","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.jep.2026.121325_bib36","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuint.2014.06.001","article-title":"Neuroprotection against A\u03b225-35-induced apoptosis by Salvia miltiorrhiza extract in SH-SY5Y cells","volume":"75","author":"Yu","year":"2014","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.jep.2026.121325_bib37","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/724134","article-title":"A rat model of thrombosis in common carotid artery induced by implantable wireless light-emitting diode device","author":"Yeh","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jep.2026.121325_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2024.116871","article-title":"Elucidating the distinctive regulatory effects and mechanisms of active compounds in Salvia miltiorrhiza bunge via network pharmacology: unveiling their roles in the modulation of platelet activation and thrombus formation","volume":"484","author":"Zhang","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2026.121325_bib39","article-title":"Tissue-type plasminogen activator-inhibitor complex as an early predictor of septic shock: a retrospective, single-center study","author":"Zhong","year":"2022","journal-title":"Dis. Markers"},{"issue":"6","key":"10.1016\/j.jep.2026.121325_bib40","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.thromres.2007.07.013","article-title":"The influence of the pulsatility of the blood flow on the extent of platelet adhesion","volume":"121","author":"Zhao","year":"2008","journal-title":"Thromb. Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126001765?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126001765?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:47:06Z","timestamp":1777571226000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126001765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":40,"alternative-id":["S0378874126001765"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121325","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study on the effect of wine processing on the anti-thrombotic activity of Salvia miltiorrhiza","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121325","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121325"}}