{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:58:37Z","timestamp":1793915917364,"version":"4.8.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019538","name":"Science Fund for Distinguished Young Scholars of Sichuan Province","doi-asserted-by":"publisher","award":["2024YFZ0332"],"award-info":[{"award-number":["2024YFZ0332"]}],"id":[{"id":"10.13039\/501100019538","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504349"],"award-info":[{"award-number":["82504349"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373523"],"award-info":[{"award-number":["82373523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jep.2026.121327","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:18:44Z","timestamp":1770164324000},"page":"121327","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["San Huang decoction accelerates diabetic wound healing by restraining STING signaling to attenuate inflammation and enhance angiogenesis"],"prefix":"10.1016","volume":"362","author":[{"given":"Long","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinghao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranran","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoshuang","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2633-0783","authenticated-orcid":false,"given":"Daojiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.121327_bib1","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1056\/NEJMra1615439","article-title":"Diabetic foot ulcers and their recurrence","volume":"376","author":"Armstrong","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2026.121327_bib2","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/s41423-022-00919-5","article-title":"Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair","volume":"19","author":"Audu","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jep.2026.121327_bib3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13047-020-00393-0","article-title":"Organizational changes in diabetic foot care practices for patients at low and moderate risk after implementing a comprehensive foot care program in Alberta, Canada","volume":"13","author":"Chan","year":"2020","journal-title":"J. Foot Ankle Res."},{"key":"10.1016\/j.jep.2026.121327_bib4","doi-asserted-by":"crossref","DOI":"10.2337\/db21-1108","article-title":"Inhibition of CCL28\/CCR10-mediated eNOS downregulation improves skin wound healing in the obesity-induced mouse model of type 2 diabetes","author":"Chen","year":"2022","journal-title":"Diabetes db211108"},{"key":"10.1016\/j.jep.2026.121327_bib6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1089\/cell.2016.0050","article-title":"An overview on Current issues and challenges of endothelial progenitor cell-based neovascularization in patients with diabetic foot ulcer","volume":"19","author":"Das","year":"2017","journal-title":"Cell. Reprogr."},{"key":"10.1016\/j.jep.2026.121327_bib7","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1177\/15347346211013189","article-title":"Update of topical interventions for healing diabetic Ulcers\u2014A systematic review","volume":"22","author":"De Sousa","year":"2023","journal-title":"Int. J. Low. Extrem. Wounds"},{"key":"10.1016\/j.jep.2026.121327_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113946","article-title":"Sanhuang Jiangtang tablet protects type 2 diabetes osteoporosis via AKT-GSK3\u03b2-NFATc1 signaling pathway by integrating bioinformatics analysis and experimental validation","volume":"273","author":"He","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121327_bib10","doi-asserted-by":"crossref","first-page":"7856","DOI":"10.1038\/s41467-023-43364-2","article-title":"A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing","volume":"14","author":"Huang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2026.121327_bib11","article-title":"Identification of hub genes and pathways associated with cellular senescence in diabetic foot ulcers via comprehensive transcriptome analysis","volume":"28","author":"Huang","year":"2024","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.jep.2026.121327_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/1753-0407.70035","article-title":"Commentary on \u201cFactors associated with diabetic foot ulcers and lower limb amputations in type 1 and type 2 diabetes supported by real\u2010world data from the German\/Austrian DPV registry.\u201d","volume":"16","author":"Javanian","year":"2024","journal-title":"J. Diabetes"},{"issue":"11","key":"10.1016\/j.jep.2026.121327_bib13","doi-asserted-by":"crossref","first-page":"13422","DOI":"10.1021\/acsami.3c16061","article-title":"Hydrogel loaded with peptide-containing nanocomplexes: symphonic cooperation of photothermal antimicrobial nanoparticles and prohealing peptides for the treatment of infected wounds","volume":"16","author":"Jia","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jep.2026.121327_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-46726-3","article-title":"Effect of saxagliptin on endothelial function in patients with type 2 diabetes: a prospective multicenter study","volume":"9","author":"Kajikawa","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2026.121327_bib15","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s11658-024-00542-4","article-title":"The direct binding of bioactive peptide Andersonin-W1 to TLR4 expedites the healing of diabetic skin wounds","author":"Li","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.jep.2026.121327_bib16","article-title":"Peptide RL\u2010QN15 Regulates Functions of Epidermal Stem Cells to Accelerate Skin Wound Regeneration via the FZD8\/\u03b2\u2010Catenin Axis","volume":"20240090","author":"Li","year":"2025","journal-title":"Exploration"},{"key":"10.1016\/j.jep.2026.121327_bib17","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/s41401-023-01193-5","article-title":"Lonicerin promotes wound healing in diabetic rats by enhancing blood vessel regeneration through Sirt1-mediated autophagy","volume":"45","author":"Lin","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2026.121327_bib19","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.168945","article-title":"Activated cGAS\/STING signaling elicits endothelial cell senescence in early diabetic retinopathy","volume":"8","author":"Liu","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.jep.2026.121327_bib20","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jare.2022.10.014","article-title":"Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS\/STING signaling dependent on LKB1\/AMPK\/ULK1-mediated autophagy","volume":"51","author":"Lu","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.jep.2026.121327_bib21","doi-asserted-by":"crossref","DOI":"10.11604\/pamj.2022.41.34.30815","article-title":"Speciation and antifungal susceptibility of Candida isolates from diabetic foot ulcer patients in a tertiary hospital in Kenya","volume":"41","author":"Musyoki","year":"2022","journal-title":"Pan Afr Med. J."},{"key":"10.1016\/j.jep.2026.121327_bib22","series-title":"Surgery of Traditional Chinese Medicine","first-page":"198","year":"2020"},{"key":"10.1016\/j.jep.2026.121327_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/250201","article-title":"Glycemic variability assessed by continuous glucose monitoring and short-term outcome in diabetic patients undergoing percutaneous coronary intervention: an observational pilot study","author":"Nusca","year":"2015","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.jep.2026.121327_bib24","volume":"vol. 1","year":"2020"},{"key":"10.1016\/j.jep.2026.121327_bib26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3390\/antibiotics8040193","article-title":"Diabetic foot ulcers: current advances in antimicrobial therapies and emerging treatments","volume":"8","author":"Ramirez-Acu\u00f1a","year":"2019","journal-title":"Antibiotics"},{"issue":"5","key":"10.1016\/j.jep.2026.121327_bib27","first-page":"1187","article-title":"Ultra-short cyclic peptide Cy (RL-QN15) acts as a TLR4 antagonist to expedite oral ulcer healing","volume":"46","author":"Ru","year":"2025","journal-title":"Zool. Res."},{"key":"10.1016\/j.jep.2026.121327_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdiacomp.2019.107516","article-title":"Evaluation of a comprehensive diabetic foot ulcer care quality model","volume":"34","author":"Schechter","year":"2020","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.jep.2026.121327_bib30","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3390\/ph15050497","article-title":"Repurposing dimethyl fumarate for cardiovascular diseases: pharmacological effects, molecular mechanisms, and therapeutic promise","volume":"15","author":"Thomas","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jep.2026.121327_bib31","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202401299RR","article-title":"Homoplantaginin alleviates high glucose\u2010induced vascular endothelial senescence by inhibiting mtDNA\u2013cGAS\u2013STING pathway via blunting DRP1\u2013 mitochondrial fission \u2013VDAC1 axis","volume":"38","author":"Wang","year":"2024","journal-title":"FASEB J."},{"issue":"18","key":"10.1016\/j.jep.2026.121327_bib32","doi-asserted-by":"crossref","first-page":"19503","DOI":"10.1021\/acs.jmedchem.5c01734","article-title":"Cyclic heptapeptide FZ1 acts as an integrin alphavbeta3 agonist to facilitate diabetic skin wound healing by enhancing angiogenesis","volume":"68","author":"Wang","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jep.2026.121327_bib33","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.3390\/cells11213363","article-title":"Clinical evaluation tool for vascular health\u2013endothelial function and cardiovascular disease management","volume":"11","author":"Wen","year":"2022","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.jep.2026.121327_bib34","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.24272\/j.issn.2095-8137.2024.134","article-title":"Peptide Cy (RL-QN15) accelerates hair regeneration in diabetic mice by binding to the Frizzled-7 receptor","volume":"45","author":"Wu","year":"2024","journal-title":"Zool. Res."},{"key":"10.1016\/j.jep.2026.121327_bib36","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.4239\/wjd.v13.i12.1014","article-title":"Diabetic foot ulcer: challenges and future","volume":"13","author":"Yang","year":"2022","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.jep.2026.121327_bib37","doi-asserted-by":"crossref","first-page":"964","DOI":"10.2337\/dc19-1614","article-title":"Global disability burdens of diabetes-related lower-extremity complications in 1990 and 2016","volume":"43","author":"Zhang","year":"2020","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jep.2026.121327_bib39","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s11658-021-00283-8","article-title":"HIF-1\u03b1\/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury","volume":"26","author":"Zhao","year":"2021","journal-title":"Cell. Mol. Biol. Lett."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126001789?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126001789?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:15:13Z","timestamp":1776154513000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126001789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":32,"alternative-id":["S0378874126001789"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121327","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"San Huang decoction accelerates diabetic wound healing by restraining STING signaling to attenuate inflammation and enhance angiogenesis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121327","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"121327"}}